The herbicide metolachlor induces liver cytochrome P450s 2B1/2 and 3A1/2, but not thyroxine-uridine dinucleotide phosphate glucuronosyltransferase and associated thyroid gland activity

International Journal of Toxicology

Volumn 22, Issue 4, 2003, Pages 287-295

  Dalton, Shana R ^a   Miller, Richard T ^a,b   Meyer, Sharon A ^a,c  

^a NORTH CAROLINA STATE UNIVERSITY   (United States)

^b GLAXOSMITHKLINE   (United States)

^c UNIVERSITY OF LOUISIANA AT MONROE   (United States)

Author keywords

Chloroacetanilide; CYP2B; Herbicides; Metolachlor; Thyroid; UGT

Indexed keywords

CHLOROACETANILIDE; CYTOCHROME P450 2B1; CYTOCHROME P450 2B2; CYTOCHROME P450 3A1; CYTOCHROME P450 3A2; GLUCURONOSYLTRANSFERASE; LIOTHYRONINE; METOLACHLOR; PHENOBARBITAL; THYROTROPIN; THYROXINE; THYROXINE URIDINE DINUCLEOTIDE PHOSPHATE GLUCURONOSYLTRANSFERASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL HYPERPLASIA; CELL PROLIFERATION; CELL STRUCTURE; CONTROLLED STUDY; ENZYME ACTIVITY; GLUCURONIDATION; HYPERTROPHY; IMMUNOBLOTTING; LIOTHYRONINE BLOOD LEVEL; LIVER CARCINOGENESIS; LIVER MICROSOME; LIVER TUMOR; LIVER WEIGHT; MALE; NONHUMAN; RAT; THYROID FOLLICLE; THYROID FUNCTION; THYROTROPIN BLOOD LEVEL; THYROXINE BLOOD LEVEL; THYROXINE METABOLISM;

ACETAMIDES; ANIMALS; ARYL HYDROCARBON HYDROXYLASES; BODY WEIGHT; CYTOCHROME P-450 CYP2B1; EATING; GLUCURONIDES; GLUCURONOSYLTRANSFERASE; HERBICIDES; HYPERPLASIA; LIVER; MALE; MEMBRANE PROTEINS; ORGAN SIZE; RATS; RATS, SPRAGUE-DAWLEY; STEROID HYDROXYLASES; THYROID GLAND; THYROID HORMONES;

ANIMALIA; ENTEROBACTERIA PHAGE T4; GOSSYPIUM HIRSUTUM; ZEA MAYS;

EID: 0042195101     PISSN: 10915818     EISSN: None     Source Type: Journal    
DOI: 10.1080/10915810305121     Document Type: Article

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