Influence of TNFα gene polymorphisms on TNFα production and disease

Human Immunology

Volumn 62, Issue 11, 2001, Pages 1191-1199

  Hajeer, Ali H ^a   Hutchinson, Ian V ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Association studies; MHC; Microsatellite; Polymorphism; SNP; TNF

Indexed keywords

HLA ANTIGEN CLASS 1; HLA ANTIGEN CLASS 2; HLA DR ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN; TUMOR NECROSIS FACTOR ALPHA; MICROSATELLITE DNA;

ALLELE; CHROMOSOME 6P; CYTOKINE PRODUCTION; DNA POLYMORPHISM; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; HUMAN; IN VITRO STUDY; INFLAMMATION; PRIORITY JOURNAL; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; ANIMAL; ARTICLE; AUTOIMMUNE DISEASE; BIOSYNTHESIS; GENE EXPRESSION REGULATION; GENETIC POLYMORPHISM; GENETICS; GRAFT REJECTION; IMMUNOLOGY; INFECTION;

ANIMALS; AUTOIMMUNE DISEASES; GENE EXPRESSION REGULATION; GRAFT REJECTION; HUMANS; INFECTION; MICROSATELLITE REPEATS; POLYMORPHISM, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0034740493     PISSN: 01988859     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0198-8859(01)00322-6     Document Type: Article

References (78)

1. The pathophysiology of tumor necrosis factors
2. The two different receptors for tumor necrosis factor mediate distinct cellular responses
3. Complementary DNA cloning of a receptor for tumor necrosis factor and demonstration of a shed form of the receptor
4. Stabilization of the bioactivity of tumornecrosis factor by its soluble receptors
5. Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1 TNFRI, define a family of dominantly inherited autoinfiammatory autoinflammatory syndromes
6. Highly informative typing of the human TNF locus using six adjacent polymorphic markers
7. A highly polymorphic CA repeat marker at the human tumor necrosis factor alpha (TNFA alpha) locus
8. TNF-alpha gene polymorphism: Clinical and biological implications
9. Association of TNF2, a TNF-alpha promoter polymorphism, with septic shock susceptibility and mortality: A multicenter study
10. An intragenic polymorphism in the human tumor necrosis factor alpha (TNFA) chainencoding gene
11. Association between an intronic TNFA polymorphism (+691) and TNF locus microsatellites
12. Genetic analysis of the 3′ untranslated region of the tumour turnout necrosis factor shows a highly conserved region in rheumatoid arthritis affected and unaffected subjects
13. Sequence analysis of the tumor necrosis factor gene in pediatric patients with autoimmunity autolmmunity
14. Association between HLA-DR2 and production of tumour turnout necrosis factor alpha and interleukin lby 1by mononuclear cells activated by lipopolysaccharide
15. Heritable major histocompatibility complex class II-associated differences in production of tumor necrosis factor alpha: Relevance to genetic predisposition to systemic lupus erythematosus
16. Association of tumor necrosis factor (TNF) and class II major histocompatibility complex alleles with the secretion of TNF-alpha and TNF-beta by human mononuclear cells: A possible link to insulin-dependent diabetes mellitus
17. Monocyte function in IDDM patients and healthy individuals
18. Familial differences in endotoxin-induced TNF release in whole blood mononuclear ceils cells in vitro: Relationship to TNF gene polymorphism
19. A genetic marker of high TNF-alpha production in heart transplant recipients
20. Comparison of cytokine production in cultures of whole human blood and purified mononuclear cells
21. Distribution of four polymorphisms in the tumour turnout necrosis factor (TNF) genes in patients with inflammatory bowel disease (IBD)
22. Tumour necrosis factor (TNF) gene polymorphism influences TNF-alpha production in lipopolysaccharide (LPS)-stimulated whole blood cell culture in healthy humans
23. Increased frequency of the uncommon allele of a tumour turnout necrosis factor alpha gene polymorphism in rheumatoid arthritis and systemic lupus erythematosus
24. TNF-alpha promoter polymorphisms, production and susceptibility to multiple sclerosis in different groups of patients
25. Multiple sclerosis: The frequency of allelic forms of tumor necrosis factor and lymphotoxin-lympho toxin -alpha
26. Gene polymorphism at position - 308 Of the Tumor-Necrosis-Factor-Alpha (TNF-alpha) in multiple sclerosis and it's influence on the regulation of TNF-alpha production
27. Identification of an AP-2 element in the -323 to -285 region of the TNF-alpha gene
28. Effects ofa of a polymorphism in the human tumor necrosis factor alpha promoter on transcriptional activation
29. Relevance of the tumor necrosis factor alpha (TNF alpha) -308 promoter polymorphism in TNF alpha gene regulation
30. A genomic polymorphism within the tumor necrosis factor locus influences plasma tumor necrosis factor-alpha concentrations and outcome of patients with severe sepsis
31. Identification of three new single nucleotide polymorphisms in the human tumor necrosis factor-alpha gene promoter
32. Functional analysis of a new polymorphism in the human TNF alpha gene promoter
33. Effects of tumor necrosis factor gene polymorphisms on patients with congestive heart failure
34. A polymorphism that affects OCT-1 I binding to the TNF promoter region is associated with severe malaria
35. Functional consequences of a polymorphism affecting NF-kappaB p50-p50 p5O binding to the TNF promoter region
36. Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: Implications for joint and gut-associated immunopathologies
37. Transgenic models for arthritis: Useful clues to be gained?
38. Characterization of tumor necrosis factor-deficient mice
39. Relation of a TNF gene polymorphism to severe sepsis in trauma patients
40. Polymorphic structure of the tumor necrosis factor (TNF) locus: An NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced level of TNF-beta production
41. Pilot study assessing TNF gene polymorphism as a prognostic marker for disease progression in neonates with sepsis
42. Variation in the TNF-alpha promoter region associated with susceptibility to cerebral malaria
43. A tumor necrosis factor-alpha (TNFα) promoter polymorphism is associated with chronic hepatitis B infection
44. Tumor necrosis factor alpha promoter polymorphism at position -238 is associated with chronic active hepatitis C infection
45. Tumor necrosis factor gene polymorphisms in patients with cirrhosis from chronic hepatitis C virus infection
46. Tumour necrosis factor c2 microsatellite allele is associated with the rate of HIV disease progression
47. Polymorphisms within the human tumor necrosis factor-alpha promoter region in human immunodeficiency virus type 1 I-seropositive persons
48. Association of tumor necrosis factor microsatellite polymorphisms with HLA-DRBl DRBI*04-bearing haplotypes in rheumatoid arthritis patients
49. TNF microsatellite a2, b3 and d2 alleles are associated with systemic lupus erythematosus
50. HLA-TNF haplotype heterogeneity in Greek SLE patients
51. A genetic association between systemic lupus erythematosus erythernatosus and tumor necrosis factor alpha
52. TNF-308A and HLA-DR3 alleles contribute independently to susceptibility to systemic lupus erythematosus
53. TNF alphaa pivotal role in rheumatoid arthritis?
54. Comparative genetic association of human leukocyte antigen class II and tumor necrosis factor-alpha with dermatitis herpetiformis
55. Different gene loci within the HLA-DR and TNF regions are independently associated with susceptibility and severity in Spanish rheumatoid arthritis patients
56. Primary association of tumor necrosis factor-region genetic markers with susceptibility to rheumatoid arthritis
57. Low T cell production of TNFalpha and IFNgamma in ankylosing spondylitis: Its relation to HLA-B27 and influence of the TNF-308 gene polymorphism
58. Genetic polymorphism of the human tumor necrosis factor region in insulin-dependent diabetes mellitus. Linkage disequilibrium of TNFab microsatellite alleles with HLA haplotypes
59. Excessive fat accumulation is associated with the TNF alpha-308 G/A promoter polymorphism in women but not in men
60. Tumor necrosis factor-alpha-238 and -308 polymorphisms do not associated with traits related to obesity and insulin resistance
61. Tumor necrosis factor polymorphism in multiple sclerosis: No additional association independent of HLA
62. On simple repetitive DNA sequences and complex diseases
63. Tumor necrosis factor microsatellite haplotypes are different in male and female patients with RA
64. Tumor necrosis factor alpha-308 alleles in multiple sclerosis and optic neuritis
65. Tumour necrosis factor microsatellites show association with multiple sclerosis
66. Cytokine gene polymorphisms predict acute graft rejection following renal transplantation
67. Evidence for a genetic predisposition towards acute rejection after kidney and simultaneous kidney-pancreas transplantation
68. The effect of polymorphisms in tumor necrosis factor-alpha, interleukin-10, and transforming growth factor-betal genes in acute hepatic allograft rejection
69. Cytokine gene polymorphisms and relevance to forms of rejection
70. Tunor necrosis factoralpha gene polymorphism and death due to acute cellular rejection of heart transplants
71. Tumour necrosis factor-alpha gene polymorphism: Implications in kidney transplantation
72. Recipient tumor necrosis factor-alpha and interleukin-10 gene polymorphisms associate with early mortality and acute graft-versus-host disease severity in HLA-matched sibling bone marrow transplants
73. Tumor necrosis factor genetic polymorphisms correlate with infections after renal transplantation
74. Significance of tumor necrosis factor microsatellite polymorphism in renal transplantation