Molecular medicine of TFF-peptides: From gut to brain

Histology and Histopathology

Volumn 16, Issue 1, 2001, Pages 319-334

  Hoffman, W ^a   Jagla, W ^a   Wiede, A ^a  

^a UNIVERSITY HOSPITAL MAGDEBURG   (Germany)

Author keywords

Cell migration; Conjunctiva; Epithelia; Goblets cells; Inflammatory bowel disease; Mucins; Neuropeptide; Oxytocin; Pituitary; Respiratory tract; Restitution; Salivary glands; TFF domain; Ulcer; Uterus

Indexed keywords

NEUROPEPTIDE; OXYTOCIN; STOMACH MUCIN; TREFOIL PEPTIDE;

CELL MIGRATION; CELL SURFACE; CONJUNCTIVA; ENTERITIS; EPITHELIUM CELL; GOBLET CELL; HUMAN; HYPOTHALAMUS HYPOPHYSIS SYSTEM; MOLECULAR DYNAMICS; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN SECRETION; PROTEIN SYNTHESIS; PROTEIN TRANSPORT; RESPIRATORY SYSTEM; REVIEW; SALIVARY GLAND; SECRETORY CELL; TUMOR; ULCER; ULCER HEALING; UTERUS;

ANIMALS; BRAIN; BRAIN CHEMISTRY; DIGESTIVE PHYSIOLOGY; DIGESTIVE SYSTEM; ESTROGENS; GASTROINTESTINAL DISEASES; GROWTH SUBSTANCES; HUMANS; MUCINS; MUSCLE PROTEINS; NEUROPEPTIDES; PEPTIDES; PROTEIN BIOSYNTHESIS; PROTEINS; TUMOR SUPPRESSOR PROTEINS;

LOTUS;

EID: 0035148302     PISSN: 02133911     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (173)

1. The ulceration-associated cell lineage (UACL) reiterates the Brunner's gland differentiation programme but acquires the proliferative organization of the gastric gland
2. Experimental ulceration leads to sequential expression of spasmolytic polypeptide, intestinal trefoil factor, epidermal growth factor and transforming growth factor alpha mRNAs in rat stomach
3. Expression of human mucin genes in respiratory, digestive, and reproductive tracts ascertained by in situ hybridization
4. Oral trefoil peptides protect against ethanol- and indomethacin-induced gastric injury in rats
5. Expression of the oestrogen responsive protein pS2 in human breast cancer
6. The MUC6 secretory mucin gene is expressed in a wide variety of epithelial tissues
7. Differential expression of the pS2 protein in the human prostate and prostate cancer: Association with premalignant changes and neuroendocrine differentiation
8. A trefoil domain in the major rabbit zona pellucida protein
9. Structure of Xenopus laevis TFF-gene xP4.1, differentially expressed to its duplicated homolog xP4.2
10. Effects of TFF-peptides on epithelial cell migration and intracellular signaling in vitro
11. Genomic organization of the 3′-region of the human MUC5AC mucin gene: Additional evidence for a common ancestral gene for the 11p15.5 mucin gene family
12. H NMR-based determination of the secondary structure of porcine pancreatic spasmolytic polypeptide: One of a new family of "trefoil" motif containing cell growth factors
13. Solution structure of a trefoil-motif-containing cell growth factor, porcine spasmolytic protein
14. Oxytocin and sexual behavior
15. Homodimerization and hetero-oligomerization of the single-domain trefoil protein pNR-2/pS2 through cysteine 58
16. Localization of mucin (MUC2 and MUC3) messenger RNA and peptide expression in human normal intestine and colon cancer
17. Transcription factor NF-κB signals antianoikic function of trefoil factor 3 on intestinal epithelial cells
18. Immunoprecipitation and characterization of a binding protein specific for the peptide, intestinal trefoil factor
19. Modulation of epidermal growth factor effects on epithelial ion transport by intestinal trefoil factor
20. Combined intestinal trefoil factor and epidermal growth factor is prophylactic against indomethacin-induced gastric damage in the rat
21. Expression and purification of a trefoil peptide motif in a β-galactosidase fusion protein and its use to search for trefoil-binding sites
22. Characterisation of the single copy trefoil peptides intestinal trefoil factor and pS2 and their ability to form covalent dimers
23. The gene encoding human intestinal trefoil factor (TFF3) is located on chromosome 21q22.3 clustered with other members of the trefoil peptide family
24. Oral human spasmolytic polypeptide protects against aspirin-induced gastric injury in rats
25. Crystal structure of a disulfide-linked "trefoil" motif found in a large family of putative growth factors
26. The APC protein binds A/T rich DNA sequences
27. Trefoil factor expression in normal and diseased human salivary glands
28. Trefoil peptides promote epithelial migration through a transforming growth factor β-independent pathway
29. Trefoil factor family domain peptides in the human respiratory tract
30. Induction of TFF1 gene expression in pancreas overexpressing transforming growth factor α
31. Intestinal trefoil factor controls the expression of the adenomatous polyposis coli-catenin and the E-cadherin-catenin complexes in human colon carcinoma cells
32. Mutated epithelial cadherin is associated with increased tumorigenicity and loss of adhesion and of responsiveness to the motogenic trefoil factor 2 in colon carcinoma cells
33. In vivo restitution of airway epithelium
34. Daily patterns of secretion of neurohypophyseal hormones in man: Effect of age
35. Receptor binding of pancreatic spasmolytic polypeptide in intestinal mucosal cells and membranes
36. Receptor binding of pancreatic spasmolytic polypeptide (PSP) in rat intestinal mucosal cell membranes inhibits the adenylate cyclase activity
37. Pancreatic spasmolytic polypeptide: Crystallization, circular dichroism analysis, and preliminary X-ray diffraction studies
38. Pancreatic spasmolytic polypeptide: First three-dimensional structure of a member of the mammalian trefoil family of peptides
39. Mucin genes expressed by the ocular surface epithelium
40. Crystallization and preliminary X-ray diffraction studies of pancreatic spasmolytic polypeptide
41. Human trefoil peptides: Genomic structure in 21q22.3 and coordinated expression
42. Tanycytes in the human median eminence contain intestinal trefoil factor (hlTF)
43. The pS2 protein in colorectal carcinomas and metastases
44. The expression of the trefoil peptides pS2 and human spasmolytic polypeptide (hSP) in 'gastric metaplasia' of the proximal duodenum: Implications for the nature of 'gastric metaplasia'
45. Spasmolytic polypeptide is a major antral peptide: Distribution of the trefoil peptides human spasmolytic polypeptide and pS2 in the stomach
46. Hyperplastic polyps: A cell lineage which both synthesizes and secretes trefoil-peptides and has phenotypic similarity with the ulcer-associated cell lineage
47. Expression of the trefoil peptides pS2 and human spasmolytic polypeptide (hSP) in Barret's metaplasia and the native oesophageal epithelium: Delineation of epithelial phenotype
48. Primary mucinous carcinomas of the skin express TFF1, TFF3, estrogen receptor, and progesterone receptors
49. The mucous neck cell in the human gastric corpus: A distinctive, functional cell lineage
50. Cloning and characterization of zona pellucida genes and cDNAs from a variety of mammalian species: The ZPA, ZPB and ZPC gene families
51. The DNA sequence of human chromosome 21
52. xP1 and xP4: P-domain peptides expressed in Xenopus laevis stomach mucosa
53. P-domains as shuffled cysteine-rich modules in integumentary mucin C.1 (FIM-C.1) from Xenopus laevis
54. Expression of spasmolysin (FIM-A.1): An integumentary mucin from Xenopus laevis
55. xP2, a new member of the P-domain peptide family of potential growth factors, is synthesized in Xenopus laevis skin
56. hP1.B, a human P-domain peptide homologous with rat intestinal trefoil factor, is expressed also in the ulcer-associated cell lineage and the uterus
57. Expression of the pNR-2/pS2 protein in diverse human epithelial tumours
58. Prognostic significance of pS2 protein expression in pulmonary adenocarcinoma
59. Cytokine regulation of pS2 gene expression in mouse astrocytes
60. pS2 gene especially expressed in the late G1/S phase of mouse astrocytes
61. Expression of pS2 gene in rat brain
62. Expression cloning of gastric mucin complementary DNA and localization of mucin gene expression
63. Primary structure and processing of lysosomal α-glucosidase; Homology with the intestinal sucrase-isomaltase complex
64. A new repetitive protein from Xenopus laevis skin highly homologous to pancreatic spasmolytic polypeptide
65. The P-domain or trefoil motif: A role in renewal and pathology of mucous epithelia?
66. Different mucins are produced by the surface epithelium and the submucosa in human trachea: Identification of MUC5AC as a major mucin from the goblet cells
67. Identification of the true human orthologue of the mouse Zp1 gene: Evidence for greater complexity in the mammalian zona pellucida?
68. cDNA cloning of rat pS2 peptide and expression of trefoil peptides in acetic acid-induced colitis
69. Differential expression of the TFF-peptides xP1 and xP4 in the gastrointestinal tract of Xenopus laevis
70. Secretion of TFF-peptides by human salivary glands
71. Co-localization of TFF3 peptide and oxytocin in the human hypothalamus
72. Sequence of the pS2 mRNA induced by estrogen in human breast cancer cell line MCF-7
73. Similarities of integumentary mucin B.1 from Xenopus laevis and prepro-von Willebrand factor at their amino-terminal regions
74. Pancreatic spasmolytic polypeptide (PSP): I. Preparation and initial chemical characterization of a new polypeptide from porcine pancreas
75. Intestinal trefoil factor induces inactivation of extracellular signal-regulated protein kinase in intestinal epithelial cells
76. Effects of growth factors and trefoil peptides on migration and replication in primary oxyntic cultures
77. Expression of trefoil peptides pS2 and human spasmolytic polypeptide in gastric metaplasia at the margin of duodenal ulcers
78. Distinct pathways of cell migration and antiapoptotic response to epithelial injury: Structure-function analysis of human intestinal trefoil factor
79. Regulation of cell motility by mitogen-activated protein kinase
80. Role of spasmolytic polypeptide in healing of stress-induced gastric lesions in rats
81. Activation of genes for spasmolytic peptide, transforming growth factor alpha and for cyclooxygenase (COX)-1 and COX-2 during gastric adaptation to aspirin damage in rats
82. Expression of pS2 protein in endometrial carcinomas: Correlation with clinicopathologic features and sex steroid receptor status
83. Differential expression of mucins and trefoil peptides in native epithelium, Barrett's metaplasia and squamous cell carcinoma of the oesophagus
84. Epithelial restitution in the gastrointestinal tract
85. Trefoil factor-2, human spasmolytic polypeptide, promotes branching morphogenesis in MCF-7 cells
86. Secretory peptides TFF1 and TFF3 synthesized in human conjunctival goblet cells
87. Gastric mucosa abnormalities and tumorigenesis in mice lacking the pS2 trefoil protein
88. Phosphorylation of β-catenin and epidermal growth factor receptor by intestinal trefoil factor
89. Expression of the pS2 gene in normal, benign and neoplastic human stomach
90. An immunohistochemical survey of pS2 expression in human epithelial cancers
91. Gastric carcinoma exhibits distinct types of cell differentiation: An immunohistochemical study of trefoil peptides (TFF1 and TFF2) and mucins (MUC1, MUC2, MUC5AC, and MUC6)
92. Dimerization of human pS2 (TFF1) plays a key role in its protective/healing effects
93. Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor
94. Cloning of cDNA sequences of hormone-regulated genes from the MCF-7 human breast cancer cell line
95. Expression of human intestinal trefoil factor in malignant cells and its regulation by oestrogen in breast cancer cells
96. The human two domain trefoil protein, TFF2, is glycosylated in vivo in the stomach
97. Migration of IEC-6 cells: A model for mucosal healing
98. Pancreatic spasmolytic polypeptide protects the gastric mucosa but does not inhibit acid secretion or motility
99. Phosphorylation and free pool of β-catenin are regulated by tyrosine kinases and tyrosine phosphatases during epithelial cell migration
100. Nuclear and cytoplasmic localizations of the adenomatous polyposis coli protein
101. The human trefoil peptide, TFF1, is present in different molecular forms that are intimately associated with mucus in normal stomach
102. Human small intestinal maltase-glucoamylase cDNA cloning: Homology to sucrase-isomaltase
103. Differential expression of human high-molecular-weight salivary mucin (MG1) and low-molecular-weight salivary mucin (MG2)
104. Identification of a major human high molecular weight salivary mucin (MG1) as tracheobronchial mucin MUC5B
105. Patterns of expression of trefoil peptides and mucins in gastric polyps with and without malignant transformation
106. Differential expression of human spasmolytic polypeptide (trefoil factor family-2) in pancreatic carcinomas, and mucin-producing tumors of the pancreas
107. The prognostic value of immunohistochemical analysis of squamous cell cervical carcinoma for pS2
108. Trefoil factor family (TFF)-domain peptides in the mouse: Embryonic gastrointestinal expression and wounding response
109. Effects of pancreatic spasmolytic polypeptide (PSP) on epithelial cell function
110. Somatic mutations of the trefoil factor family 1 gene in gastric cancer
111. The kinetic organization of the ulcer-associated cell lineage (UACL): Delineation of a novel putative stem-cell region
112. Structure of porcine pancreatic spasmolytic polypeptide at 1.95 A resolution
113. Antipeptide antibodies against the pNR-2 oestrogen-regulated protein of human breast cancer cells and detection of pNR-2 expression in normal tissues by immunohistochemistry
114. Human spasmolytic polypeptide is a cytoprotective agent that stimulates cell migration
115. Transgenic mice that overexpress the human trefoil peptide pS2 have an increased resistance to intestinal damage
116. Identification of human intestinal trefoil factor. Goblet cell-specific expression of a peptide targeted for apical secretion
117. NMR-based structural studies of the pNR-2/pS2 single domain trefoil peptide: Similarities to porcine spasmolytic peptide and evidence for a monomeric structure
118. High resolution solution structure of human pNR-2/pS2: A single trefoil motif protein
119. Distribution and metabolism of intravenously administered trefoil factor 2/porcine spasmolytic polypeptide in the rat
120. Metabolism of oral trefoil factor 2 (TFF2) and the effect of oral and parenteral TFF2 on gastric and duodenal ulcer healing in the rat
121. Intestinal trefoil factor (TFF3) and pS2 (TFF1), but not spasmolytic polypeptide (TFF2) mRNAs are co-expressed in normal, hyperplastic, and neoplastic human breast epithelium
122. An integumentary mucin (FIM-B.1) from Xenopus laevis homologous with von Willebrand factor
123. Molecular and cellular analysis of rP1.B in the rat hypothalamus: In situ hybridization and immunohistochemistry of a new P-domain neuropeptide
124. Human intestinal trefoil factor is expressed in human hypothalamus and pituitary: Evidence for a novel neuropeptide
125. Immunohistochemical localization of pancreatic spasmolytic polypeptide (PSP) in the pig
126. The pS2/TFF1 trefoil factor, from basic research to clinical applications
127. Specific expression of the pS2 gene in subclasses of breast cancers in comparison with expression of the estrogen and progesterone receptors and the oncogene ERBB2
128. Breast cancer-associated pS2 protein: Synthesis and secretion by normal stomach mucosa
129. Induction of pS2 and hSP genes as markers of mucosal ulceration of the digestive tract
130. Revsied amino acid sequence of pancreatic spasmolytic polypeptide exhibits greater similarity with an inducible pS2 peptide found in a human breast cancer cell line
131. Differential behavioral effects of TFF peptides: Injections of synthetic TFF3 into the rat amygdala
132. Breast cancer-associated protein pS2 expression in tumors of the biliary tract
133. The pathogenesis of duodenal gastric metaplasia: The role of loxal goblet cell transformation
134. Mechanisms for rapid re-epithelialization of the gastric mucosal surface
135. Identification and characterization of rat intestinal trefoil factor: Tissue- and cell-specific member of the trefoil protein family
136. Characterization of a putative receptor for intestinal trefoil factor in rat small intestine: Identification by in situ binding and ligand blotting
137. Intestinal trefoil factor binds to intestinal epithelial cells and induces nitric oxide production: Priming and enhancing effects of mucin
138. Human spasmolytic polypeptide decreases proton permeation through gastric mucus in vivo and in vitro
139. Conserved expression of intestinal trefoil factor in the human colonic adenoma-carcinoma sequence
140. The trefoil gene family are coordinately expressed immediate-early genes: EGF receptor- and MAP kinase-dependent interregulation
141. Intestinal trefoil factor confers colonic epithelial resistance to apoptosis
142. Expression of the breast cancer associated gene pS2 and the pancreatic spasmolytic polypeptide gene (hSP) in diffuse type of stomach carcinoma
143. A new family of growth factor-like peptides: "trefoil" disulphide loop structures as a common feature in breast cancer associated peptide (pS2), pancreatic spasmolytic polypeptide (PSP), and frog skin peptides (spasmolysins)
144. Isolation and characterization of putative trefoil peptide receptors
145. Pancreatic spasmolytic polypeptide (PSP): II. Radioimmunological determination of PSP in porcine tissues, plasma and pancreatic juice
146. The amino acid sequence of pancreatic spasmolytic polypeptide
147. hSP, the domain-duplicated homolog of pS2 protein, is co-expressed with pS2 in stomach but not in breast carcinoma
148. pS2/TFF1 interacts directly with the VWFC cysteine-rich domains of mucins
149. Trefoil peptide TFF2 (spasmolytic polypeptide) potently accelerates healing and reduces inflammation in a rat model of colitis
150. Expression of intestinal trefoil factor mRNA is downregulated during progression of colorectal carcinoms
151. Overexpression of intestinal trefoil factor in human colon carcinoma cells reduces cellular growth in vitro and in vivo
152. H. pylori colocalises with MUC5AC in the human stomach
153. Assembly and routing of von Willebrand factor variants: The requirements for disulfide-linked dimerization reside within the carboxy-terminal 151 amino acids
154. Expression of a breast-cancer-associated protein (pS2) in human neuro-endocrine tumours
155. TFF1 gene expression in human medullary thyroid carcinoma
156. Association of the human spasmolytic polypeptide and an estrogen-induced breast cancer protein (pS2) with human pancreatic carcinoma
157. Expression of the breast cancer-associated protein pS2 in adenosquamous carcinomas of the gastrointestinal tract
158. Expression pattern of breast-cancer-associated protein pS2/BCEI in colorectal tumors
159. MUC5B is a major gel-forming, oligomeric mucin from human salivary gland, respiratory tract and endocervix: Identification of glycoforms and C-terminal cleavage
160. Localization of TFF3, a new mucus-associated peptide of the human respiratory tract
161. Synthesis and localization of the mucin-associated TFF-peptides in the human uterus
162. pS2 transfection of murine adenocarcinoma cell line 410.4 enhances dispersed growth pattern in a 3-D collagen gel
163. Short-chain fatty acids promote the migration of colonic epithelial cells in vitro
164. Epidermal growth factor, epidermal growth factor receptors, intestinal growth, and adaptation
165. Peptide gene expression in gastrointestinal mucosal ulceration: Ordered sequence or redundancy?
166. The expression of growth factors in the pancreas in chronic pancreatitis
167. Aspects of the biology of regeneration and repair in the human gastrointestinal tract
168. Induction of a novel epidermal growth factor-secreting cell lineage by mucosal ulceration in human gastrointestinal stem cells
169. Epidermal growth factor (EGF/URO) induces expression of regulatory peptides in damaged human gastrointestinal tissues
170. Trefoil peptide gene expression in gastrointestinal epithelial cells in inflammatory bowel disease
171. Rolling in the clover: Trefoil factor family (TFF)-domain peptides, cell migration and cancer
172. Detection of pS2 messenger RNA in gynecological cancers