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Volumn 105, Issue 10, 2000, Pages 1395-1406

CaM kinase signaling induces cardiac hypertrophy and activates the MEF2 transcription factor in vivo

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN; MYOCYTE ENHANCER FACTOR 2; PROTEIN KINASE (CALCIUM,CALMODULIN); PROTEIN KINASE (CALCIUM,CALMODULIN) I; PROTEIN KINASE (CALCIUM,CALMODULIN) IV; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

EID: 19244386873     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI8551     Document Type: Article
Times cited : (435)

References (71)
  • 1
    • 0033152768 scopus 로고    scopus 로고
    • Cardiac hypertrophy: Sorting out the circuitry
    • McKinsey, T.A., and Olson, E.N. 1999. Cardiac hypertrophy: sorting out the circuitry. Curr. Opin. Genet. Dev. 9:267-274.
    • (1999) Curr. Opin. Genet. Dev. , vol.9 , pp. 267-274
    • McKinsey, T.A.1    Olson, E.N.2
  • 2
    • 0030969371 scopus 로고    scopus 로고
    • The cellular and molecular response of cardiac myocytes to mechanical stress
    • Sadoshima, J., and Izumo, S. 1997. The cellular and molecular response of cardiac myocytes to mechanical stress. Annu. Rev. Physiol. 59:551-571.
    • (1997) Annu. Rev. Physiol. , vol.59 , pp. 551-571
    • Sadoshima, J.1    Izumo, S.2
  • 3
    • 0033520388 scopus 로고    scopus 로고
    • Stress pathways and heart failure
    • Chien, K.R. 1999. Stress pathways and heart failure. Cell. 98:555-558.
    • (1999) Cell , vol.98 , pp. 555-558
    • Chien, K.R.1
  • 4
    • 0032554679 scopus 로고    scopus 로고
    • Success in failure: Modeling cardiac decompensation in transgenic mice
    • MacLellan, W.R., and Schneider, M.D. 1998. Success in failure: modeling cardiac decompensation in transgenic mice. Circulation. 97:1433-1435.
    • (1998) Circulation , vol.97 , pp. 1433-1435
    • MacLellan, W.R.1    Schneider, M.D.2
  • 5
    • 0025988326 scopus 로고
    • The α-adrenergic stimulation of atrial natriuretic factor expression in cardiac myocytes requires calcium influx, protein kinase C, and calmodulin-regulated pathways
    • Sei, C.A., et al. 1991. The α-adrenergic stimulation of atrial natriuretic factor expression in cardiac myocytes requires calcium influx, protein kinase C, and calmodulin-regulated pathways. J. Biol. Chem. 266:15910-15916.
    • (1991) J. Biol. Chem. , vol.266 , pp. 15910-15916
    • Sei, C.A.1
  • 6
    • 0022492397 scopus 로고
    • Mechanisms of release and renal tubular action of atrial natriuretic factor
    • Sonnenberg, H. 1986. Mechanisms of release and renal tubular action of atrial natriuretic factor. Fed. Proc. 45:2106-2110.
    • (1986) Fed. Proc. , vol.45 , pp. 2106-2110
    • Sonnenberg, H.1
  • 7
    • 0025105250 scopus 로고
    • Extracellular calcium regulates expression of the gene for atrial natriuretic factor
    • LaPointe, M.C., Deschepper, C.F., Wu, J.P., and Gardner, D.G. 1990. Extracellular calcium regulates expression of the gene for atrial natriuretic factor. Hypertension. 15:20-28.
    • (1990) Hypertension , vol.15 , pp. 20-28
    • LaPointe, M.C.1    Deschepper, C.F.2    Wu, J.P.3    Gardner, D.G.4
  • 8
    • 0025064028 scopus 로고
    • Effects of pertussis toxin on α1-agonist-mediated phosphatidylinositide turnover and myocardial cell hypertrophy in neonatal rat myocytes
    • Karliner, J.S., Kariya, T., and Simpson, P.C. 1990. Effects of pertussis toxin on α1-agonist-mediated phosphatidylinositide turnover and myocardial cell hypertrophy in neonatal rat myocytes. Experientia. 46:81-84.
    • (1990) Experientia , vol.46 , pp. 81-84
    • Karliner, J.S.1    Kariya, T.2    Simpson, P.C.3
  • 9
    • 0028576403 scopus 로고
    • Regulation of ANP secretion by endothelin-1 in cultured atrial myocytes: Desensitization and receptor subtype
    • Leite, M.F., Page, E., and Ambler, S.K. 1994. Regulation of ANP secretion by endothelin-1 in cultured atrial myocytes: desensitization and receptor subtype. Am. J. Physiol. 267:H2193-H2203.
    • (1994) Am. J. Physiol. , vol.267
    • Leite, M.F.1    Page, E.2    Ambler, S.K.3
  • 10
    • 0027722248 scopus 로고
    • Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro
    • Sadoshima, J., Xu, Y., Slayter, H.S., and Izumo, S. 1993. Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro. Cell. 75:977-984.
    • (1993) Cell , vol.75 , pp. 977-984
    • Sadoshima, J.1    Xu, Y.2    Slayter, H.S.3    Izumo, S.4
  • 11
    • 0000266364 scopus 로고    scopus 로고
    • Modulation or contractility in human cardiac hypertrophy by essential myosin light chain isoforms
    • Schaub, M.C., Hefti, M.A., Zeullig, R.A., and Morano, I. 1998. Modulation or contractility in human cardiac hypertrophy by essential myosin light chain isoforms. Cardiovasc. Res. 37:381-404.
    • (1998) Cardiovasc. Res. , vol.37 , pp. 381-404
    • Schaub, M.C.1    Hefti, M.A.2    Zeullig, R.A.3    Morano, I.4
  • 12
    • 0032540267 scopus 로고    scopus 로고
    • A calcineurin-dependent transcriptional pathway for cardiac hypertrophy
    • Molkentin, J.D., et al. 1998. A calcineurin-dependent transcriptional pathway for cardiac hypertrophy. Cell. 17:215-228.
    • (1998) Cell , vol.17 , pp. 215-228
    • Molkentin, J.D.1
  • 13
    • 0032508640 scopus 로고    scopus 로고
    • Prevention of cardiac hypertrophy in mice by calcineurin inhibition
    • Sussman, M.A., et al. 1998. Prevention of cardiac hypertrophy in mice by calcineurin inhibition. Science. 281:1690-1693.
    • (1998) Science , vol.281 , pp. 1690-1693
    • Sussman, M.A.1
  • 14
    • 0032506233 scopus 로고    scopus 로고
    • Transient cardiac expression of constitutively active Gαq leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways
    • Mende, U., et al. 1998. Transient cardiac expression of constitutively active Gαq leads to hypertrophy and dilated cardiomyopathy by calcineurin-dependent and independent pathways. Proc. Natl. Acad. Sci. USA. 95:13893-13898.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 13893-13898
    • Mende, U.1
  • 15
    • 0033981108 scopus 로고    scopus 로고
    • Targeted inhibition of calcineurin prevents agonist-induced cardiomyocyte hypertrophy
    • Taigen, T., De Windt, L.J., Lim, H.W., and Molkentin, J.D. 2000. Targeted inhibition of calcineurin prevents agonist-induced cardiomyocyte hypertrophy. Proc. Natl. Acad. Sci. USA. 97:1196-1201.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 1196-1201
    • Taigen, T.1    De Windt, L.J.2    Lim, H.W.3    Molkentin, J.D.4
  • 16
    • 0033515618 scopus 로고    scopus 로고
    • Failure or calcineurin inhibitors to prevent pressure-overload left ventricular hypertrophy in rats
    • Zhang, W., et al. 1999. Failure or calcineurin inhibitors to prevent pressure-overload left ventricular hypertrophy in rats. Circ. Res. 84:722-728.
    • (1999) Circ. Res. , vol.84 , pp. 722-728
    • Zhang, W.1
  • 17
    • 0033515619 scopus 로고    scopus 로고
    • Pressure overload induces severe hypertrophy in mice treated with cyclosporin, an inhibitor of calcineurin
    • Ding, B., et al. 1999. Pressure overload induces severe hypertrophy in mice treated with cyclosporin, an inhibitor of calcineurin. Circ. Res. 84:729-734.
    • (1999) Circ. Res. , vol.84 , pp. 729-734
    • Ding, B.1
  • 18
    • 0033515643 scopus 로고    scopus 로고
    • Cyclosporine attenuates pressure-overload hypertrophy in mice while enhancing susceptibility to decompensation and heart failure
    • Meguro, T., et al. 1999. Cyclosporine attenuates pressure-overload hypertrophy in mice while enhancing susceptibility to decompensation and heart failure. Circ. Res. 84:735-740.
    • (1999) Circ. Res. , vol.84 , pp. 735-740
    • Meguro, T.1
  • 19
    • 0031751301 scopus 로고    scopus 로고
    • Calcineurin inhibitors and cardiac hypertrophy
    • Luo, Z., Shyu, K.G., Gulaberto, A., and Walsh, K. 1998. Calcineurin inhibitors and cardiac hypertrophy. Nat. Med. 10:1092-1093.
    • (1998) Nat. Med. , vol.10 , pp. 1092-1093
    • Luo, Z.1    Shyu, K.G.2    Gulaberto, A.3    Walsh, K.4
  • 20
    • 0033515576 scopus 로고    scopus 로고
    • Prevention of cardiac hypertrophy by calcineurin inhibition: Hope or hype?
    • Olson, E.N., and Molkentin, J.D. 1999. Prevention of cardiac hypertrophy by calcineurin inhibition: hope or hype? Circ. Res. 84:623-632.
    • (1999) Circ. Res. , vol.84 , pp. 623-632
    • Olson, E.N.1    Molkentin, J.D.2
  • 22
    • 0032762988 scopus 로고    scopus 로고
    • Calcineurin plays a critical role in pressure overload-induced cardiac hypertrophy
    • Shimoyama, M., et al. 1999. Calcineurin plays a critical role in pressure overload-induced cardiac hypertrophy. Circulation. 100:2449-2454.
    • (1999) Circulation , vol.100 , pp. 2449-2454
    • Shimoyama, M.1
  • 23
    • 0027234582 scopus 로고
    • Targeted developmental overexpression of calmodulin induces proliferative and hypertrophic growth of cardiomycytes in transgenic mice
    • Gruver, C.L., DeMayo, F., Goldstein, M.A., and Means, A.R. 1993. Targeted developmental overexpression of calmodulin induces proliferative and hypertrophic growth of cardiomycytes in transgenic mice. Endocrinology. 133:376-388.
    • (1993) Endocrinology , vol.133 , pp. 376-388
    • Gruver, C.L.1    DeMayo, F.2    Goldstein, M.A.3    Means, A.R.4
  • 24
    • 0030609163 scopus 로고    scopus 로고
    • 2+/calmodulin-dependenc protein kinase II regulates atrial natriureric factor gene expression in ventricular myocytes
    • 2+/calmodulin-dependenc protein kinase II regulates atrial natriureric factor gene expression in ventricular myocytes. J. Biol. Chem. 272:31203-31208.
    • (1997) J. Biol. Chem. , vol.272 , pp. 31203-31208
    • Ramirez, M.T.1    Zhao, X.L.2    Schulman, H.3    Brown, J.H.4
  • 25
    • 0028177833 scopus 로고
    • Involvement of cytoplasmic calcium and protein kinases in the regulation of atrial natriuretic factor secretion by contraction rate and endothelin
    • McDonough, P.M., Stella, S.L., and Glembotski, C.C. 1994. Involvement of cytoplasmic calcium and protein kinases in the regulation of atrial natriuretic factor secretion by contraction rate and endothelin. J. Biol. Chem. 269:9466-9472.
    • (1994) J. Biol. Chem. , vol.269 , pp. 9466-9472
    • McDonough, P.M.1    Stella, S.L.2    Glembotski, C.C.3
  • 26
    • 0026739478 scopus 로고
    • Protein kinase C and calmodulin kinase are required for endothelin-stimulated atrial natriuretic factor secretion from primary atrial myocytes
    • Irons, C.E., Sei, C.A., Hidaka, H., and Glembotski, C.C. 1992. Protein kinase C and calmodulin kinase are required for endothelin-stimulated atrial natriuretic factor secretion from primary atrial myocytes. J. Biol. Chem. 267:5211-5216.
    • (1992) J. Biol. Chem. , vol.267 , pp. 5211-5216
    • Irons, C.E.1    Sei, C.A.2    Hidaka, H.3    Glembotski, C.C.4
  • 29
    • 0032437107 scopus 로고    scopus 로고
    • Transcriptional control of muscle development by myocyte enhancer factor-2 (MEF2) proteins
    • Black, B., and Olson, E.N. 1998. Transcriptional control of muscle development by myocyte enhancer factor-2 (MEF2) proteins. Annu. Rev. Cell Dev. Biol. 14:167-196.
    • (1998) Annu. Rev. Cell Dev. Biol. , vol.14 , pp. 167-196
    • Black, B.1    Olson, E.N.2
  • 30
    • 0027390601 scopus 로고
    • Fos/jun repression of cardiac-specific transcription in quiescent and growth-stimulated myocytes is targeted at a tissue-specific cis element
    • McBride, K., Robitaille, L., Tremblay, S., Argentin, S., and Nemer, M. 1993. Fos/jun repression of cardiac-specific transcription in quiescent and growth-stimulated myocytes is targeted at a tissue-specific cis element. Mol. Cell. Biol. 13:600-612.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 600-612
    • McBride, K.1    Robitaille, L.2    Tremblay, S.3    Argentin, S.4    Nemer, M.5
  • 31
    • 0028178720 scopus 로고
    • Transforming growth factor-response elements of the skeletal α-actin gene
    • MacLellan, W.R., Lee, T., Schwartz, R.J., and Schneider, M.D. 1994. Transforming growth factor-response elements of the skeletal α-actin gene. J. Biol. Chem. 269:16754-16760.
    • (1994) J. Biol. Chem. , vol.269 , pp. 16754-16760
    • MacLellan, W.R.1    Lee, T.2    Schwartz, R.J.3    Schneider, M.D.4
  • 32
    • 0025822785 scopus 로고
    • Isolation and characterization of the mouse cardiac myosin heavy chain genes
    • Gulick, J., Subramaniam, A., Neumann, J., and Robbins, J. 1991. Isolation and characterization of the mouse cardiac myosin heavy chain genes. J. Biol. Chem. 266:9180-9185.
    • (1991) J. Biol. Chem. , vol.266 , pp. 9180-9185
    • Gulick, J.1    Subramaniam, A.2    Neumann, J.3    Robbins, J.4
  • 34
    • 0033010960 scopus 로고    scopus 로고
    • Transcriptional activity of MEF2 during mouse embryogenesis monitored with a MEF2-dependent transgene
    • Naya, F.J., Wu, C., Richardson, J.A., Overbeek, P., and Olson, E.N. 1999. Transcriptional activity of MEF2 during mouse embryogenesis monitored with a MEF2-dependent transgene. Development. 126:2045-2052.
    • (1999) Development , vol.126 , pp. 2045-2052
    • Naya, F.J.1    Wu, C.2    Richardson, J.A.3    Overbeek, P.4    Olson, E.N.5
  • 35
    • 0002972659 scopus 로고
    • Assays for β-galactosidase
    • J.M. Miller, editor. Cold Spring Harbor Laboratory Press. Cold Spring Harbor, New York, USA
    • Miller, J.M. 1972. Assays for β-galactosidase. In Molecular genetics. J.M. Miller, editor. Cold Spring Harbor Laboratory Press. Cold Spring Harbor, New York, USA. 352-355.
    • (1972) Molecular Genetics , pp. 352-355
    • Miller, J.M.1
  • 37
    • 0028955960 scopus 로고
    • Echocardiographic assessment of left ventricular mass and systolic function in mice
    • Gardin, J.M., et al. 1995. Echocardiographic assessment of left ventricular mass and systolic function in mice. Circ. Res. 76:907-914.
    • (1995) Circ. Res. , vol.76 , pp. 907-914
    • Gardin, J.M.1
  • 38
    • 0024366273 scopus 로고
    • A new myocyte-specific enhancer-binding factor that recognizes a conserved element associated with multiple muscle-specific genes
    • Gossett, L.A., Kelvin, D.J., Sternberg, E.A., and Olson, E.N. 1989. A new myocyte-specific enhancer-binding factor that recognizes a conserved element associated with multiple muscle-specific genes. Mol. Cell. Biol. 9:5022-5033.
    • (1989) Mol. Cell. Biol. , vol.9 , pp. 5022-5033
    • Gossett, L.A.1    Kelvin, D.J.2    Sternberg, E.A.3    Olson, E.N.4
  • 39
    • 0026505414 scopus 로고
    • Purification and characterization of a brain-specific multifunctional calmodulin-dependent protein kinase from rat cerebellum
    • Miyano, O., Kameshita, I., and Fujisawa, H. 1992. Purification and characterization of a brain-specific multifunctional calmodulin-dependent protein kinase from rat cerebellum. J. Biol. Chem. 267:1198-1203.
    • (1992) J. Biol. Chem. , vol.267 , pp. 1198-1203
    • Miyano, O.1    Kameshita, I.2    Fujisawa, H.3
  • 40
    • 0032938219 scopus 로고    scopus 로고
    • Left ventricular hypertrophy in hypertension: Stimuli, patterns, and consequences
    • Devereux, R.B., and Roman, M.J. 1999. Left ventricular hypertrophy in hypertension: stimuli, patterns, and consequences. Hypertens. Res. 22:1-9.
    • (1999) Hypertens. Res. , vol.22 , pp. 1-9
    • Devereux, R.B.1    Roman, M.J.2
  • 41
    • 0030911475 scopus 로고    scopus 로고
    • Control of cardiac morphogenesis and myogenesis by the myogenic transcription factor MEF2C
    • Lin, Q., Schwarz, J., Buchana, C., and Olson, E.N. 1997. Control of cardiac morphogenesis and myogenesis by the myogenic transcription factor MEF2C. Science. 276:1404-1407.
    • (1997) Science , vol.276 , pp. 1404-1407
    • Lin, Q.1    Schwarz, J.2    Buchana, C.3    Olson, E.N.4
  • 42
    • 0026782992 scopus 로고
    • Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors
    • Yu, Y.T., et al. 1992. Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors. Genes Dev. 6:1783-1798.
    • (1992) Genes Dev. , vol.6 , pp. 1783-1798
    • Yu, Y.T.1
  • 43
    • 0027270775 scopus 로고
    • A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage
    • Breitbart, R.E., et al. 1993. A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage. Development. 118:1095-1106.
    • (1993) Development , vol.118 , pp. 1095-1106
    • Breitbart, R.E.1
  • 45
    • 0026636560 scopus 로고
    • Induction of atrial natriuretic factor and myosin light chain-2 gene expression in cultured ventricular myocytes by electrical stimulation of contraction
    • McDonough, P.M., and Glembotski, C.C. 1992. Induction of atrial natriuretic factor and myosin light chain-2 gene expression in cultured ventricular myocytes by electrical stimulation of contraction. J. Biol. Chem. 267:11665-11668.
    • (1992) J. Biol. Chem. , vol.267 , pp. 11665-11668
    • McDonough, P.M.1    Glembotski, C.C.2
  • 48
    • 0034595213 scopus 로고    scopus 로고
    • MEF2 responds to multiple calcium-regulated signals in the control of skeletal muscle fiber type
    • In press
    • Wu, H., et al. 2000. MEF2 responds to multiple calcium-regulated signals in the control of skeletal muscle fiber type. EMBO J. In press.
    • (2000) EMBO J.
    • Wu, H.1
  • 49
    • 0033592696 scopus 로고    scopus 로고
    • MEF2 is upregulated during cardiac hypertrophy and is required for normal pose-natal growth of the myocardium
    • Kolodziejczyk, S.M., et al. 1999. MEF2 is upregulated during cardiac hypertrophy and is required for normal pose-natal growth of the myocardium. Curr. Biol. 9:1203-1206.
    • (1999) Curr. Biol. , vol.9 , pp. 1203-1206
    • Kolodziejczyk, S.M.1
  • 50
    • 0032529188 scopus 로고    scopus 로고
    • A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type
    • Chin, E.R., et al. 1998. A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type. Genes Dev. 15:2499-2509.
    • (1998) Genes Dev. , vol.15 , pp. 2499-2509
    • Chin, E.R.1
  • 51
    • 0027197933 scopus 로고
    • Signal-transduction pathways of angiotensin II-induced c-fos gene expression in cardiac myocytes in vitro
    • Sadoshima, J., and Izumo, S. 1993. Signal-transduction pathways of angiotensin II-induced c-fos gene expression in cardiac myocytes in vitro. Circ. Res. 73:424-438.
    • (1993) Circ. Res. , vol.73 , pp. 424-438
    • Sadoshima, J.1    Izumo, S.2
  • 52
    • 0028889199 scopus 로고
    • M-CAT, CArG, and Sp1 elements are required for α1-adrenergic induction of the skeletal α-actin promoter during cardiac myocyte hypertrophy
    • Karns, L.R., Kariya, K., and Simpson, P.C. 1995. M-CAT, CArG, and Sp1 elements are required for α1-adrenergic induction of the skeletal α-actin promoter during cardiac myocyte hypertrophy. J. Biol. Chem. 270:410-417.
    • (1995) J. Biol. Chem. , vol.270 , pp. 410-417
    • Karns, L.R.1    Kariya, K.2    Simpson, P.C.3
  • 53
    • 0029863245 scopus 로고    scopus 로고
    • Selective regulation of the atrial natriuretic peptide gene by individual components of the activator protein-1 complex
    • Kovacic-Milivojevic, B., Wong, V.S.H., and Gardner, D.G. 1996. Selective regulation of the atrial natriuretic peptide gene by individual components of the activator protein-1 complex. Endocrinology. 137:1108-1117.
    • (1996) Endocrinology , vol.137 , pp. 1108-1117
    • Kovacic-Milivojevic, B.1    Wong, V.S.H.2    Gardner, D.G.3
  • 54
    • 15844391229 scopus 로고    scopus 로고
    • Serum response factor mediates AP-1-dependent induction of the skeletal α-actin promoter in ventricular myocytes
    • Paradis, P., MacLellan, W.R., Belaguli, N.S., Schwartz, R.J., and Schneider, M.D. 1996. Serum response factor mediates AP-1-dependent induction of the skeletal α-actin promoter in ventricular myocytes. J. Biol. Chem. 271:10827-10833.
    • (1996) J. Biol. Chem. , vol.271 , pp. 10827-10833
    • Paradis, P.1    MacLellan, W.R.2    Belaguli, N.S.3    Schwartz, R.J.4    Schneider, M.D.5
  • 55
    • 0030612599 scopus 로고    scopus 로고
    • Angiotensin II type 1a receptor gene expression in the heart: AP-1 and GATA-4 mediate the response to pressure overload
    • Herzig, T.C., et al. 1997. Angiotensin II type 1a receptor gene expression in the heart: AP-1 and GATA-4 mediate the response to pressure overload. Proc. Natl. Acad. Sci. USA. 94:7543-7548.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 7543-7548
    • Herzig, T.C.1
  • 56
    • 0030698652 scopus 로고    scopus 로고
    • Cis-acting sequences that mediate induction of the α-myosin heavy chain gene expression during left ventricular hypertrophy due to aortic constriction
    • Hasegawam, K., Lee, S.J., Jobe, S.M., Markham, B.E., and Kitsis, R.N. 1997. Cis-acting sequences that mediate induction of the α-myosin heavy chain gene expression during left ventricular hypertrophy due to aortic constriction. Circulation. 96:3943-3953.
    • (1997) Circulation , vol.96 , pp. 3943-3953
    • Hasegawam, K.1    Lee, S.J.2    Jobe, S.M.3    Markham, B.E.4    Kitsis, R.N.5
  • 57
    • 0031675951 scopus 로고    scopus 로고
    • Requirement of the MADS-box transcription factor MEF2C for vascular development
    • Lin, Q., et al. 1998. Requirement of the MADS-box transcription factor MEF2C for vascular development. Development. 125:4565-4574.
    • (1998) Development , vol.125 , pp. 4565-4574
    • Lin, Q.1
  • 58
    • 0033610891 scopus 로고    scopus 로고
    • 2+/calmodulin-dependent protein kinase kinase beta
    • 2+/calmodulin-dependent protein kinase kinase beta. J. Biol. Chem. 273-.31880-31889.
    • (1998) J. Biol. Chem. , vol.273 , pp. 31880-31889
    • Anderson, K.A.1
  • 59
    • 0027495710 scopus 로고
    • 2+/calmodulin-dependent protein kinase IV expressed in insect cells
    • 2+/calmodulin-dependent protein kinase IV expressed in insect cells. J. Biol. Chem. 268:26171-26178.
    • (1993) J. Biol. Chem. , vol.268 , pp. 26171-26178
    • Gruzalegui, F.H.1    Means, A.R.2
  • 60
    • 0028917370 scopus 로고
    • The multifunctional calcium/calmodulin-dependent protein kinase: From form to function
    • Braun, A.P., and Schulman, H. 1995. The multifunctional calcium/calmodulin-dependent protein kinase: from form to function. Annu. Rev. Physiol. 57:417-445.
    • (1995) Annu. Rev. Physiol. , vol.57 , pp. 417-445
    • Braun, A.P.1    Schulman, H.2
  • 61
    • 0032697805 scopus 로고    scopus 로고
    • Calcineurin enhances MEF2 DNA binding activity in calcium-dependent survival of cerebellar granule neurons
    • Mao, Z., and Weidmann, M. 1999. Calcineurin enhances MEF2 DNA binding activity in calcium-dependent survival of cerebellar granule neurons. J. Biol. Chem. 274:31102-31107.
    • (1999) J. Biol. Chem. , vol.274 , pp. 31102-31107
    • Mao, Z.1    Weidmann, M.2
  • 62
    • 0032705145 scopus 로고    scopus 로고
    • MEF2: A transcriptional target for signaling pathways controlling skeletal muscle growth and differentiation
    • Naya, J.F., and Olson, E.N. 1999. MEF2: a transcriptional target for signaling pathways controlling skeletal muscle growth and differentiation. Curr. Opin. Cell Biol. 11:683-688.
    • (1999) Curr. Opin. Cell Biol. , vol.11 , pp. 683-688
    • Naya, J.F.1    Olson, E.N.2
  • 63
    • 0034635987 scopus 로고    scopus 로고
    • Signal-dependent activation of the MEF2 transcription factor by dissociation from historic deacetylases
    • Lu, J., McKinsey, T.A., Nicol, R.L., and Olson, E.N. 2000. Signal-dependent activation of the MEF2 transcription factor by dissociation from historic deacetylases. Proc. Natl. Acad. Sci. USA. 97:4070-4075.
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 4070-4075
    • Lu, J.1    McKinsey, T.A.2    Nicol, R.L.3    Olson, E.N.4
  • 64
    • 0034614611 scopus 로고    scopus 로고
    • Ca2+-dependent gene expression mediated by MEF2 transcription factors
    • Blaeser, F., Ho, N., Prywes, R., and Chatila, T.A. 2000. Ca2+-dependent gene expression mediated by MEF2 transcription factors. J. Biol. Chem. 275:197-209.
    • (2000) J. Biol. Chem. , vol.275 , pp. 197-209
    • Blaeser, F.1    Ho, N.2    Prywes, R.3    Chatila, T.A.4
  • 65
    • 0027943988 scopus 로고
    • 2+/calmodulin-dependent protein kinase type II and type IV involves phosphorylation of a site that negatively regulates activity
    • 2+/calmodulin-dependent protein kinase type II and type IV involves phosphorylation of a site that negatively regulates activity. Genes Dev. 8:2527-2539.
    • (1994) Genes Dev. , vol.8 , pp. 2527-2539
    • Sun, P.1    Enslen, H.2    Myung, P.S.3    Maurer, R.A.4
  • 66
    • 0027981633 scopus 로고
    • Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression
    • Matthews, R.P., et al. 1994. Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression. Mol. Cell. Biol. 14:6107-6116.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 6107-6116
    • Matthews, R.P.1
  • 67
    • 0032102257 scopus 로고    scopus 로고
    • Dilated cardiomyopathy in transgenic mice expressing a dominant-negative CREB transcription factor in the heart
    • Fentzke, R.C., Korcarz, C.E., Lang, R.M., Lin, H., and Leiden, J.M. 1998. Dilated cardiomyopathy in transgenic mice expressing a dominant-negative CREB transcription factor in the heart. J. Clin. Invest. 101:2415-2426.
    • (1998) J. Clin. Invest. , vol.101 , pp. 2415-2426
    • Fentzke, R.C.1    Korcarz, C.E.2    Lang, R.M.3    Lin, H.4    Leiden, J.M.5
  • 68
    • 0025772161 scopus 로고
    • Unique phosphorylation site on the cardiac ryanodine receptor regulates calcium channel activity
    • Witcher, D.R., Kovacs, R.J., Schulman, H., Cefali, D.C., and Jones, L.R. 1991. Unique phosphorylation site on the cardiac ryanodine receptor regulates calcium channel activity. J. Biol. Chem. 266:11144-11152.
    • (1991) J. Biol. Chem. , vol.266 , pp. 11144-11152
    • Witcher, D.R.1    Kovacs, R.J.2    Schulman, H.3    Cefali, D.C.4    Jones, L.R.5
  • 70
    • 0022921924 scopus 로고
    • Sequence analysis of phospholamban. Identification of phosphorylation sites and two major structural domains
    • Simmerman, H.K., Collins, J.H., Theibert, L.J., Wegener, A.D., and Jones, L.R. 1986. Sequence analysis of phospholamban. Identification of phosphorylation sites and two major structural domains. J. Biol. Chem. 261:13333-13341.
    • (1986) J. Biol. Chem. , vol.261 , pp. 13333-13341
    • Simmerman, H.K.1    Collins, J.H.2    Theibert, L.J.3    Wegener, A.D.4    Jones, L.R.5


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