Norepinephrine-induced oxidative stress causes PC-12 cell apoptosis by both endoplasmic reticulum stress and mitochondrial intrinsic pathway: Inhibition of phosphatidylinositol 3-kinase survival pathway

American Journal of Physiology - Cell Physiology

Volumn 290, Issue 5, 2006, Pages

  Mao, Weike ^a   Iwai, Chikao ^a   Keng, Peter C ^a   Vulapalli, Raju ^a   Liang, Chang Seng ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Caspase 12; Cytochrome c; Nerve growth factor; Superoxide dismutase; Z Ala Thr Ala Asp fluoromethyl ketone

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CASPASE 12; CASPASE 13; CASPASE 3; CASPASE 3 INHIBITOR; CASPASE 9; CASPASE 9 INHIBITOR; CATALASE; CHAPERONE; CYTOCHROME C; GLUCOSE REGULATED PROTEIN 78; MESSENGER RNA; NERVE GROWTH FACTOR; NORADRENALIN; PHOSPHATIDYLINOSITOL KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; SERINE; SUPEROXIDE DISMUTASE; THAPSIGARGIN; TRANSCRIPTION FACTOR; WORTMANNIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL STRAIN; CELL SURVIVAL; CONTROLLED STUDY; DRUG EFFECT; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; GENE REPRESSION; GENE TRANSLOCATION; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATIVE STRESS; PHEOCHROMOCYTOMA CELL; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; APOPTOSIS; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOPLASMIC RETICULUM; MITOCHONDRIA; OXIDATIVE STRESS; PC12 CELLS; RATS; SIGNAL TRANSDUCTION;

EID: 33646388416     PISSN: 03636143     EISSN: 15221563     Source Type: Journal    
DOI: 10.1152/ajpcell.00369.2005     Document Type: Article

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