Neurturin-deficient mice develop dry eye and keratoconjunctivitis sicca

Investigative Ophthalmology and Visual Science

Volumn 44, Issue 10, 2003, Pages 4223-4229

  Song, Xiu Jun ^a,c   Li, De Quan ^a   Farley, William ^a   Luo, Li Hui ^a   Heuckeroth, Robert O ^b   Milbrandt, Jeffrey ^b   Pflugfelder, Stephen C ^a  

^a CULLEN EYE INSTITUTE   (United States)

^b WASHINGTON UNIVERSITY   (United States)

^c HEBEI MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE INDUCED NEUTROPHIL CHEMOATTRACTANT; GELATINASE B; HLA ANTIGEN CLASS 2; INTERLEUKIN 1BETA; MACROPHAGE INFLAMMATORY PROTEIN 2; MESSENGER RNA; MUCIN; NEURTURIN; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CORNEA EPITHELIUM; CORNEA PERMEABILITY; DRY EYE; HISTOPATHOLOGY; IMMUNOHISTOCHEMISTRY; KERATOCONJUNCTIVITIS SICCA; LACRIMATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; CELL COUNT; CORNEA; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLUORESCEIN; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; FLUOROPHOTOMETRY; GOBLET CELLS; HISTOCOMPATIBILITY ANTIGENS CLASS II; INTERLEUKIN-1; KERATOCONJUNCTIVITIS; LACRIMAL APPARATUS; MATRIX METALLOPROTEINASE 9; MICE; MICE, KNOCKOUT; MUCINS; NERVE GROWTH FACTORS; NEURTURIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TEARS;

EID: 0141653766     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.02-1319     Document Type: Article

References (53)

1. Schein OD, Munoz B, Tielsch JM, Bandeen-Roche K, West S. Prevalence of dry eye among the elderly. Am J Ophthalmol. 1997;124:723-728.
2. Hikichi T, Yoshida A, Fukui Y. Prevalence of dry eye in Japanese eye centers. Graefes Arch Clin Exp Ophthalmol. 1995;233:555-558.
3. Bron AJ, Mengher LS. The ocular surface in keratoconjunctivitis sicca. Eye. 1989;3:428-437.
4. Fox RI, Robinson C, Curd J. Sjögren's syndrome: proposed criteria for classification. Arthritis Rheum. 1994;29:577-583.
5. Lemp MA. Evaluation and differential diagnosis of keratoconjunctivitis sicca. J Rheumatol Suppl. 2000;61:11-14.
6. Fujihara T, Nagano T, Nakamura M, Shirasawa E. Lactoferrin suppresses loss of comeal epithelial integrity in a rabbit short-term dry eye model. J Ocul Pharmacol Ther. 1998;14:99-107.
7. Fujihara T, Murakami T, Fujita H, Nakamura M, Nakata K, Improvement of comeal barrier function by the P2Y(2) agonist INS365 in a rat dry eye model. Invest Ophthalmol Vis Sci. 2001;42:96-100.
8. Burgalassi S, Panichi L, Chetoni P, Saettone MF, Boldrini E. Development of a simple dry eye model in the albino rabbit and evaluation of some tear substitutes. Ophthalmic Res. 1999;31:229-235.
9. Dursun D, Wang M, Monroy D, et al. A mouse model of keratoconjunctivitis sicca. Invest Ophthalmol Vis Sci. 2002;43:632-638.
10. Golden JP, DeMaro JA, Osbome PA, Milbrandt J, Johnson EM Jr. Expression of neurturin, GDNF, and GDNF family-receptor mRNA in the developing and mature mouse. Exp Neurol. 1999;158:504-528.
11. Rossi J, Luukko K, Poteryaev D, et al. Retarded growth and deficits in the enteric and parasympathetic nervous system in mice lacking GFR alpha2, a functional neurturin receptor. Neuron. 1999;22:243-252.
12. Pezeshki G, Franke B, Engèle J. Evidence for a ligand-specific signaling through GFRalpha-1, but not GFRalpha-2, in the absence of Ret. J Neurosci Res. 2001;66:390-395.
13. Heuckeroth RO, Enomoto H, Grider JR, et al. Gene targeting reveals a critical role for neurturin in the development and maintenance of enteric, sensory, and parasympathetic neurons. Neuron. 1999;22:253-263.
14. Afonso AA, Monroy D, Stem ME, Feuer WJ, Tseng SC, Pflugfelder SC. Correlation of tear fluorescein clearance and Schirmer test scores with ocular irritation symptoms. Ophthalmology. 1999;106:803-810.
15. Sobrin L, Liu Z, Monroy DC, et al. Regulation of MMP-9 activity in human tear fluid and corneal epithelial culture supernatant. Invest Ophthalmol Vis Sci. 2000;41:1703-1709.
16. Li DQ, Tseng SC. Three patterns of cytokine expression potentially involved in epithelial-fibroblast interactions of human ocular surface. J Cell Physiol. 1995;163:61-79.
17. Mathers WD. Why the eye becomes dry: a cornea and lacrimal gland feedback model. CLAO J. 2000;26:159-165.
18. Stem ME, Beuerman RW, Fox RI, Gao J, Mircheff AK, Pflugfelder SC. The pathology of dry eye: the interaction between the ocular surface and lacrimal glands. Cornea. 1998;17:584-589.
19. Jordan A, Baum J. Basic tear flow: does it exist? Ophthalmology. 1980;87:920-930.
20. Pflugfelder SC. Tear fluid influence on the ocular surface, Adv Exp Med Biol. 1998;438:611-617.
21. Gupta A, Heigle T, Pflugfelder SC. Nasolacrimal stimulation of aqueous tear production. Cornea. 1997;16:645-648.
22. Ehinger B. Ocular and orbital vegetative nerves. Acta Physiol Scand Suppl. 1966;268:1-35.
23. Yasui T, Karita K, Izumi H, Tamai M. Correlation between vasodilation and secretion in the lacrimal gland elicited by stimulation of the cornea and facial nerve root of the cat. Invest Ophthalmol Vis Sci. 1997;38:2476-2482.
24. Nikkinen A, Uusitalo H, Lehtosalo JI, Palkama A. Distribution of adrenergic nerves in the lacrimal glands of guinea-pig and rat. Exp Eye Res. 1985;40:751-756.
25. Barendregt PJ, van der Heijde GL, Breedveld FC, Markusse HM. Parasympathetic dysfunction in rheumatoid arthritis patients with ocular dryness. Ann Rheum Dis. 1996;55:612-615.
26. Bacman S, Berra A, Sterin-Borda L, Borda E. Muscarinic acetylcholine receptor antibodies as a new marker of dry eye Sjögren syndrome. Invest Ophthalmol Vis Sci. 2001;42:321-327.
27. Collins M, Seeto R, Campbell L, Ross M. Blinking and comeal sensitivity. Acta Ophthalmol (Copenh). 1989;67:525-531.
28. Toda I, Asano-Kato N, Komai-Hori Y, Tsubota K. Dry eye after laser in situ keratomileusis. Am J Ophthalmol. 2001;132:1-7.
29. 2 esthesiometer. Invest Ophthalmol Vis Sci. 1999;40:513-519.
30. Nelson JD. Diagnosis of keratoconjunctivitis sicca. Int Ophthalmol Clin. 1994;34:37-56.
31. Pflugfelder SC. Differential diagnosis of dry eye conditions. Adv Dent Res. 1996;10:9-12.
32. Pflugfelder SC, Tseng SCG, Yoshino K, Monroy D, Felix C, Reis BL. Correlation of goblet cell density and mucosal epithelial membrane mucin expression with rose bengal staining in patients with ocular irritation. Ophthalmology. 1997;104:223-235.
33. Pflugfelder SC. Advances in the diagnosis and management of keratoconjunctivitis sicca. Curr Opin Ophthalmol. 1998;9:50-53.
34. Gobbels M, Spitznas M. Corneal epithelial permeability of dry eyes before and after treatment with artificial tears. Ophthalmology. 1992;99:873-878.
35. Yokoi N, Kinoshita S. Clinical evaluation of corneal epithelial barrier function with the slit-lamp fluorophotometer. Cornea. 1995;14:485-489.
36. Nelson JD, Wright JC. Conjunctival goblet cell densities in ocular surface disorders. Arch Ophthalmol. 1984;102:1049-1051.
37. Gipson IK, Inatomi T. Cellular origin of mucins of the ocular surface tear film. Adv Exp Med Biol. 1998;438:221-227.
38. Inatomi T, Spurr-Michaud S, Tisdale AS, Zhan Q, Feldman ST, Gipson IK. Expression of secretory mucin genes by human conjunctival epithelia. Invest Ophthalmol Vis Sci. 1996;37:1684-1692.
39. Pflugfelder SC, Solomon A, Stem ME. The diagnosis and management of dry eye: a twenty-five-year review. Cornea. 2000;19:644-649.
40. Barton K, Nava A, Monroy DC, Pflugfelder SC. Cytokines and tear function in ocular surface disease. Adv Exp Med Biol. 1998;438:461-469.
41. Afonso AA, Sobrin L, Monroy DC, Selzer M, Lokeshwar B, Pflugfelder SC. Tear fluid gelatinase B activity correlates with IL-1α concentration and fluorescein clearance in ocular rosacea. Invest Ophthalmol Vis Sci. 1999;40:2506-2512.
42. Solomon A, Dursun D, Liu Z, Xie Y, Macri A, Pflugfelder SC. Proand anti-inflammatory forms of interleukin-1 in the tear fluid and conjunctiva of patients with dry-eye disease. Invest Ophthalmol Vis Sci. 2001;42:2283-2292.
43. Tishler M, Yaron I, Geyer O, Shirazi I, Naftaliev E, Yaron M. Elevated tear interleukin-6 levels in patients with Sjogren syndrome. Ophthalmology. 1998;105:2327-2329.
44. Virtanen T, Konttinen YT, Honkanen N, Harkonen M, Tervo T. Tear fluid plasmin activity of dry eye patients with Sjögren's syndrome. Acta Ophthalmol Scand. 1997;75:137-141.
45. Dinarello CA, Biologic basis for interleukin-1 in disease. Blood. 1996;87:2095-2147.
46. Dinarello CA, Wolff SM. The role of interleukin-1 in disease. N Engl J Med. 1993;328:106-113.
47. Selvan RS, Kapadia HB, Platt JL. Complement-induced expression of chemokine genes in endothelium: regulation by IL-1-dependent and -independent mechanisms. J Immunol. 1998;161:4388-4395.
48. Calkins CM, Bensard DD, Shames BD, et al. IL-1 regulates in vivo C-X-C chemokine induction and neutrophil sequestration following endotoxemia. J Endotoxin Res. 2002;8:59-67.
49. Tessier PA, Naccache PH, Clark-Lewis I, Gladue RP, Neote KS, McColl SR. Chemokine networks in vivo: involvement of C-X-C and C-C chemokines in neutrophil extravasation in vivo in response to TNF-alpha. J Immunol. 1997;159:3595-3602.
50. Xue ML, Thakur A, Willcox M. Gene expression of pro-inflammatory cytokines and chemokines in mouse eye infected with Pseudomonas aeruginosa. Clin Exp Ophthalmol. 2002;30:196-99.
51. Kernacki KA, Barrett RP, Hobden JA, Hazlett LD. Macrophage inflammatory protein-2 is a mediator of polymorphonuclear neutrophil influx in ocular bacterial infection. J Immunol. 2000;164:1037-1045.
52. Yan XT, Tumpey TM, Kunkel SL, Oakes JE, Lausch RN. Role of MIP-2 in neutrophil migration and tissue injury in the herpes simplex virus-1-infected cornea. Invest Ophthalmol Vis Sci. 1998;39:1854-1862.
53. Li DQ, Lokeshwar BL, Solomon A, Monroy D, Ji Z, Pflugfelder SC. Regulation of MMP-9 production by human corneal epithelial cells. Exp Eye Res. 2001;73:449-459.