TFF peptides in the human efferent tear ducts

Investigative Ophthalmology and Visual Science

Volumn 43, Issue 11, 2002, Pages 3359-3364

  Paulsen, Friedrich P ^a   Hinz, Margitta ^a   Schaudig, Ulrich ^a   Thale, Andreas B ^a   Hoffmann, Werner ^a  

^a UNIVERSITY OF KIEL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; PEPTIDE TFF; PEPTIDE TFF1; PEPTIDE TFF2; PEPTIDE TFF3; TREFOIL PEPTIDE; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; ARTICLE; CHILD; CLINICAL ARTICLE; EPITHELIUM CELL; FEMALE; FLOW KINETICS; GOBLET CELL; HEALING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LACRIMAL DUCT; LACRIMAL SAC; MALE; PEPTIDE ANALYSIS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SALIVARY GLAND; SEROSA; TEAR FILM; WESTERN BLOTTING;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; BLOTTING, WESTERN; CHILD; CHILD, PRESCHOOL; EPITHELIAL CELLS; EYE PROTEINS; FEMALE; GOBLET CELLS; GROWTH SUBSTANCES; HUMANS; IMMUNOENZYME TECHNIQUES; MALE; MIDDLE AGED; MUCINS; MUSCLE PROTEINS; NASOLACRIMAL DUCT; NEUROPEPTIDES; PEPTIDES; PROTEIN BIOSYNTHESIS; PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR SUPPRESSOR PROTEINS;

EID: 0036846770     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (58)

1. Jones LT. Epiphora II: Its relation of the anatomic structures and surgery of the medial canthal region. Am J Ophthalmol. 1957;43:203-212.
2. Thale A, Paulsen F, Rochels R, Tillmann B. Functional anatomy of the human efferent tear ducts: A new theory of tear outflow mechanism. Graefes Arch Clin Exp Ophthalmol. 1998;236:674-678.
3. Paulsen FP, Thale AB, Hallmann UJ, Schaudig U, Tillmann BN. The cavernous body of the human efferent tear ducts: Function in tear outflow mechanism. Invest Ophthalmol Vis Sci. 2000;41:965-970.
4. Hurwitz JJ. The lacrimal system. In: Hurwitz JJ, ed. The Eye. Philadelphia: Lippincott-Raven; 1996;23-29.
5. Hurwitz JJ, Maisey MN, Welham RAN. Quantitative lacrimal scintillography: method and physiological application. Br J Ophthalmol. 1975;59:308-312.
6. Murube del Castillo J. On gravity as one of the impelling forces of lacrimal flow. Asahi Evening News. January 20, 1978;51-59.
7. Nik NA, Hurwitz JJ, Chin Sang H. The mechanism of tear flow after DCT and Jones' tube surgery. Arch Ophthalmol. 1984;102:1643-1649.
8. Schirmer O. Studien zur physiologie und pathologie der tränenabsonderung und tränenabfuhr. Arch Ophthalmol. 1903;56:197-212.
9. Rohen JW. Haut und sinnesorgane. In: Möllendorf W von, ed. Handbuch der Mikroskopischen Anatomie des Menschen. Vol. 3. Berlin: Springer; 1964:448-451.
10. Paulsen F, Thale A, Kohla G, et al. Functional anatomy of human lacrimal duct epithelium. Anat Embryol. 1998;198:1-12.
11. Thale A, Paulsen F, Kohla G, Schauer R, Rochels R, Tillmann B. Die ableitenden tränenwege unter physiologischen und immunologischen gesichtspunkten. Ophthalmologe. 2001;98:56-63.
12. Berry M, Ellingham RB, Corfield AP. Polydispersity of normal human conjunctival mucins. Invest Ophthalmol Vis Sci. 1996;37:2559-2571.
13. Gipson IK, Inatomi T. Mucin genes expressed by the ocular surface epithelium. Prog Retinal Eye Res. 1997;16:81-98.
14. Corfield AP, Carrington SD, Hicks SJ, Berry M, Ellingham RB. Ocular mucins: Purification, metabolism and functions. Prog Retinal Eye Res. 1997;16:627-656.
15. Danjo Y, Watanable H, Tisdale AS, et al. Alterations of mucin in human conjunctival epithelia in dry eye. Invest Ophthalmol Vis Sci. 1998;39:2602-2609.
16. Jagla W, Wiede A, Hoffmann W. Localization of TFF3 peptide to porcine conjunctival goblet cells. Cell Tissue Res. 1999;296:525-530.
17. Langer G, Jagla W, Behrens-Baumann W, Walter S, Hoffmann W. Secretory peptides TFF1 and TFF3 synthesized in human conjunctival goblet cells. Invest Ophthalmol Vis Sci. 1999;40:2220-2224.
18. Langer G, Jagla W, Behrens-Baumann W, Walter S, Hoffmann W. Ocular TFF peptides: New mucus-associated secretory products of conjunctival goblet cells. In: Sullivan DA, ed. Lacrimal Gland, Tear Film, and Dry Eye Syndromes. 3rd Ed. New York: Kluwer Academic, Plenum Publishers; In press.
19. Langer G, Walter S, Behrens-Baumann W, Hoffmann W. TFF-peptide: Neue mukus-assoziierte sekretionsprodukte der konjunktiva. Ophthalmologe. 2001;98:976-979.
20. Wright NA, Hoffmann W, Otto WR, Rio M-C, Thim L. Rolling in the clover: The trefoil factor family (TFF)-domain peptides, cell migration and cancer. FEBS Lett. 1997;408:121-123.
21. Hoffmann W, Hauser F. The P-domain or trefoil motif: A role in renewal and pathology of mucous epithelia? Trends Biochem Sci. 1993;18:239-243.
22. Hoffmann W, Jagla W, Wiede A. Molecular medicine of TFF peptides: From gut to brain. Histol Histopathol. 2001;16:319-334.
23. Hoffmann W, Jagla W. Cell type specific expression of secretory TFF peptides: Colocalization with mucins and synthesis in the brain. Int Rev Cytol. 2001;213:147-181.
24. Jagla W, Wiede A, Dietzmann K, Rutkowski K, Hoffmann W. Co-localization of TFF3 peptide and oxytocin in the human hypothalamus. FASEB J. 2000;14:1126-1131.
25. Dignass A, Lynch-Devaney K, Kindon H, Thim L, Podolsky DK. Trefoil peptides promote epithelial migration though a transforming growth factor β-independent pathway. J Clin Invest. 1994;94:376-383.
26. Göke MN, Cook JR, Kunert KS, Fini ME, Gipson IK, Podolsky DK. Trefoil peptides promote restitution of wounded corneal epithelial cells. Exp Cell Res. 2001;264:337-344.
27. Oertel M, Graness A, Thim L, Bühling F, Kalbacher H, Hoffmann W. Trefoil factor family-peptides promote migration of human bronchial epithelial cells: Synergistic effect with epidermal growth factor. Am J Respir Cell Mol Biol. 2001;25:418-424.
28. Taupin DR, Kinoshita K, Podolsky. DK. Intestinal trefoil factor confers colonic epithelial resistance to apoptosis. Proc Natl Acad Sci USA. 2000;97:799-804.
29. Kinoshita T, Taupin DR, Itoh H, Podolsky DK. Distinct pathways of cell migration and antiapoptotic response to epithelial injury: Structure-function analysis of human intestinal trefoil factor. Mol Cell Biol. 2000;20:4680-4690.
30. Chen Y-H, Lu Y, De Plaen IG, Wang L-Y, Tan X-D. Transcription factor NF-κB signals antianoikic function of trefoil factor 3 on intestinal epithelial cells. Biochem Biophys Res Commun. 2000;274:576-582.
31. Williams R, Stamp GWH, Lalani E-N, Pignatelli M. pS2 transfection of murine adenocarcinoma cell-line (410.4) enhances dispersed growth pattern in 3-D collagen gel. J Cell Sci. 1996;109:63-71.
32. Emami S, Le Floch N, Bruyneel E, et al. Induction of scattering and cellular invasion by trefoil peptides in src- and RhoA-transformed kidney and colonic epithelial cells. FASEB J. 2001;15:351-361.
33. Schwarz H, Jagla W, Wiede A, Hoffmann W. Ultrastructural colocalization of TFF3-peptide and oxytocin in the neural lobe of the porcine pituitary. Res Cell Tissue. 2001;305:411-416.
34. Wright N. Aspects of the biology of regeneration and repair in the human gastrointestinal tract. Phil Trans R Soc Lond B. 1998;353:925-933.
35. Wiede A, Hinz M, Canzler E, Franke K, Quednow C, Hoffmann W. Synthesis and localization of the mucin-associated TFF peptides in the human uterus. Cell Tissue Res. 2001;303:109-115.
36. Wiede A, Jagla W, Welte T, Köhnlein T, Busk H, Hoffmann W. Localization of TFF3, a new mucus-associated peptide of the human respiratory tract. Am J Respir Crit Care Med. 1999;159:1330-1335.
37. Jagla W, Wiede A, Kölle S, Hoffmann W. Differential expression of the TFF peptides xP1 and xP4 in the gastrointestinal tract of Xenopus laevis. Cell Tissue Res. 1998;291:13-18.
38. Jagla W, Wiede A, Hinz M, et al. Secretion of TFF peptides by human salivary glands. Cell Tissue Res. 1999;298:161-166.
39. Robbins PD, Hahnel E, Sterrett GF, Harvey J, Carrello S, Hahnel R. Expression of the pS2 gene in breast cancer: A comparison of pS2 protein radioimmunoassay and immunohistochemistry. Pathology. 1993;25:255-260.
40. Taupin D, Ooi K, Yeomans N, Giraud A. Conserved expression of intestinal trefoil factor in the human colonic adenoma-carcinoma sequence. Lab Invest. 1996;75:25-32.
41. Taupin D, Pedersen J, Familari M, Cook G, Yeomans N, Giraud AS. Augmented intestinal trefoil factor (TFF3) and loss of pS2 (TFF1) expression precedes metaplastic differentiation of gastric epithelium. Lab Invest. 2001;81:397-408.
42. Rio MC, Bellocq JP, Daniel JY, et al. Breast cancer-associated pS2 protein: Synthesis and secretion by normal stomach mucosa. Science. 1988;241:705-708.
43. Lefebvre O, Wolf C, Kédinger M, et al. The mouse one P-domain (pS2) and two P-domain (mSP) genes exhibit distinct patterns of expression. J Cell Biol. 1993;122:191-198.
44. Pigott NH, Henry JA, May FEB, Westley BR. Antipeptide antibodies against the pNR-2 oestrogen-regulated protein of human breast cancer cells and detection of pNR-2 expression in normal tissues by immunohistochemistry. J Pathol. 1991;163:95-104.
45. Inatomi T, Spurr-Michaud S, Tisdale AS, Zhan Q, Feldman ST, Gipson I. Expression of secretory mucin genes by human conjunctival epithelia. Invest Ophthalmol Vis Sci. 1996;37:1684-1692.
46. Jumblatt MM, McKenzie RW, Jumblatt JE. MUC5AC mucin is a component of the human precorneal tear film. Invest Ophthalmol Vis Sci. 1999;40:43-49.
47. Nielsen PA, Mandel U, Therkildsen MH, Clausen H. Differential expression of human high-molecular-weight salivary mucin (MG1) and low-molecular-weight salivary mucin (MG2). J Dent Res. 1996;75:1820-1826.
48. Nielsen PA, Bennett EP, Wandall HH, Therkildsen MH, Hannibal J, Clausen H. Identification of a major human high molecular weight salivary mucin (MG1) as tracheobronchial mucin MUC5B. Glycobiology. 1997;7:413-419.
49. Hauser F, Poulsom R, Chinery R, et al. hP1.B, a human P-domain peptide homologous with rat intestinal trefoil factor, is expressed also in the ulcer-associated cell lineage and the uterus. Proc Natl Acad Sci USA. 1993;90:6961-6965.
50. Babyatsky MW, de Beaumont M, Thim L, Podolsky DK. Oral trefoil peptides protect against ethanol- and indomethacin-induced gastric injury in rats. Gastroenterology. 1996;110:489-497.
51. Chadwick MP, Westley BR, May FEB. Homodimerization and hetero-oligomerization of the single-domain trefoil protein pNR-2/pS2 through cysteine 58. Biochem J. 1997;327:117-123.
52. Chinery R, Bates PA, De A, Freemont PS. Characterisation of the single copy trefoil peptides intestinal trefoil factor and pS2 and their ability to form covalent dimers. FEBS Lett. 1995;357:50-54.
53. Verdugo P. Goblet cells secretion and mucogenesis. Annu Rev Physiol. 1990;52:157-176.
54. Hoffmann W, Joba W. Biosynthesis and molecular architecture of gel-forming mucins: Implications from an amphibian model system. Biochem Soc Trans. 1995;23:805-810.
55. Tomasetto C, Masson R, Linaires J-L, et al. pS2/TFF1 interacts directly with the VWFC cysteine-rich domains of mucins. Gastroenterology. 2000;118:70-80.
56. Paulsen F, Pufe T, Schaudig U, et al. Detection of natural peptide antibiotics in human nasolacrimal ducts. Invest Ophthalmol Vis Sci. 2001;42:2157-2163.
57. Paulsen F, Pufe T, Schaudig U,. et al. Protection of human efferent tear ducts by antimicrobial peptides. In: Sullivan DA, ed. Lacrimal Gland, Tear Film and Dry Eye Syndromes. 3. New York: Kluwer Academic, Plenum Publishers. In press.
58. Paulsen F, Thale A, Maune S, Tillmann B. Primary acquired dacryostenosis: Histopathology and pathophysiology. Ophthalmology. 2001;108:2329-2336.