Nerve Growth Factor Inhibits Apoptosis in Memory B Lymphocytes via Inactivation of p38 MAPK, Prevention of Bcl-2 Phosphorylation, and Cytochrome c Release

Journal of Biological Chemistry

Volumn 276, Issue 42, 2001, Pages 39027-39036

  Torcia, Maria ^a,b   De Chiara, Giovanna ^a   Nencioni, Lucia ^a   Ammendola, Serena ^a   Labardi, Danilo ^a   Lucibello, Maria ^a,d   Rosini, Paolo ^b   Marlier, Lionel N J L ^a,d   Bonini, Paolo ^a   Dello Sbarba, Persio ^b   Palamara, Anna Teresa ^a,c   Zambrano, Nicola ^c   Russo, Tommaso ^c   Garaci, Enrico ^a   Cozzolino, Federico ^a,d  

^a UNIVERSITY OF ROME TOR VERGATA   (Italy)

^b UNIVERSITY OF FLORENCE   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^d CNR   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; CELLS; ENZYMES; MUTAGENESIS;

NERVE GROWTH FACTOR (NGF);

BIOCHEMISTRY;

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CYTOCHROME C; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; NERVE GROWTH FACTOR; PROTEIN BCL 2; SERINE; SYNAPTOPHYSIN; THREONINE; DNA FRAGMENT; ENZYME INHIBITOR; IMIDAZOLE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; MITOGEN ACTIVATED PROTEIN KINASE P38; PYRIDINE DERIVATIVE; RECOMBINANT PROTEIN; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOCRINE EFFECT; B LYMPHOCYTE; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INACTIVATION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; IN VITRO STUDY; IN VIVO STUDY; MEMORY CELL; MITOCHONDRION; MOLECULAR BIOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; ANIMAL; CELL CULTURE; CELL NUCLEUS; CHEMISTRY; CYTOSOL; DRUG ANTAGONISM; FLUORESCENCE MICROSCOPY; IMMUNOLOGICAL MEMORY; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN BINDING; PROTEIN TRANSPORT; RAT; SERODIAGNOSIS; TIME;

ANIMALIA; JANUS;

ANIMALS; APOPTOSIS; B-LYMPHOCYTES; CELL NUCLEUS; CELLS, CULTURED; CYTOCHROME C GROUP; CYTOSOL; DNA FRAGMENTATION; ENZYME INHIBITORS; HUMANS; IMIDAZOLES; IMMUNOLOGIC MEMORY; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE KINASE 4; MICROSCOPY, FLUORESCENCE; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; NERVE GROWTH FACTOR; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-BCL-2; PYRIDINES; RATS; RECOMBINANT PROTEINS; SERINE; THREONINE; TIME FACTORS;

EID: 0035914312     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M102970200     Document Type: Article

References (64)

1. Scaffidi, C., Kirchhoff, S., Krammer, P. H., and Peter, M. E. (1999) Curr. Opin. Immunol, 11, 277-285
2. Jacobson, M. D., Weil, M., and Raff, M. C. (1997) Cell 88, 347-354
3. Green, D. R. (1998) Cell 94, 695-698
4. Reed, J. C. (1997) Nature 387, 773-776
5. Adams, J. M., and Cory, S. (1998) Science 281, 1322-1326
6. Green, D. R. (2000) Cell 102, 1-4
7. Brenner, C., Cadiou, H., Vieira, H. L., Zamzami, N., Marzo, I., Xie, Z., Leber, B., Andrews, D., Duclohier, H., Reed, J. C., and Kroemer, G. (2000) Oncogene 19, 329-336
8. Shimizu, S., Konishi, A., Kodama, T., and Tsujimoto, Y. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 3100-3105
9. Shimizu, S., Narita, M., and Tsujimoto, Y. (1999) Nature 399, 483-487
10. Vander Heiden, M. G., Li, X. X., Gottleib, E., Hill, R. B., Thompson, C. B., and Colombini, M. (2001) J. Biol. Chem. 276, 19414-19419
11. Cheng, E. H., Kirsch, D. G., Clem, R. J., Ravi, R., Kastan, M. B., Bedi, A., Ueno, K., and Hardwick, J. M. (1997) Science 278, 1966-1968
12. Haldar, S., Chintapalli, J., and Croce, C. M. (1996) Cancer Res. 56, 1253-1255
13. Haldar, S., Jena, N., and Croce, C. M. (1995) Proc. Natl. Acad. Sci. U. S. A. 92, 4507-4511
14. Srivastava, R. K., Mi, Q. S., Hardwick, J. M., and Longo, D. L. (1999) Proc. Natl. Acad. Sci. U. S. A. 96, 3775-3780
15. Navarro, P., Valverde, A. M., Benito, M., and Lorenzo, M. (1999) J. Biol. Chem. 274, 18857-18863
16. Ojala, P. M., Yamamoto, K., Castanos-Velez, E., Biberfeld, P., Korsmeyer, S. J., and Makela, T. P. (2000) Nat. Cell Biol. 2, 819-825
17. Rosini, P., De Chiara, G., Lucibello, M., Garaci, E., Cozzolino, F., and Torcia, M. (2000) Biochem. Biophys. Res. Commun. 278, 753-759
18. Ito, T., Deng, X., Carr, B., and May, W. S. (1997) J. Biol. Chem. 272, 11671-11673
19. Ruvolo, P. P., Deng, X., Carr, B. K., and May, W. S. (1998) J. Biol. Chem. 273, 25436-25442
20. Ruvolo, P. P., Deng, X., Ito, T., Carr, B. K., and May, W. S. (1999) J. Biol. Chem. 274, 20296-20300
21. Dimmeler, S., Breitschopf, K., Haendeler, J., and Zeiher, A. M. (1999) J. Exp. Med. 189, 1815-1822
22. Breitschopf, K., Haendeler, J., Malchow, P., Zeiher, A. M., and Dimmeler, S. (2000) Mol. Cell. Biol. 20, 1886-1896
23. Levi-Montalcini, R. (1987) Science 237, 1154-1162
24. Torcia, M., Bracci-Laudiero, L., Lucibello, M., Nencioni, L., Labardi, D., Rubartelli, A., Cozzolino, F., Aloe, L., and Garaci, E. (1996) Cell 85, 345-356
25. Greenlund, L. J., Korsmeyer, S. J., and Johnson, E. M., Jr. (1995) Neuron 15, 649-661
26. Katoh, S., Mitsui, Y., Kitani, K., and Suzuki, T. (1996) Biochem. Biophys. Res. Commun. 229, 653-657
27. Pincelli, C., Haake, A. R., Benassi, L., Grassilli, E., Magnoni, C., Ottani, D., Polakowska, R., Franceschi, C., and Giannetti, A. (1997) J. Invest. Dermatol. 109, 757-764
28. Kummer, J. L., Rao, P. K., and Heidenreich, K. A. (1997) J. Biol. Chem. 272, 20490-20494
29. Maroney, A. C., Finn, J. P., Bozyczko-Coyne, D., O'Kane, T. M., Neff, N. T., Tolkovsky, A. M., Park, D. S., Yan, C. Y., Troy, C. M., and Greene, L. A. (1999) J. Neurochem. 73, 1901-1912
30. Le Niculescu, H., Bonfoco, E., Kasuya, Y., Claret, F. X., Green, D. R., and Karin, M. (1999) Mol. Cell. Biol. 19, 751-763
31. Horstmann, S., Kahle, P. J., and Borasio, G. D. (1998) J. Neurosci. Res. 52, 483-490
32. Chu, Y., Solski, P. A., Khosravi-Far, R., Der, C. J., and Kelly, K. (1996) J. Biol. Chem. 271, 6497-6501
33. Tibbles, L. A., and Woodgett, J. R. (1999) Cell Mol. Life Sci. 55, 1230-1254
34. Raingeaud, J., Whitmarsh, A. J., Barrett, T., Derijard, B., and Davis, R. J. (1996) Mol. Cell. Biol. 16, 1247-1255
35. Zha, J., Harada, H., Yang, E., Jockel, J., and Korsmeyer, S. J. (1996) Cell 87, 619-628
36. Wang, H. G., Rapp, U. R., and Reed, J. C. (1996) Cell 87, 629-638
37. Malmqvist, M., and Karlsson, R. (1997) Curr. Opin. Chem. Biol. 1, 378-383
38. Chang, B. S., Minn, A. J., Muchmore, S. W., Fesik, S. W., and Thompson, C. B. (1997) EMBO J. 16, 968-977
39. Lee, J. C., Kassis, S., Kumar, S., Badger, A., and Adams, J. L. (1999) Pharmacol. Ther. 82, 389-397
40. Maundrell, K., Antonsson, B., Magnenat, E., Camps, M., Muda, M., Chabert, C., Gillieron, C., Boschert, U., Vial-Knecht, E., Martinou, J. C., and Arkinstall, S. (1997) J. Biol. Chem. 272, 25238-25242
41. Yamamoto, K., Ichijo, H., and Korsmeyer, S. J. (1999) Mol. Cell. Biol. 19, 8469-8478
42. Basu, A., You, S. A., and Haldar, S. (2000) Int. J. Oncol. 16, 497-500
43. Fan, M., Goodwin, M., Vu, T., Brantley-Finley, C., Gaarde, W. A., and Chambers, T. C. (2000) J. Biol. Chem. 275, 29980-29985
44. Thomas, A., Giesler, T., and White, E. (2000) Oncogene 19, 5259-5269
45. Johnson, L. N., and Barford, D. (1993) Annu. Rev. Biophys. Biomol. Struct. 22, 199-232
46. Fang, X., Yu, S., Eder, A., Mao, M., Bast, R. C., Boyd, D., and Mills, G. B. (1999) Oncogene 18, 6635-6640
47. Verma, S., Zhao, L., and Chinnadurai, G. (2001) J. Biol. Chem. 276, 4671-4676
48. Zhu, W., Cowie, A., Wasfy, G. W., Penn, L. Z., Leber, B., and Andrews, D. W. (1996) EMBO J. 15, 4130-4141
49. Green, D. R., and Reed, J. C. (1998) Science 281, 1309-1312
50. Melamed, I., Turner, C. E., Aktories, K., Kaplan, D. R., and Gelfand, E. W. (1995) J. Exp. Med. 181, 1071-1079
51. Kharbanda, S., Saxena, S., Yoshida, K., Pandey, P., Kaneki, M., Wang, Q., Cheng, K., Chen, Y. N., Campbell, A., Sudha, T., Yuan, Z. M., Narula, J., Weichselbaum, R., Nalin, C., and Kufe, D. (2000) J. Biol. Chem. 275, 322-327
52. Tamura, K., Sudo, T., Senftleben, U., Dadak, A. M., Johnson, R., and Karin, M. (2000) Cell 102, 221-231
53. Kroemer, G., and Reed, J. C. (2000) Nat. Med. 6, 513-519
54. Kirsch, D. G., Doseff, A., Chau, B. N., Lim, D. S., Souza-Pinto, N. C., Hansford, R., Kastan, M. B., Lazebnik, Y. A., and Hardwick, J. M. (1999) J. Biol. Chem. 274, 21155-21161
55. Clem, R. J., Cheng, E. H., Karp, C. L., Kirsch, D. G., Ueno, K., Takahashi, A., Kastan, M. B., Griffin, D. E., Earnshaw, W. C., Veliuona, M. A., and Hardwick, J. M. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 554-559
56. Chadebech, P., Brichese, L., Baldin, V., Vidal, S., and Valette, A. (1999) Biochem. Biophys. Res. Commun. 262, 823-827
57. Wang, S., Wang, Z., Boise, L., Dent, P., and Grant, S. (1999) Biochem. Biophys. Res. Commun. 259, 67-72
58. Grillot, D. A., Merino, R., Pena, J. C., Fanslow, W. C., Finkelman, F. D., Thompson, C. B., and Nunez, G. (1996) J. Exp. Med. 183, 381-391
59. Bredesen, D. E., and Rabizadeh, S. (1997) Trends Neurosci. 20, 287-290
60. Majdan, M., Lachance, C., Gloster, A., Aloyz, R., Zeindler, C., Bamji, S., Bhakar, A., Belliveau, D., Fawcett, J., Miller, F. D., and Barker, P. A. (1997) J. Neurosci. 17, 6988-6998
61. Ye, X., Mehlen, P., Rabizadeh, S., VanArsdale, T., Zhang, H., Shin, H., Wang, J. J., Leo, E., Zapata, J., Hauser, C. A., Reed, J. C., and Bredesen, D. E. (1999) J. Biol. Chem. 274, 30202-30208
62. Khursigara, G., Orlinick, J. R., and Chao, M. V. (1999) J. Biol. Chem. 274, 2597-2600
63. Baud, V., Liu, Z. G., Bennett, B., Suzuki, N., Xia, Y., and Karin, M. (1999) Genes Dev. 13, 1297-1308
64. Hall-Jackson, C. A., Goedert, M., Hedge, P., and Cohen, P. (1999) Oncogene 18, 2047-2054