The environmental pollutant 1,1-Dichloro-2,2-bis (p-chlorophenyl)ethylene induces rat hepatic cytochrome P450 2B and 3A expression through the constitutive androstane receptor and pregnane X receptor

Molecular Pharmacology

Volumn 64, Issue 2, 2003, Pages 474-481

  Wyde, Michael E ^a   Bartolucci, Erika ^a   Ueda, Akiko ^c   Zhang, He ^b   Yan, Binfang ^b   Negishi, Masahiko ^c   You, Li ^a  

^a CIIT CENTERS FOR HEALTH RESEARCH   (United States)

^b UNIVERSITY OF RHODE ISLAND   (United States)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHYLENE; ANDROGEN RECEPTOR; ANDROSTANE RECEPTOR; CELL NUCLEUS RECEPTOR; CHLORPHENOTANE; CYTOCHROME P450 2B; CYTOCHROME P450 3A; PHENOBARBITAL; PREGNANE X RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME INDUCTION; LACTATION; LIVER; MALE; NONHUMAN; POLLUTANT; PREGNANCY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RAT STRAIN; RECEPTOR INTRINSIC ACTIVITY; TRANSCRIPTION INITIATION;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 CYP2B1; CYTOCHROME P-450 CYP3A; CYTOCHROME P-450 ENZYME SYSTEM; DICHLORODIPHENYL DICHLOROETHYLENE; ENVIRONMENTAL POLLUTANTS; FEMALE; HEPATOCYTES; MALE; OXIDOREDUCTASES, N-DEMETHYLATING; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; TRANSCRIPTION FACTORS;

EID: 0042343720     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.64.2.474     Document Type: Article

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