3′-Methoxy-4′-nitroflavone, a reported aryl hydrocarbon receptor antagonist, enhances Cyp1a1 transcription by a dioxin responsive element-dependent mechanism

Archives of Biochemistry and Biophysics

Volumn 416, Issue 1, 2003, Pages 68-80

  Zhou, Junguo ^a   Gasiewicz, Thomas A ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

3 Methoxy 4 nitroflavone; Aryl hydrocarbon receptor; Cyp1a1; Differential gene induction; Dioxin responsive element; Luciferase reporter gene

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 3' METHOXY 4' NITROFLAVONE; AROMATIC HYDROCARBON RECEPTOR; CYTOCHROME P450 1A1; DIOXIN; FLAVONE DERIVATIVE; NUCLEOTIDE; UNCLASSIFIED DRUG; 3'-METHOXY-4'-NITROFLAVONE; CHLORAMPHENICOL ACETYLTRANSFERASE; FLAVONOID; LUCIFERASE;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; DRUG POTENCY; GENE CONTROL; GENE MUTATION; GENETIC TRANSCRIPTION; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REPORTER GENE; TRANSCRIPTION INITIATION; ANIMAL; CELL CULTURE; DNA RESPONSIVE ELEMENT; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; GENE DELETION; GENETICS; LIVER TUMOR; METABOLISM; PROMOTER REGION; TIME;

ANIMALS; CHLORAMPHENICOL O-ACETYLTRANSFERASE; CYTOCHROME P-450 CYP1A1; DIOXINS; DOSE-RESPONSE RELATIONSHIP, DRUG; FLAVONOIDS; GENES, REPORTER; LIVER NEOPLASMS, EXPERIMENTAL; LUCIFERASES; MICE; PROMOTER REGIONS (GENETICS); RECEPTORS, ARYL HYDROCARBON; RESPONSE ELEMENTS; SEQUENCE DELETION; TETRACHLORODIBENZODIOXIN; TIME FACTORS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0037707577     PISSN: 00039861     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0003-9861(03)00274-1     Document Type: Article

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