Mucins and TFF peptides of the tear film and lacrimal apparatus

Progress in Histochemistry and Cytochemistry

Volumn 41, Issue 1, 2006, Pages 1-53

  Paulsen, Friedrich P ^a   Berry, Monica S ^b  

^a MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

Author keywords

Conjunctiva; Cornea; Dry eye; Lacrimal apparatus; Lacrimal gland; MUC; Mucin; Nasolacrimal ducts; Ocular surface; Precorneal tear film; Preocular fluid; Rheology; Tear film; Tear outflow; TFF peptides

Indexed keywords

MUCIN; TREFOIL PEPTIDE;

ANTIMICROBIAL ACTIVITY; ARTICLE; DRY EYE; EPITHELIUM CELL; EYELID; FLOW KINETICS; HUMAN; LACRIMAL APPARATUS; MEMBRANE BINDING; NERVE CELL; PROTEIN SECRETION; SURFACE PROPERTY; TEAR FILM;

LOTUS; MAMMALIA;

EID: 33745207121     PISSN: 00796336     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.proghi.2006.03.001     Document Type: Article

References (275)

1. Aarbiou J., Verhoosel R.M., Van Wetering S., De Boer W.I., Van Krieken J., Litvinov S.V., et al. Neutrophil defensins enhance lung epithelial wound closure and mucin gene expression in vitro. Am J Respir Cell Mol Biol 30 (2004) 193-201
2. Abraham S.N., and Beachey E.H. Host defenses against adhesion of bacteria to mucosal surfaces. In: Gallin J.F., and Fauci A.S. (Eds). Advances in host defense mechanisms vol. 4 (1985), Raven Press, New York 63-88
3. Acosta M.C., Peral A., Luna C., Pintor J., Belmonte C., and Gallar J. Tear secretion induced by selective stimulation of corneal and conjunctival sensory nerve fibers. Invest Ophthalmol Vis Sci 45 (2004) 2333-2336
4. Aknin M.-L.R., Berry M., Dick A.D., and Khan-Lim D. Normal but not altered mucins activate neutrophils. Cell Tissue Res 318 (2004) 545-551
5. Allen M., Wright P., and Reid L. The human lacrimal gland A histochemical and organ culture study of the secretory cells. Arch Ophthalmol 88 (1972) 493-497
6. Amrith S., Goh P.S., and Wang S.-C. Tear flow dynamics in the human nasolacrimal ducts - a pilot study using dynamic magnetic resonance imaging. Graefe's Arch Clin Exp Ophthalmol 243 (2005) 127-131
7. Arango M.E., Li P., Komatsu M., Montes C., Carraway C.A., and Carraway K.L. Production and localization of Muc4/sialomucin complex and its receptor tyrosine kinase erbB2 in the rat lacrimal gland. Invest Ophthalmol Vis Sci 42 (2001) 2749-2756
8. Argüeso P., Herreras J.M., Calonge M., Citores L., Pastor J.C., and Girbes T. Analysis of human ocular mucus: effects of neuraminidase and chitinase enzymes. Cornea 17 (1998) 200-207
9. Argüeso P., Balaram M., Spurr-Michaud S., Keutmann H.T., Dana R., and Gipson I.K. Decreased levels of the goblet cell mucin MUC5AC in tears of patients with Sjogren syndrome. Invest Ophthalmol Vis Sci 43 (2002) 1004-1011
10. Argüeso P., Spurr-Michaud S., Russo C.L., Tisdale A., and Gipson I.K. MUC16 mucin is expressed by the human ocular surface epithelia and carries the H185 carbohydrate epitope. Invest Ophthalmol Vis Sci 44 (2003) 2487-2495
11. Ayub M., Thale A., Hedderich J., Tillmann B., and Paulsen F. The cavernous body of the human efferent tear ducts functions in regulation of tear outflow. Invest Ophthalmol Vis Sci 44 (2003) 4900-4907
12. Bacman S., Berra A., Sterin-Borda L., and Borda E. Muscarinic acetylcholine receptor antibodies as a new marker of dry eye Sjögren's syndrom. Invest Ophthalmol Vis Sci 42 (2001) 321-327
13. Basbaum C., Lemjabbar H., Longphre M., Li D., Gensch E., and McNamara N. Control of mucin transcription by diverse injury-induced signaling pathways. Am J Respir Crit Care Med 160 (1999) 44-48
14. Bast Jr. R.C., Feenay M., Lazarus H., Nadler L.M., Colvin R.B., and Knapp R.C. Reactivity of a monoclonal antibody with human ovarian carcinoma. J Clin Invest 68 (1981) 1331-1337
15. Baudouin C. The pathology of dry eye. Surv Ophthalmol 45 (2001) S211-S220
16. Baughan L.W., Robertello F.J., Sarrett D.C., Denny P.A., and Denny P.C. Salivary mucin as related to oral Streptococcus mutans in elderly people. Oral Microbiol Immunol 15 (2000) 10-14
17. Baus-Loncar M., and Giraud A.S. Trefoil factors multiple regulatory pathways for trefoil factor (TFF) genes cell. Mol Life Sci 62 (2005) 2921-2931
18. Baus-Loncar M., Kayademir T., Takaishi S., and Wang T. Trefoil factor family 2 deficiency and immune response. Cell Mol Life Sci 62 (2005) 2947-2955
19. Belmonte C., Gallar J., Pozo M.A., and Rebollo I. Excitation by irritant chemical substances of sensory afferent units in the cat's cornea. J Physiol 437 (1991) 709-725
20. Belmonte C., Acosta M.C., and Gallar J. Neural basis of sensation in intact and injured corneas. Exp Eye Res 78 (2004) 513-525
21. Berry M., Ellingham R.B., and Corfield A.P. Polydispersity of normal human conjunctival mucins. Invest Ophthalmol Vis Sci 37 (1996) 2559-2571
22. Berry M., Ellingham R.B., and Corfield A.P. Membrane-associated mucins in normal human conjunctiva. Invest Ophthalmol Vis Sci 41 (2000) 398-403
23. Berry M., McMaster T.J., Corfield A.P., and Miles M.J. Exploring the molecular adhesion of ocular mucins. Biomacromolecules 2 (2001) 498-503
24. Berry M., Harris A., Lumb R., and Powell K. Commensal ocular bacteria degrade mucins. Br J Ophthalmol 86 (2002) 1412-1416
25. Berry M., Corfield A.P., Harris A., and Khan-Lim D. Functional processing of ocular mucins. Adv Exp Med Biol 506 Pt A (2002) 283-288
26. Berry M., Harris A., and Corfield A.P. Patterns of mucin adherence to contact lenses. Invest Ophthalmol Vis Sci 44 (2003) 567-572
27. Berry M., Brayshow D.J., and McMaster T.J. Dynamic molecular resolution imaging of preocular fluid impressions. Br J Ophthalmol 88 (2004) 1460-1466
28. Berry M., Ellingham R.B., and Corfield A.P. Human preocular mucins reflect changes in surface physiology. Br J Ophthalmol 88 (2004) 377-383
29. Brayshow D.J., Berry M., and McMaster T.J. Optimisation of sample preparation methods for air imaging of ocular mucins by AFM. Ultramicroscopy 97 (2003) 289-296
30. Brayshow D.J., Berry M., and McMaster T.J. Molecular adsorption: early stage surface exploration. Ultramicroscopy 100 (2004) 145-151
31. Bron A.J., Benjamin L., and Snibson G.R. Meibomian gland disease. Classification and grading of lid changes eye 5 (1991) 395-411
32. Busse H., and Müller K. Zur Enstehung der idiopathischen Dakryostenose. Klin Monatsbl Augenheilkd 170 (1977) 627-632
33. Calonge M., Diebold Y., Saez B., Enriquez de Salamanca A., Garcia-Vazquez C., Corrales R.M., et al. Impression cytology of the ocular surface: a review. Exp Eye Res 78 (2004) 457-472
34. Carlstedt I., Lindgren H., and Sheehan J.K. The macromolecular structure of human cervical mucus glycoproteins. J Biochem 213 (1983) 427-435
35. Carlstedt I., Sheenan J.K., Corfield A.P., and Gallagher J.T. Mucous glycoproteins: a gel of a problem. Essays Biochem 20 (1985) 40-76
36. Carlstedt I., Herrmann A., Hovenberg H., Lindell G., Nordman H., Wickström C., et al. 'Soluble' and 'insoluble' mucins - identification of distinct populations. Biochem Soc Trans 23 (1995) 845-851
37. Carraway K.L., Price-Schiavi S.A., Komatsu M., Idris N., Perez A., Li P., et al. Multiple facets of sialomucin complex/MUC4, a membrane mucin and erbb2 ligand, in tumors and tissues (Y2K update). Front Biosci 5 (2000) D95-D107
38. Carraway K.L., Perez A., Idris N., Jepson S., Arango M., Komatsu M., et al. Muc4/sialomucin complex, the intramembrane ErbB2 ligand, in cancer and epithelia: to protect and to survive. Prog Nucl Acid Res Mol Biol 71 (2002) 149-185
39. Celli J., Gregor B., Turner B., Afdhal N.H., Bansil R., and Erramilli S. Viscoelastic properties and dynamics of porcine gastric mucin. Biomacromolecules 6 (2005) 1329-1333
40. Chen H.B., Yamabayashi S., Ou B., Tanaka Y., Ohno S., and Tsukahara S. Structure and composition of rat precorneal tear film. A study by an in vivo cryofixation. Invest Ophthalmol Vis Sci 38 (1997) 381-387
41. Chen Y.-H., Lu Y., De Plaen I.G., Wang L.-Y., and Tan X.-D. Transcription factor NF-κB signals antianoikic function of trefoil factor 3 on intestinal epithelial cells. Biochem Biophys Res Commun 274 (2000) 576-582
42. Chinery R., Wllliamson J., and Poulsom R. The gene encoding human intestinal trefoil factor (TFF3) is located on chromosome 21q223 clustered with other members of the trefoil peptide family. Genomics 32 (1996) 281-284
43. Chodosh J., Nordquist R.E., and Kennedy R.C. Comparative anatomy of mammalian conjunctival lymphoid tissue: a putative mucosal immune site. Dev Comp Immunol 22 (1998) 621-630
44. Connor C.G., Campbell J.B., Steel S.A., and Burker J.H. The effects of daily wear contact lenses on goblet cell density. J Am Optom Assoc 65 (1994) 792-794
45. Corfield T. Bacterial sialidases - roles in pathogenicity and nutrition. Glycobiology 2 (1992) 509-521
46. Corfield A.P., Carrington S.D., Hicks S.J., Berry M., and Ellingham R. Ocular mucins: purification, metabolism and functions. Prog Retinal Eye Res 16 (1997) 627-656
47. Corfield A.P., Caroll D., Myerscough N., and Probert C.S. Mucins in the gastrointestinal tract in health and disease. Front Biosci 6 (2001) D1321-D1357
48. Corfield A.P., Donapaty S.R., Carrington S.D., Hicks S.J., Schauer R., and Kohla G. Identification of 9-O-acetyl-N-acetylneuraminic acid in normal canine pre-ocular tear film secreted mucins and its depletion in Keratoconjunctivitis sicca. Glycoconj J 22 (2005) 409-416
49. Corrales R.M., Calonge M., Herreras J.M., Saez V., Mayo A., and Chaves F.J. Levels of mucin gene expression in normal human conjunctival epithelium in vivo. Curr Eye Res 27 (2003) 323-328
50. Corrales R.M., Calonge M., Herreras J.M., Saez V., and Chaves F.J. Human epithelium from conjunctival impression cytology expresses MUC7 mucin gene. Cornea 22 (2003) 665-671
51. Dana M.R., and Hamrah P. Role of immunity and inflammation in corneal and ocular surface disease associated with dry eye. Adv Exp Med Biol 506 Pt B (2002) 729-738
52. Danjo Y., Watanabe H., Tisdale A.S., George M., Tsumura T., Abelson M.B., et al. Alteration of mucin in human conjunctival epithelia in dry eye. Invest Ophthalmol Vis Sci 39 (1998) 2602-2609
53. Davies J.R., Hovenberg H.W., Linden C.J., Howard R., Richardson P.S., Sheehan J.K., et al. Mucins in airway secretions from healthy and chronic bronchitic subjects. Biochem J 313 (1996) 431-439
54. Denton D.A., Nelson J.F., and Tarjan E. Water and salt intake of wild rabbits (Oryctolagus cuniculus (L)) following dipsogenic stimuli. J Physiol 326 (1985) 285-301
55. Desseyn J.L., Aubert J.P., Porchet N., and Laine A. Evolution of the large secreted gel-forming mucins. Mol Biol Evol 17 (2000) 1175-1184
56. Diebold Y., Rios J.D., Hodges R.R., Rawe I., and Dartt D.A. Presence of nerves and their receptors in mouse and human conjunctival goblet cells. Invest Ophthalmol Vis Sci 42 (2001) 2270-2282
57. Duke-Elder S. Trachoma and allied infections. Trans Ophthalmol Soc UK 81 (1961) 343-349
58. Duke-Elder S.S., and Gloster J. The protective mechanism. The movements of the eyelids. In: Duke-Elder S.S. (Ed). System of ophthalmology the physiology of the eye and of vision vol. 4 (1968), Henry Kimpton, London 414-419
59. Dwyer T.M., and Farley J.M. Human neutrophil elastase releases two pools of mucinlike glycoconjugate from tracheal submucosal gland cells. Am J Physiol Lung Cell Mol Physiol 278 (2000) L675-L682
60. Einerhand A.W., Renes I.B., Makkink M.K., van der Sluis M., Buller H.A., and Decker J. Role of mucins in inflammatory bowel disease: important lessons from experimental models. Eur J Gastroenterol Hepatol 14 (2002) 757-765
61. Ellingham R.B., Berry M., Stevenson D., and Corfield A.P. Secreted human conjunctival mucus contains MUC5AC glycoforms. Glycobiology 9 (1999) 1181-1189
62. Engelmann K., Kinlough C.L., Müller S., Razawi H., Baldus S.E., Hughey R.P., et al. Transmembrane and secreted MUC1 probes show trafficking-dependent changes in O-glycan core profiles. Glycobiology 15 (2005) 1111-1124
63. Enss M.L., Cornberg M., Wagner S., Gebert A., Henrichs M., Eisenblatter R., et al. Proinflammatory cytokines trigger MUC gene expression and mucin release in the intestinal cancer cell line LS180. Inflamm Res 49 (2000) 162-169
64. Faillard H., and Schauer R. Glycoproteins as lubricants, protective agents, carriers, structural proteins and as participants in other functions. In: Gottschalk A. (Ed). Their compostion, structure, and function. 2nd ed. Part B (1972), Amsterdam, Elsevier 1246-1267
65. Fischer B.M., and Voynow J.A. Neutrophil elastase induces MUC5AC gene expression in airway epithelium via a pathway involving reactive oxygen species. Am J Respir Cell Mol Biol 26 (2002) 447-452
66. Fischer B.M., Cuellar J.G., Diehl M.L., deFreytas A.M., Zhang J., Carraway K.L., et al. Neutrophil elastase increases MUC4 expression in normal human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol 284 (2003) L671-L679
67. Fisk B., Hudson J.M., Kavanagh J., Wharton J.T., Murray J.L., Ioannides C.G., et al. Existent proliferative responses of peripheral blood mononuclear cells from healthy donors and ovarian cancer patients to HER-2 peptides. Anticancer Res 17 (1997) 45-53
68. Fleiszig S.M.J., Zaidi T.S., Ramphal R., and Pier G.B. Modulation of Pseudomonas aeruginosa adherence to the corneal surface by mucus. Infect Immun 62 (1994) 1799-1804
69. Florey H.W. Observations on the functions of mucus and the early stages of bacterial invasion of the intestinal mucosa. J Pathol Bacteriol 37 (1933) 283-289
70. Forstner J.F. Intestinal mucins in health and disease. Digestion 17 (1978) 234-263
71. Foulks G.N., and Bron A. Meibomian gland dysfunction: a clinical scheme for description, diagnosis, classification, and grading. Ocular Surf 1 (2003) 107-126
72. Gallar J., Pozo M.A., Tuckett R.P., and Belmonte C. Response of sensory units with unmyelinated fibres to mechanical, thermal and chemical stimulation of the cat's cornea. J Physiol 468 (1993) 609-622
73. Gao J., Schwalb T.A., Adedeo J.V., Ghosn C.R., and Stern M.E. The role of apoptosis in the pathogenesis of canine keratoconjunctivitis sicca: the effect of topical Cyclosporin A therapy. Cornea 17 (1998) 654-663
74. Gao J., Cha S., Jonsson R., Opalko J., and Peck A.B. Detection anti-type 3 muscarinic acetylcholine receptor autoantibodies in the sera of Sjögrens's syndrome patients by use of a transfected cell line assay. Arthritis Rheum 50 (2004) 2615-2621
75. Gipson I.K., Moccia R., Spurr-Michaud S., Argüeso P., Gargiulo A.R., Hill III J.A., et al. The Amount of MUC5B mucin in cervical mucus peaks at midcycle. J Clin Endocrinol Metab 86 (2001) 594-600
76. Gipson I.K., Spurr-Michaud S.J., Tisdale A.D., Kublin C., Cintron C., and Keutmann H. Stratified squamous epithelia produce mucin-like glycoproteins. Tissue Cell 27 (1995) 397-404
77. Gormezano I., Schneiderman N., Deaux E., and Fuentes I. Nictitating membrane: classical conditioning and extinction in the albino rabbit. Science 138 (1962) 33-34
78. Gururaja T.L., Ramasubbu N., Venugopalan P., Reddy M.S., Ramalingam L., and Levine M.J. Structural features of the human salivary mucin, MUC7. Glycoconj J 15 (1998) 457-467
79. Gururaja T.L., Levine J.H., Tran D.T., Naganagowda G.A., Ramalingam K., Ramasubbu N., et al. Candidacidal activitiy prompted by N-terminus histatin-like domain of human salivary mucin (MUC7). Biochim Biophys Acta 1431 (1999) 107-119
80. Halben R. Beiträge zur Anatomie der Tränenwege. Albrecht von Graefe's Arch Klin Exp Ophthalmol 57 (1904) 61-92
81. Halila M. Detection of ovarian cancer marker CA 125 in human seminal plasma. Tumour Biol 6 (1985) 207-212
82. Hanisch F.G., Uhlenbruck G., Dienst C., Stottrop M., and Hippauf E. Ca 125 and Ca 19-9: two cancer-associated sialylsaccharide antigens on a mucus glycoprotein from human milk. Eur J Biochem 149 (1985) 323-330
83. Hauser F., Poulsom R., Chinery R., Rogers L.A., Handby A.M., Wright N.A., et al. hP1B, a human P-domain peptide homologous with rat intestinal trefoil factor, is expressed also in the ulcer-associated cell lineage and the uterus. Proc Natl Acad Sci USA 90 (1993) 6961-6965
84. Herrmann A., Davies J.R., Lindell G., Martensson S., Packer N.H., Swallow D.M., et al. Studies on the "insoluble" glycoprotein complex from human colon Identification of reduction-insensitive MUC2 oligomers and C-terminal cleavage. J Biol Chem 274 (1999) 15828-15836
85. Hingorani M., Metz D., and Lightman S.L. Characterisation of the normal conjunctival leukocyte population. Exp Eye Res 64 (1997) 905-912
86. Hodges R.R., and Dartt D.A. Regulatory pathways in lacrimal gland epithelium. Int Rev Cytol 231 (2003) 129-200
87. Hodges R.R., Zoukhri D., Sergheraert C., Zieske J.D., and Dartt D.A. Identification of vasoactive intestinal peptide receptor subtypes in the lacrimal gland and their signal-transducing components. Invest Ophthalmol Vis Sci 38 (1997) 610-619
88. Hodson S.A. Corneal stromal swelling. Prog Ret Eye Res 16 (1997) 99-116
89. Hoffmann W., and Joba W. Biosynthesis and molecular architecture of gel-forming mucins: implications for an amphibian model system. Biochem Soc Trans 23 (1995) 805-810
90. Hoffmann W., and Jagla W. Cell type specific expression of secretory TFF peptides: colocalization with mucins and synthesis in the brain. Int Rev Cytol 213 (2001) 147-181
91. Hoffmann W., Jagla W., and Wiede A. Molecular medicine of TFF-peptides: from gut to brain. Histol Histopathol 16 (2001) 319-334
92. Hoffmann W. Trefoil factors TFF (trefoil factor family) peptide-triggered signals promoting mucosal restitution. Cell Mol Life Sci 62 (2005) 2932-2938
93. Hori Y., Spurr-Michaud S., Russo C.L., Argüeso P., and Gipson I.K. Differential regulation of membrane-associated mucins in the human ocular surface epithelium. Invest Ophthalmol Vis Sci 45 (2004) 114-122
94. Hu Y., Carvajal M.E., and Carraway K.J. Sialomucin complex (rMuc4) expression during development of the rat cornea. Curr Eye Res 21 (2000) 820-823
95. Hutch J.A. The role of urethral mucus in the bladder defense mechanism. J Urol 103 (1970) 165-167
96. Imbert Y., Darling D.S., Jumblatt M.M., Foulks G.N., Couzin E.G., Steele P.S., and Young Jr. W.W. Muc1 splice variants in human ocular surface tissues: possible differences between dry eye patients and normal controls. ARVO abstract 5596-B366 (2006)
97. Ito T., and Shibasaki S. Lichtmikroskopische Untersuchungen über die Glandula lacrimalis des Menschen. Arch Histol Jap 25 (1964) 117-144
98. Jagla W., Wiede A., Dietzmann K., Gulicher D., Gerlach K.L., and Hoffmann W. Secretion of TFF-peptides by human salivary glands. Cell Tissue Res 298 (1999) 161-166
99. Jansen A., Varoga D., Woon C.W., Podolsky D., Barker N., and Paulsen F. Restitution of wounded cornea by TFF-peptides. ARVO Abstract 58 (2004) 1413
100. Jensen O.A., Falbe-Hansen I., Jacobsen T., and Michelsen A. Mucosubstances of the acini of the human lacrimal gland (orbital part) I. Histochemical identification. Acta Ophthalmol (Copenh) 47 (1969) 605-619
101. Jepson S., Komatsu M., Haq B., Arango M.E., Huang D., Carraway C.A., et al. Muc4/sialomucin complex, the intramembrane ErbB2 ligand, induces specific phosphorylation of ErbB2 and enhances expression of p27(kip), but does not activate mitogen-activated kinase or protein kinaseB/Akt pathways. Oncogene 21 (2002) 7524-7532
102. Johnson M.E., and Murphy P.J. Changes in the tear film and ocular surface from dry eye syndrome. Prog Retin Eye Res 23 (2004) 449-474
103. Jones L.T. The lacrimal apparatus: practical fundamentals of anatomy and physiology. Trans Am Acad Ophthalmol Otolaryngol 62 (1958) 669-687
104. Jumblatt J.E., Cunningham L.T., Li Y., and Jumblatt M.M. Characterization of human ocular mucin secretion mediated by 15(S)-HETE. Cornea 21 (2002) 818-824
105. Jumblatt M.M., McKenzie R.W., Steele P.S., Emberts C.G., and Jumblatt J.E. MUC7 expression in the human lacrimal gland and conjunctiva. Cornea 22 (2003) 41-45
106. Jung H.H., Lee J.H., Kim Y.T., Lee S.D., and Park J.H. Expression of mucin genes in chronic ethmoiditis. Am J Rhino 14 (2000) 163-170
107. Kabawat S.E., Bast Jr. R.C., Bhan A.K., Welch W.R., and Knapp R.C. Tissue distribution of a coelomic-epithelium-related antigen recognized by the monoclonal antibody OC125. Int J Gynecol Pathol 2 (1983) 275-285
108. Kakizaki H., Zako M., Miyaishi O., Nakano T., Asamoto K., and Iwaki M. The lacrimal canaliculus and sac bordered by the Horner's muscle form the functional lacrimal drainage system. Ophthalmology 112 (2005) 710-716
109. Kessler T.L., Mercer H.J., Zieske J.D., McCarthy D.M., and Dartt D.A. Stimulation of goblet cell mucous secretion by activation of nerves in rat conjunctiva. Curr Eye Res 14 (1995) 985-992
110. Kim C.H., Kim H.J., Song K.S., Seong J.K., Kim K.S., Lee J.G., et al. MUC8 as a ciliated cell marker in human nasal epithelium. Acta Otolaryngol 125 (2005) 76-81
111. Kim K.C., Wasano K., Niles R.M., Schuster J.E., Stone P.J., and Brody J.S. Human neutrophil elastase releases cell surface mucins from primary cultures of hamster tracheal epithelial cells. Proc Natl Acad Sci USA 84 (1987) 9304-9308
112. Kim K.C., Lee B.C., Pou S., and Ciccolella D. Effects of activation of polymorphonuclear leukocytes on airway goblet cell mucin release in a co-culture system. Inflamm Res 52 (2003) 258-262
113. King-Smith P.E., Fink B.A., Fogot N., Nichols K.K., Hill R.M., and Wilson G.S. The thickness of the human precorneal tear film: evidence from reflection spectra. Invest Ophthalmol Vis Sci 41 (2000) 3348-3359
114. Knop N., and Knop E. Conjunctiva-associated lymphoid tissue in the human eye. Invest Ophthalmol Vis Sci 41 (2000) 1270-1279
115. Knop E., Knop N., and Pleyer U. In: Kriegelstein G.K., and Weinreb R.N. (Eds). Clinical aspects of MALT. Uveitis and immunological disorders (2005), Springer, Berlin, Heidelberg 67-87
116. Knop E., and Knop N. Lacrimal drainage-associated lymphoid tissue (LDALT): a part of the human mucosal immune system. Invest Ophthalmol Vis Sci 42 (2001) 566-574
117. Kohri K., Ueki I.F., and Nadel J.A. Neutrophil elastase induces mucin production by ligand-dependent epidermal growth factor receptor activation. Am J Physiol Lung Cell Mol Physiol 283 (2002) L531-L540
118. Komatsu M., Arango M.E., and Carraway K.L. Synthesis and secretion of Muc4/sialomucin complex: implication of intracellular proteolysis. Biochem J 368 (2002) 41-48
119. Kovacs I., Ludany A., Koszegi T., Feher J., Kovacs B., Szolcsanyi J., et al. Substance P released from sensory nerve endings influences tear secretion and goblet cell function in the rat. Neuropeptides 39 (2005) 395-402
120. Krause CFT. Handbuch der menschlichen Anatomie, vol. 1, Part 2. 2nd ed. Hannover: Hahn, 1842. p. 514-9.
121. Krause WJ. Hilfsorgane des Auges. In: Krause WJ, editor. Allgemeine und microscopische Anatomie. vol. 89. Hannover: Hahn. 1876. p. 550-72, 138-40 [Z Zellforsch].
122. Kuerer H.M., Peoples G.E., Sahin A.A., Murray J.L., Singletary S.E., Castilleja A., et al. Axillary lymph node cellular immune response to HER-2/neu peptides in patients with carcinoma of the breast. J Interferon Cytokine 22 (2002) 583-592
123. Kühnel W. Vergleichende histologische, histochemische und elektronen-mikroskopische Untersuchungen an Tränendrüsen. Z Zellforsch 89 (1968) 550-572
124. Lamblin G., Degroote S., Perini J.M., Delmotte P., Scharfman A., Davril M., et al. Human airway mucin glycosylation: a combinatory of carbohydrate determinants which vary in cystic fibrosis. Glycoconj J 18 (2001) 661-684
125. Lange C., Fernandez J., Shim D., Spurr-Michaud S., Tisdale A., and Gipson I.K. Mucin gene expression is not regulated by estrogen and/or progesterone in the ocular surface epithelia of mice. Exp Eye Res 77 (2003) 59-68
126. Langer G., Jagla W., Behrens-Baumann W., Walters S., and Hoffmann W. Secretory peptides TFF1 and TFF3 synthesized in human conjunctival goblet cells. Invest Ophthalmol Vis Sci 40 (1999) 2220-2224
127. Leiper K., Campbell B.J., Jenkinson M.D., Milton J., Yu L.G., Democratis J., et al. Interaction between bacterial peptides, neutrophils and goblet cells: a possible mechanism for neutrophil recruitment and goblet cell depletion in colitis. Clin Sci (Lond) 101 (2001) 395-402
128. Lemjabbar H., and Basbaum C. Platelet-activating factor receptor and ADAM10 mediate responses to Staphylococcus aureus in epithelial cells. Nat Med 8 (2002) 41-46
129. Lemp M.A. Report of the National Eye Institute/Industry workshop on clinical trials in dry eyes. CLAO J 21 (1995) 221-232
130. Lemullois M., Rossignol B., and Maudit P. Immunolocalization of myoepithelial cells in isolated acini of rat exorbital lacrimal gland: cellular distribution of muscarinic receptors. Biol Cell 86 (1996) 175-181
131. Li J.D., Dohrman A.F., Gallup M., Miyata S., Gum J.R., Kim Y.S., et al. Transcriptional activation of mucin by Pseudomonas aeruginosa lipopolysaccharide in the pathogenesis of cystic fibrosis lung disease. Proc Natl Acad Sci USA 94 (1997) 967-972
132. Lin J., Tsuprun V., Kawano H., Paparella M.M., Zhang Z., Anway R., et al. Characterization of mucins in human middle ear and Eustachian tube. Am J Physiol Lung Cell Mol Physiol 280 (2001) L1157-L1167
133. Linberg J.V. Discussion of lacrimal sac daryoliths. Ophthalmology 108 (2001) 1312
134. Linberg J.V., and McCormick S.A. Primary acquired nasolacrimal duct obstruction A clinicopathologic report and biopsy technique. Ophthalmology 93 (1986) 1055-1063
135. Liu Z., Carvajal M., Carothers Carraway C.A., Carraway K.L., and Pflugfelder S.C. Increased expression of the type 1 growth factor receptor family in the conjunctival epithelium of patients with keratoconjunctivitis sicca. Am J Ophthalmol 129 (2000) 472-480
136. Liu B., Rayment S.A., Gyurko C., Oppenheim F.G., Offner G.D., and Troxler R.F. The recombinant N-terminal region of human salivary mucin MG2 (MUC7) contains a binding domain for oral Streptococci and exhibits candidacidal activity. Biochem J 345 (2000) 557-564
137. Lomako J., Lomako W.M., Decker S.J., Carraway C.A., and Carraway K.L. Non-apoptotic desquamation of cells from corneal epithelium: putative role for Muc4/sialomucin complex in cell release and survival. J Cell Physiol 202 (2005) 115-124
138. Longman R.J., Douthwaite J., Sylvester P.A., Poulsom R., Corfield A.P., Thomas M.G., et al. Coordinated localisation of mucins and trefoil peptides in the ulcer associated cell lineage and the gastrointestinal mucosa. Gut 47 (2000) 792-800
139. Mauriello Jr. J.A., Palydowycz S., and DeLuca J. Clinicopathologic study of lacrimal sac and nasal mucosa in 44 patients with complete acquired nasolacrimal duct obstruction. Ophthal Plast Reconstr Surg 8 (1992) 13-21
140. McCulley J.P., and Shine W.E. Meibomian gland function and the tear lipid layer. Ocular Surf 1 (2003) 97-106
141. McDermott A.M. Defensins and other antimicrobial peptides at the ocular surface. Ocular Surf 2 (2004) 229-247
142. McKenzie R.W., Jumblatt J.E., and Jumblatt M.M. Quantification of MUC2 and MUC5AC transcripts in human conjunctiva. Invest Ophthalmol Vis Sci 41 (2000) 703-708
143. McLemore M.R., and Aouizerat B. Introducing the MUC16 gene: implications for prevention and early detection in epithelial ovarian cancer. Biol Res Nurs 6 (2005) 262-267
144. McNamara N.A. Innate defense of the ocular surface. Eye Contact Lens 29 Suppl 1 (2003) S10-S13 (discussion S26-9, S192-4)
145. McNeer R.R., Carraway C.A., Fregien N.L., and Carraway K.L. Characterization of the expression and steroid hormone control of sialomucin complex in the rat uterus: implications for uterine receptivity. J Cell Physiol 176 (1998) 110-119
146. McNamara N.A., Andika R., Kwong M., Sack R.A., and Fleiszig S.M. Interaction of Pseudomonas aeruginosa with human tear fluid components. Curr Eye Res 30 (2005) 517-525
147. Mehrotra R., Thornton D.J., and Sheehan J.K. Isolation and physical characterization of the MUC7 (MG2) mucin from slaiva: evidence for self association. Biochem J 334 (1998) 415-422
148. Millar T.J., Herok G., Koutavas H., Martin D.K., and Anderton P.J. Immunohistochemical and histochemical characterization of epithelial cells of rabbit lacrimal glands in tissue sections and cell cultures. Tissue Cell 28 (1996) 301-312
149. Mitchell S., Abel P., Madaan S., Jeffs J., Chaudhary K., Stamp G., et al. Androgen-dependent regulation of human MUC1 mucin expression. Neoplasia 4 (2002) 9-18
150. Mitoma J., Petryniak B., Hiraoka N., Yeh J.C., Lowe J.B., and Fukuda M. Extended core 1 and core 2 branched O-glycans differentially modulate sialyl Lewis X-type L-selectin ligand activity. J Biol Chem 278 (2003) 9953-9961
151. Moniaux N., Escande F., Batra S.K., Porchet N., Laine A., and Aubert J.P. Alternative splicing generates a family of putative secreted and membrane-associated MUC4 mucins. Eur J Biochem 267 (2000) 4536-4544
152. Muskett F.W., May F.E., Westley B.R., and Feeney J. Solution structure of the disulfide-linked dimer of human intestinal trefoil factor (TFF3): the intermolecular orientation and interactions are markedly different from those of other dimeric trefoil proteins. Biochemistry 42 (2003) 15139-15147
153. Nguyen D.H., Toshida H., Schurr J., and Beuermann R.W. Microarray analysis of the rat lacrimal gland following the loss of parasympathetic control of secretion. Physiol Genomics 18 (2004) 108-118
154. Nielsen P.A., Bennett E.P., Wandall H.H., Therkildsen M.H., Hannibal J., and Clausen H. Identification of a major human high molecular weight salivary mucin (MG1) as tracheobronchial mucin MUC5B. Glycobiology 7 (1997) 413-419
155. Norn M. Tear stix tests for leucocyte-esterase, nitrite, haemoglobin, and albumin in normals and in a clinical series. Acta Ophthalmol (Copenh) 67 (1989) 192-198
156. Norn M.S. Corneal and superficial conjunctival pigmentation in Eskimos, Mongols, and Caucasians. Acta Ophthalmol (Copenh) 63 (1985) 454-458
157. Österlind G. An investigation into the presence of lymphatic tissue in the human conjunctiva, and its biologic and clinical importance. Acta Ophthalmol 23 (1944) 1-79
158. Otto W.R., and Thim L. Trefoil factors Trefoil factor family-interacting proteins. Cell Mol Life Sci 62 (2005) 2939-2946
159. Owens H., and Phillips J. Spreading of the tears after a blink: velocity and stabilization time in healthy eyes. Cornea 20 (2001) 484-487
160. Paulsen F., Thale A., Kohla G., Schauer R., Rochels R., Parwaresch R., et al. Functional anatomy of human lacrimal duct epithelium. Anat Embryol (Berl) 198 (1998) 1-12
161. Paulsen F., Thale A., Hallmann U., Schaudig U., and Tillmann B. The cavernous body of the human efferent tear ducts - function in tear outflow mechanism. Invest Ophthalmol Vis Sci 41 (2000) 965-970
162. Paulsen F., Hallmann U., Paulsen J., and Thale A. Innervation of the cavernous body of the human efferent tear ducts and function in tear outflow mechanism. J Anat 197 (2000) 373-381
163. Paulsen F., Paulsen J., Thale A., and Tillmann B. Mucosa-associated lymphoid tissue (MALT) in the human efferent tear ducts. Virchows Arch 437 (2000) 185-189
164. Paulsen F., Pufe T., Schaudig U., Held-Feindt J., Lehmann J., Schröder J.-M., et al. Detection of natural peptide antibiotics in human nasolacrimal ducts. Invest Ophthalmol Vis Sci 42 (2001) 2157-2163
165. Paulsen F., Thale A., Maune S., and Tillmann B. Primary acquired dacryostenosis - histopathology and pathophysiology. Ophthalmology 108 (2001) 2329-2336
166. Paulsen F., Pufe T., Schaudig U., Held-Feindt J., Lehmann J., Schröder J.-M., et al. Protection of human efferent tear ducts by antimicrobial peptides. Adv Exp Med Biol 506 (2002) 547-553
167. Paulsen F., Paulsen J., Thale A., Schaudig U., and Tillmann B. Organized mucosa associated lymphoid tissue in human nasolacrimal ducts. Adv Exp Med Biol 506 (2002) 873-876
168. Paulsen F., Föge M., Thale A., Tillmann B., and Mentlein R. Absorption of lipophilic substances from tear fluid by the epithelium of the nasolacrimal ducts. Invest Ophthalmol Vis Sci 43 (2002) 3137-3143
169. Paulsen F., Thale A., and Schaudig U. Ableitende Tränenwege und Trockenes Auge. Ophthalmologe 99 (2002) 566-574
170. Paulsen F.P., Hinz M., Schaudig U., Thale A.B., and Hoffmann W. TFF-peptides in the human efferent tear ducts. Invest Ophthalmol Vis Sci 43 (2002) 3359-3364
171. Paulsen F. The human nasolacrimal ducts. Adv Anat Embryol Cell Biol 170 (2003) 1-106
172. Paulsen F., Schaudig U., and Thale A. Drainage of tears - impact on the ocular surface and lacrimal system. Ocular Surf 1 (2003) 180-191
173. Paulsen F., Corfield A., Hinz M., Hoffmann W., Schaudig U., Thale A., et al. Characterization of mucins in human lacrimal sac and nasolacrimal duct. Invest Ophthalmol Vis Sci 44 (2003) 1807-1813
174. Paulsen F., Langer G., Hoffmann W., and Berry M. Human lacrimal gland mucins. Cell Tissue Res 316 (2004) 167-177
175. Paulsen F., Corfield A., Hinz M., Hoffmann W., Schaudig U., Thale A., et al. Tränenabfluss - Bedeutung von Muzinen und TFF-Peptiden. Ophthalmologe 101 (2004) 19-24
176. Paulsen F., Varoga D., Steven P., and Pufe T. Antimicrobial peptides at the ocular surface. In: Zierhut M., Stern M.E., and Sullivan D.A. (Eds). Immunology of lacrimal gland and tear film (2005), Taylor & Francis, London 97-104
177. Paulsen F., Schaudig U., Fabian A., Ehrich D., and Sel S. Production of TFF peptides and single mucins is augmented in dacryolithiasis. Graefe′s Arch Clin Exp Ophthalmol (2006) (in press)
178. Pavlidis M., Stupp T., Grenebach U., Busse H., and Thanos S. Ultrasonic visualization of the effect of blinking on the lacrimal pump mechanism. Graefe's Arch Clin Exp Ophthalmol 243 (2005) 228-234
179. Paz H.B., Tisdale A.S., Danjo Y., Spurr-Michaud S.J., Argüeso P., and Gipson I.K. The role of calcium in mucin packaging within goblet cells. Exp Eye Res 77 (2003) 69-75
180. Perez A., Barco R., Fernandez I., Price-Schiavi S.A., and Carraway K.L. PEA3 transactivates the Muc4/sialomucin complex promoter in mammary epithelial and tumor cells. J Biol Chem 278 (2003) 36942-36952
181. Perra M.T., Serra A., Sirigu P., and Turno F. A histochemical and immunohistochemical study of certain defense mechanisms in the human lacrimal sac epithelium. Arch Histol Cytol 58 (1995) 517-522
182. Pettersen C.A., and Adler K.B. Airways inflammation and COPD: epithelial-neutrophil interactions. Chest 121 Suppl 5 (2002) 142S-150S
183. Peuravuori H., Aho V.V., Aho H.J., Collan Y., and Saari K.M. Bactericidal/permeability-increasing protein in lacrimal gland and in tears of healthy subjects. Graefe's Arch Clin Exp Ophthalmol 26 (2005) 1-6
184. Pflugfelder S.C., and Stern M.E. Dry eye: inflammation of the lacrimal functional unit. In: Kriegelstein G.K., and Weinreb R.N. (Eds). Uveitis and immunological disorders (2005), Springer, Berlin, Heidelberg 11-22
185. Pflugfelder S.C., Liu Z., Monroy D., Li D.-Q., Carvajal M., Price-Schiavi S.A., et al. Detection of sialomucin complex (MUC4) in human ocular surface epithelium and tear fluid. Invest Ophthalmol Vis Sci 41 (2000) 1316-1326
186. Pigott N.H., Henry J.A., May F.E.B., and Westley B.R. Antipeptide antibodies against the pNR-2 oestrogen-regulated protein of human breast cancer cells and detection of pNR-2 expression in normal tissues by immunohistochemistry. J Pathol 163 (1991) 95-104
187. Pisella P.J., Malet F., Lejeune S., Brignole F., Debbasch C., Bara J., et al. Ocular surface changes induced by contact lens wear. Cornea 20 (2001) 820-825
188. Porchet N., and Aubert J.P. MUC genes: mucin or not mucin ? That is the question. M S-Med Sci 20 (2004) 569-574
189. Prakobphol A., Tangemann K., Rosen S.D., Hoover C.I., Leffler H., and Fischer S.J. Separate oligosaccharide determinants mediate interactions of the low-molecular-weight salivary mucin with neutrophils and bacteria. Biochemistry 38 (1999) 6817-6825
190. Prydal J.I., and Campbell F.W. Study of precorneal tear film thickness and structure by interferometry and confocal microscopy. Invest Ophthalmol Vis Sci 33 (1992) 1995-2005
191. Prydal J.I., Artal P., Woon H., and Campbell F.W. Study of human precorneal tear film thickness and structure using laser interferometry. Invest Ophthalmol Vis Sci 33 (1992) 2006-2011
192. Prydal J.I., Kerr M.M., and Dilly P.N. Comparison of tear film thickness in three species determined by the glass fibre method and confocal microscopy. Eye 7 (1993) 472-475
193. Radnot M., and Bölcs S. Fine structure of the epithelial cell surfaces in the lacrimal sac. Klin Monatsbl Augenheilkd 159 (1971) 158-164
194. Radnot M. Die Flimmerhaare des Tränensackepithels. Klin Monatsbl Augenheilkd 170 (1977) 428-432
195. Ramsauer V.P., Carraway C.A., Salas P.J., and Carraway K.L. Muc4/sialomucin complex, the intramembrane ErbB2 ligand, translocates ErbB2 to the apical surface in polarized epithelial cells. J Biol Chem 278 (2003) 30142-30147
196. Raynal B.D., Hardingham T.E., Sheehan J.K., and Thornton D.J. Calcium-dependent protein interactions in MUC5B provide reversible cross-links in salivary mucus. J Biol Chem 278 (2003) 28703-28710
197. Ren J., Li Y., and Kufe D. Protein kinase C delta regulates function of the DF3/MUC1 carcinoma antigen in beta-catenin signaling. J Biol Chem 277 (2002) 17616-17622
198. Reuter G, Schauer R, Bumm P. Sialic acids of human nasal mucin, possible targets of influenza C viruses. In: Schauer R, Yamakawa T, editors. Sialic acids. Proceedings of the Japanese-German symposium on sialic acids. Berbel-Mendel, Kiel; 1988. p. 259-260.
199. Reuter G., Struwe R., Feige J., Brede R., Bumm P., and Schauer R. Analysis of carbohydrate composition and sialidase activity in oral secretions of patients with tumors in the upper aerodigestive tract. Eur Arch Otorhinolaryngol 249 (1992) 5-11
200. Rio M.C., Bellocq J.P., Daniel J.Y., Tomasetto C., Lathe R., Chenard M.P., et al. Breast cancer-associated pS2 protein: synthesis and secretion by normal stomach mucosa. Science 241 (1988) 705-708
201. Rivas L., Rodriguez J.J., and Murube J. Glandulas seosas en el saco lagrimal. Arch Soc Esp Oftal 60 (1991) 173-176
202. Roberton A.M., Wiggins R., Horner P.J., Greenwood R., Crowley T., Fernandes A., et al. A novel bacterial mucinase, glycosulfatase, is associated with bacterial vaginosis. J Clin Microbiol 43 (2005) 5504-5508
203. Round A.N., Berry M., McMaster T.J., Stoll S., Gowers D., Corfield A.P., et al. Heterogeneity and persistence length in human ocular mucins. Biophys J 83 (2002) 1661-1670
204. Round A.N., Berry M., McMaster T.J., Corfield A.P., and Miles M.J. Glycopolymer charge density determines conformation in human ocular mucin gene products: an atomic force microscope study. J Struct Biol 145 (2004) 246-253
205. Ruchaud-Sparagano M.H., Westley B.R., and May F.E. The trefoil protein TFF1 is bound to MUC5AC in human gastric mucosa. Cell Mol Life Sci 61 (2004) 1946-1954
206. Sack R.A., Tan K.O., and Tan A. Diurnal tear cycle: evidence for a nocturnal inflammatory constitutive tear fluid. Invest Ophthalmol Vis Sci 33 (1992) 626-640
207. Sack R.A., Beaton A., Sathe S., Morris C., Willcox M., and Bogart B. Towards a closed eye model of the pre-ocular tear layer. Prog Retin Eye Res 19 (2000) 649-668
208. Sack R.A., Sathe S., and Beaton A. Tear turnover and immune and inflammatory processes in the open-eye and closed-eye environments: relationship to extended wear contact lens use. Eye Contact Lens 29 Suppl. 1 (2003) S80-S82
209. Sakata M., Sack R.A., Sathe S., Holden B., and Beaton A.R. Polymorphonuclear leukocyte cells and elastase in tears. Cur Eye Res 16 (1997) 810-819
210. Schäfer G., Hoffmann W., Berry M., and Paulsen F. Altersabhängige Produktion Tränendrüsen-assoziierte Muzine - Rolle in der Pathophysiologie des Trockenen Auges. Ophthalmologe 102 (2005) 175-183
211. Schauer R. Sialinsäurereiche Schleime als bioaktive Schmierstoffe. Nachr Chem Tech Lab 40 (1992) 1227-1231
212. Schauer R. Enzyme als Werkzeuge für die Analyse der Struktur und Funktion von sialylierten Glykokonjugaten. BIO-forum 20 (1997) 541-544
213. Schaumberg D.A., Sullivan D.A., and Dana M.R. Epidemiology of dry eye syndrome. Adv Exp Med Biol 506 (2002) 989-998
214. Schulz B.L., Sloane A.J., Robinson L.J., Sebastian L.T., Ganville A.R., Song Y., et al. Mucin glycosylation changes in cystic fibrosis lung disease are not manifest in submucosal gland secretions. Biochem J 387 (2005) 911-919
215. Seifert P., Spitznas M., Koch F., and Cusumano A. The architecture of human accessory lacrimal glands. Ger J Ophthalmol 2 (1993) 444-454
216. Seifert P., and Spitznas M. Demonstration of nerve fibers in human accessory lacrimal glands. Graefes Arch Clin Exp Ophthalmol 232 (1994) 107-114
217. Seifert P., Spitznas M., Koch F., and Cusumano A. Light and electron microscopic morphology of accessory lacrimal glands. In: Sullivan D.A. (Ed). Lacrimal gland, tear film, and dry eye syndromes: basic science and clinical relevance (1994), Plenum Press, New York 9-23
218. Seifert P., Stuppi S., Spitznas M., and Weihe E. Differential distribution of neuronal markers and neuropeptides in the human lacrimal gland. Graefe's Arch Clin Exp Ophthalmol 234 (1996) 232-240
219. Seifert P., Stuppi S., and Spitznas M. Distribution pattern of nervous tissue and peptidergic nerve fibres in accessory lacrimal glands. Curr Eye Res 16 (1997) 298-302
220. Sheehan J.K., Kirkham S., Howard M., Woodman P., Kutay S., Brazeau C., et al. Identification of molecular intermediates in the assembly pathway of the MUC5AC mucin. J Biol Chem 279 (2004) 15698-15705
221. Shim J.J., Dabbagh K., Ueki I.F., Dao-Pick T., Burgel P.R., Takeyama K., et al. IL-13 induces mucin production by stimulating epidermal growth factor receptors and by activating neutrophils. Am J Physiol Lung Cell Mol Physiol 280 (2001) L134-L140
222. Sirigu P., Maxia C., Puxeddu R., Zuca I., Piras F., and Perra M.T. The presence of a local immune system in the upper blind and lower part of the human nasolacrimal duct. Arch Histol Cytol 63 (2000) 431-439
223. Situ H., and Bobek L. In vitro assessment of antifungal therapeutic potential of salivary histatin-5, two variants of histatin 5, and salivary mucin (MUC7) domain 1. Antimicrob Agents Chemother 44 (2000) 1485-1493
224. Somia N.N., Rash G.S., Epstein E.E., Wachowiak M., Sundine M.J., Stermel R.W., et al. A computer analysis of reflex eyelid motion in normal subjects and in facial neuropathy. Clin Biomech (Bristol, Avon) 15 (2000) 766-771
225. Song X.J., Li D.Q., Farley W., Luo L.H., Heuckeroth R.O., Milbrandt J., et al. Neuturin-deficient mice develop dry eye and keratoconjunctivitis sicca. Invest Ophthalmol Vis Sci 44 (2003) 4223-4229
226. Stern M.E., and Pflugfelder S.C. Inflammation in dry eye. Ocular Surf 2 (2004) 124-130
227. Stern M.E., Beuermann R.W., Fox R.I., Gao J., Mircheff A.K., and Pflugfelder S.C. The pathology of dry eye: the interaction between the ocular surface and lacrimal glands. Cornea 17 (1998) 584-589
228. Steven P., Schäfer G., Nölle B., Hinz M., Hoffmann W., and Paulsen F. Distribution of TFF peptides in corneal disease and pterygium. Peptides 25 (2004) 819-825
229. Stöckelhuber M., Stöckelhuber B.M., and Welsch U. Human glands of Moll: histochemical and ultrastructural characterization of the glands of Moll in the human eyelid. J Invest Dermatol 121 (2003) 28-36
230. Sullivan D.A., Wickham L.A., Rocha E., Krenzer K.L., Sullivan B.D., Steagall R., et al. Androgens and dry eye in Sjogren's syndrome. Ann N Y Acad Sci 876 (1999) 312-324
231. Sullivan D.A., Sullivan B.D., Ullman M.D., Rocha E.M., Krenzer K.L., Cermak J.M., et al. Androgen influence on the meibomian gland. Invest Ophthalmol Vis Sci 41 (2000) 3732-3742
232. Sullivan D.A. Tearful relationships? Sex, hormones, the lacrimal gland, and aqueous-deficient dry eye. Ocular Surf 2 (2004) 92-123
233. Suuronen E.J., McLaughlin C.R., Stys P.K., Nakamura M., Munger R., and Griffith M. Functional innervation in tissue engineered models for in vitro study and testing purposes. Toxicol Sci 82 (2004) 525-533
234. Tabak L.A. In defense of the oral cavity: structure, biosynthesis, and function of salivary mucins. Annu Rev Physiol 57 (1995) 547-564
235. Takata K., Matzusaki T., and Tajika Y. Aquaporins: water channel proteins of the cell membrane. Prog Histochem Cytochem 39 (2004) 1-83
236. Tarjan E., Denton D.A., McKinley M.J., Nelson J.F., and Weisinger R.S. What makes wild rabbits drink?. J Physiol (Paris) 79 (1984) 466-470
237. Taupin D.R., Kinoshita K., and Podolsky D.K. Intestinal trefoil factor confers colonic epithelial resistance to apoptosis. Proc Natl Acad Sci USA 20 (2000) 4680-4690
238. Tei M., Moccia R., and Gipson I.K. Developmental expression of mucin genes ASGP (rMuc4) and rMuc5ac by the rat ocular surface epithelium. Invest Ophthalmol Vis Sci 40 (1999) 1944-1951
239. Tei M., Spurr-Michaud S.J., Tisdale A.S., and Gipson I.K. Vitamin A deficiency alters the expression of mucin genes by the rat ocular surface epithelium. Invest Ophthalmol Vis Sci 41 (2000) 82-88
240. Thakur A., and Willcox M.D.P. Chemotactic activity of tears and bacteria isolated during adverse responses. Exp Eye Res 66 (1998) 129-137
241. Thale A., Paulsen F., Rochels R., and Tillmann B. Functional anatomy of human efferent tear ducts - a new theory of tear outflow. Graefe's Arch Clin Exp Ophthalmol 236 (1998) 674-678
242. Thim L., and May F.E.B. Structure of mammalian trefoil factors and functional insights. Cell Mol Life Sci 62 (2005) 2956-2973
243. Thim L., Madsen F., and Poulsen S.S. Effect of trefoil factors on the viscoelastic properties of mucus gels. Eur J Clin Invest 32 (2002) 519-527
244. Thomsson K.A., Prakobphol A., Leffler H., Reddy M.S., Levine M.J., Fischer S.J., et al. The salivary mucin MG1 (MUC5B) carries a repertoire of unique oligosaccharides that is large and divers. Glycobiology 12 (2002) 1-14
245. Tomasetto C., and Rio M.C. Trefoil factors Pleiotropic effects of Trefoil Factor 1 deficiency. Cell Mol Life Sci 62 (2005) 2916-2920
246. Tomasetto C., Masson R., Linaires J.L., Wendling C., Lefebvre O., Chenard M.P., et al. pS2/TFF1 interacts directly with the VWFC cysteine-rich domains of mucins. Gastroenterology 118 (2000) 70-80
247. Tran C.H., Routledge C., Miller F., and Hodson S.A. Examination of murine tear film. Invest Ophthalmol Vis Sci 44 (2003) 3520-3525
248. Tseng S.C., Hirst L.W., Maumenee A.E., Kenyon K.R., Sun T.T., and Green W.R. Possible mechanisms for the loss of goblet cells in mucin-deficient disorders. Ophthalmology 91 (1984) 545-552
249. Tsubota K., Fukagawa K., Fujihara T., Shimmura S., Saito I., Saito K., et al. Regulation of human leukocyte antigen expression in human conjunctival epithelium. Invest Ophthalmol Vis Sci 40 (1999) 28-34
250. Tsuda K. On the histology of ductulus lacrimalis in adult, especially on its innervation. Tohoku J Exp Med 56 (1952) 233-243
251. Van Seuningen I., Pigny P., Perrais M., Porchet N., and Aubert J.P. Transcriptional regulation of the 11p15 mucin genes Towards new biological tools in human therapy, in inflammatory diseases and cancer?. Front Biosci 6 (2001) D1216-D1234
252. Verdugo P. Mucin exocytosis. Am Rev Respir Dis 144 (1991) 33-37
253. Verdugo P., Aitken M., Langley L., and Villalon M.J. Molecular mechanism of product storage and release in mucin secretion II The role of extracellular Ca++. Biorheology 24 (1987) 625-633
254. Verdugo P., Deyrup-Olsen I., Aitken M., Villalon M., and Johnson D. Molecular mechanism of mucin secretion: I. The role of intragranular charge shielding. J Dent Res 66 (1987) 506-508
255. Vimal D.B., Khullar M., Gupta S., and Ganguly N.K. Intestinal mucins: the binding sites for Salmonella typhimurium. Mol Cell Biochem 204 (2000) 107-117
256. Von Mensdorff-Pouilly S., Kinarsky L., Engelmann K., Baldus S.E., Verhejjen R.H., Hollingsworth M.A., et al. Sequence-variant repeats of MUC1 show higher conformational flexibility, are less densely O-glycosylated and induce differential B lymphocyte responses. Glycobiology 15 (2005) 735-746
257. Wahrenbrock M., Borsig L., Le D., Varki N., and Varki A. Selectin-mucin interactions as a probable molecular explanation for the association of Trousseau syndrome with mucinous adenocarcinomas. J Clin Invest 112 (2003) 853-862
258. Walker W.A. Host defense mechanisms in the gastrointestinal tract. Pediatrics 57 (1976) 901-916
259. Wang B., Lim D.J., Han J., Kim Y.S., Basbaum C.B., and Li J.D. Novel cytoplasmic proteins of nontypeable Haemophilus influenzae up-regulate human MUC5AC mucin transcription via a positive p38 mitogen-activated protein kinase pathway and a negative phosphoinositide 3-kinase-Akt pathway. J Biol Chem 277 (2002) 949-957
260. Wang J., Fonn D., Simpson T.L., and Jones L. Precorneal and pre- and postlens tear film thickness measured indirectly with optical coherence tomography. Invest Ophthalmol Vis Sci 44 (2003) 2524-2528
261. Wei G.X., and Bobek L.A. In vitro synergic antifungal effect of MUC7 12-mer with histatin-5 12-mer or miconazole. J Antimicrob Chemother 53 (2004) 750-758
262. Wei G.X., and Bobek L.A. Human salivary mucin MUC7 12-mer-L and 12-mer-D peptidees: antifungal activity in saliva, enhancement of activity with protease inhibitor cocktail or EDTA, and cytotoxicity to human cells. Antimicrob Agents Chemother 49 (2005) 2336-2342
263. Werncke T. Ein Beitrag zur Anatomie des Tränensackes, speziell zur Frage der Tränensackdrüsen. Klin Monatsbl Augenheilkd 43 (1905) 191-205
264. Wickström C., and Carlstedt I. N-terminal cleavage of the salivary MUC5B mucin - analogy with the von Willebrand propolypeptide?. J Biol Chem 276 (2001) 47116-47121
265. Wiggins R., Hicks S., Soothill P.W., Millar M.R., and Corfield A.P. Mucinases and sialidases: their role in the pathogenesis of sexually transmitted infections in the female genital tract. Sex Transm Inf 77 (2001) 402-408
266. Willcox M.C.P., and Stapleton F. Ocular bacteriology. Med Microb Rev 7 (1996) 123-131
267. Willcox M.D., Morris C.A., Thakur A., Sack R.A., Wickson J., and Boey W. Complement and complement regulatory proteins in human tears. Invest Ophthalmol Vis Sci 38 (1997) 1-8
268. von Wolfring E. Untersuchungen über die Drüsen der Bindehaut des Auges. Centrbl Med Wiss 10 (1872) 852-854
269. Wotherspoon A.C., Hardman-Lea S., and Isaacson P.G. Mucosa-associated lympoid tissue (MALT) in the human conjunctiva. J Pathol 174 (1994) 33-37
270. Wreschner D.H., McGuckin M.A., Williams S.J., Baruch A., Yoeli M., Ziv R., et al. Generation of ligand-receptor alliances by "SEA" module-mediated cleavage of membrane-associated mucin proteins. Protein Sci 11 (2002) 698-706
271. Wright N. Aspects of the biology of regeneration and repair in the human gastrointestinal tract. Phil Trans R Soc Lond B 353 (1998) 925-933
272. Yin B.W., and Lloyd K.O. Molecular cloning of the CA125 ovarian cancer antigen: identification as a new mucin, MUC16. J Biol Chem 276 (2001) 27371-27375
273. Yoon J.H., Kim K.S., Kim H.U., Linton J.A., and Lee J.G. Effects of TNF-alpha and IL-1 beta on mucin, lysozyme, IL-6 and IL-8 in passage-2 normal human nasal epithelial cells. Acta Otolaryngol 119 (1999) 905-910
274. Zhao H., Jumblatt J.E., Wood T.O., and Jumblatt M.M. Quantification of MUC5AC protein in human tears. Cornea 20 (2001) 873-877
275. Zoukhri D., and Kublin C.L. Impaired neurotransmitter release from lacrimal and salivary gland nerves of a murine model of Sjögren's syndrome. Invest Ophthalmol Vis Sci 42 (2001) 925-932