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Volumn 5, Issue 9, 2006, Pages 994-1000

ATR-Chk1 axis protects BCR/ABL leukemia cells from the lethal effect of DNA double-strand breaks

Author keywords

ATR; BCR ABL; Checkpoint; Chk1; Drug resistance

Indexed keywords

ATR PROTEIN; BCR ABL PROTEIN; CAFFEINE; CHECKPOINT KINASE 1; CISPLATIN; DOUBLE STRANDED DNA; ENZYME INHIBITOR; HISTONE; HISTONE H2AX; MITOMYCIN C; SB 18078; UNCLASSIFIED DRUG;

EID: 33646414521     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.5.9.2722     Document Type: Article
Times cited : (55)

References (77)
  • 1
    • 0033628016 scopus 로고    scopus 로고
    • Kinases of the Src family: Structure and functions
    • Mosc
    • Tatosyan AG, Mizenina OA. Kinases of the Src family: Structure and functions. Biochemistry (Mosc) 2000; 65:49-58.
    • (2000) Biochemistry , vol.65 , pp. 49-58
    • Tatosyan, A.G.1    Mizenina, O.A.2
  • 2
    • 0032541677 scopus 로고    scopus 로고
    • Tyrosine kinase receptor-activated signal transduction pathways which lead to oncogenesis
    • Porter AC, Vaillancourt RR. Tyrosine kinase receptor-activated signal transduction pathways which lead to oncogenesis. Oncogene 1998; 17:1343-52.
    • (1998) Oncogene , vol.17 , pp. 1343-1352
    • Porter, A.C.1    Vaillancourt, R.R.2
  • 3
    • 0030766684 scopus 로고    scopus 로고
    • Signal transduction pathways involved in BCR-ABL transformation
    • Sawyers CL. Signal transduction pathways involved in BCR-ABL transformation. Baillieres Clin Haematol 1997; 10:223-31.
    • (1997) Baillieres Clin Haematol , vol.10 , pp. 223-231
    • Sawyers, C.L.1
  • 4
    • 0032032270 scopus 로고    scopus 로고
    • Bcr-Abl exerts its antiapoptotic effect against diverse apoptotic stimuli through blockage of mitochondrial release of cytochrome C and activation of caspase-3
    • Amarante-Mendes GP, Naekyung Kim C, Liu L, Huang Y, Perkins CL, Green DR, Bhalla K. Bcr-Abl exerts its antiapoptotic effect against diverse apoptotic stimuli through blockage of mitochondrial release of cytochrome C and activation of caspase-3. Blood 1998; 91:1700-5.
    • (1998) Blood , vol.91 , pp. 1700-1705
    • Amarante-Mendes, G.P.1    Naekyung Kim, C.2    Liu, L.3    Huang, Y.4    Perkins, C.L.5    Green, D.R.6    Bhalla, K.7
  • 5
    • 0032924293 scopus 로고    scopus 로고
    • v-src induces cisplatin resistance by increasing the repair of cisplatin-DNA interstrand cross-links in human gallbladder adenocarcinoma cells
    • Masumoto N, Nakano S, Fujishima H, Kohno K, Niho Y. v-src induces cisplatin resistance by increasing the repair of cisplatin-DNA interstrand cross-links in human gallbladder adenocarcinoma cells. Int J Cancer 1999; 80:731-7.
    • (1999) Int J Cancer , vol.80 , pp. 731-737
    • Masumoto, N.1    Nakano, S.2    Fujishima, H.3    Kohno, K.4    Niho, Y.5
  • 6
    • 0034222135 scopus 로고    scopus 로고
    • Role of erbB2 in breast cancer chemosensitivity
    • Yu D, Hung MC. Role of erbB2 in breast cancer chemosensitivity. Bioessays 2000; 22:673-80.
    • (2000) Bioessays , vol.22 , pp. 673-680
    • Yu, D.1    Hung, M.C.2
  • 9
    • 0035500808 scopus 로고    scopus 로고
    • TFIIH functions are altered by the P210BCR-ABL oncoprotein produced on the Philadelphia chromosome
    • Maru Y, Bergmann E, Coin F, Egly JM, Shibuya M. TFIIH functions are altered by the P210BCR-ABL oncoprotein produced on the Philadelphia chromosome. Mutat Res 2001; 483:83-8.
    • (2001) Mutat Res , vol.483 , pp. 83-88
    • Maru, Y.1    Bergmann, E.2    Coin, F.3    Egly, J.M.4    Shibuya, M.5
  • 13
    • 0034651959 scopus 로고    scopus 로고
    • Acquired loss of p53 induces blastic transformation in p210(bcr/abl)-expressing hematopoietic cells: A transgenic study for blast crisis of human CML
    • Honda H, Ushijima T, Wakazono K, Oda H, Tanaka Y, Aizawa S, Ishikawa T, Yazaki Y, Hirai H. Acquired loss of p53 induces blastic transformation in p210(bcr/abl)-expressing hematopoietic cells: A transgenic study for blast crisis of human CML. Blood 2000; 95:1144-50.
    • (2000) Blood , vol.95 , pp. 1144-1150
    • Honda, H.1    Ushijima, T.2    Wakazono, K.3    Oda, H.4    Tanaka, Y.5    Aizawa, S.6    Ishikawa, T.7    Yazaki, Y.8    Hirai, H.9
  • 14
    • 0024435565 scopus 로고
    • Rearrangements in the p53 gene in Philadelphia chromosome positive chronic myelogenous leukemia
    • Kelman Z, Prokocimer M, Peller S, Kahn Y, Rechavi G, Manor Y, Cohen A, Rotter V. Rearrangements in the p53 gene in Philadelphia chromosome positive chronic myelogenous leukemia. Blood 1989; 74:2318-24.
    • (1989) Blood , vol.74 , pp. 2318-2324
    • Kelman, Z.1    Prokocimer, M.2    Peller, S.3    Kahn, Y.4    Rechavi, G.5    Manor, Y.6    Cohen, A.7    Rotter, V.8
  • 15
    • 0026666779 scopus 로고
    • Clonal evolution in a myeloid cell line transformed to interleukin-3 independent growth by retroviral transduction and expression of p210bcr/abl
    • Laneuville P, Sun G, Timm M, Vekemans M. Clonal evolution in a myeloid cell line transformed to interleukin-3 independent growth by retroviral transduction and expression of p210bcr/abl. Blood 1992; 80:1788-97.
    • (1992) Blood , vol.80 , pp. 1788-1797
    • Laneuville, P.1    Sun, G.2    Timm, M.3    Vekemans, M.4
  • 16
    • 0020008941 scopus 로고
    • Chromosome abnormalities in malignant hematologic diseases
    • Rowley JD, Testa JR. Chromosome abnormalities in malignant hematologic diseases. Adv Cancer Res 1982; 36:103-48.
    • (1982) Adv Cancer Res , vol.36 , pp. 103-148
    • Rowley, J.D.1    Testa, J.R.2
  • 17
    • 0033891416 scopus 로고    scopus 로고
    • Increase in mutant frequencies in mice expressing the BCR-ABL activated tyrosine kinase
    • Salloukh HF, Laneuville P. Increase in mutant frequencies in mice expressing the BCR-ABL activated tyrosine kinase. Leukemia 2000; 14:1401-4.
    • (2000) Leukemia , vol.14 , pp. 1401-1404
    • Salloukh, H.F.1    Laneuville, P.2
  • 18
    • 0034489370 scopus 로고    scopus 로고
    • Consistent loss of heterozygosity at 14Q32 in lymphoid blast crisis of chronic myeloid leukemia
    • Sercan HO, Sercan ZY, Kizildag S, Undar B, Soydan S, Sakizli M. Consistent loss of heterozygosity at 14Q32 in lymphoid blast crisis of chronic myeloid leukemia. Leuk Lymphoma 2000; 39:385-90.
    • (2000) Leuk Lymphoma , vol.39 , pp. 385-390
    • Sercan, H.O.1    Sercan, Z.Y.2    Kizildag, S.3    Undar, B.4    Soydan, S.5    Sakizli, M.6
  • 19
    • 0036014978 scopus 로고    scopus 로고
    • Molecular mechanisms of resistance to STI571 in chronic myeloid leukemia
    • Gorre ME, Sawyers CL. Molecular mechanisms of resistance to STI571 in chronic myeloid leukemia. Curr Opin Hematol 2002; 9:303-7.
    • (2002) Curr Opin Hematol , vol.9 , pp. 303-307
    • Gorre, M.E.1    Sawyers, C.L.2
  • 20
    • 0035064790 scopus 로고    scopus 로고
    • Mechanisms of resistance imatinib (STI571) in preclinical models and in leukemia patients
    • Weisberg E, Griffin JD. Mechanisms of resistance imatinib (STI571) in preclinical models and in leukemia patients. Drug Resist Updat 2001; 4:22-8.
    • (2001) Drug Resist Updat , vol.4 , pp. 22-28
    • Weisberg, E.1    Griffin, J.D.2
  • 21
    • 0029087475 scopus 로고
    • Alternative signals to RAS for hematopoietic transformation by the BCR-ABL oncogene
    • Goga A, McLaughlin J, Afar DE, Saffran DC, Witte ON. Alternative signals to RAS for hematopoietic transformation by the BCR-ABL oncogene. Cell 1995; 82:981-8.
    • (1995) Cell , vol.82 , pp. 981-988
    • Goga, A.1    McLaughlin, J.2    Afar, D.E.3    Saffran, D.C.4    Witte, O.N.5
  • 23
    • 0028950123 scopus 로고
    • Genetic requirement for Ras in the transformation of fibroblasts and hematopoietic cells by the Bcr-Abl oncogene
    • Sawyers CL, McLaughlin J, Witte ON. Genetic requirement for Ras in the transformation of fibroblasts and hematopoietic cells by the Bcr-Abl oncogene. J Exp Med 1995; 181:307-13.
    • (1995) J Exp Med , vol.181 , pp. 307-313
    • Sawyers, C.L.1    McLaughlin, J.2    Witte, O.N.3
  • 24
    • 0028263606 scopus 로고
    • Negative regulation of p120GAP GTPase promoting activity by p210bcr/abl: Implication for RAS-dependent Philadelphia chromosome positive cell growth
    • Skorski T, Kanakaraj P, Ku DH, Nieborowska-Skorska M, Canaani E, Zon G, Perussia B, Calabretta B. Negative regulation of p120GAP GTPase promoting activity by p210bcr/abl: Implication for RAS-dependent Philadelphia chromosome positive cell growth. J Exp Med 1994; 179:1855-65.
    • (1994) J Exp Med , vol.179 , pp. 1855-1865
    • Skorski, T.1    Kanakaraj, P.2    Ku, D.H.3    Nieborowska-Skorska, M.4    Canaani, E.5    Zon, G.6    Perussia, B.7    Calabretta, B.8
  • 27
    • 0033178667 scopus 로고    scopus 로고
    • STAT5 activation by BCR-Abl contributes to transformation of K562 leukemia cells
    • de Groot RP, Raaijmakers JA, Lammers JW, Jove R, Koenderman L. STAT5 activation by BCR-Abl contributes to transformation of K562 leukemia cells. Blood 1999; 94:1108-12.
    • (1999) Blood , vol.94 , pp. 1108-1112
    • De Groot, R.P.1    Raaijmakers, J.A.2    Lammers, J.W.3    Jove, R.4    Koenderman, L.5
  • 28
    • 0033583530 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription (STAT)5 activation by BCR/ABL is dependent on intact Src homology (SH)3 and SH2 domains of BCR/ABL and is required for leukemogenesis
    • Nieborowska-Skorska M, Wasik MA, Slupianek A, Salomoni P, Kitamura T, Calabretta B, Skorski T. Signal transducer and activator of transcription (STAT)5 activation by BCR/ABL is dependent on intact Src homology (SH)3 and SH2 domains of BCR/ABL and is required for leukemogenesis. J Exp Med 1999; 189:1229-42.
    • (1999) J Exp Med , vol.189 , pp. 1229-1242
    • Nieborowska-Skorska, M.1    Wasik, M.A.2    Slupianek, A.3    Salomoni, P.4    Kitamura, T.5    Calabretta, B.6    Skorski, T.7
  • 30
    • 0034653929 scopus 로고    scopus 로고
    • STAT5 activation contributes to growth and viability in Bcr/Abl-transformed cells
    • Sillaber C, Gesbert F, Frank DA, Sattler M, Griffin JD. STAT5 activation contributes to growth and viability in Bcr/Abl-transformed cells. Blood 2000; 95:2118-25.
    • (2000) Blood , vol.95 , pp. 2118-2125
    • Sillaber, C.1    Gesbert, F.2    Frank, D.A.3    Sattler, M.4    Griffin, J.D.5
  • 31
    • 0035855648 scopus 로고    scopus 로고
    • Cooperative and redundant effects of STAT5 and Ras signaling in BCR/ABL transformed hematopoietic cells
    • Hoover RR, Gerlach MJ, Koh EY, Daley GQ. Cooperative and redundant effects of STAT5 and Ras signaling in BCR/ABL transformed hematopoietic cells. Oncogene 2001; 20:5826-35.
    • (2001) Oncogene , vol.20 , pp. 5826-5835
    • Hoover, R.R.1    Gerlach, M.J.2    Koh, E.Y.3    Daley, G.Q.4
  • 33
    • 0035469895 scopus 로고    scopus 로고
    • Adhesion to fibronectin selectively protects Bcr-Abl+ cells from DNA damage-induced apoptosis
    • van der Kuip H, Goetz AW, Miething C, Duyster J, Aulitzky WE. Adhesion to fibronectin selectively protects Bcr-Abl+ cells from DNA damage-induced apoptosis. Blood 2001; 98:1532-41.
    • (2001) Blood , vol.98 , pp. 1532-1541
    • Van Der Kuip, H.1    Goetz, A.W.2    Miething, C.3    Duyster, J.4    Aulitzky, W.E.5
  • 34
    • 0035449355 scopus 로고    scopus 로고
    • Cell cycle checkpoint signaling through the ATM and ATR kinases
    • Abraham RT. Cell cycle checkpoint signaling through the ATM and ATR kinases. Genes Dev 2001; 15:2177-96.
    • (2001) Genes Dev , vol.15 , pp. 2177-2196
    • Abraham, R.T.1
  • 35
    • 0142154314 scopus 로고    scopus 로고
    • ATM, ATR and DNA-PK: Initiators of the cellular genotoxic stress responses
    • Yang J, Yu Y, Hamrick HE, Duerksen-Hughes PJ. ATM, ATR and DNA-PK: Initiators of the cellular genotoxic stress responses. Carcinogenesis 2003; 24:1571-80.
    • (2003) Carcinogenesis , vol.24 , pp. 1571-1580
    • Yang, J.1    Yu, Y.2    Hamrick, H.E.3    Duerksen-Hughes, P.J.4
  • 36
    • 0037365789 scopus 로고    scopus 로고
    • ATM and related protein kinases: Safeguarding genome integrity
    • Shiloh Y. ATM and related protein kinases: Safeguarding genome integrity. Nat Rev Cancer 2003; 3:155-68.
    • (2003) Nat Rev Cancer , vol.3 , pp. 155-168
    • Shiloh, Y.1
  • 38
    • 30344461008 scopus 로고    scopus 로고
    • BCR/ABL modifies the kinetics and fidelity of DNA double-strand breaks repair in hematopoietic cells
    • Amst
    • Slupianek A, Nowicki MO, Koptyra M, Skorski T. BCR/ABL modifies the kinetics and fidelity of DNA double-strand breaks repair in hematopoietic cells. DNA Repair (Amst) 2006; 5:243-50.
    • (2006) DNA Repair , vol.5 , pp. 243-250
    • Slupianek, A.1    Nowicki, M.O.2    Koptyra, M.3    Skorski, T.4
  • 39
    • 0033590179 scopus 로고    scopus 로고
    • DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis
    • Dasika GK, Lin SC, Zhao S, Sung P, Tomkinson A, Lee EY. DNA damage-induced cell cycle checkpoints and DNA strand break repair in development and tumorigenesis. Oncogene 1999; 18:7883-99.
    • (1999) Oncogene , vol.18 , pp. 7883-7899
    • Dasika, G.K.1    Lin, S.C.2    Zhao, S.3    Sung, P.4    Tomkinson, A.5    Lee, E.Y.6
  • 40
    • 0034707047 scopus 로고    scopus 로고
    • The DNA damage response: Putting checkpoints in perspective
    • Zhou BB, Elledge SJ. The DNA damage response: Putting checkpoints in perspective. Nature 2000; 408:433-9.
    • (2000) Nature , vol.408 , pp. 433-439
    • Zhou, B.B.1    Elledge, S.J.2
  • 41
    • 0033399453 scopus 로고    scopus 로고
    • Anticancer drug targets: Cell cycle and checkpoint control
    • Shapiro GI, Harper JW. Anticancer drug targets: Cell cycle and checkpoint control. J Clin Invest 1999; 104:1645-53.
    • (1999) J Clin Invest , vol.104 , pp. 1645-1653
    • Shapiro, G.I.1    Harper, J.W.2
  • 42
    • 0030802463 scopus 로고    scopus 로고
    • 2 delay potentiates cell death by apoptosis and/or the induction of giant cells in colorectal tumor cells with disrupted p53 function
    • 2 delay potentiates cell death by apoptosis and/or the induction of giant cells in colorectal tumor cells with disrupted p53 function. Clin Cancer Res 1997; 3:1371-81.
    • (1997) Clin Cancer Res , vol.3 , pp. 1371-1381
    • Bracey, T.S.1    Williams, A.C.2    Paraskeva, C.3
  • 43
    • 0033533612 scopus 로고    scopus 로고
    • 14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage
    • Chan TA, Hermeking H, Lengauer C, Kinzler KW, Vogelstein B. 14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage. Nature 1999; 401:616-20.
    • (1999) Nature , vol.401 , pp. 616-620
    • Chan, T.A.1    Hermeking, H.2    Lengauer, C.3    Kinzler, K.W.4    Vogelstein, B.5
  • 44
    • 0029808466 scopus 로고    scopus 로고
    • Cell cycle checkpoints: Preventing an identity crisis
    • Elledge SJ. Cell cycle checkpoints: Preventing an identity crisis. Science 1996; 274:1664-72.
    • (1996) Science , vol.274 , pp. 1664-1672
    • Elledge, S.J.1
  • 45
    • 1542725073 scopus 로고    scopus 로고
    • Targeting the checkpoint kinases: Chemosensitization versus chemoprotection
    • Zhou BB, Bartek J. Targeting the checkpoint kinases: Chemosensitization versus chemoprotection. Nat Rev Cancer 2004; 4:216-25.
    • (2004) Nat Rev Cancer , vol.4 , pp. 216-225
    • Zhou, B.B.1    Bartek, J.2
  • 46
    • 0038418869 scopus 로고    scopus 로고
    • Chk1 and Chk2 kinases in checkpoint control and cancer
    • Bartek J, Lukas J. Chk1 and Chk2 kinases in checkpoint control and cancer. Cancer Cell 2003; 3:421-9.
    • (2003) Cancer Cell , vol.3 , pp. 421-429
    • Bartek, J.1    Lukas, J.2
  • 47
    • 0037329056 scopus 로고    scopus 로고
    • The p53-Mdm2 module and the ubiquitin system
    • Michael D, Oren M. The p53-Mdm2 module and the ubiquitin system. Semin Cancer Biol 2003; 13:49-58.
    • (2003) Semin Cancer Biol , vol.13 , pp. 49-58
    • Michael, D.1    Oren, M.2
  • 48
    • 0141757504 scopus 로고    scopus 로고
    • P53 and radiation responses
    • Fei P, El-Deiry WS. P53 and radiation responses. Oncogene 2003; 22:5774-83.
    • (2003) Oncogene , vol.22 , pp. 5774-5783
    • Fei, P.1    El-Deiry, W.S.2
  • 49
    • 0034660865 scopus 로고    scopus 로고
    • E1A overcomes the apoptosis block in BCR-ABL+ leukemia cells and renders cells susceptible to induction of apoptosis by chemotherapeutic agents
    • Stiewe T, Parssanedjad K, Esche H, Opalka B, Putzer BM. E1A overcomes the apoptosis block in BCR-ABL+ leukemia cells and renders cells susceptible to induction of apoptosis by chemotherapeutic agents. Cancer Res 2000; 60:3957-64.
    • (2000) Cancer Res , vol.60 , pp. 3957-3964
    • Stiewe, T.1    Parssanedjad, K.2    Esche, H.3    Opalka, B.4    Putzer, B.M.5
  • 52
    • 13944275218 scopus 로고    scopus 로고
    • Treatment of chronic myeloid leukemia cells with imatinib (STI571) impairs p53 accumulation in response to DNA damage
    • Goldberg Z, Levav Y, Krichevsky S, Fibach E, Haupt Y. Treatment of chronic myeloid leukemia cells with imatinib (STI571) impairs p53 accumulation in response to DNA damage. Cell Cycle 2004; 3:1188-95.
    • (2004) Cell Cycle , vol.3 , pp. 1188-1195
    • Goldberg, Z.1    Levav, Y.2    Krichevsky, S.3    Fibach, E.4    Haupt, Y.5
  • 54
    • 0036569855 scopus 로고    scopus 로고
    • Ku affects the ataxia and Rad 3-related/CHK1-dependent S phase checkpoint response after camptothecin treatment
    • Wang H, Wang X, Zhou XY, Chen DJ, Li GC, Iliakis G, Wang Y. Ku affects the ataxia and Rad 3-related/CHK1-dependent S phase checkpoint response after camptothecin treatment. Cancer Res 2002; 62:2483-7.
    • (2002) Cancer Res , vol.62 , pp. 2483-2487
    • Wang, H.1    Wang, X.2    Zhou, X.Y.3    Chen, D.J.4    Li, G.C.5    Iliakis, G.6    Wang, Y.7
  • 55
    • 22844453014 scopus 로고    scopus 로고
    • A comparison of the action of amifostine and melatonin on DNA-damaging effects and apoptosis induced by idarubicin in normal and cancer cells
    • Majsterek I, Gloc E, Blasiak J, Reiter RJ. A comparison of the action of amifostine and melatonin on DNA-damaging effects and apoptosis induced by idarubicin in normal and cancer cells. J Pineal Res 2005; 38:254-63.
    • (2005) J Pineal Res , vol.38 , pp. 254-263
    • Majsterek, I.1    Gloc, E.2    Blasiak, J.3    Reiter, R.J.4
  • 56
    • 0034694162 scopus 로고    scopus 로고
    • Analysis of chromate-induced DNA-protein crosslinks with the comet assay
    • Merk O, Reiser K, Speit G. Analysis of chromate-induced DNA-protein crosslinks with the comet assay. Mutat Res 2000; 471:71-80.
    • (2000) Mutat Res , vol.471 , pp. 71-80
    • Merk, O.1    Reiser, K.2    Speit, G.3
  • 57
    • 0032861343 scopus 로고    scopus 로고
    • Megabase chromatin domains involved in DNA double-strand breaks in vivo
    • Rogakou EP, Boon C, Redon C, Bonner WM. Megabase chromatin domains involved in DNA double-strand breaks in vivo. J Cell Biol 1999; 146:905-16.
    • (1999) J Cell Biol , vol.146 , pp. 905-916
    • Rogakou, E.P.1    Boon, C.2    Redon, C.3    Bonner, W.M.4
  • 58
    • 0035930537 scopus 로고    scopus 로고
    • Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress
    • Ward IM, Chen J. Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress. J Biol Chem 2001; 276:47759-62.
    • (2001) J Biol Chem , vol.276 , pp. 47759-47762
    • Ward, I.M.1    Chen, J.2
  • 59
    • 0035834693 scopus 로고    scopus 로고
    • ATM phosphorylates histone H2AX in response to DNA double-strand breaks
    • Burma S, Chen BP, Murphy M, Kurimasa A, Chen DJ. ATM phosphorylates histone H2AX in response to DNA double-strand breaks. J Biol Chem 2001; 276:42462-7.
    • (2001) J Biol Chem , vol.276 , pp. 42462-42467
    • Burma, S.1    Chen, B.P.2    Murphy, M.3    Kurimasa, A.4    Chen, D.J.5
  • 60
    • 0037385724 scopus 로고    scopus 로고
    • Measurement of prompt DNA double-strand breaks in mammalian cells without including heat-labile sites: Results for cells deficient in nonhomologous end joining
    • Stenerlow B, Karlsson KH, Cooper B, Rydberg B. Measurement of prompt DNA double-strand breaks in mammalian cells without including heat-labile sites: Results for cells deficient in nonhomologous end joining. Radiat Res 2003; 159:502-10.
    • (2003) Radiat Res , vol.159 , pp. 502-510
    • Stenerlow, B.1    Karlsson, K.H.2    Cooper, B.3    Rydberg, B.4
  • 61
    • 0025988295 scopus 로고
    • DNA double-strand breaks measured in individual cells subjected to gel electrophoresis
    • Olive PL, Wlodek D, Banath JP. DNA double-strand breaks measured in individual cells subjected to gel electrophoresis. Cancer Res 1991; 51:4671-6.
    • (1991) Cancer Res , vol.51 , pp. 4671-4676
    • Olive, P.L.1    Wlodek, D.2    Banath, J.P.3
  • 62
    • 28444483130 scopus 로고    scopus 로고
    • H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair
    • Chowdhury D, Keogh MC, Ishii H, Peterson CL, Buratowski S, Lieberman J. gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair. Mol Cell 2005; 20:801-9.
    • (2005) Mol Cell , vol.20 , pp. 801-809
    • Chowdhury, D.1    Keogh, M.C.2    Ishii, H.3    Peterson, C.L.4    Buratowski, S.5    Gamma-, L.J.6
  • 63
    • 16444379514 scopus 로고    scopus 로고
    • 2/M checkpoint activation by etoposide through the Akt/GSK3 pathway to inhibit apoptosis
    • 2/M checkpoint activation by etoposide through the Akt/GSK3 pathway to inhibit apoptosis. Oncogene 2005; 24:1973-81.
    • (2005) Oncogene , vol.24 , pp. 1973-1981
    • Jin, Z.H.1    Kurosu, T.2    Yamaguchi, M.3    Arai, A.4    Miura, O.5
  • 65
    • 0036463987 scopus 로고    scopus 로고
    • Disabling Abl-perspectives on Abl kinase regulation and cancer therapeutics
    • Sawyers CL. Disabling Abl-perspectives on Abl kinase regulation and cancer therapeutics. Cancer Cell 2002; 1:13-5.
    • (2002) Cancer Cell , vol.1 , pp. 13-15
    • Sawyers, C.L.1
  • 67
    • 4243926785 scopus 로고    scopus 로고
    • Imatinib and chronic myeloid leukemia: Validating the promise of molecularly targeted therapy
    • Druker BJ. Imatinib and chronic myeloid leukemia: Validating the promise of molecularly targeted therapy. Eur J Cancer 2002; 38;S70-6.
    • (2002) Eur J Cancer , vol.38
    • Druker, B.J.1
  • 70
    • 0038454621 scopus 로고    scopus 로고
    • Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment
    • Bhatia R, Holtz M, Niu N, Gray R, Snyder DS, Sawyers CL, Arber DA, Slovak ML, Forman SJ. Persistence of malignant hematopoietic progenitors in chronic myelogenous leukemia patients in complete cytogenetic remission following imatinib mesylate treatment. Blood 2003; 101:4701-7.
    • (2003) Blood , vol.101 , pp. 4701-4707
    • Bhatia, R.1    Holtz, M.2    Niu, N.3    Gray, R.4    Snyder, D.S.5    Sawyers, C.L.6    Arber, D.A.7    Slovak, M.L.8    Forman, S.J.9
  • 71
    • 0038721475 scopus 로고    scopus 로고
    • The CNS is a sanctuary for leukemic cells in mice receiving imatinib mesylate for Bcr/Abl-induced leukemia
    • Wolff NC, Richardson JA, Egorin M, Ilaria Jr RL. The CNS is a sanctuary for leukemic cells in mice receiving imatinib mesylate for Bcr/Abl-induced leukemia. Blood 2003; 101:5010-3.
    • (2003) Blood , vol.101 , pp. 5010-5013
    • Wolff, N.C.1    Richardson, J.A.2    Egorin, M.3    Ilaria Jr., R.L.4
  • 72
    • 3242816121 scopus 로고    scopus 로고
    • Clinical resistance to imatinib: Mechanisms and implications
    • Hochhaus A, Hughes T. Clinical resistance to imatinib: Mechanisms and implications. Hematol Oncol Clin North Am 2004; 18:641-56.
    • (2004) Hematol Oncol Clin North Am , vol.18 , pp. 641-656
    • Hochhaus, A.1    Hughes, T.2
  • 74
    • 0037049768 scopus 로고    scopus 로고
    • BCR/ABL regulates response to DNA damage: The role in resistance to genotoxic treatment and in genomic instability
    • Skorski T. BCR/ABL regulates response to DNA damage: The role in resistance to genotoxic treatment and in genomic instability. Oncogene 2002; 21:8591-604.
    • (2002) Oncogene , vol.21 , pp. 8591-8604
    • Skorski, T.1
  • 75
    • 1642421759 scopus 로고    scopus 로고
    • BCR/ABL translocates to the nucleus and disrupts an ATR-dependent intra-S phase checkpoint
    • Dierov J, Dierova R, Carroll M. BCR/ABL translocates to the nucleus and disrupts an ATR-dependent intra-S phase checkpoint. Cancer Cell 2004; 5:275-85.
    • (2004) Cancer Cell , vol.5 , pp. 275-285
    • Dierov, J.1    Dierova, R.2    Carroll, M.3
  • 76
    • 3242879828 scopus 로고    scopus 로고
    • Chk1 in the DNA damage response: Conserved roles from yeasts to mammals
    • Amst
    • Chen Y, Sanchez Y. Chk1 in the DNA damage response: Conserved roles from yeasts to mammals. DNA Repair (Amst) 2004; 3:1025-32.
    • (2004) DNA Repair , vol.3 , pp. 1025-1032
    • Chen, Y.1    Sanchez, Y.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.