Monomeric and dimeric disintegrins: Platelet active agents from viper venom

Toxin Reviews

Volumn 25, Issue 3, 2006, Pages 435-464

  McLane, Mary Ann ^a   Zhang, Xiaoming ^a   Tian, Jing ^a   Paquette Straub, Carrie ^a  

^a UNIVERSITY OF DELAWARE   (United States)

Author keywords

Disintegrin; Inhibitory profiles; Platelet aggregation

Indexed keywords

ACCUTIN; ADENOSINE DIPHOSPHATE; ALBOLABRIN; ALPHA2B BETA3 INTEGRIN; APPLAGGIN; ARGINYLGLYCYLASPARTIC ACID; BARBOURIN; BASILICIN; BITISTATIN; BOTHRASPERIN; CERASTATIN; CEREBERIN; COLLAGEN; CONTORTROSTATIN; COTIARIN; CROTAVIRIN; DISINTEGRIN; ECHISTATIN; ERISTOSTATIN; FIBRINOGEN; FLAVOSTATIN; GABONIN; INTEGRIN RECEPTOR; JERDONATIN; KISTRIN; SNAKE VENOM; TRIFLAVIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; USSURISTATIN 1; USSURISTATIN 2;

AMINO ACID SEQUENCE; CELL STRAIN MCF 7; DRUG BINDING SITE; DRUG POTENCY; HEPATOMA CELL; HUMAN; IC 50; MELANOMA CELL; MUTATION; NONHUMAN; OSTEOSARCOMA CELL; PROTEIN MOTIF; REVIEW; STRUCTURE ACTIVITY RELATION; SYSTEMATIC REVIEW; THROMBOCYTE AGGREGATION; THROMBOCYTE AGGREGATION INHIBITION; THROMBOCYTE RICH PLASMA;

MINK CELL FOCUS-FORMING VIRUS; VIPERINAE;

EID: 33646341259     PISSN: 15569543     EISSN: 15569551     Source Type: Journal    
DOI: 10.1080/15569540600567420     Document Type: Review

References (115)

1. Andrews, R. K., Berndt, M. C. (2004). Platelet physiology and thrombosis. Thromb. Res. 114(5-6):447-453.
2. Bennett, J. S. (2001). Novel platelet inhibitors. Annu. Rev. Med. 52(1):161-184.
3. Benveniste, J., Chignard, M. (1985). A role for PAF-acether (platelet-activating factor) in platelet-dependent vascular diseases? Circulation 72(4):713-717.
4. Beviglia, L., Stewart, G. J., Niewiarowski, S. (1995). Effect of four disintegrins on the adhesive and metastatic properties of B16F10 melanoma cells in a murine model. Oncol. Res. 7(1):7-20.
5. Bilgrami, S., Tomar, S., Yadav, S., Kaur, P., Kumar, J., Jabeen, T., Sharma, S., Singh, T. P. (2004). Crystal structure of schistatin, a disintegrin homodimer from saw-scaled viper (Echis carinatus) at Å resolution. J. Mol. Biol. 341(3):829-837.
6. Butera, D., Fontes Piazza, R. M., McLane, M. A., Chammas, R., Moura da Silva, A. M. (2005). Molecular Engineering of an EGFP/disintegrin-based integrin marker. Toxicon 46:178-184.
7. Butera, D., Skielka, K., McLane, M., Paquette-Straub, C., Ducancel, F., Moura da Silva, A. (2003). Cloning, expression, and characterization of a bi-functional disintegrin/alkaline phosphatase hybrid protein. Prot. Expr. Purif. 31(2):286-291.
8. Calvete, J. J. (2004). Structures of integrin domains and concerted conformational changes in the bidirectional signaling mechanism of alphaII(b)β3. Exp. Biol. Med. 229(8):732-744.
9. Calvete, J. J., Fox, J. W., Agelan, A., Niewiarowski, S., Marcinkiewicz, C. (2002). The presence of the WGD motif in CC8 heterodimeric disintegrin increases its inhibitory effect on αII(b)β3, α(v)β3, and α5β1 integrins. Biochemistry 41(6):2014-2021.
10. Calvete, J. J., Moreno, M., Theakston, R. D., Kisiel, D. G., Marcinkiewicz, C. (2003). Snake venom disintegrins: novel dimeric disintegrins and structural diversification by disulphide bond engineering. Biochem. J. 372(Pt 3):725-734.
11. Chang, C. P., Chang, J. C., Chang, H. H., Tsai, W. J., Lo, S. J. (2001). Positional importance of Pro53 adjacent to the Arg49-Gly50-Asp51 sequence of rhodostomin in binding to integrin αII(b)β3. Biochem. J. 357(Pt1):57-64.
12. Chang, H. H., Lin, C. H., Lo, S. J. (1999). Recombinant rhodostomin substrates induce transformation and active calcium oscillation in human platelets. Exp. Cell Res. 250(2):387-400.
13. Chang, M. C., Wang, B. R., Huang, T. F. (1995). Characterization of endothelial cell differential attachment to fibrin and fibrinogen and its inhibition by Arg-Gly-Asp- containing peptides. Thromb. Haemost. 74(2):764-769.
14. Chao, B. H., Jakubowski, J. A., Savage, B., Chow, E. P., Marzec, U. M., Harker, L. A., Maraganore, J. M. (1989). Agkistrodon piscivorus piscivorus platelet aggregation inhibitor: a potent inhibitor of platelet activation. Proc. Natl. Acad. Sci. USA 86:8050-8054.
15. Chen, Y. L., Huang, T. F., Chen, S. W., Tsai, I. H. (1995). Determination of the structure of two novel echistatin variants and comparison of the ability of echistatin variants to inhibit aggregation of platelets from different species. Biochem. J. 305(Pt 2):513-520.
16. Chiang, H. S., Swaim, M. W., Huang, T. F. (1995a). Characterization of platelet aggregation induced by human breast carcinoma and its inhibition by snake venom peptides, trigramin and rhodostomin. Breast Canc. Res. Treat. 33(3):225-235.
17. Chiang, H. S., Yang, R. S., Huang, T. F. (1995b). The Arg-Gly-Asp-containing peptide, rhodostomin, inhibits in vitro cell adhesion to extracellular matrices and platelet aggregation caused by saos-2 human osteosarcoma cells. Br. J. Canc. 71(2):265-270.
18. Clark, E. A., Trikha, M., Markland, F. S., Brugge, J. S. (1994). Structurally distinct disintegrins contortrostatin and multisquamatin differentially regulate platelet tyrosine phosphorylation. J. Biol. Chem. 269(35):21940-21943.
19. Coelho, A. L., de-Freitas, M. S., Oliveira-Carvalho, A., Moura-Neto, V., Zingali, R. B., Barja-Fidalgo, C. (1999). Effects of jarastatin, a novel snake venom disintegrin, on neutrophil migration and actin cytoskeleton dynamics. Exp. Cell Res. 251(2):379-387.
20. Coelho, A. L., De Freitas, M. S., Mariano-Oliveira, A., Rapozo, D. C., Pinto, L. F., Niewiarowski, S., Zingali, R. B., Marcinkiewicz, C., Barja-Fidalgo, C. (2004). RGD- and MLD-disintegrins, jarastatin and EC3, activate integrin-mediated signaling modulating the human neutrophils chemotaxis, apoptosis and IL-8 gene expression. Exp. Cell Res. 292(2):371-384.
21. Coller, B. S. (2001). Anti-GPIIb/IIIa drugs: current strategies and future directions. Thromb. Haemost. 86(1):427-443.
22. Dennis, M. S., Carter, P., Lazarus, R. A. (1993). Binding interactions of kistrin with platelet glycoprotein IIb-IIIa: analysis by site-directed mutagenesis. Proteins 15(3):312-321.
23. Dennis, M. S., Henzel, W. J., Pitti, R. M., Lipari, M. T., Napier, M. A., Deisher, T. A., Bunting, S., Lazarus, R. A. (1990). Platelet glycoprotein IIb-IIIa protein antagonists from snake venoms: evidence for a family of platelet-aggregation inhibitors. Proc. Natl. Acad. Sci. USA 87(7):2471-2475.
24. Farndale, R. W., Sixma, J. J., Barnes, M. J., De Groot, P. G. (2004). The role of collagen in thrombosis and hemostasis. J. Thromb. Haemost. 2(4):561-573.
25. FitzGerald, G. A. (1991). Mechanisms of platelet activation: thromboxane A2 as an amplifying signal for other agonists. Am. J Cardiol. 68(7):11B-15B.
26. Francischetti, I. M. B., My-Pham, V., Harrison, J., Garfield, M. K., Ribeiro, J. M. C. (2004). Bitis gabonica (Gaboon viper) snake venom gland: toward a catalog for the full-length transcripts (cDNA) and proteins. Gene 337:55-69.
27. Fujii, Y., Okuda, D., Fujimoto, Z., Horii, K., Morita, T., Mizuno, H. (2003). Crystal structure of trimestatin, a disintegrin containing a cell adhesion recognition motif RGD. J. Mol. Biol. 332(5):1115-1122.
28. Fujisawa, Y., Kuroda, S., Notoya, K., Konishi, H., Terashita, Z. (1994). Halystatin, a novel disintegrin from Agkistrodon halys, is a potent inhibitor of bone resorption and platelet aggregation. J. Takeda Res. Lab. 53:39-56.
29. Gan, Z. R., Gould, R. J., Jacobs, J. W., Friedman, P. A., Polokoff, M. A. (1988). Echistatin. A potent platelet aggregation inhibitor from the venom of the viper, Echis carinatus. J. Biol. Chem. 263(36):19827-19832.
30. Garsky, V. M., Lumma, P. K., Freidinger, R. M., Pitzenberger, S. M., Randall, W. C., Veber, D. F., Gould, R. J., Friedman, P. A. (1989). Chemical synthesis of echistatin, a potent inhibitor of platelet aggregation from Echis carinatus: synthesis and biological activity of selected analogs. Proc. Natl. Acad. Sci. U.S.A. 86(11):4022-4026.
31. Gasmi, A., Srairi, N., Guermazi, S., Dkhil, H., Karoui, H., El-Ayeb, M. (2001). Amino acid structure and characterization of a heterodimeric disintegrin from Vipera lebetina venom. Biochim. Biophys. Acta 1547(1):51-56.
32. Gould, R. J., Polokoff, M. A., Friedman, P. A., Huang, T. F., Holt, J. C., Cook, J. J., Niewiarowski, S. (1990). Disintegrins: a family of integrin inhibitory proteins from viper venoms. Proc. Soc. Exp. Biol. Med. 195(2):168-171.
33. Hantgan, R. R., Stahle, M. C., Connor, J. H., Lyles, D. S., Horita, D. A., Rocco, M., Nagaswami, C., Weisel, J. W., McLane, M. A. (2004). The disintegrin echistatin stabilizes integrin αII(b)β3's open conformation and promotes its oligomerization. J. Mol. Biol. 342(5):1625-1636.
34. Harrington, R. A. (1997). Design and methodology of the PURSUIT trial: evaluating eptifibatide for acute ischemic coronary syndromes. Platelet Glycoprotein IIb-IIIa in Unstable Angina: Receptor Suppression Using Integrilin Therapy. Am. J. Cardiol. 80(4A):34B-38B.
35. Hirsh, J., Weitz, J. I. (1999). New antithrombotic agents. Lancet 353(9162):1431-1436.
36. Hong, S. Y., Koh, Y. S., Chung, K. H., Kim, D. S. (2002). Snake venom disintegrin, saxatilin, inhibits platelet aggregation, human umbilical vein endothelial cell proliferation, and smooth muscle cell migration. Thromb. Res. 105(1):79-86.
37. Huang, F., Hong, E. (2004). Platelet glycoprotein IIb/IIIa inhibition and its clinical use. Curr. Med. Chem. Cardiovasc. Hematol. Agents 2(3):187-196.
38. Huang, T. F., Holt, J. C., Lukasiewicz, H., Niewiarowski, S. (1987). Trigramin. A low molecular weight peptide inhibiting fibrinogen interaction with platelet receptors expressed on glycoprotein IIb- IIIa complex. J. Biol. Chem. 262(33):16157-16163.
39. Huang, T. F., Liu, C. Z., Ouyang, C. H., Teng, C. M. (1991a). Halysin, an antiplatelet Arg-Gly-Asp-containing snake venom peptide, as fibrinogen receptor antagonist. Biochem. Pharmacol. 42(6):1209-1219.
40. Huang, T. F., Sheu, J. R., Teng, C. M. (1991b). A potent antiplatelet peptide, triflavin, from Trimeresurus flavoviridis snake venom. Biochem. J. 277(Pt 2):351-357.
41. Huang, T. F., Wang, W. J., Teng, C. M., Liu, C. S., Ouyang, C. (1991c). Purification and characterization of an antiplatelet peptide, arietin, from Bitis arietans venom. Biochim. Biophys. Acta 1074(1):136-143.
42. Huang, T. F., Wang, W. J., Teng, C. M., Ouyang, C. (1991d). Mechanism of action of the antiplatelet peptide, arietin, from Bitis arietans venom. Biochim. Biophys. Acta 1074(1):144-150.
43. Huang, T. F., Peng, H. C., Teng, C. M., Ouyang, C. (1992). An antiplatelet peptide, gabonin, from Bitis gabonica snake venom. Arch. Biochem. Biophys. 298(1):13-20.
44. Hynes, R. O. (2002). Integrins: Bidirectional, Allosteric Signaling Machines. Cell 110(6):673-687.
45. Kamiguti, A. S., Markland, F. S., Zhou, Q., Laing, G. D., Theakston, R. D., Zuzel, M. (1997). Proteolytic cleavage of the β1 subunit of platelet α2β1 integrin by the metalloproteinase jararhagin compromises collagen-stimulated phosphorylation of pp72. J. Biol Chem. 272(51):32599-32605.
46. Kang, I. C., Chung, K. H., Lee, S. J., Yun, Y., Moon, H. M., Kim, D. S. (1998). Purification and molecular cloning of a platelet aggregation inhibitor from the snake (Agkistrodon halys brevicaudus) venom. Thromb. Res. 91(2):65-73.
47. Kang, I. C., Lee, Y. D., Kim, D. S. (1999). A novel disintegrin salmosin inhibits tumor angiogenesis. Cancer Res. 59(15):3754-3760.
48. Kawasaki, T., Sakai, Y., Taniuchi, Y., Sato, K., Maruyama, K., Shimizu, M., Kaku, S., Yano, S., Inagaki, O., Tomioka, K., Yanagisawa, I., Takenaka, T. (1996). Biochemical characterization of a new disintegrin, flavostatin, isolated from Trimeresurus flavoviridis venom. Biochimie 78(4):245-252.
49. Kini, R. M., Morita, T., Rosing, J. (2000). Classification and nomenclature of prothrombin activators isolated from snake venoms. Registry of Exogenous Hemostatic Factors of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis 2000, www.med.unc.edu/isth/SSC/communications/exogenous/kinisnake.pdf-
50. Kisiel, D. G., Calvete, J. J., Katzhendler, J., Fertala, A., Lazarovici, P., Marcinkiewicz, C. (2004). Structural determinants of the selectivity of KTS-disintegrins for the α1β1 integrin. FEBS Lett. 577(3):478-482.
51. Knight, L. C., Maurer, A. H., Romano, J. E. (1996). Comparison of iodine-123-disintegrins for imaging thrombi and emboli in a canine model. J. Nucl. Med. 37(3):476-482.
52. Larson, L. (2004). Primary Hemostasis, in: McKenzie, S. (ed.), Clinical Laboratory Hematology, Upper Saddle River, NJ: Pearson Education.
53. Lee, G., Chan, W., Hurle, M. R., DesJarlais, R. L., Watson, F., Sathe, G. M., Wetzel, R. (1993). Strong inhibition of fibrinogen binding to platelet receptor α IIb β 3 by RGD sequences installed into a presentation scaffold. Protein Eng. 6(7):745-754.
54. Lee, L. W., Peng, H. C., Ko, W. C., Hung, W. C., Su, C. H., Lin, C. H., Huang, T. F., Yen, M. H., Sheu, J. R. (1999). Triflavin potentiates the antiplatelet activity of platelet activating factor receptor antagonist on activated neutrophil-induced platelet aggregation. Eur. J. Pharmacol. 364(2-3):239-246.
55. Liu, C. Z., Peng, H. C., Huang, T. F. (1995). Crotavirin, a potent platelet aggregation inhibitor purified from the venom of the snake Crotalus viridis. Toxicon 33(10):1289-1298.
56. Liu, J. W., Du, X. Y., Liu, P., Chen, X., Xu, J. M., Wu, X. F., Zhou, Y. C. (2000). Purification, characterization, and cDNA sequence of halysetin, a disintegrin-like/cysteine-rich protein from the venom of Agkistrodon halys Pallas. Biochem. Biophys. Res. Comm. 278(1):112-118.
57. Lombardi, P., Pelagalli, A., Avallone, L., Angelo, D., Belisario, M. A., Angelo, A., Staiano, N. (1999). Species-dependent specificity of platelet aggregation inhibitors from snake venom. J. Comp. Pathol. 121(2):185-190.
58. Marcinkiewicz, C. (2005). Functional characteristics of snake venom disintegrins: potential therapeutic implication. Curr. Pharm. Design 11(7):815-827.
59. Marcinkiewicz, C., Vijay Kumar, S., McLane, M. A., Niewiarowski, S. (1997). Significance of RGD loop and C-terminal domain of echistatin for recognition of αIIb β3 and α(v) β3 integrins and expression of ligand-induced binding site. Blood 90(4):1565-1575.
60. Marcinkiewicz, C., Calvete, J. J., Marcinkiewicz, M. M., Raida, M., Vijay, K. S., Huang, Z., Lobb, R. R., Niewiarowski, S. (1999a). EC3, a novel heterodimeric disintegrin from Echis carinatus venom, inhibits α4 and α5 integrins in an RGD-independent manner. J. Biol. Chem. 274(18):12468-12473.
61. Marcinkiewicz, C., Calvete, J. J., Vijay-Kumar, S., Marcinkiewicz, M. M., Raida, M., Schick, P., Lobb, R. R., Niewiarowski, S. (1999b). Structural and functional characterization of EMF10, a heterodimeric disintegrin from Eristocophis macmahoni venom that selectively inhibits α5β1 integrin. Biochemistry 38(40):13302-13309.
62. Marcinkiewicz, C., Taooka, Y., Yokosaki, Y., Calvete, J. J., Marcinkiewicz, M. M., Lobb, R. R., Niewiarowski, S., Sheppard, D. (2000). Inhibitory effects of MLDG-containing heterodimeric disintegrins reveal distinct structural requirements for interaction of the integrin α9β 1 with VCAM-1, tenascin-C, and osteopontin. J. Biol. Chem. 275(41):31930-31937.
63. Markland, F. S. (1998). Snake venoms and the hemostatic system. Toxicon 36(12):1749-1800.
64. Marrakchi, N., Barbouche, R., Bon, C., Ayeb, M. E. (1997). Cerastatin, a new potent inhibitor of platelet aggregation from the venom of the Tunisian viper, Cerastes cerastes. Toxicon 35(1):125-135.
65. Maruyama, K., Kawasaki, T., Sakai, Y., Taniuchi, Y., Shimizu, M., Kawashima, H., Takenaka, T. (1997). Isolation and amino acid sequence of flavostatin, a novel disintegrin from the venom of Trimeresurus flavoviridis. Peptides 18(1):73-78.
66. Mazur, P., Henzel, W. J., Seymour, J. L., Lazarus, R. A. (1991). Ornatins: potent glycoprotein IIb-IIIa antagonists and platelet aggregation inhibitors from the leech Placobdella ornata. Eur. J. Biochern. 202(3):1073-1082.
67. Mazurov, A. V., Leytin, V. L., Repin, V. S., Forster, W. (1984). Platelet prostanoids in interaction of platelets with collagen substrates. II. Effects of exogenous arachidonic acid, stable PG endoperoxides analogue, and aspirin. Biomed. Biochim. Acta 43: S373-376.
68. McLane, M. A., Kowalska, M. A., Silver, L., Shattil, S. J., Niewiarowski, S. (1994). Interaction of disintegrins with the α IIb β3 receptor on resting and activated human platelets. Biochem. J. 301(Pt 2):429-436.
69. McLane, M. A., Marcinkiewicz, C., Vijay-Kumar, S., Wierzbicka-Patynowski, I., Niewiarowski, S. (1998). Viper venom disintegrins and related molecules. Proc. Soc. Exp. Biol. Med. 219(2):109-119.
70. McLane, M. A., Sanchez, E. E., Wong, A., Paquette-Straub, C., Perez, J. C. (2004). Disintegrins. Curr. Drug Targets Cardiovasc. Haematol. Disord 4(4):327-355.
71. McQuade, P., Knight, L. C., Welch, M. J. (2004). Evaluation of 64Cu- and 125I-radiolabeled bitistatin as potential agents for targeting αvβ3 integrins in tumor angiogenesis. Bioconjug. Chem. 15(5):988-996.
72. Moreno-Murciano, M., Paz, Monleon, D., Calvete, J. J., Celda, B., Marcinkiewicz, C. (2003). Amino acid sequence and homology modeling of obtustatin, a novel non-RGD-containing short disintegrin isolated from the venom of Vipera lebetina obtusa. Prot. Science 12, 366-371.
73. Murugappan, S., Shankar, G., Kunapuli, S. P. (2004). Platelet receptors for adenine nucleotides and thromboxane A2. Semin. Thromb. Hemost. 30:411-418.
74. Musial, J., Niewiarowski, S., Rucinski, B., Stewart, G. J., Cook, J. J., Williams, J. A., Edmunds, L. H., Jr. (1990). Inhibition of platelet adhesion to surfaces of extracorporeal circuits by disintegrins. RGD-containing peptides from viper venoms. Circulation 82(1):261-273.
75. O'Toole, T. E., Loftus, J. C., Du, X. P., Glass, A. A., Ruggeri, Z. M., Shattil, S. J., Plow, E. F., Ginsberg, M. H. (1990). Affinity modulation of the αIIb β3 integrin (platelet GPIIb-IIIa) is an intrinsic property of the receptor. Cell Regul. 1(12):883-893.
76. Okuda, D., Morita, T. (2001). Purification and characterization of a new RGD/KGD-containing dimeric disintegrin, piscivostatin, from the venom of Agkistrodon piscivorus piscivorus: the unique effect of piscivostatin on platelet aggregation. J. Biochem. 130(3):407-415.
77. Okuda, D., Nozaki, C., Sekiya, F., Morita, T. (2001). Comparative biochemistry of disintegrins isolated from snake venom: consideration of the taxonomy and geographical distribution of snakes in the genus Echis. J. Biochem. 129(4):615-620.
78. Okuda, D., Koike, H., Morita, T. (2002). A new gene structure of the disintegrin family: a subunit of dimeric disintegrin has a short coding region. Biochemistry 41(48):14248-14254.
79. Oshikawa, K., Terada, S. (1999). Ussuristatin 2, a novel KGD-bearing disintegrin from Agkistrodon ussuriensis venom. J. Biochem. 125(1):31-35.
80. Ovbiagele, B., Kidwell, C. S., Saver, J. L. (2005). Expanding indications for statins in cerebral ischemia: a quantitative study. Arch. Neurol. 62(1):67-72.
81. Pfaff, M., McLane, M. A., Beviglia, L., Niewiarowski, S., Timpl, R. (1994). Comparison of disintegrins with limited variation in the RGD loop in their binding to purified integrins α IIb β 3, α V β3 and α 5 β 1 and in cell adhesion inhibition. Cell Adhes. Commun. 2(6):491-501.
82. Pinto, A., Angulo, Y., Jiminez, R., Lomonte, B. (2003). Isolation of bothrasperin, a disintegrin with potent platelet aggregation inhibitory activity, from the venom of the snake Bothrops asper. Rev. Biol. Trop. 51(1):253-259.
83. Pirkle, H., Stocker, K. (1991). Thrombin-like enzymes from snake venoms: an inventory. For the Subcommittee on Nomenclature of Exogenous Hemostatic Factors of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis. Thromb. Haemost. 65(4):444-450.
84. 2+ cation. Biochem. J. 335(Pt 2):247-257.
85. Rahman, S., Flynn, G., Aitken, A., Patel, Y., Hussain, F., Lu, X., Loftus, J. C., French, D., Wijelath, E., Strand, K., Savidge, G. F. (2000). Differential recognition of snake venom proteins expressing specific Arg-Gly-Asp (RGD) sequence motifs by wild-type and variant integrin αIIbβ3: further evidence for distinct sites of RGD ligand recognition exhibiting negative allostery. Biochem. J. 345Pt 3:701-709.
86. Rahman, S., Lu, X., Kakkar, V. V., Authi, K. S. (1995). The integrin αIIb β3 contains distinct and interacting binding sites for snake-venom RGD (Arg-Gly-Asp) proteins. Evidence that the receptor-binding characteristics of snake-venom RGD proteins are related to the amino acid environment flanking the sequence RGD. Biochem. J. 312(Pt 1):223-232.
87. Roth, G. J., Calverley, D. C. (1994). Aspirin, platelets, and thrombosis: theory and practice. Blood 83(4):885-898.
88. Rucinski, B., Niewiarowski, S., Holt, J. C., Soszka, T., Knudsen, K. A. (1990). Batroxostatin, an Arg-Gly-Asp-containing peptide from Bothrops atrox, is a potent inhibitor of platelet aggregation and cell interaction with fibronectin. Biochim. Biophys. Acta. 1054(3):257-262.
89. Savage, B., Marzec, U. M., Chao, B. H., Harker, L. A., Maraganore, J. M., Ruggeri, Z. M. (1990). Binding of the snake venom-derived proteins applaggin and echistatin to the arginine-glycine-aspartic acid recognition site(s) on platelet glycoprotein IIb. IIIa complex inhibits receptor function. J. Biol. Chem. 265(20):11766-11772.
90. Scaloni, A., Di Martino, E., Miraglia, N., Pelagalli, A., Della Morte, R., Staiano, N., Pucci, P. (1996). Amino acid sequence and molecular modelling of glycoprotein IIb- IIIa and fibronectin receptor iso-antagonists from Trimeresurus elegans venom. Biochem. J. 319(Pt 3):775-782.
91. Scarborough, R. M., Rose, J. W., Hsu, M. A., Phillips, D. R., Fried, V. A., Campbell, A. M., Nannizzi, L., Charo, I. F. (1991). Barbourin. A GPIIb-IIIa-specific integrin antagonist from the venom of Sistrurus m. barbouri. J. Biol Chem. 266(15):9359-9362.
92. Scarborough, R. M., Rose, J. W., Naughton, M. A., Phillips, D. R., Nannizzi, L., Arfsten, A., Campbell, A. M., Charo, I. F. (1993). Characterization of the integrin specificities of disintegrins isolated from American pit viper venoms. J. Biol. Chem. 268(2):1058-1065.
93. Selnick, H. G., Barrow, J. C., Nantermet, M. G., Connolly, T. M. (2003). Non-peptidic small-molecule antagonists of the human platelet thrombin receptor PAR-1. Curr. Med. Chem. Cardiovasc. Hematol. Agents 1(1):47-59.
94. Shattil, S. J., Newman, P. J. (2004). Integrins: dynamic scaffolds for adhesion and signaling in platelets. Blood 104(6):1606-1615.
95. Shebuski, R. J., Ramjit, D. R., Bencen, G. H., Polokoff, M. A. (1989). Characterization and platelet inhibitory activity of bitistatin, a potent arginine-glycine-aspartic acid-containing peptide from the venom of the viper Bitis arietans. J. Biol. Chem. 264(36):21550-21556.
96. Sheu, J. R., Lin, C. H., Huang, T. F. (1994). Triflavin, an antiplatelet peptide, inhibits tumor cell- extracellular matrix adhesion through an arginine-glycine- aspartic acid-dependent mechanism. J. Lab. Clin. Med. 123(2):256-263.
97. Smith, J. B., Theakston, R. D., Coelho, A. L., Barja, F., Calvete, J. J., Marcinkiewicz, C. (2002). Characterization of a monomeric disintegrin, ocellatusin, present in the venom of the Nigerian carpet viper, Echis ocellatus. FEBS Lett. 512(1-3):111-115.
98. Terada, S. (2000). Isolation and primary structures of platelet aggregation inhibitors from Gloydius halys brevicaudus venom. Fukuoka Univ. Sci. Reports 30:71-78.
99. Tomar, S., Yadav, S., Chandra, V., Kumar, P., Singh, T. P. (2001). Purification, crystallization and preliminary X-ray diffraction studies of disintegrin (schistatin) from saw-scaled viper (Echis carinatus). Acta Crystallogr. D. Biol. Crystallogr. 57(Pt 11):1669-1670.
100. Trikha, M., De Clerck, Y. A., Markland, F. S. (1994a). Contortrostatin, a snake venom disintegrin, inhibits β1 integrin-mediated human metastatic melanoma cell adhesion and blocks experimental metastasis. Cancer Res. 54(18):4993-4998.
101. Trikha, M., Rote, W. E., Manley, P. J., Lucchesi, B. R., Markland, F. S. (1994b). Purification and characterization of platelet aggregation inhibitors from snake venoms. Thromb. Res. 73(1):39-52.
102. Tselepis, V. H., Green, L. J., Humphries, M. J. (1997). An RGD to LDV motif conversion within the disintegrin kistrin generates an integrin antagonist that retains potency but exhibits altered receptor specificity. Evidence for a functional equivalence of acidic integrin-binding motifs. J. Biol. Chem. 272(34):21341-21348.
103. Wang, J. H., Wu, Y., Ren, F., Lu, L., Zhao, B. C. (2004). Cloning and characterization of Adinbitor, a novel disintegrin from the snake venom of Agkistrodon halys brevicaudus stejneger. Acta Biochim. Biophys. Sin. 36(6):425-429.
104. Wierzbicka-Patynowski, I., Niewiarowski, S., Marcinkiewicz, C., Calvete, J. J., Marcinkiewicz, M. M., McLane, M. A. (1999). Structural requirements of echistatin for the recognition of αv β3 and α5 β1 integrins. J. Biol. Chem. 274(53):37809-37814.
105. Williams, J., Rucinski, B., Holt, J., Niewiarowski, S. (1990). Elegantin and albolabrin purified peptides from viper venoms: homologies with the RGDS domain of fibrinogen and von Willebrand factor. Biochim. Biophys. Acta 1039(1):81-89.
106. Wright, P. S., Saudek, V., Owen, T. J., Harbeson, S. L., Bitonti, A. J. (1993). An echistatin C-terminal peptide activates GPIIbIIIa binding to fibrinogen, fibronectin, vitronectin and collagen type I and type IV. Biochem. J. 293(Pt 1):263-267.
107. Xiao, T., Takagi, J., Coller, B. S., Wang, J. H., Springer, T. A. (2004). Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics. Nature 432(7013):59-67.
108. Xiong, J. P., Stehle, T., Diefenbach, B., Zhang, R., Dunker, R., Scott, D. L., Joachimiak, A., Goodman, S. L., Arnaout, M. A. (2001). Crystal structure of the extracellular segment of integrin αv β3. Science 294(5541):339-345.
109. Xiong, J. P., Stehle, T., Zhang, R., Joachimiak, A., Frech, M., Goodman, S. L., Arnaout, M. A. (2002). Crystal structure of the extracellular segment of integrin α V β 3 in complex with an Arg-Gly-Asp ligand. Science 296(5565):151-155.
110. Yamada, T., Kidera, A. (1996). Tailoring echistatin to possess higher affinity for integrin α(IIb)β(3). FEBS Lett. 387(1):11-15.
111. Yamakawa, Y., Omori, S., Maeyama, J. (1991). Primary structures of cytotoxic factors isolated from habu (Trimeresurus flavoviridis) venom. J. Biochem. 109(5):667-669.
112. Yang, Z. H., Jing, J., Tang, J. G. (2001). Inhibition of platelet aggregation of a mutant proinsulin molecule engineered by introduction of a native Arg-Gly-Asp sequence. Appl. Biochem. Biotechnol. 90(1):1-10.
113. Yeh, C. H., Peng, H. C., Yih, J. B., Huang, T. F. (1998). A new short chain RGD-containing disintegrin, accutin, inhibits the common pathway of human platelet aggregation. Biochim. Biophys. Acta 1425(3):493-504.
114. Zhou, Q., Hu, P., Ritter, M. R., Swenson, S. D., Argounova, S., Epstein, A. L., Markland, F. S. (2000). Molecular cloning and functional expression of contortrostatin, a homodimeric disintegrin from southern copperhead snake venom. Arch. Biochem. Biophys. 375(2):278-288.
115. Zhou, X. D., Dinga, C. H., Taia, H., Jina, Y., Chena, R. Q., Lua, Q. M., Wanga, W. Y, Xiong, U. L. (2004). A novel disintegrin, jerdonatin, inhibits platelet aggregation and sperm-egg binding. Comp. Biochem. Physiol. B Biochem. Mol. Biol. 139(1):117-122.