Transcription factor regulation in mammary epithelial cells

Domestic Animal Endocrinology

Volumn 23, Issue 1-2, 2002, Pages 25-32

  Groner, Bernd ^a  

^a INSTITUTE FOR TUMOR BIOLOGY AND EXPERIMENTAL THERAPY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CASEIN; CCAAT ENHANCER BINDING PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYTOKINE RECEPTOR; DNA; GLUCOCORTICOID RECEPTOR; JANUS KINASE; MILK PROTEIN; PROLACTIN; STAT5 PROTEIN; TRANSCRIPTION FACTOR;

BREAST DEVELOPMENT; BREAST EPITHELIUM; CELL DIFFERENTIATION; CHILDBIRTH; CONFERENCE PAPER; DIMERIZATION; HORMONE RESPONSIVE ELEMENT; LACTATION; NONHUMAN; PREGNANCY; PROMOTER REGION; PROTEIN PHOSPHORYLATION; TRANSCRIPTION REGULATION;

ANIMALS; CASEINS; DIMERIZATION; DNA-BINDING PROTEINS; EPITHELIAL CELLS; FEMALE; GENE EXPRESSION REGULATION; LACTATION; MAMMARY GLANDS, ANIMAL; MILK PROTEINS; PHOSPHORYLATION; PREGNANCY; PROLACTIN; PROMOTER REGIONS (GENETICS); RECEPTORS, GLUCOCORTICOID; STAT5 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS;

EID: 0036638507     PISSN: 07397240     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0739-7240(02)00142-X     Document Type: Conference Paper

References (37)

1. Multiple hormone interactions in the developmental biology of the mammary gland
2. Beta-casein mRNA sequesters a single stranded nucleic acid binding protein which negatively regulates the β-casein gene promoter
3. The C/EBPβ transcription factor regulates epithelial cell proliferation and differentiation in the mammary gland
4. Composite response elements mediate hormonal and developmental regulation of milk protein gene expression
5. Regulation of milk protein gene expression
6. Characterisation of Stat5a and Stat5b homodimers and heterodimers and their association with the glucocorticoid receptor in mammary cells
7. Functional interactions between Stat5 and the glucocorticoid receptor
8. Regulation of gene expression by prolactin
9. Prolactin mediated gene activation in mammary epithelial cells
10. Prolactin stimulated pathways in mammary epithelial cells
11. The structure, regulation and function of the Janus kinases (JAKs) and the signal transducers and activators of transcription (STATs)
12. Jak2 is essential for signaling through a variety of cytokine receptors
13. STATs and gene regulation
14. Signaling by the cytokine superfamily in normal and transformed cells
15. Cytokine receptor independent, constitutively active variants of MGF-Stat5
16. Regulation of mammary gland factor/Stat5a during mammary gland development
17. The significance of tetramerization in promoter recruitment by Stat5
18. Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor family and confers the prolactin response
19. Beta-casein gene promoter activity is regulated by the hormone-mediated relief of transcriptional repression and a mammary gland specific nuclear factor
20. Developmental and environmental regulation of a mammary gland specific nuclear factor essential for transcription of the gene encoding β-casein
21. Mammary gland nuclear factor (MGF) activity is positively regulated by lactogenic hormones and negatively by milk stasis
22. Prolactin induces phosphorylation of tyrosine 694 of mammary gland factor (MGF), a prerequisite for DNA binding and induction of transcription
23. Identification of tyrosine residues in the intracellular domain of the erythropoietin receptor crucial for Stat5 activation
24. Suppression of interleukin-3-induced gene expression by a C-terminal truncated Stat5: Role of Stat5 in proliferation
25. Stat5a and Stat5b proteins have essential and non-essential, or redundant, roles in cytokine responses
26. Cloning and expression of two closely related homologues of MGF-Stat5 involved in prolactin signal transduction in mouse mammary tissue
27. Deletion of the carboxyl terminal transactivation domain of MGF-Stat5 results in enhanced DNA binding and a dominant negative phenotype
28. Comparison of the transactivation domains of Stat5 and Stat6 in lymphoid and in mammary epithelial cells
29. Steroid hormone receptors: Many actors in search of a plot
30. Molecular determinants of glucocorticoid receptor function and tissue sensitivity to glucocorticoids
31. Prolactin and glucocorticoid hormones synergistically induce expression of transfected rat β-casein gene promoter constructs in a mammary epithelial cell line
32. Promoter-dependent synergy between glucocorticoid receptor and Stat5 in the activation of β-casein gene transcription
33. Specific DNA binding of Stat5, but not of glucocorticoid receptor, is required for the their functional cooperation in the regulation of gene transcription
34. Interactions in the transcriptional regulation exerted by Stat5 and by members of the steroid hormone receptor family
35. p300/CBP enhances the prolactin mediated transcriptional induction through direct interaction with the transactivation domain of Stat5, but does not participate in the Stat5 mediated suppression of the glucocorticoid response
36. The nuclear factor YY1 participates in repression of the β-casein gene promoter in mammary epithelial cells and is counteracted by mammary gland factor during lactogenic hormone induction
37. Lactogenic hormone activation of Stat5 and transcription of the beta-casein gene in mammary epithelial cells is independent of p42 MAP kinase activation