Acquired loss of p53 induces blastic transformation in p210(bcr)/abl)- expressing hematopoietic cells: A transgenic study for blast crisis of human CML

Blood

Volumn 95, Issue 4, 2000, Pages 1144-1150

  Honda, Hiroaki ^b   Ushijima, Toshikazu ^b   Wakazono, Kuniko ^b   Oda, Hideaki ^b   Tanaka, Yuji ^b   Aizawa, Shin Ichi ^b   Ishikawa, Takatoshi ^b   Yazaki, Yoshio ^b   Hirai, Hisamaru ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; PROTEIN P53;

ALLELISM; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLAST CELL CRISIS; BLAST TRANSFORMATION; CELL PROLIFERATION; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; CROSS BREEDING; FEMALE; HEMATOPOIETIC CELL; HUMAN; HUMAN CELL; IMMUNOPATHOLOGY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 0034651959     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v95.4.1144.004k04_1144_1150     Document Type: Article

References (36)

1. Champlin RE, Golde DW. Chronic myelogenous leukemia: recent advances. Blood. 1985;65:1039.
2. Rowley JD. A new consistent chromosomal abnormality in chronic myelogenous leukemia identified by quinacrine fluorescence and Giemsa staining. Nature. 1973;243:290.
3. de Klein A, van Kessel AG, Grosveld G, et al. A cellular oncogene is translocated to the Philadelphia chromosome in chronic myelocytic leukaemia. Nature. 1982;300:765.
4. Groffen J, Stephenson JR, Heisterkamp N, de-Klein A, Bartram CR, Grosveld G. Philadelphia chromosomal breakpoints are clustered within a limited region, bcr, on chromosome 22. Cell. 1984;36:93.
5. Shtivelman E, Lifshitz B, Gale RP, Canaani E. Fused transcript of abl and bcr genes in chronic myelogenous leukaemia. Nature. 1985;315:550.
6. Konopka JB, Watanabe SM, Witte ON. An alternation of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity. Cell. 1984;37:1035.
7. Rowley JD, Testa JR. Chromosome abnormalities in malignant hematologic diseases. Adv Cancer Res. 1982;36:103.
8. Miller C, Mohandas T, Wolf D, Prokocimer M, Rotter V, Koeffler HP. Human p53 gene localized to short arm of chromosome 17. Nature. 1986;319: 783.
9. Ahuja H, Bar-Eli M, Advani SH, Benchimol S, Cline MJ. Alterations in the p53 gene and the clonal evolution of the blast crisis of chronic myelocytic leukemia. Proc Natl Acad Sci U S A. 1989;86:6783.
10. Kelman Z, Prokocimer M, Peller S, et al. Rearrangements in the p53 gene in Philadelphia chromosome positive chronic myelogenous leukemia. Blood. 1989;74:2318.
11. Feinstein E, Cimino G, Gale RP, et al. p53 in chronic myelogenous leukemia in acute phase. Proc Natl Acad Sci U S A. 1991;88:6293.
12. bcr/abl gene of the Philadelphia chromosome. Science. 1990;247:824.
13. Elefanty AG, Hariharan IK, Cory S. bcr-abl, the hallmark of chronic myeloid leukaemia in man, induces multiple haemopoietic neoplasms in mice. EMBO J. 1990;9:1069.
14. Kelliher MA, McLaughlin J, Witte ON, Rosenberg N. Induction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and BCR/ABL. Proc Natl Acad Sci U S A. 1990;87:6649.
15. Sirard C, Lapidot T, Vormoor J, et al. Normal and leukemic SCID-repopulating cells (SRC) coexist in the bone marrow and peripheral blood from CML patients in chronic phase, whereas leukemic SRC are detected in blast crisis. Blood. 1996;87: 1539.
16. Wang JCY, Lapidot T, Cashman JD, et al. High level engraftment of NOD/SCID mice by primitive normal and leukemic hematopoietic cells from patients with chronic myeloid leukemia in chronic phase. Blood. 1998;91:2406.
17. Daley GQ. Animal models for BCR/ABL-induced leukemias. Leuk Lymphoma. 1993;11:57.
18. Honda H, Yamashita Y, Ozawa K, Mano H. Cloning and characterization of mouse tec promoter. Biochem Biophys Res Commun. 1996;223:422.
19. Honda H, Ozawa K, Yazaki Y, Hirai H. Identification of PU.1 and Sp1 as essential transcriptional factors for the promoter activity of mouse tec gene. Biochem Biophys Res Commun. 1997;234: 376.
20. Mano H, Ishikawa F, Nishida J, Hirai H, Takaku F. A novel protein-tyrosine kinase, tec, is preferentially expressed in liver. Oncogene. 1990;5:1781.
21. 1-positive leukemias. Blood. 1998;91:2067.
22. Elefanty AG, Gory S. Hematologic disease induced in BALB/c mice by a bcr-abl retrovirus is influenced by the infection conditions. Mol Cell Biol. 1992;12:1755.
23. Kelliher MA, Weckstein DJ, Knott AG, Wortis HH, Rosenberg N. ABL oncogenes directly stimulate two distinct target cells in bone marrow from 5-fluorouracil-treated mice. Oncogene. 1993;8: 1249.
24. Tsukada T, Tomooka Y, Takai S, et al. Enhanced proliferative potential in culture of cells from p53-deficient mice. Oncogene. 1993;8:3313.
25. Yagi T, Tokunaga T, Furuya Y, et al. A novel ES cell line, TT2, with high germline-differentiating potency. Anal Biochem. 1993;214:70.
26. Ushijima T, Makino H, Okonogi H, Hosoya T, Sugimura T, Nagao M. Mutation, loss of heterozygosity, and recombination of the p53 gene in mouse forestomach tumors induced by 2-amino-3,4-dimethylimidazo[4,5-1]quinoline. Mol Carcinog. 1995;12:23.
27. bcr/abl tyrosine kinase. Proc Natl Acad Sci U S A. 1996;93:13,137.
28. Donehower LA, Harvey M, Slagle BL, et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumors. Nature. 1992;356:215.
29. Jacks T, Remington L, Williams BO, et al. Tumor spectrum analysis in p53-mutant mice. Curr Biol. 1994;1:4.
30. Harvey M, McArthur MJ, Montgomery CA Jr, Bradley A, Donehower LA. Genetic background alters the spectrum of tumors that develop in p53-deficient mice. FASEB J. 1993;7:938.
31. Sallouk H, Brain J, Laneuville P. Increased mutation rate precedes leukemic transformation in p190Bcr/abl transgenic mice [abstract]. Blood 1997;90(suppl):251a.
32. Nakai H, Misawa S. Chromosome 17 abnormalities and inactivation of the p53 gene in chronic myeloid leukemia and their prognostic significance. Leuk Lymphoma. 1995;19:213.
33. Daley GQ, van Etten RA, Baltimore D. Blast crisis in a murine model of chronic myelogenous leukemia Proc Natl Acad Sci U S A. 1991;88:11,335.
34. Gishinzky ML, White JJ, Witte ON. Efficient transplantation of BCR-ABL-induced chronic myelogenous leukemia-like syndrome in mice. Proc Natl Acad Sci U S A. 1993;90:3755.
35. Pear WS, Miller JP, Xu L, et al. Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving p210bcr/abl-transduced bone marrow. Blood. 1998;92:3780.
36. Li S, Ilaria RL Jr, Million RP, Daley GQ, Van Etten RA. The p190, p210, and p230 forms of the BCR/ ABL oncogene induce a similar chronic myelogenous leukemia-like syndrome in mice but have different lymphoid leukemogenic activity. J Exp Med. 1999;189:1399.