Dopamine regulation of amiloride-sensitive sodium channels in lung cells

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 290, Issue 4, 2006, Pages

  Helms, My N ^a   Chen, Xi Juan ^a   Ramosevac, Semra ^a   Eaton, Douglas C ^a   Jain, Lucky ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Epithelial sodium channels; Exchange protein activated by cAMP; Ion transport; L2 lung cells; Single channel recording

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); AMILORIDE; ANTIPORTER; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; DOPAMINE; DOPAMINE RECEPTOR BLOCKING AGENT; FORSKOLIN; GUANINE NUCLEOTIDE BINDING PROTEIN; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; OKADAIC ACID; OUABAIN; PERTUSSIS TOXIN; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHOLIPASE A2 INHIBITOR; PHOSPHOPROTEIN DARPP 32; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR; RAP1 PROTEIN; SODIUM CHANNEL; SULPIRIDE; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; CHROMONE DERIVATIVE; CYCLIC AMP; DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; ENZYME INHIBITOR; EPITHELIAL SODIUM CHANNEL; ISOQUINOLINE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE; MORPHOLINE DERIVATIVE; PHOSPHATASE; PHOSPHATIDYLINOSITOL 3 KINASE; PPP1R1B PROTEIN, RAT; PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE; STIMULATORY GUANINE NUCLEOTIDE BINDING PROTEIN; SULFONAMIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; DRUG SENSITIVITY; LUNG ALVEOLUS CELL TYPE 2; NONHUMAN; PRIORITY JOURNAL; RAT; ANIMAL; CELL LINE; CYTOLOGY; DRUG ANTAGONISM; LUNG; LUNG ALVEOLUS; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELL LINE; CHROMONES; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOPAMINE; DOPAMINE AND CAMP-REGULATED PHOSPHOPROTEIN 32; DOPAMINE ANTAGONISTS; ENZYME INHIBITORS; EPITHELIAL SODIUM CHANNEL; GTP-BINDING PROTEIN ALPHA SUBUNITS, GS; ISOQUINOLINES; LUNG; MITOGEN-ACTIVATED PROTEIN KINASES; MORPHOLINES; NA(+)-K(+)-EXCHANGING ATPASE; PHOSPHORIC MONOESTER HYDROLASES; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PULMONARY ALVEOLI; RATS; RECEPTORS, DOPAMINE D1; RECEPTORS, DOPAMINE D2; SODIUM CHANNELS; SRC-FAMILY KINASES; SULFONAMIDES;

EID: 33646576910     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00486.2004     Document Type: Article

References (93)

1. Adir Y, Azzam ZS, Lecuona E, Leal S, Pesce L, Dumasius V, Bertorello AM, Factor P, Young JB, Ridge KM, and Sznajder JI. Augmentation of endogenous dopamine production increases lung liquid clearance. Am J Respir Crit Care Med 169: 757-763, 2004.
2. Al-Baldawi NF, Stockand JD, Al Khalili OK, Yue G, and Eaton DC. Aldosterone induces Ras methylation in A6 epithelia. Am J Physiol Cell Physiol 279: C429-C439, 2000.
3. Aperia A, Eklof AC, Holtback U, Nowicki S, Sundelof M, and Greengard P. The renal dopamine system. Adv Pharmacol 42: 870-873, 1998.
4. +-ATPase activity in renal tubule cells. Proc Natl Acad Sci USA 88: 2798-2801, 1991.
5. Banihashemi B and Albert PR. Dopamine-D2S receptor inhibition of calcium influx, adenylyl cyclase, and mitogen-activated protein kinase in pituitary cells: distinct Galpha and Gbetagamma requirements. Mol Endocrinol 16: 2393-2404, 2002.
6. Barnard ML, Olivera WG, Rutschman DM, Bertorello AM, Katz AI, and Sznajder JI. Dopamine stimulates sodium transport and liquid clearance in rat lung epithelium. Am J Respir Crit Care Med 156: 709-714, 1997.
7. Barnard ML, Ridge KM, Saldias F, Friedman E, Gare M, Guerrero C, Lecuona E, Bertorello AM, Katz AI, and Sznajder JI. Stimulation of the dopamine 1 receptor increases lung edema clearance. Am J Respir Crit Care Med 160: 982-986, 1999.
8. Bos JL. Epac: a new cAMP target and new avenues in cAMP research. Nat Rev Mol Cell Biol 4: 733-738, 2003.
9. Boucher RC. Regulation of airway surface liquid volume by human airway epithelia. Pflügers Arch 445: 495-498, 2003.
10. Boucher RC. New concepts of the pathogenesis of cystic fibrosis lung disease. Eur Respir J 23: 146-158, 2004.
11. Chen J, Rusnak M, Luedtke RR, and Sidhu A. D1 dopamine receptor mediates dopamine-induced cytotoxicity via the ERK signal cascade. J Biol Chem 279: 39317-39330, 2004.
12. Chen XJ, Eaton DC, and Jain L. β-Adrenergic regulation of amiloride-sensitive lung sodium channels. Am J Physiol Lung Cell Mol Physiol 282: L609-L620, 2002.
13. Christensen AE, Selheim F, de RJ, Dremier S, Schwede F, Dao KK, Martinez A, Maenhaut C, Bos JL, Genieser HG, and Doskeland SO. cAMP analog mapping of Epac1 and cAMP kinase. Discriminating analogs demonstrate that Epac and cAMP kinase act synergistically to promote PC-12 cell neurite extension. J Biol Chem 278: 35394-35402, 2003.
14. Chua BA and Perks AM. The effect of dopamine on lung liquid production by in vitro lungs from fetal guinea-pigs. J Physiol 513: 283-294, 1998.
15. Cullen KA, McCool J, Anwer MS, and Webster CR. Activation of cAMP-guanine exchange factor confers PKA-independent protection from hepatocyte apoptosis. Am J Physiol Gastrointest Liver Physiol 287: G334-G343, 2004.
16. Desdouits F, Siciliano JC, Nairn AC, Greengard P, and Girault JA. Dephosphorylation of Ser-137 in DARPP-32 by protein phosphatases 2A and 2C: different roles in vitro and in striatonigral neurons. Biochem J 330: 211-216, 1998.
17. Douglas WH and Kaighn ME. Clonal isolation of differentiated rat lung cells. In Vitro 10: 230-237, 1974.
18. Eaton DC. Intracellular sodium ion activity and sodium transport in rabbit urinary bladder. J Physiol 316: 527-544, 1981.
19. Eaton DC, Hamilton KL, and Johnson KE. Intracellular acidosis blocks the basolateral Na-K pump in rabbit urinary bladder. Am J Physiol Renal Fluid Electrolyte Physiol 247: F946-F954, 1984.
20. Enserink JM, Christensen AE, de Rooij J, van Triest M, Schwede F, Genieser HG, Doskeland SO, Blank JL, and Bos JL. A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK. Nat Cell Biol 4: 901-906, 2002.
21. Frame MC. Newest findings on the oldest oncogene; how activated src does it. J Cell Sci 117: 989-998, 2004.
22. Garty H and Palmer LG. Epithelial sodium channels: function, structure, and regulation. Physiol Rev 77: 359-396, 1997.
23. + channel inhibition by endothelin. J Biol Chem 276: 42610-42617, 2001.
24. Grewal SS, Fass DM, Yao H, Ellig CL, Goodman RH, and Stork PJ. Calcium and cAMP signals differentially regulate cAMP-responsive element-binding protein function via a Rap1-extracellular signal-regulated kinase pathway. J Biol Chem 275: 34433-34441, 2000.
25. Gudermann T, Kalkbrenner F, and Schultz G. Diversity and selectivity of receptor-G protein interaction. Annu Rev Pharmacol Toxicol 36: 429-459, 1996.
26. Gudermann T, Schoneberg T, and Schultz G. Functional and structural complexity of signal transduction via G-protein-coupled receptors. Annu Rev Neurosci 20: 399-427, 1997.
27. Guerrero C, Lecuona E, Pesce L, Ridge KM, and Sznajder JI. Dopamine regulates Na-K-ATPase in alveolar epithelial cells via MAP-KERK-dependent mechanisms. Am J Physiol Lung Cell Mol Physiol 281: L79-L85, 2001.
28. Guerrero C, Pesce L, Lecuona E, Ridge KM, and Sznajder JI. Dopamine activates ERKs in alveolar epithelial cells via Ras-PKC-dependent and Grb2/Sos-independent mechanisms. Am J Physiol Lung Cell Mol Physiol 282: L1099-L1107, 2002.
29. + transport by basal nitric oxide. Am J Respir Cell Mol Biol 30: 720-728, 2004.
30. Hendron E and Stockand JD. Activation of mitogen-activated protein kinase (mitogen-activated protein kinase/extracellular signal-regulated kinase) cascade by aldosterone. Mol Biol Cell 13: 3042-3054, 2002.
31. Hussain T and Lokhandwala MF. Renal dopamine receptors and hypertension. Exp Biol Med (Maywood) 228: 134-142, 2003.
32. Igishi T and Gutkind JS. Tyrosine kinases of the Src family participate in signaling to MAP kinase from both Gq and Gi-coupled receptors. Biochem Biophys Res Commun 244: 5-10, 1998.
33. + channel by cytosolic ATP. J Biol Chem 278: 38276-38286, 2003.
34. Jain L, Chen XJ, Malik B, Al-Khalili OK, and Eaton DC. Antisense oligonucleotides against the α-subunit of ENaC decrease lung epithelial cation-channel activity. Am J Physiol Lung Cell Mol Physiol 276: L1046-L1051, 1999.
35. Jain L, Chen XJ, Ramosevac S, Brown LA, and Eaton DC. Expression of highly selective sodium channels in alveolar type II cells is determined by culture conditions. Am J Physiol Lung Cell Mol Physiol 280: L646-L658, 2001.
36. 2+ release and exocytosis in pancreatic beta-cells. J Biol Chem 278: 8279-8285, 2003.
37. 2+-controlled activation of Ras and extracellular signal-regulated kinases by Gs-coupled receptors. J Biol Chem 279: 46497-46508, 2004.
38. Laird AD and Shalloway D. Oncoprotein signalling and mitosis. Cell Signal 9: 249-255, 1997.
39. Lazrak A, Samanta A, and Matalon S. Biophysical properties and molecular characterization of amiloride- sensitive sodium channels in A549 cells. Am J Physiol Lung Cell Mol Physiol 278: L848-L857, 2000.
40. Lecuona E, Garcia A, and Sznajder JI. A novel role for protein phosphatase 2A in the dopaminergic regulation of Na,K-ATPase. FEBS Lett 481: 217-220, 2000.
41. Lewis SA, Wills NK, and Eaton DC. Basolateral membrane potential of a tight epithelium: ionic diffusion and electrogenic pumps. J Membr Biol 41: 117-148, 1978.
42. +-ATPase. Am J Physiol Renal Fluid Electrolyte Physiol 269: F673-F680, 1995.
43. Liu G, Ghahremani MH, Banihashemi B, and Albert PR. Diacylglycerol and ceramide formation induced by dopamine D2S receptors via Gβγ-subunits in Balb/c-3T3 cells. Am J Physiol Cell Physiol 284: C640-C648, 2003.
44. Luttrell DK, Hausdorff WP, Moyers JE, Gilmer TM, Parsons SJ, Caron MG, and Lefkowitz RJ. Overexpression of pp60c-src is associated with altered regulation of adenylyl cyclase. Cell Signal 4: 531-541, 1992.
45. Luttrell LM, Daaka Y, and Lefkowitz RJ. Regulation of tyrosine kinase cascades by G-protein-coupled receptors. Curr Opin Cell Biol 11: 177-183, 1999.
46. Ma HP, Li L, Zhou ZH, Eaton DC, and Warnock DG. ATP masks stretch activation of epithelial sodium channels in A6 distal nephron cells. Am J Physiol Renal Physiol 282: F501-F505, 2002.
47. Ma HP, Saxena S, and Warnock DG. Anionic phospholipids regulate native and expressed ENaC. J Biol Chem 277: 7641-7644, 2002.
48. Marunaka Y and Eaton DC. Effects of vasopressin and cAMP on single amiloride-blockable Na channels. Am J Physiol Cell Physiol 260: C1071-C1084, 1991.
49. + channel and decreases its surface expression in Xenopus oocytes. Mol Biol Cell 9: 3417-3427, 1998.
50. Matalon S and O'Brodovich HM. Sodium channels in alveolar epithelial cells: molecular characterization, biophysical properties, and physiological significance. Annu Rev Physiol 61: 627-661, 1999.
51. Matthay MA and Wiener-Kronish JP. Intact epithelial barrier function is critical for the resolution of alveolar edema in humans. Am Rev Respir Dis 142: 1250-1257, 1990.
52. Mei FC, Qiao J, Tsygankova OM, Meinkoth JL, Quilliam LA, and Cheng X. Differential signaling of cyclic AMP: opposing effects of exchange protein directly activated by cyclic AMP and cAMP-dependent protein kinase on protein kinase B activation. J Biol Chem 277: 11497-11504, 2002.
53. +-ATPase in renal tubule cells. Proc Natl Acad Sci USA 86: 8068-8072, 1989.
54. Missale C, Nash SR, Robinson SW, Jaber M, and Caron MG. Dopamine receptors: from structure to function. Physiol Rev 78: 189-225, 1998.
55. Mohler PJ, Kreda SM, Boucher RC, Sudol M, Stutts MJ, and Milgram SL. Yes-associated protein 65 localizes p62(c-Yes) to the apical compartment of airway epithelia by association with EBP50. J Cell Biol 147: 879-890, 1999.
56. Nagao M, Kaziro Y, and Itoh H. The Src family tyrosine kinase is involved in Rho-dependent activation of c-Jun N-terminal kinase by Galpha12. Oncogene 18: 4425-4434, 1999.
57. Neve KA, Seamans JK, and Trantham-Davidson H. Dopamine receptor signaling. J Recept Signal Transduct Res 24: 165-205, 2004.
58. Nishi A, Bibb JA, Matsuyama S, Hamada M, Higashi H, Nairn AC, and Greengard P. Regulation of DARPP-32 dephosphorylation at PKA- and Cdk5-sites by NMDA and AMPA receptors: distinct roles of calcineurin and protein phosphatase-2A. J Neurochem 81: 832-841, 2002.
59. Nishi A, Snyder GL, Nairn AC, and Greengard P. Role of calcineurin and protein phosphatase-2A in the regulation of DARPP-32 dephosphorylation in neostriatal neurons. J Neurochem 72: 2015-2021, 1999.
60. Obara Y, Labudda K, Dillon TJ, and Stork PJ. PKA phosphorylation of Src mediates Rap1 activation in NGF and cAMP signaling in PC12 cells. J Cell Sci 117: 6085-6094, 2004.
61. Olivera W, Ridge K, Wood LD, and Sznajder JI. Active sodium transport and alveolar epithelial Na-K-ATPase increase during subacute hyperoxia in rats. Am J Physiol Lung Cell Mol Physiol 266: L577-L584, 1994.
62. Ory S and Morrison DK. Signal transduction: implications for Ras-dependent ERK signaling. Curr Biol 14: R277-R278, 2004.
63. Palmer LG and Frindt G. Gating of Na channels in the rat cortical collecting tubule: effects of voltage and membrane stretch. J Gen Physiol 107: 35-45, 1996.
64. Parmar SS, Barthwal JP, Seth PK, and James EC. High affinity neurotransmitter and drug receptors in human lung preparations. Proc West Pharmacol Soc 31: 209-212, 1988.
65. Porter AC and Vaillancourt RR. Tyrosine kinase receptor-activated signal transduction pathways which lead to oncogenesis. Oncogene 17: 1343-1352, 1998.
66. Qiao J, Mei FC, Popov VL, Vergara LA, and Cheng X. Cell cycle-dependent subcellular localization of exchange factor directly activated by cAMP. J Biol Chem 277: 26581-26586, 2002.
67. Ridge KM, Dada L, Lecuona E, Bertorello AM, Katz AI, Mochly-Rosen D, and Sznajder JI. Dopamine-induced exocytosis of Na,K-ATPase is dependent on activation of protein kinase C-epsilon and -delta. Mol Biol Cell 13: 1381-1389, 2002.
68. Rosenthal W, Gudermann T, Antaramian A, Seibold A, Lonergan M, Arthus MF, Hendy GN, Birnbaumer L, Bichet DG, and Birnbaumer M. Gs-activating receptors: modes of transmembrane signalling and genetic defects. Adv Second Messenger Phosphoprotein Res 28: 47-55, 1993.
69. Saldías FJ, Comellas AP, Pesce L, Lecuona E, and Sznajder JI. Dopamine increases lung liquid clearance during mechanical ventilation. Am J Physiol Lung Cell Mol Physiol 283: L136-L143, 2002.
70. Saldias FJ, Lecuona E, Comellas AP, Ridge KM, and Sznajder JI. Dopamine restores lung ability to clear edema in rats exposed to hyperoxia. Am J Respir Crit Care Med 159: 626-633, 1999.
71. Sartori C and Matthay MA. Alveolar epithelial fluid transport in acute lung injury: new insights. Eur Respir J 20: 1299-1313, 2002.
72. Schmitt JM and Stork PJ. PKA phosphorylation of Src mediates cAMP's inhibition of cell growth via Rap1. Mol Cell 9: 85-94, 2002.
73. Schoneberg T, Schulz A, and Gudermann T. The structural basis of G-protein-coupled receptor function and dysfunction in human diseases. Rev Physiol Biochem Pharmacol 144: 143-227, 2002.
74. Shi H, Asher C, Chigaev A, Yung Y, Reuveny E, Seger R, and Garty H. Interactions of beta and gamma ENaC with Nedd4 can be facilitated by an ERK-mediated phosphorylation. J Biol Chem 277: 13539-13547, 2002.
75. Shi MM, Kugelman A, Iwamoto T, Tian L, and Forman HJ. Quinone-induced oxidative stress elevates glutathione and induces gamma-glutamylcysteine synthetase activity in rat lung epithelial L2 cells. J Biol Chem 269: 26512-26517, 1994.
76. Sidhu A and Niznik HB. Coupling of dopamine receptor subtypes to multiple and diverse G proteins. Int J Dev Neurosci 18: 669-677, 2000.
77. Soto F, Lambrecht G, Nickel P, Stuhmer W, and Busch AE. Antagonistic properties of the suramin analogue NF023 at heterologously expressed P2X receptors. Neuropharmacology 38: 141-149, 1999.
78. ras and fra-2 and transcription-independent decrease in myc, jun, and fos. Am J Physiol Cell Physiol 276: C1154-C1161, 1999.
79. + channel subunit proteins. J Biol Chem 275: 25760-25765, 2000.
80. + reabsorption by the aldosterone-induced small G protein K-Ras2A. J Biol Chem 274: 35449-35455, 1999.
81. Stork PJ and Schmitt JM. Crosstalk between cAMP and MAP kinase signaling in the regulation of cell proliferation. Trends Cell Biol 12: 258-266, 2002.
82. Su WY, Day BJ, Kang BH, Crapo JD, Huang YC, and Chang LY. Lung epithelial cell-released nitric oxide protects against PMN-mediated cell injury. Am J Physiol Lung Cell Mol Physiol 271: L581-L586, 1996.
83. +-ATPase. J Appl Physiol 93: 1860-1866, 2002.
84. Thomas CP, Auerbach SD, Zhang C, and Stokes JB. The structure of the rat amiloride-sensitive epithelial sodium channel gamma subunit gene and functional analysis of its promoter. Gene 228: 111-122, 1999.
85. Thomas SM and Brugge JS. Cellular functions regulated by Src family kinases. Annu Rev Cell Dev Biol 13: 513-609, 1997.
86. Walker EH, Perisic O, Ried C, Stephens L, and Williams RL. Structural insights into phosphoinositide 3-kinase catalysis and signalling. Nature 402: 313-320, 1999.
87. Ware LB and Matthay MA. Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome. Am J Respir Crit Care Med 163: 1376-1383, 2001.
88. Yamauchi J, Itoh H, Shinoura H, Miyamoto Y, Tsumaya K, Hirasawa A, Kaziro Y, and Tsujimoto G. G alpha q-dependent activation of mitogen-activated protein kinase kinase 4/c-Jun N-terminal kinase cascade. Biochem Biophys Res Commun 288: 1087-1094, 2001.
89. York RD, Molliver DC, Grewal SS, Stenberg PE, McCleskey EW, and Stork PJ. Role of phosphoinositide 3-kinase and endocytosis in nerve growth factor-induced extracellular signal-regulated kinase activation via Ras and Rap1. Mol Cell Biol 20: 8069-8083, 2000.
90. York RD, Yao H, Dillon T, Ellig CL, Eckert SP, McCleskey EW, and Stork PJ. Rap1 mediates sustained MAP kinase activation induced by nerve growth factor. Nature 392: 622-626, 1998.
91. Yue G, Edinger RS, Bao HF, Johnson JP, and Eaton DC. The effect of rapamycin on single ENaC channel activity and phosphorylation in A6 cells. Am J Physiol Cell Physiol 279: C81-C88, 2000.
92. Yue G, Malik B, Yue G, and Eaton DC. Phosphatidylinositol 4,5-bisphosphate (PIP2) stimulates epithelial sodium channel activity in A6 cells. J Biol Chem 277: 11965-11969, 2002.
93. Zhou L and Hershenson MB. Mitogenic signaling pathways in airway smooth muscle. Respir Physiol Neurobiol 137: 295-308, 2003.