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Volumn 66, Issue 10, 2006, Pages 5258-5269

Regulation of microtubule-dependent protein transport by the TSC2/mammalian target of rapamycin pathway

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; CAVEOLIN 1; GREEN FLUORESCENT PROTEIN; MICROTUBULE PROTEIN; RAPAMYCIN; TUBERIN; TUBULIN;

EID: 33744919546     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-05-4510     Document Type: Article
Times cited : (43)

References (38)
  • 1
    • 18144399578 scopus 로고    scopus 로고
    • mTOR-targeted therapy of cancer with rapamycin derivatives
    • Vignot S, Faivre S, Aguirre D, Raymond E. mTOR-targeted therapy of cancer with rapamycin derivatives. Ann Oncol 2005;16:525-37.
    • (2005) Ann Oncol , vol.16 , pp. 525-537
    • Vignot, S.1    Faivre, S.2    Aguirre, D.3    Raymond, E.4
  • 2
    • 11244297916 scopus 로고    scopus 로고
    • Dysregulation of the TSC-mTOR pathway in human disease
    • Inoki K, Corradetti MN, Guan KL. Dysregulation of the TSC-mTOR pathway in human disease. Nat Genet 2005; 37:19-24.
    • (2005) Nat Genet , vol.37 , pp. 19-24
    • Inoki, K.1    Corradetti, M.N.2    Guan, K.L.3
  • 4
    • 0038304516 scopus 로고    scopus 로고
    • Rheb is an essential regulator of S6K in controlling cell growth in Drosophila
    • Stocker H, Radimerski T, Schindelholz B, et al. Rheb is an essential regulator of S6K in controlling cell growth in Drosophila. Nat Cell Biol 2003;5:559-65.
    • (2003) Nat Cell Biol , vol.5 , pp. 559-565
    • Stocker, H.1    Radimerski, T.2    Schindelholz, B.3
  • 5
    • 0038643484 scopus 로고    scopus 로고
    • Rheb promotes cell growth as a component of the insulin/TOR signalling network
    • Saucedo LJ, Gao X, Chiarelli DA, Li L, Pan D, Edgar BA. Rheb promotes cell growth as a component of the insulin/ TOR signalling network. Nat Cell Biol 2003;5:566-71.
    • (2003) Nat Cell Biol , vol.5 , pp. 566-571
    • Saucedo, L.J.1    Gao, X.2    Chiarelli, D.A.3    Li, L.4    Pan, D.5    Edgar, B.A.6
  • 6
    • 0038141979 scopus 로고    scopus 로고
    • Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins
    • Zhang Y, Gao X, Saucedo LJ, Ru B, Edgar BA, Pan D. Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins. Nat Cell Biol 2003;5:578-81.
    • (2003) Nat Cell Biol , vol.5 , pp. 578-581
    • Zhang, Y.1    Gao, X.2    Saucedo, L.J.3    Ru, B.4    Edgar, B.A.5    Pan, D.6
  • 7
    • 0043127125 scopus 로고    scopus 로고
    • Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling
    • Inoki K, Li Y, Xu T, Guan KL. Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev 2003;17:1829-34.
    • (2003) Genes Dev , vol.17 , pp. 1829-1834
    • Inoki, K.1    Li, Y.2    Xu, T.3    Guan, K.L.4
  • 8
    • 0041356888 scopus 로고    scopus 로고
    • Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner
    • Castro AF, Rebhun JF, Clark GJ, Quilliam LA. Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner. J Biol Chem 2003; 278:32493-6.
    • (2003) J Biol Chem , vol.278 , pp. 32493-32496
    • Castro, A.F.1    Rebhun, J.F.2    Clark, G.J.3    Quilliam, L.A.4
  • 9
    • 0036714127 scopus 로고    scopus 로고
    • Akt regulates growth by directly phosphorylating Tsc2
    • Potter CJ, Pedraza LG, Xu T. Akt regulates growth by directly phosphorylating Tsc2. Nat Cell Biol 2002;4: 658-65.
    • (2002) Nat Cell Biol , vol.4 , pp. 658-665
    • Potter, C.J.1    Pedraza, L.G.2    Xu, T.3
  • 10
    • 0036713778 scopus 로고    scopus 로고
    • TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
    • Inoki K, Li Y, Zhu T, Wu J, Guan KL. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol 2002;4: 648-57.
    • (2002) Nat Cell Biol , vol.4 , pp. 648-657
    • Inoki, K.1    Li, Y.2    Zhu, T.3    Wu, J.4    Guan, K.L.5
  • 11
    • 18544375193 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin
    • Dan HC, Sun M, Yang L, et al. Phosphatidylinositol 3-kinase/Akt pathway regulates tuberous sclerosis tumor suppressor complex by phosphorylation of tuberin. J Biol Chem 2002;277:35364-70.
    • (2002) J Biol Chem , vol.277 , pp. 35364-35370
    • Dan, H.C.1    Sun, M.2    Yang, L.3
  • 12
    • 0345167800 scopus 로고    scopus 로고
    • TSC2 mediates cellular energy response to control cell growth and survival
    • Inoki K, Zhu T, Guan KL. TSC2 mediates cellular energy response to control cell growth and survival. Cell 2003;115:577-90.
    • (2003) Cell , vol.115 , pp. 577-590
    • Inoki, K.1    Zhu, T.2    Guan, K.L.3
  • 13
    • 3142594193 scopus 로고    scopus 로고
    • The LKB1 tumor suppressor negatively regulates mTOR signaling
    • Shaw RJ, Bardeesy N, Manning BD, et al. The LKB1 tumor suppressor negatively regulates mTOR signaling. Cancer Cell 2004;6:91-9.
    • (2004) Cancer Cell , vol.6 , pp. 91-99
    • Shaw, R.J.1    Bardeesy, N.2    Manning, B.D.3
  • 14
    • 0037178781 scopus 로고    scopus 로고
    • Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action
    • Hara K, Maruki Y, Long X, et al. Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action. Cell 2002;110:177-89.
    • (2002) Cell , vol.110 , pp. 177-189
    • Hara, K.1    Maruki, Y.2    Long, X.3
  • 15
    • 0037178786 scopus 로고    scopus 로고
    • mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
    • Kim DH, Sarbassov DD, Ali SM, et al. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell 2002;110:163-75.
    • (2002) Cell , vol.110 , pp. 163-175
    • Kim, D.H.1    Sarbassov, D.D.2    Ali, S.M.3
  • 16
    • 3342895823 scopus 로고    scopus 로고
    • Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-in dependent pathway that regulates the cytoskeleton
    • Sarbassov dos D, Ali SM, Kim DH, et al. Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-in dependent pathway that regulates the cytoskeleton. Curr Biol 2004;14: 1296-302.
    • (2004) Curr Biol , vol.14 , pp. 1296-1302
    • Sarbassov Dos, D.1    Ali, S.M.2    Kim, D.H.3
  • 17
    • 7944235758 scopus 로고    scopus 로고
    • Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
    • Jacinto E, Loewith R, Schmidt A, et al. Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive. Nat Cell Biol 2004;6:1122-8.
    • (2004) Nat Cell Biol , vol.6 , pp. 1122-1128
    • Jacinto, E.1    Loewith, R.2    Schmidt, A.3
  • 18
    • 32044465506 scopus 로고    scopus 로고
    • TOR signaling in growth and metabolism
    • Wullschleger S, Loewith R, Hall MN. TOR signaling in growth and metabolism. Cell 2006;124:471-84.
    • (2006) Cell , vol.124 , pp. 471-484
    • Wullschleger, S.1    Loewith, R.2    Hall, M.N.3
  • 19
    • 0030809956 scopus 로고    scopus 로고
    • Control of amino acid permease sorting in the late secretory pathway of Saccharomyces cerevisiae by SEC13, LST4, LST7 and LST8
    • Roberg KJ, Bickel S, Rowley N, Kaiser CA. Control of amino acid permease sorting in the late secretory pathway of Saccharomyces cerevisiae by SEC13, LST4, LST7 and LST8. Genetics 1997;147:1569-84.
    • (1997) Genetics , vol.147 , pp. 1569-1584
    • Roberg, K.J.1    Bickel, S.2    Rowley, N.3    Kaiser, C.A.4
  • 20
    • 0035019467 scopus 로고    scopus 로고
    • Tuberin-dependent membrane localization of polycystin-1: A functional link between polycystic kidney disease and the TSC2 tumor suppressor gene
    • Kleymenova E, Ibraghimov-Beskrovnaya O, Kugoh H, et al. Tuberin-dependent membrane localization of polycystin-1: a functional link between polycystic kidney disease and the TSC2 tumor suppressor gene. Mol Cell 2001;7:823-32.
    • (2001) Mol Cell , vol.7 , pp. 823-832
    • Kleymenova, E.1    Ibraghimov-Beskrovnaya, O.2    Kugoh, H.3
  • 21
    • 1842861671 scopus 로고    scopus 로고
    • Tuberin is a component of lipid rafts and mediates caveolin-1 localization: Role of TSC2 in post-Golgi transport
    • Jones KA, Jiang X, Yamamoto Y, Yeung RS. Tuberin is a component of lipid rafts and mediates caveolin-1 localization: role of TSC2 in post-Golgi transport. Exp Cell Res 2004;295:512-24.
    • (2004) Exp Cell Res , vol.295 , pp. 512-524
    • Jones, K.A.1    Jiang, X.2    Yamamoto, Y.3    Yeung, R.S.4
  • 22
    • 0036753494 scopus 로고    scopus 로고
    • Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control
    • Loewith R, Jacinto E, Wullschleger S, et al. Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Mol Cell 2002; 10:457-68.
    • (2002) Mol Cell , vol.10 , pp. 457-468
    • Loewith, R.1    Jacinto, E.2    Wullschleger, S.3
  • 23
    • 0035976615 scopus 로고    scopus 로고
    • Phosphatidic acid-mediated mitogenic activation of mTOR signaling
    • Fang Y, Vilella-Bach M, Bachmann R, Flanigan A, Chen J. Phosphatidic acid-mediated mitogenic activation of mTOR signaling. Science 2001;294:1942-5.
    • (2001) Science , vol.294 , pp. 1942-1945
    • Fang, Y.1    Vilella-Bach, M.2    Bachmann, R.3    Flanigan, A.4    Chen, J.5
  • 24
    • 0037623417 scopus 로고    scopus 로고
    • GβL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR
    • Kim DH, Sarbassov dos D, Ali SM, et al. GβL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR. Mol Cell 2003;11:895-904.
    • (2003) Mol Cell , vol.11 , pp. 895-904
    • Kim, D.H.1    Sarbassov Dos, D.2    Ali, S.M.3
  • 25
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • Sarbassov dos D, Guertin DA, Ali SM, Sabatini DM. Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 2005;307:1098-101.
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov Dos, D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 26
    • 3342958797 scopus 로고    scopus 로고
    • The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins
    • Harrington LS, Findlay GM, Gray A, et al. The TSC1-2 tumor suppressor controls insulin-PI3K signaling via regulation of IRS proteins. J Cell Biol 2004; 166:213-23.
    • (2004) J Cell Biol , vol.166 , pp. 213-223
    • Harrington, L.S.1    Findlay, G.M.2    Gray, A.3
  • 27
    • 0742289586 scopus 로고    scopus 로고
    • Microtubule organization and function in epithelial cells
    • Musch A. Microtubule organization and function in epithelial cells. Traffic 2004;5:1-9.
    • (2004) Traffic , vol.5 , pp. 1-9
    • Musch, A.1
  • 28
  • 31
    • 0029929297 scopus 로고    scopus 로고
    • CLIPs for organelle-microtubule interactions
    • Rickard JE, Kreis TE. CLIPs for organelle-microtubule interactions. Trends Cell Biol 1996;6:178-83.
    • (1996) Trends Cell Biol , vol.6 , pp. 178-183
    • Rickard, J.E.1    Kreis, T.E.2
  • 33
    • 0346995280 scopus 로고    scopus 로고
    • Differential effects of rapamycin on mammalian target of rapamycin signaling functions in mammalian cells
    • Edinger AL, Linardic CM, Chiang GG, Thompson CB, Abraham RT. Differential effects of rapamycin on mammalian target of rapamycin signaling functions in mammalian cells. Cancer Res 2003;63: 8451-60.
    • (2003) Cancer Res , vol.63 , pp. 8451-8460
    • Edinger, A.L.1    Linardic, C.M.2    Chiang, G.G.3    Thompson, C.B.4    Abraham, R.T.5
  • 34
    • 0025597940 scopus 로고
    • BIK1, a protein required for microtubule function during mating and mitosis in Saccharomyces cerevisiae, colocalizes with tubulin
    • Berlin V, Styles CA, Fink GR. BIK1, a protein required for microtubule function during mating and mitosis in Saccharomyces cerevisiae, colocalizes with tubulin. J Cell Biol 1990;111:2573-86.
    • (1990) J Cell Biol , vol.111 , pp. 2573-2586
    • Berlin, V.1    Styles, C.A.2    Fink, G.R.3
  • 36
    • 17744372880 scopus 로고    scopus 로고
    • Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts
    • Akhmanova A, Hoogenraad CC, Drabek K, et al. Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts. Cell 2001;104: 923-35.
    • (2001) Cell , vol.104 , pp. 923-935
    • Akhmanova, A.1    Hoogenraad, C.C.2    Drabek, K.3
  • 37
    • 18444369936 scopus 로고    scopus 로고
    • Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170
    • Fukata M, Watanabe T, Noritake J, et al. Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170. Cell 2002;109:873-85.
    • (2002) Cell , vol.109 , pp. 873-885
    • Fukata, M.1    Watanabe, T.2    Noritake, J.3
  • 38
    • 10644281068 scopus 로고    scopus 로고
    • Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration
    • Watanabe T, Wang S, Noritake J, et al. Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration. Dev Cell 2004;7:871-83.
    • (2004) Dev Cell , vol.7 , pp. 871-883
    • Watanabe, T.1    Wang, S.2    Noritake, J.3


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