Perturbation of microtubule polymerization by quercetin through tubulin binding: A novel mechanism of its antiproliferative activity

Biochemistry

Volumn 41, Issue 43, 2002, Pages 13029-13038

  Gupta, Kamlesh ^a   Panda, Dulal ^a  

^a INDIAN INSTITUTE OF TECHNOLOGY BOMBAY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

MICROTUBULES;

CELLS; FLUORESCENCE; PERTURBATION TECHNIQUES; POLYMERIZATION; TUMORS;

PROTEINS;

ANTIOXIDANT; COLCHICINE; CYSTEINE; FLAVONOID; GUANOSINE TRIPHOSPHATASE; QUERCETIN; TRYPTOPHAN; TUBULIN; VINBLASTINE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL PROLIFERATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DEPOLYMERIZATION; DISSOCIATION CONSTANT; DRUG MECHANISM; ENZYME ACTIVITY; FLUORESCENCE; IN VITRO STUDY; MICROTUBULE ASSEMBLY; PRIORITY JOURNAL; PROTEIN ASSEMBLY; STOICHIOMETRY; TITRIMETRY;

ANILINO NAPHTHALENESULFONATES; ANIMALS; BINDING, COMPETITIVE; CIRCULAR DICHROISM; COLCHICINE; CYSTEINE; DITHIONITROBENZOIC ACID; ENZYME ACTIVATION; GOATS; GROWTH INHIBITORS; GTP PHOSPHOHYDROLASES; KINETICS; MICROTUBULES; POLYMERS; PROTEIN BINDING; QUERCETIN; SOLUBILITY; SPECTROMETRY, FLUORESCENCE; SULFHYDRYL REAGENTS; TUBULIN; TUBULIN MODULATORS; VINBLASTINE;

EID: 0037195283     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi025952r     Document Type: Article

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