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Volumn 27, Issue 5, 2006, Pages 972-981

Conjugated linoleic acid stimulates an anti-tumorigenic protein NAG-1 in an isomer specific manner

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 3; CONJUGATED LINOLEIC ACID; GLYCOGEN SYNTHASE KINASE 3BETA; GROWTH FACTOR; LINOLEIC ACID; NONSTEROID ANTIINFLAMMATORY DRUG ACTIVATED PROTEIN 1; PROTEIN KINASE B; PROTEIN NAG 1; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

EID: 33646197169     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgi268     Document Type: Article
Times cited : (112)

References (51)
  • 2
    • 0023616164 scopus 로고
    • Anticarcinogens from fried ground beef: Heat-altered derivatives of linoleic acid
    • Ha,Y.L., Grimm,N.K. and Pariza,M.W. (1987) Anticarcinogens from fried ground beef: Heat-altered derivatives of linoleic acid. Carcinogenesis, 8, 1881-1887.
    • (1987) Carcinogenesis , vol.8 , pp. 1881-1887
    • Ha, Y.L.1    Grimm, N.K.2    Pariza, M.W.3
  • 3
    • 0029610138 scopus 로고
    • Protection of conjugated linoleic acids against 2-amino-3- methylimidazo [4,5-f] quinoline-induced colon carcinogenesis in the F344 rat: A study of inhibitory mechanisms
    • Liew,C., Schut,H.A., Chin,S.F., Pariza,M.W. and Dashwood,R.H. (1995) Protection of conjugated linoleic acids against 2-amino-3- methylimidazo [4,5-f] quinoline-induced colon carcinogenesis in the F344 rat: A study of inhibitory mechanisms. Carcinogenesis, 16, 3037-3043.
    • (1995) Carcinogenesis , vol.16 , pp. 3037-3043
    • Liew, C.1    Schut, H.A.2    Chin, S.F.3    Pariza, M.W.4    Dashwood, R.H.5
  • 4
    • 0036875675 scopus 로고    scopus 로고
    • Cis 9, trans 11 - and trans 10, cis 12-conjugated linoleic acid isomers induce apoptosis in cultured SW480 cells
    • MillerA., Stanton,C. and Devery,R. (2002) Cis 9, trans 11 - and trans 10, cis 12-conjugated linoleic acid isomers induce apoptosis in cultured SW480 cells. Anticancer Res., 22, 3879-3887.
    • (2002) Anticancer Res. , vol.22 , pp. 3879-3887
    • Miller, A.1    Stanton, C.2    Devery, R.3
  • 5
    • 0041709287 scopus 로고    scopus 로고
    • Conjugated linoleic acid downregulates insulin-like growth factor-I receptor levels in HT-29 human colon cancer cells
    • Kim,E.J., Kang,I.J., Cho,H.J., Kim,W.K., Ha,Y.L. and Park,J.H. (2003) Conjugated linoleic acid downregulates insulin-like growth factor-I receptor levels in HT-29 human colon cancer cells. J. Nutr., 133, 2675-2681.
    • (2003) J. Nutr. , vol.133 , pp. 2675-2681
    • Kim, E.J.1    Kang, I.J.2    Cho, H.J.3    Kim, W.K.4    Ha, Y.L.5    Park, J.H.6
  • 6
    • 0242576963 scopus 로고    scopus 로고
    • Conjugated linoleic acid inhibits cell proliferation through a p53-dependent mechanism: Effects on the expression of GI-restriction points in breast and colon cancer cells
    • Kemp,M.Q., Jeffy,B.D. and Romagnolo,D.F. (2003) Conjugated linoleic acid inhibits cell proliferation through a p53-dependent mechanism: Effects on the expression of GI-restriction points in breast and colon cancer cells. J. Nutr., 133, 3670-3677.
    • (2003) J. Nutr. , vol.133 , pp. 3670-3677
    • Kemp, M.Q.1    Jeffy, B.D.2    Romagnolo, D.F.3
  • 7
    • 0035527485 scopus 로고    scopus 로고
    • Conjugated linoleic acid does not inhibit development of aberrant crypt foci in colons of male Sprague-Dawley rats
    • Ealey,K.N., el-Sohemy,A. and Archer,M.C. (2001) Conjugated linoleic acid does not inhibit development of aberrant crypt foci in colons of male Sprague-Dawley rats. Nutr. Cancer, 41, 104-106.
    • (2001) Nutr. Cancer , vol.41 , pp. 104-106
    • Ealey, K.N.1    el-Sohemy, A.2    Archer, M.C.3
  • 8
    • 0033802965 scopus 로고    scopus 로고
    • Highly unsaturated (n-3) fatty acids, but not alpha-linolenic, conjugated linoleic or gamma-linolenic acids, reduce tumorigenesis in Apc(Min/+) mice
    • Petrik,M.B., McEntee,M.F., Johnson,B.T., Obukowicz,M.G. and Whelan,J. (2000) Highly unsaturated (n-3) fatty acids, but not alpha-linolenic, conjugated linoleic or gamma-linolenic acids, reduce tumorigenesis in Apc(Min/+) mice. J. Nutr., 130, 2434-2443.
    • (2000) J. Nutr. , vol.130 , pp. 2434-2443
    • Petrik, M.B.1    McEntee, M.F.2    Johnson, B.T.3    Obukowicz, M.G.4    Whelan, J.5
  • 9
    • 0035060429 scopus 로고    scopus 로고
    • Cyclooxygenase inhibitors regulate the expression of a TGF-beta superfamily member that has proapoptotic and antitumorigenic activities
    • Baek,S.J., Kim,K.S., Nixon,J.B., Wilson,L.C. and Eling,T.E. (2001) Cyclooxygenase inhibitors regulate the expression of a TGF-beta superfamily member that has proapoptotic and antitumorigenic activities. Mol. Pharmacol., 59, 901-908.
    • (2001) Mol. Pharmacol. , vol.59 , pp. 901-908
    • Baek, S.J.1    Kim, K.S.2    Nixon, J.B.3    Wilson, L.C.4    Eling, T.E.5
  • 10
    • 0036235241 scopus 로고    scopus 로고
    • Expression and regulation of nonsteroidal anti-inflammatory drug-activated gene (NAG-1) in human and mouse tissue
    • Kim,K.S., Baek,S.J., Flake,G.P., Loftin,C.D., Calvo,B.F. and Eling,T.E. (2002) Expression and regulation of nonsteroidal anti-inflammatory drug-activated gene (NAG-1) in human and mouse tissue. Gastroenterology, 122, 1388-1398.
    • (2002) Gastroenterology , vol.122 , pp. 1388-1398
    • Kim, K.S.1    Baek, S.J.2    Flake, G.P.3    Loftin, C.D.4    Calvo, B.F.5    Eling, T.E.6
  • 11
    • 0043016358 scopus 로고    scopus 로고
    • Macrophage inhibitory cytokine I reduces cell adhesion and induces apoptosis in prostate cancer cells
    • Liu,T., Bauskin,A.R., Zaunders,J., Brown,D.A., Pankhurst,S., Russell,P.J. and Breit,S.N. (2003) Macrophage inhibitory cytokine I reduces cell adhesion and induces apoptosis in prostate cancer cells. Cancer Res., 63, 5034-5040.
    • (2003) Cancer Res. , vol.63 , pp. 5034-5040
    • Liu, T.1    Bauskin, A.R.2    Zaunders, J.3    Brown, D.A.4    Pankhurst, S.5    Russell, P.J.6    Breit, S.N.7
  • 12
    • 0036201713 scopus 로고    scopus 로고
    • Resveratrol enhances the expression of non-steroidal anti-inflammatory drug-activated gene (NAG-1) by increasing the expression of p53
    • Baek,S.J., Wilson,L.C. and Eling,T.E. (2002) Resveratrol enhances the expression of non-steroidal anti-inflammatory drug-activated gene (NAG-1) by increasing the expression of p53. Carcinogenesis, 23, 425-434.
    • (2002) Carcinogenesis , vol.23 , pp. 425-434
    • Baek, S.J.1    Wilson, L.C.2    Eling, T.E.3
  • 13
    • 0038118648 scopus 로고    scopus 로고
    • Nonsteroidal antiinflammatory drug-activated gene (NAG-1) is induced by genistein through the expression of p53 in colorectal cancer cells
    • Wilson,L.C., Baek,S.J., Call,A. and Eling,T.E. (2003) Nonsteroidal antiinflammatory drug-activated gene (NAG-1) is induced by genistein through the expression of p53 in colorectal cancer cells. Int. J. Cancer, 105, 747-753.
    • (2003) Int. J. Cancer , vol.105 , pp. 747-753
    • Wilson, L.C.1    Baek, S.J.2    Call, A.3    Eling, T.E.4
  • 14
    • 10344233656 scopus 로고    scopus 로고
    • Epicatechin gallate-induced expression of NAG-1 is associated with growth inhibition and apoptosis in colon cancer cells
    • Baek,S.J., Kim,J.S., Jackson,F.R., Eling,T.E., McEntee,M.F. and Lee,S.H. (2004) Epicatechin gallate-induced expression of NAG-1 is associated with growth inhibition and apoptosis in colon cancer cells. Carcinogenesis, 25, 2425-2432.
    • (2004) Carcinogenesis , vol.25 , pp. 2425-2432
    • Baek, S.J.1    Kim, J.S.2    Jackson, F.R.3    Eling, T.E.4    McEntee, M.F.5    Lee, S.H.6
  • 15
    • 12844260806 scopus 로고    scopus 로고
    • Indole-3-carbinol and 3,3′-diindolyhnedme induce expression of NAG-1 in a p53-independent manner
    • Lee,S.H., Kim,J.S., Yamaguchi,K., Eling,T.E. and Baek,S.J. (2005) Indole-3-carbinol and 3,3'-diindolyhnedme induce expression of NAG-1 in a p53-independent manner. Biochem. Biophys. Res. Commun., 328,63-69.
    • (2005) Biochem. Biophys. Res. Commun. , vol.328 , pp. 63-69
    • Lee, S.H.1    Kim, J.S.2    Yamaguchi, K.3    Eling, T.E.4    Baek, S.J.5
  • 16
    • 1342346568 scopus 로고    scopus 로고
    • Expression of NAG-1, a transforming growth factor-{beta} superfamily member, by troglitazone requires the early growth response gene EGR-1
    • Baek,S.J., Yim,J.-S., NixonJ.B., DiAugustine,R.P. and Eling,T.E. (2004) Expression of NAG-1, a transforming growth factor-lbetal superfamily member, by troglitazone requires the early growth response gene EGR-1. J. Biol. Chem., 279, 6883-6892.
    • (2004) J. Biol. Chem. , vol.279 , pp. 6883-6892
    • Baek, S.J.1    Yim, J.-S.2    Nixon, J.B.3    DiAugustine, R.P.4    Eling, T.E.5
  • 17
    • 0037334157 scopus 로고    scopus 로고
    • Genotoxic; profiling of MCF-7 breast cancer cell line elucidates gene expression modifications underlying toxicity of the anticancer drug 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole
    • Monks,A., Harris,E., Hose,C., Connelly,J. and Sausville,E.A. (2003) Genotoxic; profiling of MCF-7 breast cancer cell line elucidates gene expression modifications underlying toxicity of the anticancer drug 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole. Mol. Pharmacol., 63, 766-772.
    • (2003) Mol. Pharmacol. , vol.63 , pp. 766-772
    • Monks, A.1    Harris, E.2    Hose, C.3    Connelly, J.4    Sausville, E.A.5
  • 18
    • 0037333442 scopus 로고    scopus 로고
    • Differential regulation of nonsteroidal anti-inflammatory drug-activated gene in normal human tracheobronchial epithelial and lung carcinoma cells by retinoids
    • Newman,D., Sakaue,M., Koo,J.S., Kim,K.S., Baek,S.J., ElingT. and Jetten,A.M. (2003) Differential regulation of nonsteroidal anti-inflammatory drug-activated gene in normal human tracheobronchial epithelial and lung carcinoma cells by retinoids. Mol. Pharmacol., 63, 557-564.
    • (2003) Mol. Pharmacol. , vol.63 , pp. 557-564
    • Newman, D.1    Sakaue, M.2    Koo, J.S.3    Kim, K.S.4    Baek, S.J.5    Eling, T.6    Jetten, A.M.7
  • 19
    • 13444282673 scopus 로고    scopus 로고
    • Cyclooxygenase inhibitors induce the expression of the tumor suppressor gene EGR-1, which results in the up-regulation of NAG-1, an antituniorigenic protein
    • Baek,S.J., Kim,J.S., Moore,S.M., Lee,S.H., Martinez,J. and Eling,T.E. (2005) Cyclooxygenase inhibitors induce the expression of the tumor suppressor gene EGR-1, which results in the up-regulation of NAG-1, an antituniorigenic protein. Mol. Pharmacol., 67, 356-364.
    • (2005) Mol. Pharmacol. , vol.67 , pp. 356-364
    • Baek, S.J.1    Kim, J.S.2    Moore, S.M.3    Lee, S.H.4    Martinez, J.5    Eling, T.E.6
  • 20
    • 9644281593 scopus 로고    scopus 로고
    • Identification of nonsteroidal anti-inflammatory drug-activated gene (NAG-1) as a novel downstream target of phosphatidylinositol 3-kinase/AKT/GSK-3beta pathway
    • Yamaguchi,K., Lee,S.H., Eling,T.E. and Baek,S.J. (2004) Identification of nonsteroidal anti-inflammatory drug-activated gene (NAG-1) as a novel downstream target of phosphatidylinositol 3-kinase/AKT/GSK-3beta pathway. J. Biol. Chem., 279, 49617-49623.
    • (2004) J. Biol. Chem. , vol.279 , pp. 49617-49623
    • Yamaguchi, K.1    Lee, S.H.2    Eling, T.E.3    Baek, S.J.4
  • 21
    • 21444459126 scopus 로고    scopus 로고
    • Protein kinase C-dependent regulation of NAG-1/placental bone morphogenic protein/MIC-1 expression in LNCaP prostate carcinoma cells
    • Shim,M. and Eling,T.E. (2005) Protein kinase C-dependent regulation of NAG-1/placental bone morphogenic protein/MIC-1 expression in LNCaP prostate carcinoma cells. J. Biol. Chem., 280, 18636-18642.
    • (2005) J. Biol. Chem. , vol.280 , pp. 18636-18642
    • Shim, M.1    Eling, T.E.2
  • 22
    • 0035948624 scopus 로고    scopus 로고
    • The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: Activating transcription factor proteins and homeostasis
    • Hai,T. and Hartman,M.G. (2001) The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: Activating transcription factor proteins and homeostasis. Gene, 273, 1-11.
    • (2001) Gene , vol.273 , pp. 1-11
    • Hai, T.1    Hartman, M.G.2
  • 23
    • 14844319300 scopus 로고    scopus 로고
    • Gene expression profiling identifies activating transcription factor 3 as a novel contributor to the proapoptotic effect of curcumin
    • Yan,C., Jamaluddin,M.S., Aggarwal,B., Myers,J. and Boyd,D.D. (2005) Gene expression profiling identifies activating transcription factor 3 as a novel contributor to the proapoptotic effect of curcumin. Mol. Cancer Ther., 4, 233-241.
    • (2005) Mol. Cancer Ther. , vol.4 , pp. 233-241
    • Yan, C.1    Jamaluddin, M.S.2    Aggarwal, B.3    Myers, J.4    Boyd, D.D.5
  • 24
    • 22744442218 scopus 로고    scopus 로고
    • Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination
    • Yan,C., Lu,D., Hai,T. and Boyd,D.D. (2005) Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination. EMBO J., 24, 2425-35.
    • (2005) EMBO J. , vol.24 , pp. 2425-2435
    • Yan, C.1    Lu, D.2    Hai, T.3    Boyd, D.D.4
  • 25
    • 0037814982 scopus 로고    scopus 로고
    • Gene modulation by the cyclooxygenase inhibitor, sulindac sulfide, in human colorectal carcinoma cells: Possible link to apoptosis
    • Bottone,F.G. Jr, Martinez,J.M., Collins,J.B., Afshari,C.A. and Eling,T.E. (2003) Gene modulation by the cyclooxygenase inhibitor, sulindac sulfide, in human colorectal carcinoma cells: Possible link to apoptosis. J. Biol. Chem., 278, 25790-25801.
    • (2003) J. Biol. Chem. , vol.278 , pp. 25790-25801
    • Bottone Jr., F.G.1    Martinez, J.M.2    Collins, J.B.3    Afshari, C.A.4    Eling, T.E.5
  • 27
    • 0035903160 scopus 로고    scopus 로고
    • Estrogen regulation of cyclin DI gene expression in ZR-75 breast cancer cells involves multiple enhancer elements
    • Castro-Rivera,E., Samudio,I. and Safe,S. (2001) Estrogen regulation of cyclin DI gene expression in ZR-75 breast cancer cells involves multiple enhancer elements. J. Biol. Chem., 276, 30853-30861.
    • (2001) J. Biol. Chem. , vol.276 , pp. 30853-30861
    • Castro-Rivera, E.1    Samudio, I.2    Safe, S.3
  • 28
    • 0035823596 scopus 로고    scopus 로고
    • Molecular cloning and characterization of human nonsteroidal anti-inflammatory drug-activated gene promoter. Basal transcription is mediated by Sp1 and Sp3
    • Baek,S.J., Horowitz,J.M. and Eling,T.E. (2001) Molecular cloning and characterization of human nonsteroidal anti-inflammatory drug-activated gene promoter. Basal transcription is mediated by Spl and Sp3. J. Biol. Chem., 276, 33384-33392.
    • (2001) J. Biol. Chem. , vol.276 , pp. 33384-33392
    • Baek, S.J.1    Horowitz, J.M.2    Eling, T.E.3
  • 29
    • 0028316766 scopus 로고
    • Serum octadeca-9,11 dienoic acid-an assay of free radical activity or a result of bacterial production?
    • Jack,C.I., Ridgway,E., Jackson,M.J. and Hind,C.R. (1994) Serum octadeca-9,11 dienoic acid-an assay of free radical activity or a result of bacterial production? Clin. Chim. Acta, 224, 139-146.
    • (1994) Clin. Chim. Acta , vol.224 , pp. 139-146
    • Jack, C.I.1    Ridgway, E.2    Jackson, M.J.3    Hind, C.R.4
  • 30
    • 0030614352 scopus 로고    scopus 로고
    • NH2-terminal deletion of beta-catenin results in stable colocalization of mutant beta-catenin with adenomatous polyposis coli protein and altered MDCK cell adhesion
    • Barth,A.I., Pollack,A.L., AltschulerY., Mostov,K.E. and Nelson,W.J. (1997) N112-terminal deletion of beta-catenin results in stable colocalization of mutant beta-catenin with adenomatous polyposis coli protein and altered MDCK cell adhesion. J. Cell, Biol., 136, 693-706.
    • (1997) J. Cell. Biol. , vol.136 , pp. 693-706
    • Barth, A.I.1    Pollack, A.L.2    Altschuler, Y.3    Mostov, K.E.4    Nelson, W.J.5
  • 31
    • 0033609070 scopus 로고    scopus 로고
    • T cell factor-activated transcription is not sufficient to induce anchorage-independent growth of epithetial cells expressing mutant beta-catenin
    • Barth,A.I., Stewart,D.B. and Nelson,W.J. (1999) T cell factor-activated transcription is not sufficient to induce anchorage-independent growth of epithetial cells expressing mutant beta-catenin. Proc. Nod Acad. Sci. USA, 96, 4947-4952.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 4947-4952
    • Barth, A.I.1    Stewart, D.B.2    Nelson, W.J.3
  • 32
    • 0033119801 scopus 로고    scopus 로고
    • Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells
    • Tetsu,O. and McCormick,F. (1999) Beta-catenin regulates expression of cyclin DI in colon carcinoma cells. Nature, 398, 422-426.
    • (1999) Nature , vol.398 , pp. 422-426
    • Tetsu, O.1    McCormick, F.2
  • 33
    • 0033801009 scopus 로고    scopus 로고
    • Activation of PPARgarnma may mediate a portion of the anticancer activity of conjugated linoleic acid
    • McCarty,M.F. (2000) Activation of PPARgarnma may mediate a portion of the anticancer activity of conjugated linoleic acid. Med. Hypotheses., 55, 187-188.
    • (2000) Med. Hypotheses. , vol.55 , pp. 187-188
    • McCarty, M.F.1
  • 34
    • 0037458680 scopus 로고    scopus 로고
    • Troglitazone, a peroxisome proliferator-activated receptor gamma (PPAR gamma) ligand, selectively induces the early growth response-I gene independently of PPAR gamma. A novel mechanism for its anti-tumorigenic activity
    • Baek,S.J., Wilson,L.C., Hsi,L.C. and Eling,T.E. (2003) Troglitazone, a peroxisome proliferator-activated receptor gamma (PPAR gamma) ligand, selectively induces the early growth response-I gene independently of PPAR gamma. A novel mechanism for its anti-tumongemc activity. J. Biol. Chem., 278, 5845-5853.
    • (2003) J. Biol. Chem. , vol.278 , pp. 5845-5853
    • Baek, S.J.1    Wilson, L.C.2    Hsi, L.C.3    Eling, T.E.4
  • 35
    • 27844442222 scopus 로고    scopus 로고
    • 1,1-Bis(3′-indolyl)-1-(p-substitutedphenyl)methanes are peroxisome proliferator-activated receptor {gamma} agomsts but decrease HCT-116 colon cancer cell survival through receptor-independent activation of early growth response-1 and NAG-1
    • ChintharlapaHi,S., Papineni,S., Baek,S.J., Liu,S. and Safe,S.H. (2005) 1,1-Bis(3′-indolyl)-I-(p-substitutedphenyl)mcthanes are peroxisome proliferator-activated receptor Igammal agomsts but decrease HCT-116 colon cancer cell survival through receptor-independent activation of early growth response-1 and NAG-1. Mol. Pharmacol., 68, 1782-1792.
    • (2005) Mol. Pharmacol. , vol.68 , pp. 1782-1792
    • Chintharlapalli, S.1    Papineni, S.2    Baek, S.J.3    Liu, S.4    Safe, S.H.5
  • 38
    • 3242788087 scopus 로고    scopus 로고
    • Conjugated linoleic acids (CLAs) decrease prostate cancer cell proliferation: Different molecular mechanisms for cis-9, trans-11 and trans-10, cis-12 isomers
    • Ochoa,J.J., Farquharson,A.J., Grant,I., Moffat,L.E., Heys,S.D. and Wahle,K.W. (2004) Conjugated linoleic acids (CLAs) decrease prostate cancer cell proliferation: Different molecular mechanisms for cis-9, trans-11 and trans-10, cis-12 isomers. Carcinogenesis, 25, 1185-1191.
    • (2004) Carcinogenesis , vol.25 , pp. 1185-1191
    • Ochoa, J.J.1    Farquharson, A.J.2    Grant, I.3    Moffat, L.E.4    Heys, S.D.5    Wahle, K.W.6
  • 39
    • 0037638993 scopus 로고    scopus 로고
    • Adenoma growth stimulation by the trans-10, cis-12 isomer of conjugated linoleic acid (CLA) is associated with changes in mucosal NF-kappaB and cyclin D1 protein levels in the Min mouse
    • Rajakangas,J., Basu,S., Sahninen,I. and Mutanen,M. (2003) Adenoma growth stimulation by the trans-10, cis-12 isomer of conjugated linoleic acid (CLA) is associated with changes in mucosal NF-kappaB and cyclin D1 protein levels in the Min mouse. J. Nutr., 133, 1943-1948.
    • (2003) J. Nutr. , vol.133 , pp. 1943-1948
    • Rajakangas, J.1    Basu, S.2    Salminen, I.3    Mutanen, M.4
  • 40
    • 0031671246 scopus 로고    scopus 로고
    • Differentiation and reversal of malignant changes in colon cancer through PPARganima
    • Sarraf,P., Mueller,E., Jones,D. et al. (1998) Differentiation and reversal of malignant changes in colon cancer through PPARganima. Nat. Med., 4, 1046--1052.
    • (1998) Nat. Med. , vol.4 , pp. 1046-1052
    • Sarraf, P.1    Mueller, E.2    Jones, D.3
  • 42
    • 0031694577 scopus 로고    scopus 로고
    • Activation of the peroxisome proliferator-activated receptor gamma promotes the development of colon tumors in C57BL/6J-APCMin/+ mice
    • Lefebvre,A.M., Chen,I., Desreumaux,P., Najib,J., Fruchart,J.C., Geboes,K., Briggs,M., Heyman,R. and Auwerx,J. (1998) Activation of the peroxisome proliferator-activated receptor gamma promotes the development of colon tumors in C57BL/6J-APCMin/+ mice. Nat. Med., 4, 1053-1057.
    • (1998) Nat. Med. , vol.4 , pp. 1053-1057
    • Lefebvre, A.M.1    Chen, I.2    Desreumaux, P.3    Najib, J.4    Fruchart, J.C.5    Geboes, K.6    Briggs, M.7    Heyman, R.8    Auwerx, J.9
  • 44
    • 0037109043 scopus 로고    scopus 로고
    • APC-dependent suppression of colon carcinogenesis by PPARgamma
    • Girnun,G.D., Smith,W.M., Drori,S. et al. (2002) APC-dependent suppression of colon carcinogenesis by PPARgamma. Proc. Natl Acad. Sci. USA, 99, 13771-13776.
    • (2002) Proc. Natl Acad. Sci. USA , vol.99 , pp. 13771-13776
    • Girnun, G.D.1    Smith, W.M.2    Drori, S.3
  • 47
    • 1342346568 scopus 로고    scopus 로고
    • Expression of NAG-1, a transforming growth factor-beta superfamily member, by troglitazone requires the early growfli response gene EGR-1
    • Baek,S.J., Kim,J.S., Nixon,J.B., DiAugustine,R.P. and Eling,T.E. (2004) Expression of NAG-1, a transforming growth factor-beta superfamily member, by troglitazone requires the early growfli response gene EGR-1. J. Biol. Chem., 279, 6883-6892.
    • (2004) J. Biol. Chem. , vol.279 , pp. 6883-6892
    • Baek, S.J.1    Kim, J.S.2    Nixon, J.B.3    DiAugustine, R.P.4    Eling, T.E.5
  • 48
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-Kinase AKT pathway in human cancer
    • Vivanco,I. and Sawyers,C.L. (2002) The phosphatidylinositol 3-Kinase AKT pathway in human cancer. Nat. Rev. Cancer, 2, 489-501.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 49
    • 1342342989 scopus 로고    scopus 로고
    • Human cancer, PTEN and the PI-3 kinase pathway
    • Parsons,R. (2004) Human cancer, PTEN and the PI-3 kinase pathway. Semin, Cell Dev. Biol., 15, 171-176.
    • (2004) Semin. Cell Dev. Biol. , vol.15 , pp. 171-176
    • Parsons, R.1
  • 50
    • 4744375264 scopus 로고    scopus 로고
    • GSK-3beta inhibition by lithium confers resistance to chemotherapy-induced apoptosis through the repression of CD95 (Fas/APO-1) expression
    • Beurel,E., Komprobst,M., Blivet-Van Eggelpoel,M.J., Ruiz-Ruiz,C., Cadoret,A., Capeau,J. and Desbois-Moudion,C. (2004) GSK-3beta inhibition by lithium confers resistance to chemotherapy-induced apoptosis through the repression of CD95 (Fas/APO-1) expression. Exp. Cell Res., 300, 354-364.
    • (2004) Exp. Cell Res. , vol.300 , pp. 354-364
    • Beurel, E.1    Kornprobst, M.2    Blivet-Van Eggelpoel, M.J.3    Ruiz-Ruiz, C.4    Cadoret, A.5    Capeau, J.6    Desbois-Moudion, C.7
  • 51
    • 10944237268 scopus 로고    scopus 로고
    • Glycogen synthase kinase 3beta is a negative regulator of growth factor-induced activation of the c-Jun N-terminal kinase
    • Liu,S., Yu,S., Hasegawa,Y., Lapushin,R., Xu,H.J., Woodgett,J.R., Mills,G.B. and Fang,X. (2004) Glycogen synthase kinase 3beta is a negative regulator of growth factor-induced activation of the c-Jun N-terminal kinase. J. Biol. Chem., 279, 51075-51081.
    • (2004) J. Biol. Chem. , vol.279 , pp. 51075-51081
    • Liu, S.1    Yu, S.2    Hasegawa, Y.3    Lapushin, R.4    Xu, H.J.5    Woodgett, J.R.6    Mills, G.B.7    Fang, X.8


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