No evidence for dualism in function and receptors: PD-L2/B7-DC is an inhibitory regulator of human T cell activation

European Journal of Immunology

Volumn 36, Issue 5, 2006, Pages 1104-1113

  Pfistershammer, Katharina ^a   Klauser, Christoph ^a   Pickl, Winfried F ^a   Stöckl, Johannes ^a   Leitner, Judith ^a   Zlabinger, Gerhard ^a   Majdic, Otto ^a   Steinberger, Peter ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Cellular immunology; Costimulatory molecules; Immunoregulation; T cells

Indexed keywords

B7 ANTIGEN; CD28 ANTIGEN; CD3 ANTIBODY; CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; DEATH RECEPTOR; IMMUNOGLOBULIN; LIGAND; MONOCLONAL ANTIBODY; PROGRAMMED DEATH 1 LIGAND 2; PROGRAMMED DEATH RECEPTOR 1; UNCLASSIFIED DRUG;

ARTICLE; ATTENUATION; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DENDRITIC CELL; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOREGULATION; IMMUNOSTIMULATION; IMMUNOTHERAPY; LIGAND BINDING; LYMPHOCYTE PROLIFERATION; PRIORITY JOURNAL; PROTEIN FUNCTION; SPECIES DIFFERENCE; T LYMPHOCYTE ACTIVATION;

ANTIGENS, CD; ANTIGENS, SURFACE; APOPTOSIS REGULATORY PROTEINS; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CYTOKINES; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LYMPHOCYTE ACTIVATION; PEPTIDES; T-LYMPHOCYTES;

EID: 33646559596     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200535344     Document Type: Article

References (35)

1. Mueller, D. L., Jenkins, M. K. and Schwartz, R. H., Clonal expansion versus functional clonal inactivation: a costimulatory signalling pathway determines the outcome of T cell antigen receptor occupancy. Annu. Rev. Immunol. 1989. 7: 445-480.
2. Linsley, P. S., Brady, W., Grosmaire, L., Aruffo, A., Damle, N. K. and Ledbetter, J. A., Binding of the B cell activation antigen B7 to CD28 costimulates T cell proliferation and interleukin 2 mRNA accumulation. J. Exp. Med. 1991. 173: 721-730.
3. Waterhouse, P., Marengere, L. E., Mittrucker, H. W. and Mak, T. W., CTLA-4, a negative regulator of T-lymphocyte activation. Immunol. Rev. 1996. 153: 183-207.
4. Carreno, B. M. and Collins, M., The B7 family of ligands and its receptors: new pathways for costimulation and inhibition of immune responses. Annu. Rev. Immunol. 2004. 20: 29-53.
5. Sharpe, A. H. and Freeman, G. J., The B7-CD28 superfamily. Nat. Rev. Immunol. 2002. 2: 116-126.
6. Gonzalo, J. A., Tian, J., Delaney, T., Corcoran, J., Rottman, J. B., Lora, J., Al-garawi A. et al., ICOS is critical for T helper cell-mediated lung mucosal inflammatory responses. Nat. Immunol. 2001. 2: 597-604.
7. Swallow, M. M., Wallin, J. J. and Sha, W. C., B7 h, a novel costimulatory homolog of B7.1 and B7.2, is induced by TNFalpha. Immunity 1999. 11: 423-432.
8. Chapoval, A. I, Ni J., Lau, J. S., Wilcox, R. A., Flies, D. B., Liu, D., Dong, H. et al., B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production. Nat. Immunol. 2001. 2: 269-274.
9. Dong, H., Zhu, G., Tamada, K. and Chen, L., B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat. Med. 1999. 5: 1365-1369.
10. Freeman, G. J., Long, A. J., Iwai, Y., Bourque, K., Chernova, T., Nishimura, H., Fitz, L. J. et al., Engagement of the PD-1 inummoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J. Exp. Med. 2000. 192: 1027-1034.
11. Ling, V., Wu, P. W., Spaulding, V., Kieleczawa, J., Luxenberg, D., Carreno, B. M. and Collins, M., Duplication of primate and rodent B7-H3 immunoglobulin V- and C-like domains: divergent history of functional redundancy and exon loss. Genomics 2003. 82: 365-377.
12. Selenko-Gebauer, N., Majdic, O., Szekeres, A., Hofler, G., Guthann, E., Korthauer, U., Zlabinger, G. et al., B7-h1 (programmed death-1 ligand) on dendritic cells is involved in the induction and maintenance of T cell anergy. J. Immunol. 2003. 170: 3637-3644.
13. Steinberger, P., Majdic, O., Derdak, S. V., Pfistershammer, K., Kirchberger, S., Klauser, C., Zlabinger, G. et al., Molecular characterization of human 4Ig-B7-H3, a member of the B7 family with four Ig-like domains. J. Immunol. 2004. 172: 2352-2359.
14. Sub, W. K., Gajewska, B. U., Okada, H., Gronski, M. A., Bertram, E. M., Dawicki, W., Duncan, G. S. et al., The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses. Nat. Immunol. 2003. 4: 899-906.
15. Prasad, D. V., Richards, S., Mai, X. M. and Dong, C., B7S1, a novel B7 family member that negatively regulates T cell activation. Immunity 2003. 18: 863-873.
16. Sica, G. L, Choi, I. H., Zhu, G., Tamada, K., Wang, S. D., Tamura, H., Chapoval, A. I. et al., B7-H4, a molecule of the B7 family, negatively regulates T cell immunity. Immunity 2003. 18: 849-861.
17. Zang, X, Loke, P., Kim, J., Murphy, K., Waitz, R. and Allison, J. P., B7x: a widely expressed B7 family member that inhibits T cell activation. Proc. Natl. Acad. Sci. USA 2003. 100: 10388-10392.
18. Dong, C., Juedes, A. E., Temann, U. A., Shresta, S., Allison, J. P., Ruddle, N. H. and Flavell, R. A., ICOS co-stimulatory receptor is essential for T-cell activation and function. Nature 2001. 409: 97-101.
19. Latchman, Y. E., Liang, S. C., Wu, Y., Chernova, T., Sobel, R. A., Klemm, M., Kuchroo, V. K. et al., PD-L1-deficient mice show that PD-L1 on T cells, antigen-presenting cells, and host tissues negatively regulates T cells. Proc. Natl. Acad. Sci. USA 2004. 101: 10691-10696.
20. Nishimura, H., Nose, M., Hiai H., Minato, N. and Honjo, T., Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITTM motif-carrying immunoreceptor. Immunity 1999. 11: 141-151.
21. Tseng, S. Y., Otsuji M., Gorski, K., Huang, X., Slansky, J. E., Pai, S. I., Shalabi, A. et al., B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells. J. Exp. Med. 2001. 193: 839-846.
22. Carter, L., Fouser, L. A., Jussif, J., Fitz, L., Deng, B., Wood, C. R., Collins, M., et al. PD-1:PD-L inhibitory pathway affects both CD4(+) and CD8(+) T cells and is overcome by IL-2. Eur. J. Immunol. 2002. 32: 634-643.
23. Latchman, Y., Wood, C. R., Chernova, T., Chaudhary, D., Borde, M., Chernova, I., Iwai Y. et al., PD-L2 is a second ligand forPD-1 and inhibits T cell activation. Nat. Immunol. 2001. 2: 261-268.
24. Liu, X, Gao, J. X., Wen, J., Yin, L, Li, O., Zuo, T., Gajewski, T. F. et al., B7DC/PDL2 promotes tumor immunity by a PD-1-independent mechanism. J. Exp. Med. 2003. 197: 1721-1730.
25. + T cells independent of the PD-1 receptor. J. Exp. Med. 2003. 198: 31-38.
26. Shin, T., Yoshimura, K., Crafton, E. B., Tsuchiya, H., Housseau, F., Koseki, H., Schulick, R. D. et al., In vivo costimulatory role of B7-DC in tuning T helper cell 1 and cytotoxic T lymphocyte responses. J. Exp. Med. 2005. 201: 1531-1541.
27. Wang, S., Bajorath, J., Flies, D. B., Dong, H., Honjo, T. and Chen, L., Molecular modeling and functional mapping of B7-H1 and B7-DC uncouple costimulatory function from PD-1 interaction. J. Exp. Med. 2003. 197: 1083-1091.
28. Brown, J. A., Dorfman, D. M., Ma, F. R., Sullivan, E. L., Munoz, O., Wood, C. R., Greenfield, E. A. and Freeman, G. J., Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production. J. Immunol. 2003. 170: 1257-1266.
29. Cai, G., Karni, A., Oliveira, E. M., Weiner, H. L., Hafler, D. A. and Freeman, G. J., PD-1 ligands, negative regulators for activation of naive, memory, and recently activated human CD4(+) T cells. Cell Immunol. 2004. 230: 89-98.
30. + T cell activation and cytolysis. Eur. J. Immunol. 2003. 33: 3117-3126.
31. Bennett, F., Luxenberg, D., Ling, V., Wang, I. M., Marquette, K., Lowe, D., Khan, N. et al., Program death-1 engagement upon TCR activation has distinct effects on costimulation and cytokine-driven proliferation: attenuation of ICOS, IL-4, and IL-21, but not CD28, IL-7, and IL-15 responses. J. Immunol. 2003. 170: 711-718.
32. Liang, L. and Sha, W. C., The right place at the right time: novel B7 family members regulate effector T cell responses. Curr. Opin. Immunol. 2002. 14: 384-390.
33. Pickl, W. F., Pimentel-Muinos, F. X. and Seed, B., Lipid rafts and pseudotyping. J. Virol. 2001. 75: 7175-7183.
34. Kinoshita, S., Su, L., Amano, M., Timmerman, L. A., Kaneshima, H. and Nolan, G. P., The T cell activation factor NF-ATc positively regulates HIV-1 replication and gene expression in T cells. Immunity 1997. 6: 235-244.
35. Pfistershammer, K., Majdic, O., Stockl, J., Zlabinger, G., Kirchberger, S., Steinberger, P. and Knapp, W., CD63 as an activation-linked T cell costimulatory element. J. Immunol. 2004. 173: 6000-6008.