Modulation of telomere terminal structure by telomerase components in Candida albicans

Nucleic Acids Research

Volumn 34, Issue 9, 2006, Pages 2710-2722

  Steinberg Neifach, Olga ^a   Lue, Neal F ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MUTANT PROTEIN; PROTEIN SUBUNIT; TELOMERASE; DNA BINDING PROTEIN; EST3 PROTEIN, FUNGUS; FUNGAL DNA; FUNGAL PROTEIN;

ARTICLE; CANDIDA ALBICANS; CELL GROWTH; CELL PROLIFERATION; CHROMOSOME STRUCTURE; CONTROLLED STUDY; GENE CONSTRUCT; GENE REPRESSION; GENETIC RECOMBINATION; MODULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; TELOMERE; CHEMISTRY; ENZYMOLOGY; GENETICS; METABOLISM; METHODOLOGY; MUTATION; NUCLEIC ACID HYBRIDIZATION; PHYSIOLOGY;

CANDIDA; CANDIDA ALBICANS;

CANDIDA ALBICANS; DNA, FUNGAL; DNA-BINDING PROTEINS; FUNGAL PROTEINS; MUTATION; NUCLEIC ACID HYBRIDIZATION; PROTEIN SUBUNITS; TELOMERASE; TELOMERE;

EID: 33646934709     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkl345     Document Type: Article

References (55)

1. Blackburn,E. (2001) Switching and signaling at the telomere. Cell, 106, 661-673.
2. Ferreira,M., Miller,K. and Cooper,J. (2004) Indecent exposure: When telomeres become uncapped. Mol. Cell, 13, 7-18.
3. Cech,T. (2004) Beginning to understand the end of the chromosome. Cell, 116, 273-279.
4. Griffith,J.D., Comeau,L., Rosenfield,S., Stansel,R.M., Bianchi,A., Moss,H. and de Lange,T. (1999) Mammalian telomeres end in a large duplex loop. Cell, 97, 503-514.
5. de Lange,T. (2002) Protection of mammalian telomeres. Oncogene, 21, 532-540.
6. Olovnikov,A. (1973) A theory of marginotomy. The incomplete copying of template margin in enzymic synthesis of polynucleotides and biological significance of the phenomenon. J. Theor. Biol., 41, 181-190.
7. Lingner,J., Cooper,J. and Cech,T. (1995) Telomerase and DNA end replication: No longer a lagging strand problem? Science, 269, 1533-1534.
8. Greider,C.W. and Blackburn,E.H. (1985) Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell, 43, 405-413.
9. Nugent,C.I. and Lundblad,V. (1998) The telomerase reverse transcriptase: components and regulation. Genes Dev., 12, 1073-1085.
10. Kelleher,C., Teixeira,M., Forstemann,K. and Lingner,J. (2002) Telomerase: Biochemical considerations for enzyme and substrate. Trends Biochem. Sci., 27, 572-579.
11. Harrington,L. (2003) Biochemical aspects of telomerase function. Cancer Lett., 194, 139-154.
12. Lundblad,V. (2003) Telomere replication: An Est fest. Curr. Biol., 13, R439-R441.
13. Hughes,T.R., Evans,S.K., Weilbaecher,R.G. and Lundblad,V. (2000) The Est3 protein is a subunit of yeast telomerase. Curr. Biol., 10, 809-812.
14. Evans,S. and Lundblad,V. (2002) The Est1 subunit of Saccharomyces cerevisiae telomerase makes multiple contributions to telomere length maintenance. Genetics, 162, 1101-1115.
15. Pennock,E., Buckley,K. and Lundblad,V. (2001) Cdc13 delivers separate complexes to the telomere for end protection and replication. Cell, 104, 387-396.
16. Taggart,A., Teng,S. and Zakian,V. (2002) Est1p as a cell cycle-regulated activator of telomere-bound telomerase. Science, 297, 1023-1026.
17. Singh,S. and Lue,N. (2003) Ever shorter telomere 1(EST1)-dependent reverse transcription by Candida telomerase in vitro: Evidence in support of an activating function. Proc. Natl Acad. Sci. USA, 100, 5718-5723.
18. Neumann,A. and Reddel,R. (2002) Telomere maintenance and cancer - Look, no telomerase. Nature Rev. Cancer, 2, 879-884.
19. Lundblad,V. (2002) Telomere maintenance without telomerase. Oncogene, 21, 522-531.
20. Kass-Eisler,A. and Greider,C. (2000) Recombination in telomere-length maintenance. Trends Biochem. Sci., 25, 200-204.
21. Garvik,B., Carson,M. and Hartwell,L. (1995) Single-stranded DNA arising at telomeres in cdc13 mutants may constitute a specific signal for the RAD9 checkpoint. Mol. Cell. Biol., 15, 6128-6138.
22. Maringele,L. and Lydall,D. (2002) EXO1-dependent single-stranded DNA at telomeres activates subsets of DNA damage and spindle checkpoint pathways in budding yeast yku70Delta mutants. Genes Dev., 16, 1919-1933.
23. Yang,Q., Zheng,Y. and Harris,C. (2005) POT1 and TRF2 cooperate to maintain telomeric integrity. Mol. Cell. Biol., 25, 1070-1080.
24. Baumann,P. and Cech,T.R. (2001) Pot1, the putative telomere end-binding protein in fission yeast and humans. Science, 292, 1171-1175.
25. Bertuch,A. and Lundblad,V. (2003) Which end: Dissecting Ku's function at telomeres and double-strand breaks. Genes Dev., 17, 2347-2350.
26. Fisher,T. and Zakian,V. (2005) Ku: A multifunctional protein involved in telomere maintenance. DNA Repair, 4, 1215-1226.
27. Gravel,S., Larrivee,M., Labrecque,P. and Wellinger,R.J. (1998) Yeast Ku as a regulator of chromosomal DNA end structure. Science, 280, 741-744.
28. Polotnianka,R.M., Li,J. and Lustig,A.J. (1998) The yeast Ku heterodimer is essential for protection of the telomere against nucleolytic and recombinational activities. Curr. Biol., 8, 831-834.
29. Chan,S. and Blackburn,E. (2003) Telomerase and ATM/Tel1p protect telomeres from nonhomologous end joining. Mol. Cell, 11, 1379-1387.
30. Kim,M., Xu,L. and Blackburn,E. (2003) Catalytically active human telomerase mutants with allele-specific biological properties. Exp. Cell Res., 288, 277-287.
31. McEachern,M.J. and Hicks,J.B. (1993) Unusually large telomeric repeats in the yeast Candida albicans. Mol. Cell. Biol., 13, 551-560.
32. Singh,S.M., Steinberg-Neifach,O., Mian,I.S. and Lue,N.F. (2002) Analysis of telomerase in Candida albicans: Potential role in telomere end protection. Eukaryot Cell, 1, 967-977.
33. Wilson,R.B., Davis,D. and Mitchell,A.P. (1999) Rapid hypothesis testing with Candida albicans through gene disruption with short homology regions. J. Bacteriol., 181, 1868-1874.
34. Fonzi,W. and Irwin,M. (1993) Isogenic strain construction and gene mapping in Candida albicans. Genetics, 134, 717-728.
35. Hoffman,C. and Winston,F. (1987) A ten-minute DNA preparation from yeast efficiently releases autonomous plasmids for transformation of Escherichia coli. Gene, 57, 267-272.
36. Dionne,I. and Wellinger,R.J. (1996) Cell cycle-regulated generation of single-stranded G-rich DNA in the absence of telomerase. Proc. Natl Acad. Sci. USA, 93, 13902-13907.
37. Cimino-Reale,G., Pascale,E., Battiloro,E., Starace,G., Verna,R. and D'Ambrosio,E. (2001) The length of telomeric G-rich strand 3′-overhang measured by oligonucleotide ligation assay. Nucleic Acids Res., 29, E35.
38. Stewart,S., Ben-Porath,I., Carey,V., O'Connor,B., Hahn,W. and Weinberg,R. (2003) Erosion of the telomeric single-strand overhang at replicative senescence. Nature Genet., 33, 492-496.
39. Enloe,B., Diamond,A. and Mitchell,A. (2000) A single-transformation gene function test in diploid Candida albicans. J. Bacteriol., 182, 5730-5736.
40. Lundblad,V. and Blackburn,E.H. (1993) An alternative pathway for yeast telomere maintenance rescues est1-senescence. Cell, 73, 347-360.
41. Teng,S., Chang,J., McCowan,B. and Zakian,V. (2000) Telomerase-independent lengthening of yeast telomeres occurs by an abrupt Rad50p-dependent, Rif-inhibited recombinational process. Mol. Cell, 6, 947-952.
42. Teng,S. and Zakian,V. (1999) Telomere-telomere recombination is an efficient bypass pathway for telomere maintenance in Saccharomyces cerevisiae. Mol. Cell. Biol., 19, 8083-8093.
43. McEachern,M.J. and Blackburn,E.H. (1996) Cap-prevented recombination between terminal telomeric repeat arrays (telomere CPR) maintains telomeres in Kluyveromyces lactis lacking telomerase. Genes Dev., 10, 1822-1834.
44. Topcu,Z., Nickles,K., Davis,C. and McEachern,M. (2005) Abrupt disruption of capping and a single source for recombinationally elongated telomeres in Kluyveromyces lactis. Proc. Natl Acad. Sci. USA, 102, 3348-3353.
45. Lendvay,T.S., Morris,D.K., Sah,J., Balasubramanian,B. and Lundblad,V. (1996) Senescence mutants of Saccharomyces cerevisiae with a defect in telomere replication identify three additional EST genes. Genetics, 144, 1399-1412.
46. McEachern,M. and Iyer,S. (2001) Short telomeres in yeast are highly recombinogenic. Mol. Cell, 7, 695-704.
47. Beernink,H., Miller,K., Deshpande,A., Bucher,P. and Cooper,J. (2003) Telomere maintenance in fission yeast requires an est1 ortholog. Curr. Biol., 13, 575-580.
48. Reichenbach,P., Hoss,M., Azzalin,C., Nabholz,M., Bucher,P. and Lingner,J. (2003) A human homolog of yeast est1 associates with telomerase and uncaps chromosome ends when overexpressed. Curr. Biol., 13, 568-574.
49. Ciudad,T., Andaluz,E., Steinberg-Neifach,O., Lue,N., Gow,N., Calderone,R. and Larriba,G. (2004) Homologous recombination in Candida albicans: Role of CaRad52p in DNA repair, integration of linear DNA fragments and telomere length. Mol. Microbiol., 53, 1177-1194.
50. Hackett,J. and Greider,C. (2003) End resection initiates genomic instability in the absence of telomerase. Mol. Cell. Biol., 23, 8450-8461.
51. Bertuch,A. and Lundblad,V. (2004) EXO1 contributes to telomere maintenance in both telomerase-proficient and telomerase-deficient Saccharomyces cerevisiae. Genetics, 166, 1651-1659.
52. Fisher,T., Taggart,A. and Zakian,V. (2004) Cell cycle-dependent regulation of yeast telomerase by Ku. Nature Struct. Mol. Biol., 11, 1198-1205.
53. Stellwagen,A., Haimberger,Z., Veatch,J. and Gottschling,D. (2003) Ku interacts with telomerase RNA to promote telomere addition at native and broken chromosome ends. Genes Dev., 17, 2384-2395.
54. Smith,C., Smith,D., De,R.J. and Blackburn,E. (2003) Telomeric protein distributions and remodeling through the cell cycle in Saccharomyces cerevisiae. Mol. Biol. Cell, 14, 556-570.
55. Cimino-Reale,G., Pascale,E., Alvino,E., Starace,G. and D'Ambrosio,E. (2003) Long telomeric C-rich 5′-tails in human replicating cells. J. Biol. Chem., 278, 2136-2140.