Novel compound 2-methyl-2H-pyrazole-3-carboxylic acid (2-methyl-4-o- tolylazo-phenyl)-amide (CH-223191) prevents 2,3,7,8-TCDD-induced toxicity by antagonizing the aryl hydrocarbon receptor

Molecular Pharmacology

Volumn 69, Issue 6, 2006, Pages 1871-1878

  Kim, Sun Hee ^a   Henry, Ellen C ^c   Kim, Dong Kyu ^b   Kim, Yun Hee ^a   Kum, Joo Shin ^a   Myoung, Sook Han ^a   Lee, Taehoon G ^a   Kang, Jong Ku ^b   Gasiewicz, Thomas A ^c   Sung, Ho Ryu ^a   Suh, Pann Ghill ^a  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

^b Chungbuk National University   (South Korea)

^c UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 METHYL 2H PYRAZOLE 3 CARBOXYLIC ACID (2 METHYL 4 O TOLYLAZO PHENYL) AMIDE; 2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AMIDE; CH 223191; CYTOCHROME P450; HYDROCARBON; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DNA BINDING; DRUG IDENTIFICATION; DRUG INHIBITION; DRUG POTENCY; DRUG SCREENING; ENZYME ACTIVITY; ENZYME INDUCTION; ESTROGEN ACTIVITY; GENE TARGETING; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IN VIVO STUDY; LIVER TOXICITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; WASTING SYNDROME;

ANIMALS; ANTIDOTES; AZO COMPOUNDS; CELL LINE, TUMOR; CYTOCHROME P-450 CYP1A1; DIOXINS; DRUG EVALUATION, PRECLINICAL; HUMANS; LIVER; MALE; MICE; MICE, INBRED ICR; PROTEIN TRANSPORT; PYRAZOLES; RECEPTORS, ARYL HYDROCARBON;

EID: 33745116617     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.105.021832     Document Type: Article

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