Expression of a carboxy terminally truncated Stat5 with no transactivation domain in the mammary glands of transgenic mice inhibits cell proliferation during pregnancy, delays onset of milk secretion, and induces apoptosis upon involution

Molecular Reproduction and Development

Volumn 73, Issue 7, 2006, Pages 841-849

  Iavnilovitch, Elena ^a   Eilon, Tali ^a   Groner, Bernd ^b   Barash, Itamar ^a  

^a VOLCANI CENTER   (Israel)

^b INSTITUTE FOR TUMOR BIOLOGY AND EXPERIMENTAL THERAPY   (Germany)

Author keywords

Cell survival; Mammary gland; Milk protein; Stat5; Transactivation domain; Transgenic mice

Indexed keywords

ALPHA LACTALBUMIN; BETA CASEIN; BETA LACTOGLOBULIN; CYTOKINE; GROWTH FACTOR; HETERODIMER; LUCIFERASE; MILK PROTEIN; PROLACTIN; STAT5 PROTEIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BLG GENE; BREAST DEVELOPMENT; CARBOXY TERMINAL SEQUENCE; CELL NUCLEUS; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVITY; GENE; GENE SEQUENCE; GENE TARGETING; INVOLUTION; LACTATION; MAMMAL CELL; MAMMARY GLAND; MOUSE; NONHUMAN; PREGNANCY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN VARIANT; SECOND TRIMESTER PREGNANCY; SIGNAL TRANSDUCTION; THIRD TRIMESTER PREGNANCY; TRANSACTIVATION; TRANSGENIC MOUSE; WILD TYPE;

ANIMALS; APOPTOSIS; CASEINS; CELL PROLIFERATION; FEMALE; LACTALBUMIN; LACTATION; LACTOGLOBULINS; MALE; MAMMARY GLANDS, ANIMAL; MICE; MICE, INBRED STRAINS; MICE, TRANSGENIC; MILK; PHENOTYPE; PREGNANCY; PROMOTER REGIONS (GENETICS); PROTEIN STRUCTURE, TERTIARY; SEQUENCE DELETION; STAT5 TRANSCRIPTION FACTOR; TRANS-ACTIVATION (GENETICS);

MAMMALIA; MUS MUSCULUS;

EID: 33744746626     PISSN: 1040452X     EISSN: 10982795     Source Type: Journal    
DOI: 10.1002/mrd.20479     Document Type: Article

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