Differential Regulation of Membrane-Associated Mucins in the Human Ocular Surface Epithelium

Investigative Ophthalmology and Visual Science

Volumn 45, Issue 1, 2004, Pages 114-122

  Hori, Yuichi ^a   Spurr Michaud, Sandra ^a   Russo, Cindy Leigh ^a   Argüeso, Pablo ^a   Gipson, Ilene K ^a  

^a SCHEPENS EYE RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; CYCLOHEXIMIDE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MESSENGER RNA; MUCIN; MUCIN 1; MUCIN 16; MUCIN 4; RETINOIC ACID; RETINOIC ACID RECEPTOR ALPHA; RETINOIC ACID RECEPTOR GAMMA; UNCLASSIFIED DRUG;

ARTICLE; CELL IMMORTALIZATION; CONJUNCTIVA; CONJUNCTIVA EPITHELIUM; EPITHELIUM CELL; GENE EXPRESSION; HUMAN; HUMAN CELL; POLYACRYLAMIDE GEL ELECTROPHORESIS; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; WESTERN BLOTTING;

BLOOD; BLOTTING, WESTERN; CA-125 ANTIGEN; CA-15-3 ANTIGEN; CELL LINE; CONJUNCTIVA; CYCLOHEXIMIDE; ELECTROPHORESIS, POLYACRYLAMIDE GEL; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; HUMANS; IMMUNOBLOTTING; MEMBRANE PROTEINS; MUCINS; PROTEIN SYNTHESIS INHIBITORS; RECEPTORS, RETINOIC ACID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRETINOIN; UP-REGULATION;

EID: 0345824723     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.03-0903     Document Type: Article

References (57)

1. Gipson IK, Inatomi T. Mucin genes expressed by the ocular surface epithelium. Prog Retin Eye Res. 1997;16:81-98.
2. Argüeso P, Gipson IK. Epithelial mucins of the ocular surface: structure, biosynthesis and function. Exp Eye Res. 2001;73:281-289.
3. Corfield AP, Myerscough N, Berry M, Clamp JR, Easty DL. Mucins synthesized in organ culture of human conjunctival tissue. Biochem Soc Trans. 1991;19:352S.
4. Rose MC. Mucins: structure, function, and role in pulmonary diseases (invited review). Am J Physiol 1992;263:L413-L429.
5. Inatomi T, Spurr-Michaud S, Tisdale AS, Zhan Q, Feldman ST, Gipson IK. Expression of secretory mucin genes by human conjunctival epithelia. Invest Ophthalmol Vis Sci. 1996;37:1684-1692.
6. Fleiszig SM, Zaidi TS, Ramphal R, Pier GB. Modulation of Pseudomonas aeruginosa adherence to the corneal surface by mucus. Infect Immun. 1994;62:1799-1804.
7. Gendler SJ, Spicer AP. Epithelial mucin genes. Annu Rev Physiol. 1995;57:607-634.
8. Williams SJ, McGuckin MA, Gotley DC, Eyre HJ, Sutherland GR, Antalis TM. Two novel mucin genes down-regulated in colorectal cancer identified by differential display. Cancer Res. 1999;59:4083-4089.
9. Williams SJ, Wreschner DH, Tran M, Eyre HJ, Sutherland GR, McGuckin MA. Muc13, a novel human cell surface mucin expressed by epithelial and hemopoietic cells. J Biol Chem. 2001;276:18327-18336.
10. Pallesen LT, Berglund L, Rasmussen LK, Petersen TE, Rasmussen JT. Isolation and characterization of MUC15, a novel cell membrane-associated mucin. Eur J Biochem. 2002;269:2755-2763.
11. Yin BW, Lloyd KO. Molecular cloning of the CA125 ovarian cancer antigen: identification as a new mucin (MUC16). J Biol Chem. 2001;276:27371-27375.
12. Gum JR Jr, Crawley SC, Hicks JW, Szymkowski DE, Kim YS. MUC17, a novel membrane-tethered mucin. Biochem Biophys Res Commun. 2002;291:466-475.
13. Lapensee L, Paquette Y, Bleau G. Allelic polymorphism and chromosomal localization of the human oviductin gene (MUC9). Fertil Steril. 1997;68:702-708.
14. Gendler SJ. MUC1, the renaissance molecule. J Mammary Gland Biol Neoplasia. 2001;6:339-353.
15. Carraway KL, Price-Schiavi SA, Komatsu M, Jepson S, Perez A, Carraway CA. Muc4/sialomucin complex in the mammary gland and breast cancer. J Mammary Gland Biol Neoplasia. 2001;6:323-337.
16. O'Brien TJ, Beard JB, Underwood LJ, Dennis RA, Santin AD, York L. The CA 125 gene: an extracellular superstructure dominated by repeat sequences. Tumour Biol. 2001;22:348-366.
17. Pflugfelder SC, Liu Z, Monroy D, et al. Detection of sialomucin complex (MUC4) in human ocular surface epithelium and tear fluid. Invest Ophthalmol Vis Sci. 2000;41:1316-1326.
18. Argueso P, Spurr-Michaud S, Russo CL, Tisdale A, Gipson IK. MUC16 mucin is expressed by the human ocular surface epithelia and carries the H185 carbohydrate epitope. Invest Ophthalmol Vis Sci. 2003;44:2487-2495.
19. Sommer A, Emran N. Topical retinoic acid in the treatment of corneal xerophthalmia. Am J Ophthalmol. 1978;86:615-617.
20. Herbort CP, Zografos L, Zwingli M, Schoeneich M. Topical retinoic acid in dysplastic and metaplastic keratinization of corneoconjunctival epithelium. Graefes Arch Clin Exp Ophthalmol. 1988;226:22-26.
21. Soong HK, Martin NF, Wagoner MD, et al. Topical retinoid therapy for squamous metaplasia of various ocular surface disorders: a multicenter, placebo-controlled double-masked study. Ophthalmology. 1988;95:1442-1446.
22. Fox RI, Chan R, Michelson JB, Belmont JB, Michelson PE. Beneficial effect of artificial tears made with autologous serum in patients with keratoconjunctivitis sicca. Arthritis Rheum. 1984;27:459-461.
23. Tsubota K, Goto E, Fujita H, et al. Treatment of dry eye by autologous serum application in Sjogren's syndrome. Br J Ophthalmol. 1999;83:390-395.
24. Tsubota K, Satake Y, Shimazaki J. Treatment of severe dry eye. Lancet. 1996;348:123.
25. Sommer A. Vitamin A deficiency and xerophthalmia. Arch Ophthalmol. 1990;108:343-344.
26. Bossenbroek NM, Sulahian TH, Ubels JL. Expression of nuclear retinoic acid receptor and retinoid X receptor mRNA in the cornea and conjunctiva. Curr Eye Res. 1998;17:462-469.
27. Mori M, Ghyselinck NB, Chambon P, Mark M. Systematic immunolocalization of retinoid receptors in developing and adult mouse eyes. Invest Ophthalmol Vis Sci. 2001;42:1312-1318.
28. Gipson IK, Spurr-Michaud S, Argueso P, Tisdale A, Ng TF, Russo CL. Mucin gene expression in immortalized human corneal-limbal and conjunctival epithelial cell lines. Invest Ophthalmol Vis Sci. 2003;44:2496-2506.
29. INK4A--and p53-dependent keratinocyte senescence mechanism that limits replicative potential independent of telomere status. Mol Cell Biol. 2002;22:5157-5172.
30. Clifford JL, Petkovich M, Chambon P, Lotan R. Modulation by retinoids of mRNA levels for nuclear retinoic acid receptors in murine melanoma cells. Mol Endocrinol. 1990;4:1546-1555.
31. Argüeso P, Balaram M, Spurr-Michaud S, Keutmann HT, Dana MR, Gipson IK. Decreased levels of the goblet cell mucin MUC5AC in tears of patients with Sjögren's syndrome. Invest Ophthalmol Vis Sci. 2002;43:1004-1011.
32. Choudhury A, Singh RK, Moniaux N, El-Metwally TH, Aubert JP, Batra SK. Retinoic acid-dependent transforming growth factor-beta 2-mediated induction of MUC4 mucin expression in human pancreatic tumor cells follows retinoic acid receptor-alpha signaling pathway. J Biol Chem. 2000;275:33929-33936.
33. Danjo Y, Hazlett LD, Gipson IK. C57BL/6 mice lacking Muc1 show no ocular surface phenotype. Invest Ophthalmol Vis Sci. 2000;41:4080-4084.
34. de Cremoux P, Extra JM, Denis MG, et al. Detection of MUC1-expressing mammary carcinoma cells in the peripheral blood of breast cancer patients by real-time polymerase chain reaction. Clin Cancer Res. 2000;6:3117-3122.
35. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970;227:680-685.
36. Towbin H, Staehelin T, Gordon J. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci U S A. 1979;76:4350-4354.
37. Fischer BM, Cuellar JG, Diehl ML, et al. Neutrophil elastase increases MUC4 expression in normal human bronchial epithelial cells. Am J Physiol. 2003;284:L671-L679.
38. Zieske JD, Hutcheon AE, Guo X, Chung EH, Joyce NC. TGF-beta receptor types I and II are differentially expressed during corneal epithelial wound repair. Invest Ophthalmol Vis Sci. 2001;42:1465-1471.
39. Burchell J, Durbin H, Taylor-Papadimitriou J. Complexity of expression of antigenic determinants, recognized by monoclonal antibodies HMFG-1 and HMFG-2, in normal and malignant human mammary epithelial cells. J Immunol. 1983;131:508-513.
40. Lange C, Fernandez J, Shim D, Spurr-Michaud S, Tisdale A, Gipson IK. Mucin gene expression is not regulated by estrogen and/or progesterone in the ocular surface epithelia of mice. Exp Eye Res. 2003;77:59-68.
41. McGuckin MA, Quin RJ, Ward BG. Progesterone stimulates production and secretion of MUC1 epithelial mucin in steroid-responsive breast cancer cell lines. Int J Oncol. 1998;12:939-945.
42. Meseguer M, Aplin JD, Caballero-Campo P, et al. Human Endometrial Mucin MUC1 is up-regulated by progesterone and down-regulated in vitro by the human blastocyst. Biol Reprod. 2001;64:590-601.
43. Bemacki SH, Nelson AL, Abdullah L, et al. Mucin gene expression during differentiation of human airway epithelia in vitro. MUC4 and MUC5B are strongly induced. Am J Respir Cell Mol Biol. 1999;20:595-604.
44. Marth C, Zeimet AG, Widschwendter M, Daxenbichler G. Regulation of CA 125 expression in cultured human carcinoma cells. Int J Biol Markers. 1998;13:207-209.
45. Danjo Y, Watanabe H, Tisdale AS, et al. Alteration of mucin in human conjunctival epithelia in dry eye. Invest Ophthalmol Vis Sci. 1998;39:2602-2609.
46. Hull SR, Sheng Z, Vanderpuye O, David C, Carraway KL. Isolation and partial characterization of ascites sialoglycoprotein-2 of the cell surface sialomucin complex of 13762 rat mammary adenocarcinoma cells. Biochem J. 1990;265:121-129.
47. Sherblom AP, Carraway KL. A complex of two cell surface glycoproteins from ascites mammary adenocarcinoma cells. J Biol Chem. 1980;255:12051-12059.
48. Wu K, Fregien N, Carraway KL. Molecular cloning and sequencing of the mucin subunit of a heterodimeric, bifunctional cell surface glycoprotein complex of ascites rat mammary adenocarcinoma cells. J Biol Chem. 1994;269:11950-11955.
49. Sheng Z, Wu K, Carraway KL, Fregien N. Molecular cloning of the transmembrane component of the 13762 mammary adenocarcinoma sialomucin complex. J Biol Chem. 1992;267:16341-16346.
50. McNeer RR, Carraway CAC, Fregien NL, Carraway KL. Characterization of the expression and steroid hormone control of sialomucin complex in the rat uterus: implications for uterine receptivity. J Cell Physiol. 1998;176:110-119.
51. Price-Schiavi SA, Carraway CA, Fregien N, Carraway KL. Posttranscriptional regulation of a milk membrane protein, the sialomucin complex (ascites sialoglycoprotein (ASGP)-I/ASGP-2, rat Muc4), by transforming growth factor-β. J Biol Chem. 1998;273:35228-35237.
52. Price-Schiavi SA, Zhu X, Aquinin R, Carraway KL. Sialomucin complex (rat Muc4) is regulated by transforming growth factor-β in mammary gland by a novel post-translational mechanism. J Biol Chem. 2000;275:17800-17807.
53. Tei M, Spurr-Michaud SJ, Tisdale AS, Gipson IK. Vitamin A deficiency alters the expression of mucin genes by the rat ocular surface epithelium. Invest Ophthalmol Vis Sci. 2000;41:82-88.
54. Brand N, Petkovich M, Krust A, et al. Identification of a second human retinoic acid receptor. Nature. 1988;332:850-853.
55. Benbrook D, Lernhardt E, Pfahl M. A new retinoic acid receptor identified from a hepatocellular carcinoma. Nature. 1988;333:669-672.
56. Martin CA, Ziegler LM, Napoli JL. Retinoic acid, dibutyryl-cAMP, and differentiation affect the expression of retinoic acid receptors in F9 cells. Proc Natl Acad Sci USA. 1990;87:4804-4808.
57. Gilbard JP, Huang AJ, Belldegrun R, Lee JS, Rossi SR, Gray KL. Open-label crossover study of vitamin A ointment as a treatment for keratoconjunctivitis sicca. Ophthalmology. 1989;96:244-246.