Carboxyl-truncated STAT5β is generated by a nucleus-associated serine protease in early hematopoietic progenitors

Blood

Volumn 91, Issue 6, 1998, Pages 1901-1908

  Meyer, Johann ^a   Jücker, Manfred ^a   Ostertag, Wolfram ^a   Stocking, Carol ^a,b  

^a UNIVERSITY OF HAMBURG   (Germany)

^b LEIBNIZ INSTITUTE FOR EXPERIMENTAL VIROLOGY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; PROTEINASE; SERINE PROTEINASE; STAT5 PROTEIN; STAT5B PROTEIN; TRANSCRIPTION FACTOR; DNA BINDING PROTEIN; MILK PROTEIN; SERINE PROTEINASE INHIBITOR; STAT5A PROTEIN, MOUSE; STAT5B PROTEIN, MOUSE; TRANSACTIVATOR PROTEIN;

ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL FRACTIONATION; CELL FUNCTION; GENE ACTIVATION; GENE EXPRESSION; HEMATOPOIESIS; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IMMUNOBLOTTING; PRIORITY JOURNAL; REGULATORY MECHANISM; ANIMAL; CELL LINE; CELL NUCLEUS; CHEMISTRY; ENZYME ACTIVATION; ENZYMOLOGY; METABOLISM; MOUSE;

ANIMALS; CELL LINE; CELL NUCLEUS; DNA-BINDING PROTEINS; ENZYME ACTIVATION; HEMATOPOIETIC STEM CELLS; MICE; MILK PROTEINS; SERINE PROTEINASE INHIBITORS; STAT5 TRANSCRIPTION FACTOR; TRANS-ACTIVATORS;

EID: 0032520260     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v91.6.1901.1901_1901_1908     Document Type: Article

References (48)

1. Metcalf D: The Molecular Control of Blood Cells. Cambridge, MA, Harvard, 1988
2. Arai K-I, Lee F, Miyajima A, Miyatake S, Arai N, Yokota T: Cytokines: Coordinators of immune and inflammatory responses. Annu Rev Biochem 59:783, 1990
3. Ihle JN: Cytokine receptor signalling. Nature 377:591, 1995
4. Schindler C, Darnell JE Jr: Transcriptional responses to polypeptide ligands: The JAK-STAT pathway. Annu Rev Biochem 64:621, 1995
5. Ihle JN: The Janus protein tyrosine kinase family and its role in cytokine signaling. Adv Immunol 60:1, 1995
6. Azam M, Erdjument-Bromage H, Kreider B, Xia M, Quelle FW, Basu R, Saris C, Tempst P, Ihle JN, Schindler C: Purification of interleukin-3 stimulated DNA binding factors demonstrates the involvement of multiple isoforms of Stat5 in signaling. EMBO J 14:1402, 1995
7. Schaefer TS, Sanders LK, Nathans D: Cooperative transcriptional activity of Jun and Stat3β, a short form of Stat3. Proc Natl Acad Sci USA 92:9097, 1995
8. Schindler C, Fu X-Y, Importa T, Aebersold R, Darnell JE Jr: Proteins of transcription factor ISGF-3: One gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha. Proc Natl Acad Sci USA 89:7836, 1992
9. Wang D, Stravopodis D, Teglund S, Kitazawa J, Ihle JN: Naturally occurring dominant negative variants of Stat5. Mol Cell Biol 16:6141, 1996
10. Zhong Z, Wen Z, Darnell JE Jr: Stat3 and Stat4: Members of the family of signal transducers and activators of transcription. Proc Natl Acad Sci USA 91:4806, 1994
11. Wakao H, Gouilleux F, Groner B: Mammary gland factor (MGF) is a novel member of the cytokine regulated transcription factor gene family and confers prolactin response. EMBO J 13:2182, 1994
12. Mui AL, Wakao H, O'Farrell A-M, Harada N, Miyajima A: Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs. EMBO J 14:1166, 1995
13. Pallard C, Gouilleux F, Benit L, Coault L, Souyri M, Levy D, Groner B, Gisselbrecht S, Dusanter-Fourt I: Thrombopoietin activates a STAT5-like factor in hematopoietic cells. EMBO J 14:2847, 1995
14. Quelle FW, Wang D, Nosaka T, Thierfelder WE, Stravopodis D, Weinstein Y, Ihle JN: Erythropoietin induces activation of Stat5 through association with specific tyrosines on the receptor that are not required for a mitogenic response. Mol Cell Biol 16:1622, 1996
15. Gouilleux G, Pallard C, Dusanter-Fourt I, Wakao H, Haldosen L, Norstedt G, Levy D, Groner B: Prolactin, growth hormone, erythropoietin, and granulocyte-macrophage colony stimulating factor induce MGF-STAT5 DNA binding activity. EMBO J 14:2005, 1995
16. Lin J-X, Migone T-S, Tsang M, Friedmann M, Weatherbee JA, Zhou L, Yamauchi A, Bloom ET, Mietz J, John S, Leonard WJ: The role of shared receptor motifs and common Stats proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15. Immunity 2:331, 1995
17. Hou J, Schindler U, Henzel WJ, Wong SC, McKnight SL: Identification and purification of human Stat proteins activated in response to IL-2. Immunity 2:321, 1995
18. Lui X, Robinson GW, Gouilleux F, Groner B, Henninghausen L: Cloning and expression of STAT5 and an additional homologue (STAT5b) involved in prolactin signal transduction in mouse mammary tissues. Proc Natl Acad Sci USA 92:8831, 1995
19. Meinke A, Barahmand-Pour F, Wöhrl S, Stoiber D, Decker T: Activation of different StatS isoforms contributes to cell-type restricted signaling in response to interferons. Mol Cell Biol 16:6937, 1996
20. Rosen RL, Winestock KD, Chen G, Liu X, Hennighausen L, Finbloom DS: Granulocyte-macrophage colony-stimulating factor preferentially activates the 94-kD STAT5A and an 80-kD STAT5A isoform in human peripheral blood monocytes. Blood 88:1206, 1996
21. Kazansky AV, Raught B, Lindsey SM, Wang Y, Rosen JM: Regulation of mammary gland factor/stat5a during mammary gland development. Mol Endocrinol 9:2349, 1995
22. Ripperger JA, Fritz S, Richter K, Hocke GM, Lottspeich F, Fey GH: Transcription factors Stat3 and Stat5b are present in rat liver nuclei late in an acute phase response and bind interleukin-6 response elements. J Biol Chem 270:29998, 1995
23. Boettiger D, Anderson D, Dexter TM: Effect of src infection on long-term marrow cultures: Increased self-renewal of hemopoietic progenitor cells without leukemia. Cell 36:763, 1984
24. Spooncer E, Heyworth CM, Dunn A, Dexter TM: Self-renewal and differentiation of interleukin-3-independent multipotent stem cells are modulated by stromal cells and serum factors. Differentiation 31:111, 1986
25. Dexter TM, Garland J, Scott D, Scolnick E, Metcalf D: Growth of factor-dependent hemopoietic precursor cell lines. J Exp Med 152:1036, 1980
26. Jücker M, Schiffer CA, Feldman RA: A tyrosine-phosphorylated protein of 140 kD is constitutively associated with the phosphoryrosine binding domain of Shc and the SH3 domains of Grb2 in acute myeloid leukemia cells. Blood 89:2024, 1997
27. Bond JS, Butler PE: Intracellular proteases. Annu Rev Biochem 56:333, 1987
28. Just U, Stocking C, Spooncer E, Dexter TM, Ostertag W: Expression of the GM-CSF gene after retroviral transfer in hematopoietic stem cell lines induces synchronous granulocyte-macrophage differentitation. Cell 64:1163, 1991
29. Darnell JR Jr: Reflections on STAT3, STAT5, and STAT6 as fat STATs. Proc Natl Acad Sci USA 93:6221, 1996
30. Wen Z, Thong Z, Darnell JE Jr: Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell 82:241, 1995
31. Stöcklin E, Wissler M, Gouilleux F, Groner B: Functional interactions between Stat5 and the glucocorticoid receptor. Nature 383:726, 1996
32. Robertson LM, Kerppola TK, Vendrell M, Luk D, Smeyne RJ, Bocchaiaro C, Morgan JI, Curran T: Regulation of c-fos expression in transgenic mice requires multiple interdependent transcription control elements. Neuron 14:241, 1995
33. Azam M, Lee C, Strehlow I, Schindler C: Functionally distinct isoforms of STATS are generated by protein processing. Immunity 6:691, 1997
34. Scholtz B, Lamb K, Rosfjord E, Kingsley M, Rizzino A: Appearance of nuclear protease activity after embryonal carcinoma cells undergo differentiation. Dev Biol 173:420, 1996
35. Tökés ZA, Clawson GA: Proteolytic activity associated with the nuclear scaffold. J Biol Chem 264:15059, 1989
36. Mellgren RL, Lu Q: Selective nuclear transport of μ-calpain. Biochem Biophys Res Commun 204:544, 1994
37. Ford AM, Bennet CA, Healy LE, Navarro E, Spooncer E, Greaves MF: Immunoglobulin heavy-chain and CD3 delta-chain gene enhancers are DNase I-hypersensitive in hemopoietic progenitor cells. Proc Natl Acad Sci USA 89:3424, 1992
38. Hampson IN, Cross MA, Heyworth CM, Fairbairn L, Spooncer E, Cowling GJ, Dexter TM: Expression and downregulation of cytotoxic cell protease 1 or granzyme "B" transcripts during myeloid differentiation of interleukin-3-dependent murine stem cell lines. Blood 80:3097, 1992
39. Hampson IN, Hampson L, Pinkoski M, Cross M, Heyworth CM, Bleackley RC, Atkinson E, Dexter TM: Identification of a serpin specifically expressed in multipotent and bipotent hematopoietic progenitor cells and in activated T cells. Blood 89:108, 1997
40. Damen J, Wakao H, Miyajima A, Krosl J, Humphries RK, Cutler RL, Krystal G: Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin-induced cell proliferation and Stat5 activation. EMBO J 14:5557, 1995
41. Mui AL-F, Wakao H, Kinoshita T, Kitamura T, Miyajima A: Suppression of interleukin-3-induced gene expression by a C-terminal truncated Stat5: Role of Stat5 in proliferation. EMBO J 15:2425, 1996
42. Ihle J: STATs: Signal transducers and activators of transcription. Cell 84:331, 1996
43. Matsumoto A, Masuhara M, Mitsui K, Yokouchi M, Ohtsubo M, Misawa H, Miyajima A, Yoshimura A: CIS, a cytokine inducible SH2 protein, is a target of the JAK-STAT5 pathway and modulates STAT5 activation. Blood 89:3148, 1997
44. Yoshimura A, Ichihara M, Kinjyo I, Moriyama M, Copeland N, Gilbert D, Jenkins N, Hara T, Miyajima A: Mouse oncostatin M: An immediate early gene induced by multiple cytokines through the JAK-STAT5 pathway. EMBO J 15:1055, 1996
45. Ciechanover A: The ubiquitin-proteasome proteolytic pathway. Cell 79:13, 1994
46. Palombella VJ, Rando OJ, Goldberg AL, Maniatis T: The ubiquitin-proteasome pathway is required for processing the NF-κB1 precursor protein and the activation of NF-κB. Cell 78:773, 1994
47. Wang X, Sato R, Brown MS, Hua X, Goldstein JL: SREBP-1, a membrane-bound transcription factor released by sterol-regulated proteolysis. Cell 77:53, 1994
48. Kopan R, Schroeter EH, Weintraub H, Nye J: Signal transduction by activated mNotch: Importance of proteolytic processing and its regulation by the extracellular domain. Proc Natl Acad Sci USA 93:1683, 1996