The disintegrin echistatin stabilizes integrin αIIbβ3's open conformation and promotes its oligomerization

Journal of Molecular Biology

Volumn 342, Issue 5, 2004, Pages 1625-1636

  Hantgan, Roy R ^a   Stahle, Mary C ^a   Connor, John H ^a   Lyles, Douglas S ^a   Horita, David A ^a   Rocco, Mattia ^b   Nagaswami, Chandrasekaran ^c   Weisel, John W ^c   McLane, Mary Ann ^d  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF GENOA   (Italy)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d UNIVERSITY OF DELAWARE   (United States)

Author keywords

conformation; disintegrin; integrin; oligomerization; thermodynamics

Indexed keywords

ALPHA2 BETA3 INTEGRIN; BETA3 INTEGRIN; DISINTEGRIN; ECHISTATIN; INTEGRIN; LEUCINE; LIGAND; METHIONINE; SNAKE VENOM; TIROFIBAN; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CHEMICAL INTERACTION; DIMERIZATION; ELECTRON MICROSCOPY; ENTHALPY; ENTROPY; LIGHT SCATTERING; MACROMOLECULE; MEASUREMENT; MUTANT; OLIGOMERIZATION; PARTICULATE MATTER; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN STABILITY; PROTEIN STRUCTURE; PURIFICATION; SEDIMENTATION; TEMPERATURE; VELOCITY;

SERPENTES;

EID: 4444378872     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2004.08.009     Document Type: Article

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