The role of the Grb2-p38 MAPK signaling pathway in cardiac hypertrophy and fibrosis

Journal of Clinical Investigation

Volumn 111, Issue 6, 2003, Pages 833-841

  Zhang, Shaosong ^a   Weinheimer, Carla ^a   Courtois, Michael ^a   Kovacs, Attila ^a   Zhang, Cindy E ^a   Cheng, Alec M ^a   Wang, Yibin ^b   Muslin, Anthony J ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FOCAL ADHESION KINASE; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; INTEGRIN; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 11; MITOGEN ACTIVATED PROTEIN KINASE 14; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN; UNCLASSIFIED DRUG; FOCAL ADHESION KINASE 1; GRB2 PROTEIN, MOUSE; PROTEIN TYROSINE KINASE; PTK2 PROTEIN, MOUSE; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL GROWTH; CONTROLLED STUDY; ENZYME ACTIVATION; GENE; GENE INDUCTION; GRB2 GENE; HAPLOTYPE; HEART MUSCLE CELL; HEART MUSCLE FIBROSIS; HEART VENTRICLE HYPERTROPHY; HEART VENTRICLE PRESSURE; MECHANICAL STRESS; MORTALITY; MOUSE; MOUSE STRAIN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TRANSGENIC MOUSE; ANIMAL; BLOOD PRESSURE; CARDIOMEGALY; FIBROSIS; HEART MUSCLE; PATHOLOGY; PHYSIOLOGY;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BLOOD PRESSURE; CARDIOMEGALY; FIBROSIS; FOCAL ADHESION KINASE 1; FOCAL ADHESION PROTEIN-TYROSINE KINASES; GRB2 ADAPTOR PROTEIN; MAP KINASE SIGNALING SYSTEM; MICE; MITOGEN-ACTIVATED PROTEIN KINASES; MYOCARDIUM; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEIN-TYROSINE KINASES; PROTEINS;

EID: 85047687695     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI16290     Document Type: Article

References (36)

1. Sadoshima, J., and Izumo, S. 1997. The cellular and molecular response of cardiac myocytes to mechanical stress. Annu. Rev. Physiol. 59:551-571.
2. Hennersdorf, M.G., and Strauer, B.E. 2001. Arterial hypertension and cardiac arrhythmias. J. Hypertens. 19:167-177.
3. Vakili, B.A., Okin, P.M., and Devereux, R.B. 2001. Prognostic implications of left ventricular hypertrophy. Am. Heart J. 141:334-341.
4. Sadoshima, J., Xu, Y., Slayter, H.S., and Izumo, S. 1993. Autocrine release of angiotensin II mediates stretch-induced hypertrophy of cardiac myocytes in vitro. Cell. 75:977-984.
5. Rockman, H.A., Wachhorst, S.P., Mao, L., and Ross, J., Jr. 1994. ANG II receptor blockade prevents ventricular hypertrophy and ANF gene expression with pressure overload in mice. Am. J. Physiol. Heart Circ. Physiol. 266:H2468-H2475.
6. Taylor, J.M., Rovin, J.D., and Parsons, J.T. 2000. A role for focal adhesion kinase in phenylephrine-induced hypertrophy of rat ventricular myocytes. J. Biol. Chem. 275:19250-19257.
7. Pham, C.G., et al. 2000. Striated muscle-specific β1D-integrin and FAK are involved in cardiac myocyte hypertrophic response pathway. Am. J. Physiol. Heart Circ. Physiol. 279:H2916-H2926.
8. Aikawa, R., et al. 2002. Integrins play a critical role in mechanical stress-induced p38 MAPK activation. Hypertension. 39:233-238.
9. Damsky, C.H., and Werb, Z. 1992. Signal transduction by integrin receptors for extracellular matrix: cooperative processing of extracellular information. Curr. Opin. Cell Biol. 4:772-781.
10. Hynes, R.O. 1992. Integrins: versatility, modulation, and signaling in cell adhesion. Cell. 69:11-25.
11. Clark, E.A., and Brugge, J.S. 1995. Integrins and signal transduction pathways: the road taken. Science. 268:233-239.
12. Kuppuswamy, D., et al. 1997. Association of tyrosine-phosphorylated c-Src with the cytoskeleton of hypertrophying myocardium. J. Biol. Chem. 272:4500-4508.
13. Schlaepfer, D.D., Hanks, S., Hunter, T., and van der Geer, P. 1994. Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase. Nature. 372:786-791.
14. Domingos, P.P., Fonseca, P.M., Nadruz, W., Jr., and Franchini, K.G. 2002. Load-induced focal adhesion kinase activation in the myocardium: role of stretch and contractile activity. Am. J. Physiol. Heart Circ. Physiol. 282:H556-H564.
15. Cheng, A.M., et al. 1998. Mammalian Grb2 regulates multiple steps in embryonic development and malignant transformation. Cell. 95:793-803.
16. Lowenstein, E.J., et al. 1992. The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling. Cell. 70:431-442.
17. Downward, J. 1994. The GRB2/Sem-5 adaptor protein. FEBS Lett. 338:113-117.
18. Pawson, T. 1994. Tyrosine kinase signaling pathways. Princess Takamatsu Symp. 24:303-322.
19. Schlessinger, J. 1994. SH2/SH3 signaling proteins. Curr. Opin. Genet. Dev. 4:25-30.
20. Gong, Q., et al. 2001. Disruption ofT cell signaling networks and development by Grb2 haploid insufficiency. Nat. Immunol. 2:29-36.
21. Rincon, M., et al. 1998. Interferon-gamma expression by Th1 effector T cells mediated by the p38 MAP kinase signaling pathway. EMBO J. 17:2817-2829.
22. Wang, Y., et al. 1998. Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family. Biol. Chem. 273:2161-2168.
23. Subramaniam, A. 1991. Tissue-specific regulation of the alpha-myosin heavy chain gene promoter in transgenic mice. J. Biol. Chem. 266:24613-24620.
24. Rogers, J.H., et al. 1999. RGS4 causes increased mortality and reduced cardiac hypertrophy in response to pressure overload. J. Clin. Invest. 104:567-576.
25. Rockman, H.A., et al. 1991. Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy. Proc. Natl. Acad. Sci. U. S. A. 88:8277-8281.
26. Xing, H., Zhang, S., Weinheimer, C., Kovacs, A., and Muslin, A.J. 2000. 14-3-3 proteins inhibit apoptosis and differentially regulate MAPK cascades. EMBO J. 19:349-358.
27. Rogers, J.H., et al. 2001. RGS4 restores cardiac contractility and normalizes hypertrophic gene induction in Gαq overexpressing mice. J. Mol. Cell. Card. 33:209-218.
28. Nemoto, S., Sheng, Z., and Lin, A. 1998. Opposing effects of Jun kinase and p38 mitogen-activated protein kinases on cardiomyocyte hypertrophy. Mol. Cell. Biol. 18:3518-3526.
29. Yue, T.L., et al. 2000. Exrtacellular signal-regulated kinase plays an essential role in hypertrophic agonists, endothelin-1 and phenylephrine-induced cardiomyocyte hypertrophy. J. Biol. Chem. 275:37895-37901.
30. Esposito, G., et al. 2001. Cardiac overexpression of a G(q) inhibitor blocks induction of extracellular signal-regulated kinase and c-Jun NH(2)-terminal kinase activity in in vivo pressure overload. Circulation. 103:1453-1458.
31. Liao, P., et al. 2001. The in vivo role of p38 MAP kinases in cardiac remodeling and restrictive cardiomyopathy Proc. Natl. Acad. Sci. U. S. A. 98:12283-12288.
32. Rodrigues, G.A., Park, M., and Schlessinger, J. 1997. Activation of the JNK pathway is essential for transformation by the Met oncogene. EMBO J. 16:2634-2645.
33. Holgado-Madruga, M., et al. 1996. A Grb2-associated docking protein in EGF- and insulin-receptor signaling. Nature. 379:560-564.
34. Weidner, K.M., et al. 1996. Interaction between Gab1 and the c-Met receptor tyrosine kinase is responsible for epithelial morphogenesis. Nature. 384:173-176.
35. Zhao, C., Yu, D.H., Shen, R., and Feng, G.S. 1999. Gab2, a new pleckstrin homology domain-containing adapter protein, acts to uncouple signaling from ERK kinase to Elk-1. J. Biol. Chem. 274:19649-19654.
36. Holgado-Madruga, M., Moscatello, D.K., Emlet, D.R., Dieterich, R., and Wong, A.J. 1997. Grb2-associated binder-1 mediates phosphatidylinositol 3-kinase activation and the promotion of cell survival by nerve growth factor. Proc. Natl. Acad. Sci. U. S. A. 94:12419-12424.