An RGD to LDV motif conversion within the disintegrin kistrin generates an integrin antagonist that retains potency but exhibits altered receptor specificity. Evidence for a functional equivalence of acidic integrin- binding motifs

Journal of Biological Chemistry

Volumn 272, Issue 34, 1997, Pages 21341-21348

  Tselepis, Vicky H ^a   Green, Linda J ^a   Humphries, Martin J ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; INTEGRIN; KISTRIN; SNAKE VENOM;

ANIMAL CELL; ARTICLE; BINDING SITE; CELL ADHESION; CHIMERA; LIGAND BINDING; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PURIFICATION; RAT; RECEPTOR BINDING; REINFORCEMENT; SEQUENCE ANALYSIS;

AMINO ACID SEQUENCE; BASE SEQUENCE; CELL ADHESION; CELL ADHESION MOLECULES; CROTALID VENOMS; DISINTEGRINS; HYDROGEN-ION CONCENTRATION; INTEGRINS; MOLECULAR SEQUENCE DATA; OLIGOPEPTIDES; PEPTIDES; RECOMBINANT FUSION PROTEINS; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

ANIMALIA; LACTATE DEHYDROGENASE-ELEVATING VIRUS; SERPENTES;

EID: 0030764956     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.272.34.21341     Document Type: Article

References (63)

1. Hynes, R. (1992) Cell 69, 11-25
2. Schwarz, M. A., Schaller, M. D., and Ginsberg, M. H. (1995) Annu. Rev. Cell Dev. Biol. 11, 549-599
3. Yamada, K. M., and Miyamoto, S. (1995) Curr. Opin. Cell Biol. 7, 681-689
4. Humphries, M. J. (1996) Curr. Opin. Cell Biol. 8, 632-640
5. Pierschbacher, M. D., and Ruoslahti, E. (1984) Nature 309, 30-33
6. Yamada, K. M., and Kennedy, D. W. (1984) J. Cell Biol. 99, 29-36
7. Pierschbacher, M. D., and Ruoslahti, E. (1987) J. Biol. Chem. 262, 17294-17298
8. Wayner, E. A., Garcia-Pardo, A., Humphries, M. J., McDonald, J. A., and Carter, W. G. (1989) J. Cell Biol. 109, 1321-1330
9. Mould, A. P., Wheldon, L. A., Komoriya, A., Wayner, E. A., Yamada, K. M., and Humphries, M. J. (1990) J. Biol. Chem. 265, 4020-4024
10. Komoriya, A., Green, L. J., Mervic, M., Yamada, S. S., Yamada, K. M., and Humphries, M. J. (1991) J. Biol. Chem. 266, 15075-15079
11. Clements, J. M., Newham, P., Shepherd, M., Gilbert, R., Dudgeon, T. J., Needham, L. A., Edwards, R. M., Berry, L., Brass, A., and Humphries, M. J. (1994) J. Cell Sci. 107, 2127-2135
12. Osborn, L., Vassallo, C., Browning, B. G., Tizard, R., Haskard, D. O., Benjamin, C. D., Dougas, I., and Kirchhausen, T. (1994) J. Cell Biol. 124, 601-608
13. Renz, M. E., Chiu, H. H., Jones, S., Fox, J., Kim, K. J., Presta, L. G., and Fong, S. (1994) J. Cell Biol. 125, 1395-1406
14. Vonderheide, R. H., Tedder, T., Springer, T. A., and Staunton, D. A. (1994) J. Cell Biol. 125, 215-222
15. Staunton, D. E., Dustin, M. L., Erickson, H. P., and Springer, T. A. (1990) Cell 61, 243-254
16. Li, R., Nortamo, P., Valmu, L., Tolvanen, M., Huuskonen, J., Kantor, C., and Gahmberg, C. G. (1993) J. Biol. Chem. 268, 17513-17518
17. Holness, C. L., Bates, P. A., Littler, A. J., Buckley, C. D., McDowall, A., Bossy, D., Hogg, N., and Simmons, D. L. (1995) J. Biol. Chem. 270, 877-884
18. Kloczewiak, M., Timmons, S., Lukas, T. J., and Hawiger, J. (1984) Biochemistry 23, 1767-1774
19. Humphries, M. J., Doyle, P. M., and Harris, C. J. (1994) Exp. Opin. Ther. Patents 4, 227-235
20. Yamada, T., Matshushima, M., Inaka, K., Ohkubu, T., Uyeda, A., Maeda, T., Titani, K., Sekiguchi, K., and Kikuchi, M. (1993) J. Biol. Chem. 268, 10588-10592
21. Knapp, A., Degenhardt, T., and Dodt, J. (1992) J. Biol. Chem. 267, 24230-24234
22. Maeda, T., Oyama, R., Ichihara-Tanaka, K., Kimizuka, F., Kato, I., Titani, K., and Sekiguchi, K. (1989) J. Biol. Chem. 264, 15165-15168
23. Maeda, T., Oyama, R., Titani, K., and Sekiguchi, K. (1993) J. Biochem. (Tokyo) 113, 29-35
24. Aota, S., Nomizu, M., and Yamada, K. M. (1994) J. Biol. Chem. 269, 24756-24761
25. Bowditch, R. D., Hariharan, M., Tominna, E. F., Smith, J. W., Yamada, K. M., Getzoff, E. D., and Ginsberg, M. H. (1994) J. Biol. Chem. 269, 10856-10863
26. O'Neil, K. T., Hoess, R. H., Jackson, S. A., Ramachandran, N. S., Mousa, S. A., and DeGrado, W. F. (1992) Proteins Struct. Funct. Genet. 14, 509-515
27. Blobel, C. P., and White, J. M. (1992) Curr. Opin. Cell Biol. 4, 760-765
28. Lazarus, R. A., and McDowell, R. S. (1993) Curr. Opin. Cell Biol. 4, 438-445
29. Niewiarowski, S., McLane, M. A., Kloczewiak, M., and Stewart, G. J. (1994) Semin. Hematol. 31, 289-300
30. Dennis, M.S., Henzel, W. J., Pitti, R. M., Lipari, M. T., Napier, M. A., Deisher, T. A., Bunting, S., and Lazarus, R. A. (1990) Proc. Natl. Acad. Sci. U. S. A. 87, 2471-2475
31. Knudsen, K. A., Tuszynski, G. P., Huang, T.-F., and Niewiarowski, S. (1988) Exp. Cell Res. 179, 42-49
32. Rucinski, B., Niewiarowski, S., Holt, J., Soszka, T., and Knudsen, K. A. (1990) Biochim. Biophys. Acta 1054, 257-262
33. Staiano, N., Villani, G. R. D., Di Martino, E., Squillacioti, C., Vuotto, P., and Di Natale, P. (1995) Biochem. Mol. Biol. Int. 35, 11-19
34. Mould, A. P., Komoriya, A., Yamada, K. M., and Humphries, M. J. (1991) J. Biol. Chem. 266, 3579-3585
35. Adler, M., Lazarus, R. A., Dennis, M. S., and Wagner, G. (1991) Science 253, 445-448
36. Green, L. J., Brierley, V. H., and Humphries, M. J. (1995) Biochem. Soc. Trans. 23, 505S
37. Akiyama, S. K., Yamada, S. S., Chen, W.-T., and Yamada, K. M. (1989) J. Cell Biol. 109, 863-875
38. Garcia-Pardo, A., Ferreira, O. C., Valinsky, J., and Bianco, C. (1989) Exp. Cell Res. 181, 420-431
39. Makarem, R., Newham, P., Askari, J. A., Green, L. J., Clements, J., Edwards, M., Humphries, M. J., and Mould, A. P. (1994) J. Biol. Chem. 269, 4005-4011
40. Mould, A. P., Akiyama, S. K., and Humphries, M. J. (1996) J. Biol. Chem. 271, 20365-20374
41. Smith, D. B., and Johnson, K. S. (1988) Gene (Amst.) 67, 31-40
42. Schagger, H., and von Jagow, G. (1987) Anal. Biochem. 166, 368-379
43. Charo, I. F., Nannizzi, L., Smith, J. W., and Cheresh, D. A. (1990) J. Cell Biol. 111, 2795-2800
44. Kozlowski, J. M., Hart, I. R., Fidler, I. J., and Hanna, N. (1984) J. Natl. Cancer Inst. 72, 913-917
45. Humphries, M. J., Akiyama, S. K., Komoriya, A., Olden, K., and Yamada, K. M. (1986) J. Cell Biol. 103, 2637-2647
46. Calvete, J. J., Schafer, W., Soszka, T., Lu, W., Cook, J. J., Jameson, B. A., and Niewiarowski, S. (1991) Biochemistry 30, 5225-5229
47. Scarborough, R. M., Rose, J. W., Naughton, M. A., Phillips, D. R., Nannizzi, L., Arfsten, A., Campbell, A. M., and Charo, I. F. (1993) J. Biol. Chem. 268, 1058-1065
48. Koivunen, E., Wang, B., and Ruoslahti, E. (1994) J. Cell Biol. 124, 373-380
49. Healy, J. M., Murayama, O., Maeda, T., Yoshino, K., Sekiguchi, K., and Kikuchi, M. (1995) Biochemistry 34, 3948-3955
50. Dennis, M. S., Carter, P., and Lazarus, R A. (1993) Proteins Struct. Funct. Genet. 15, 312-321
51. Lu, X., Williams, J. A., Deadman, J. J., Salmon, G. P., Kakkar, V. V., Wilkinson, J. M., Baruch, D., Authi, K. S., and Rahman, S. (1994) Biochem. J. 304, 929-936
52. Rahman, S., Lu, X., Kakkar, V. V., and Authi, K. S. (1995) Biochem. J. 312, 223-232
53. Lu, X., Rahman, S., Kakkar, V. V., and Authi, K. S. (1996) J. Biol. Chem. 271, 289-294
54. Nowlin, D. M., Gorcsan, F., Moscinski, M., Chiang, S.-L., Lobl, T. J., and Cardarelli, P. M. (1993) J. Biol. Chem. 268, 20352-20359
55. Cardarelli, P., Cobb, R. R., Nowlin, D. M., Scholz, W., Gorcsan, F., Moscinski, M., Yasuhara, M., Chiang, S.-L., and Lobl, T. J. (1994) J. Biol. Chem. 269, 18668-18673
56. Lam, S. C.-T., Plow, E. F., Smith, M. A., Andrieux, A., Ryckwaert, J.-J., Marguerie, G., and Ginsberg, M. H. (1987) J. Biol. Chem. 262, 947-950
57. Loftus, J. C., O'Toole, T. E., Plow, E. F., Glass, A., Frelinger, A. L., III, and Ginsberg, M. H. (1990) Science 249, 915-918
58. Smith, J. W. and Cheresh, D. A. (1990) J. Biol Chem. 265, 2168-2172
59. Edwards, J. G., Hameed, H., and Campbell, G. (1988) J. Cell Sci. 89, 507-513
60. Humphries, M. J. (1990) J. Cell Sci. 97, 585-592
61. Bjarnason, J. B., and Fox, J. W. (1995) Methods Enzymol. 248, 345-368
62. Wolfsberg, T. G., Straight, P. D., Gerena, R. L., Huovila, A. J., Primakoff, P., Myles, D. G., and White, J. M. (1995) Dev. Biol. 169, 378-383
63. Kratzschmar, J., Lum, L., and Blobel, C. P. (1996) J. Biol. Chem. 271, 4593-4596