Design and synthesis of [(2,3-dichlorophenyl)piperazin-1-yl]alkylfluorenylcarboxamides as novel ligands selective for the dopamine D3 receptor subtype

Journal of Medicinal Chemistry

Volumn 44, Issue 19, 2001, Pages 3175-3186

  Robarge, M J ^a,b   Husbands, S M ^a,d   Kieltyka, A ^c   Brodbeck, R ^c   Thurkauf, A ^c   Newman, A H ^c  

^a Intramural Research Program   (United States)

^b CELGENE CORPORATION   (United States)

^c NEUROGEN CORPORATION   (United States)

^d University of Bath   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 DIPROPYLAMINO 7 HYDROXYTETRALIN; [(2,3 DICHLOROPHENYL)PIPERAZIN 1 YL]FLUORENYLCARBOXAMIDE; AMIDE; BP 897; DOPAMINE 3 RECEPTOR; LIGAND; PSYCHOSTIMULANT AGENT; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ALKYLATION; ARTICLE; BINDING AFFINITY; DISCRIMINATIVE STIMULUS; DRUG DESIGN; DRUG SYNTHESIS; LIMBIC CORTEX; NEUROTRANSMITTER RELEASE; RECEPTOR AFFINITY; REINFORCEMENT; SENSITIZATION; STRUCTURE ACTIVITY RELATION;

AMIDES; ANIMALS; BINDING, COMPETITIVE; CHO CELLS; COMBINATORIAL CHEMISTRY TECHNIQUES; CRICETINAE; DRUG DESIGN; FLUORENES; HUMANS; LIGANDS; PIPERAZINES; RADIOLIGAND ASSAY; RECEPTORS, DOPAMINE D2; RECEPTORS, DOPAMINE D3; RECEPTORS, DOPAMINE D4; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035855846     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010146o     Document Type: Article

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