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Volumn 133, Issue 6, 2003, Pages 1943-1948

Adenoma growth stimulation by the trans-10, cis-12 isomer of conjugated linoleic acid (CLA) is associated with changes in mucosal NF-κB and cyclin D1 protein levels in the Min mouse

Author keywords

Colon cancer; Conjugated linoleic acid; Min mouse

Indexed keywords

8 ISOPROSTAGLANDIN F2 ALPHA; BETA CATENIN; CYCLIN D1; CYCLOOXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LINOLEIC ACID; SYNAPTOTAGMIN; TUMOR PROMOTER;

EID: 0037638993     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/133.6.1943     Document Type: Article
Times cited : (39)

References (49)
  • 1
    • 0025099703 scopus 로고
    • Inhibition of benzo(a)pyrene-induced mouse forestomach neoplasia by conjugated dienoic derivates of linoleic acid
    • Ha, Y. L., Storkson, J. & Pariza, M. W. (1990) Inhibition of benzo(a)pyrene-induced mouse forestomach neoplasia by conjugated dienoic derivates of linoleic acid. Cancer Res. 50: 1097-1101.
    • (1990) Cancer Res. , vol.50 , pp. 1097-1101
    • Ha, Y.L.1    Storkson, J.2    Pariza, M.W.3
  • 2
    • 0026319061 scopus 로고
    • Mammary cancer prevention by conjugated dienoic derivates of linoleic acid
    • Ip, C., Chin, S. F., Scimeca, J. A. & Pariza, M. W. (1991) Mammary cancer prevention by conjugated dienoic derivates of linoleic acid. Cancer Res. 51: 6118-6124.
    • (1991) Cancer Res. , vol.51 , pp. 6118-6124
    • Ip, C.1    Chin, S.F.2    Scimeca, J.A.3    Pariza, M.W.4
  • 3
    • 0028221810 scopus 로고
    • Conjugated linoleic acid suppresses mammary carcinogenesis and proliferative activity of the mammary gland in the rat
    • Ip, C., Singh, M., Thompson, H. J. & Scimeca, J. A. (1994) Conjugated linoleic acid suppresses mammary carcinogenesis and proliferative activity of the mammary gland in the rat. Cancer Res. 54: 1212-1215.
    • (1994) Cancer Res. , vol.54 , pp. 1212-1215
    • Ip, C.1    Singh, M.2    Thompson, H.J.3    Scimeca, J.A.4
  • 4
    • 0029759728 scopus 로고    scopus 로고
    • Dietary conjugated linoleic acid modulation of phorbol ester skin tumor promotion
    • Belury, M. A., Nickel, K. P., Bird, C. E. & Wu, Y. (1996) Dietary conjugated linoleic acid modulation of phorbol ester skin tumor promotion. Nutr. Cancer 26: 149-157.
    • (1996) Nutr. Cancer , vol.26 , pp. 149-157
    • Belury, M.A.1    Nickel, K.P.2    Bird, C.E.3    Wu, Y.4
  • 5
    • 0026566709 scopus 로고
    • Inhibitory effect of conjugated dienoic derivates of linoleic acid and β-carotene on the in vitro growth of human cancer cells
    • Shultz, T. D., Chew, B. P., Seaman, W. R. & Luedecke, L. O. (1992) Inhibitory effect of conjugated dienoic derivates of linoleic acid and β-carotene on the in vitro growth of human cancer cells. Cancer Lett 63: 125-133.
    • (1992) Cancer Lett. , vol.63 , pp. 125-133
    • Shultz, T.D.1    Chew, B.P.2    Seaman, W.R.3    Luedecke, L.O.4
  • 6
    • 0033542801 scopus 로고    scopus 로고
    • Conjugated linoleic acid inhibits proliferation and induces apoptosis of normal rat mammary epithelial cells in primary culture
    • Ip, M. M., Masso-Welch, P. A., Shoemaker, S. F., Shea-Eaton, W. K. & Ip, C. (1999) Conjugated linoleic acid inhibits proliferation and induces apoptosis of normal rat mammary epithelial cells in primary culture. Exp. Cell Res. 250: 22-34.
    • (1999) Exp. Cell Res. , vol.250 , pp. 22-34
    • Ip, M.M.1    Masso-Welch, P.A.2    Shoemaker, S.F.3    Shea-Eaton, W.K.4    Ip, C.5
  • 7
    • 0034052414 scopus 로고    scopus 로고
    • Modulation of MCF-7 breast cancer cell signal transduction by linoleic acid and conjugated linoleic acid in culture
    • Park, Y., Allen, K. G. D. & Shultz, T. D. (2000) Modulation of MCF-7 breast cancer cell signal transduction by linoleic acid and conjugated linoleic acid in culture. Anticancer Res. 20: 669-676.
    • (2000) Anticancer Res. , vol.20 , pp. 669-676
    • Park, Y.1    Allen, K.G.D.2    Shultz, T.D.3
  • 8
    • 0028823307 scopus 로고
    • Effect of timing and duration of dietary conjugated linoleic acid on mammary cancer prevention
    • Ip, C., Scimeca, J. A. & Thompson, H. (1995) Effect of timing and duration of dietary conjugated linoleic acid on mammary cancer prevention. Nutr. Cancer 24: 241-247.
    • (1995) Nutr. Cancer , vol.24 , pp. 241-247
    • Ip, C.1    Scimeca, J.A.2    Thompson, H.3
  • 9
    • 0029940254 scopus 로고    scopus 로고
    • The efficacy of conjugated linoleic acid in mammary cancer prevention is independent of the level or type of fat in the diet
    • Ip, C., Briggs, S. P., Haegele, A. D., Thompson, H. J., Storkson, J. & Scimeca, J. A. (1996) The efficacy of conjugated linoleic acid in mammary cancer prevention is independent of the level or type of fat in the diet. Carcinogenesis 17: 1045-1050.
    • (1996) Carcinogenesis , vol.17 , pp. 1045-1050
    • Ip, C.1    Briggs, S.P.2    Haegele, A.D.3    Thompson, H.J.4    Storkson, J.5    Scimeca, J.A.6
  • 10
    • 0031408652 scopus 로고    scopus 로고
    • Retention of conjugated linoleic acid in the mammary gland is associated with tumor inhibition during the post-initiation phase of carcinogenesis
    • Ip, C., Jiang, C., Thompson, H. J. & Scimeca, J. A. (1997) Retention of conjugated linoleic acid in the mammary gland is associated with tumor inhibition during the post-initiation phase of carcinogenesis. Carcinogenesis 18: 755-759.
    • (1997) Carcinogenesis , vol.18 , pp. 755-759
    • Ip, C.1    Jiang, C.2    Thompson, H.J.3    Scimeca, J.A.4
  • 11
    • 0034434397 scopus 로고    scopus 로고
    • Inverse association between dietary and serum conjugated linoleic acid and risk of breast cancer in postmenopausal women
    • Aro, A., Männistö, S., Salminen, I., Ovaskainen, M.-L., Kataja, V. & Uusitupa, M. (2000) Inverse association between dietary and serum conjugated linoleic acid and risk of breast cancer in postmenopausal women. Nutr. Cancer 38: 151-157.
    • (2000) Nutr. Cancer , vol.38 , pp. 151-157
    • Aro, A.1    Männistö, S.2    Salminen, I.3    Ovaskainen, M.-L.4    Kataja, V.5    Uusitupa, M.6
  • 12
    • 0035226223 scopus 로고    scopus 로고
    • Modulation of 2-amino-1-methyl-6-phenylimidazo[4, 5-b]pyridine induced mutation in the caecum and colon of Big Blue rats by conjugated linoleic acid and 1, 2-dithiole-3-thione
    • Yang, H., Stuart G. R., Glickman B. W. & de Boer, J. G. (2001) Modulation of 2-amino-1-methyl-6-phenylimidazo[4, 5-b]pyridine induced mutation in the caecum and colon of Big Blue rats by conjugated linoleic acid and 1, 2-dithiole-3-thione. Nutr. Cancer 39: 259-266.
    • (2001) Nutr. Cancer , vol.39 , pp. 259-266
    • Yang, H.1    Stuart, G.R.2    Glickman, B.W.3    De Boer, J.G.4
  • 13
    • 0035527485 scopus 로고    scopus 로고
    • Conjugated linoleic acid does not inhibit development of aberrant crypt foci in colons of male Sprague-Dawley rats
    • Ealy, K. N., El-Sohemy, A. & Archer, M. C. (2001) Conjugated linoleic acid does not inhibit development of aberrant crypt foci in colons of male Sprague-Dawley rats. Nutr. Cancer 41: 104-106.
    • (2001) Nutr. Cancer , vol.41 , pp. 104-106
    • Ealy, K.N.1    El-Sohemy, A.2    Archer, M.C.3
  • 14
    • 0033802965 scopus 로고    scopus 로고
    • Highly unsaturated (n-3) fatty acids, but not α-linolenic, conjugated linoleic or γ-linoleic acids, reduce tumorigenesis in ApcMin mice
    • Hansen Petrik, M. B., McEntee, M. F., Johnson, B. T., Obukowicz, M. G. & Whelean, J. (2000) Highly unsaturated (n-3) fatty acids, but not α-linolenic, conjugated linoleic or γ-linoleic acids, reduce tumorigenesis in ApcMin mice. J. Nutr. 130: 2434-2443.
    • (2000) J. Nutr. , vol.130 , pp. 2434-2443
    • Hansen Petrik, M.B.1    McEntee, M.F.2    Johnson, B.T.3    Obukowicz, M.G.4    Whelean, J.5
  • 15
    • 34547424474 scopus 로고    scopus 로고
    • Effects of conjugated linoleic acid (CLA) on adenoma formation in the ApcMin-mouse
    • Riboli E. & Lambert R., ed. IARC Scientific Publications No. 156, IARC, Lyon, France
    • Rajakangas, J., Turpeinen, A. M., Salminen, I. & Mutanen, M. (2002) Effects of conjugated linoleic acid (CLA) on adenoma formation in the ApcMin-mouse. In: Nutrition and Lifestyle: Opportunities for Cancer Prevention (Riboli E. & Lambert R., ed.), pp. 405-406. IARC Scientific Publications No. 156, IARC, Lyon, France.
    • (2002) Nutrition and Lifestyle: Opportunities for Cancer Prevention , pp. 405-406
    • Rajakangas, J.1    Turpeinen, A.M.2    Salminen, I.3    Mutanen, M.4
  • 16
    • 0030592517 scopus 로고    scopus 로고
    • Lessons from hereditary colorectal cancer
    • Kinzler, K. W. & Vogelstein, B. (1996) Lessons from hereditary colorectal cancer. Cell 87: 159-170.
    • (1996) Cell , vol.87 , pp. 159-170
    • Kinzler, K.W.1    Vogelstein, B.2
  • 18
    • 0034708763 scopus 로고    scopus 로고
    • Down regulation of beta-catenin by the colorectal tumor suppressor APC requires association with Axin and beta-catenin
    • Kawahara, K., Moshita, T., Nakamura, T., Hamada, F., Toyshima, K. & Akiyamata, T. (2000) Down regulation of beta-catenin by the colorectal tumor suppressor APC requires association with Axin and beta-catenin. J. Biol. Chem. 275: 8369-8374.
    • (2000) J. Biol. Chem. , vol.275 , pp. 8369-8374
    • Kawahara, K.1    Moshita, T.2    Nakamura, T.3    Hamada, F.4    Toyshima, K.5    Akiyamata, T.6
  • 21
    • 0033119801 scopus 로고    scopus 로고
    • β-catenin regulaten expression of cyclin D1 in colon carcinoma cells
    • Tetsu, O. & McCormick, F. (1999) β-catenin regulaten expression of cyclin D1 in colon carcinoma cells. Nature (Lond.) 398: 422-426.
    • (1999) Nature (Lond.) , vol.398 , pp. 422-426
    • Tetsu, O.1    McCormick, F.2
  • 22
    • 0033615352 scopus 로고    scopus 로고
    • PPARδ is an APC-regulated target of nonsteroidal anti-inflammatory drugs
    • He, T-C., Chan, T. A., Vogelstein, B. & Kinzler, K. W. (1999) PPARδ is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell 99: 335-345.
    • (1999) Cell , vol.99 , pp. 335-345
    • He, T.-C.1    Chan, T.A.2    Vogelstein, B.3    Kinzler, K.W.4
  • 23
    • 0035300492 scopus 로고    scopus 로고
    • Increased β-catenin expression and nuclear translocation accompany cellular hyperproliferation in vivo
    • Sellin, J. H., Umar, S., Xiao, J. & Morris, A. P. (2001) Increased β-catenin expression and nuclear translocation accompany cellular hyperproliferation in vivo. Cancer Res. 61: 2899-2906.
    • (2001) Cancer Res. , vol.61 , pp. 2899-2906
    • Sellin, J.H.1    Umar, S.2    Xiao, J.3    Morris, A.P.4
  • 24
    • 0035420212 scopus 로고    scopus 로고
    • Suppression of β-catenin inhibits the neoplastic growth of APC-mutant colon cancer cells
    • Roh, H., Green, D. W., Boswell, C. B., Pippin, J. A. & Drebin, J. A. (2001) Suppression of β-catenin inhibits the neoplastic growth of APC-mutant colon cancer cells. Cancer Res. 61: 6563-6568.
    • (2001) Cancer Res. , vol.61 , pp. 6563-6568
    • Roh, H.1    Green, D.W.2    Boswell, C.B.3    Pippin, J.A.4    Drebin, J.A.5
  • 25
    • 0034541559 scopus 로고    scopus 로고
    • Conjugated linoleic acid induces lipid peroxidation in men with abdominal obesity
    • Basu, S., Riserus, U., Turpeinen, A. & Vessby, B. (2000) Conjugated linoleic acid induces lipid peroxidation in men with abdominal obesity. Clin. Sci. (Lond.) 99: 511-516.
    • (2000) Clin. Sci. (Lond.) , vol.99 , pp. 511-516
    • Basu, S.1    Riserus, U.2    Turpeinen, A.3    Vessby, B.4
  • 26
    • 0033974072 scopus 로고    scopus 로고
    • Conjugated linoleic acid induces lipid peroxidation in humans
    • Basu, S., Smedman, A. & Vessby, B. (2000) Conjugated linoleic acid induces lipid peroxidation in humans. FEBS Lett. 468: 33-36.
    • (2000) FEBS Lett. , vol.468 , pp. 33-36
    • Basu, S.1    Smedman, A.2    Vessby, B.3
  • 27
    • 0030065476 scopus 로고    scopus 로고
    • The isoprostanes. Current knowledge and directions of future research
    • Morrow, J. D. & Roberts, L. J., II, (1996) The isoprostanes. Current knowledge and directions of future research. Biochem. Pharmacol. 51: 1-9.
    • (1996) Biochem. Pharmacol. , vol.51 , pp. 1-9
    • Morrow, J.D.1    Roberts L.J. II2
  • 28
    • 0031595825 scopus 로고    scopus 로고
    • 2α: An index for oxidative injury via free radical catalysed lipid peroxidation
    • 2α: an index for oxidative injury via free radical catalysed lipid peroxidation. Prostaglandinds Leukot. Essent. Fatty Acids 58: 319-325.
    • (1998) Prostaglandinds Leukot. Essent. Fatty Acids , vol.58 , pp. 319-325
    • Basu, S.1
  • 29
    • 0029125877 scopus 로고
    • The inhibitory effect of conjugated dienoic derivates (CLA) of linoleic acid on the growth of human tumor cell lines is in part due to increased lipid peroxidation
    • Schönberg, S. & Krokan, H. E. (1995) The inhibitory effect of conjugated dienoic derivates (CLA) of linoleic acid on the growth of human tumor cell lines is in part due to increased lipid peroxidation. Anticancer Res. 15: 1241-1246.
    • (1995) Anticancer Res. , vol.15 , pp. 1241-1246
    • Schönberg, S.1    Krokan, H.E.2
  • 30
    • 0032808680 scopus 로고    scopus 로고
    • Antioxidant enzyme defence responses of human MCF-7 and SW480 cancer cells to conjugated linoleic acid
    • O'Shea, M., Stanton, C. & Devery, R. (1999) Antioxidant enzyme defence responses of human MCF-7 and SW480 cancer cells to conjugated linoleic acid. Anticancer Res. 19: 1953-1960.
    • (1999) Anticancer Res. , vol.19 , pp. 1953-1960
    • O'Shea, M.1    Stanton, C.2    Devery, R.3
  • 31
    • 0036546501 scopus 로고    scopus 로고
    • NF-κB in cancer: From innocent bystander to major culprit
    • Karin, M., Cao, Y., Greten, F. R. & Li, Z-W. (2002) NF-κB in cancer: from innocent bystander to major culprit. Nat. Rev. Cancer 2: 301-310.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 301-310
    • Karin, M.1    Cao, Y.2    Greten, F.R.3    Li, Z.-W.4
  • 32
    • 0033596121 scopus 로고    scopus 로고
    • Activators and target genes of Rel/NF-κB transcription factors
    • Pahl, H. L. (1999) Activators and target genes of Rel/NF-κB transcription factors. Oncogene 18: 6853-6866.
    • (1999) Oncogene , vol.18 , pp. 6853-6866
    • Pahl, H.L.1
  • 33
    • 0029595394 scopus 로고
    • Transcriptional roles of nuclear factor κB and nuclear factor interleukin-6 in the tumor necrosis factor α-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells
    • Yamamoto, K., Arkawa, T., Ueda, N. & Yamamoto, S. (1995) Transcriptional roles of nuclear factor κB and nuclear factor interleukin-6 in the tumor necrosis factor α-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells. J. Biol. Chem. 270: 31315-31320.
    • (1995) J. Biol. Chem. , vol.270 , pp. 31315-31320
    • Yamamoto, K.1    Arkawa, T.2    Ueda, N.3    Yamamoto, S.4
  • 34
    • 0032588186 scopus 로고    scopus 로고
    • NF-κB controls cell growth and differentiation through transcriptional regulation of cyclin D1
    • Guttridge, D. C., Albanese, C., Reuther, J. Y., Pestell, R. G. & Baldwin A. S., Jr. (1999) NF-κB controls cell growth and differentiation through transcriptional regulation of cyclin D1. Mol. Cell. Biol. 19: 5785-5799.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 5785-5799
    • Guttridge, D.C.1    Albanese, C.2    Reuther, J.Y.3    Pestell, R.G.4    Baldwin A.S., Jr.5
  • 35
    • 0003504049 scopus 로고    scopus 로고
    • Cyclooxygenase regulates angiogenesis induced by colon cancer cells
    • Tsujii, M., Kawano, S., Tsuji, S., Sawaoka, H., Hori, M. & DuBois, R. N. (1998) Cyclooxygenase regulates angiogenesis induced by colon cancer cells. Cell 93: 705-716.
    • (1998) Cell , vol.93 , pp. 705-716
    • Tsujii, M.1    Kawano, S.2    Tsuji, S.3    Sawaoka, H.4    Hori, M.5    DuBois, R.N.6
  • 38
    • 0027487229 scopus 로고
    • AIN-93 purified diets for laboratory rodents: Final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet
    • Reeves, P. G., Nielsen, F. H. & Fahey, G. C. (1993) AIN-93 purified diets for laboratory rodents: final report of the American Institute of Nutrition ad hoc writing committee on the reformulation of the AIN-76A rodent diet. J. Nutr. 123: 1939-1951.
    • (1993) J. Nutr. , vol.123 , pp. 1939-1951
    • Reeves, P.G.1    Nielsen, F.H.2    Fahey, G.C.3
  • 39
    • 0034094189 scopus 로고    scopus 로고
    • Beef induces and rye bran prevents the formation of intestinal polyps in ApcMin mice: Relation to β-catenin and PKC isozymes
    • Mutanen, M., Pajari, A-M. & Oikarinen, S. I. (2000) Beef induces and rye bran prevents the formation of intestinal polyps in ApcMin mice: relation to β-catenin and PKC isozymes. Carcinogenesis 21: 1167-1173.
    • (2000) Carcinogenesis , vol.21 , pp. 1167-1173
    • Mutanen, M.1    Pajari, A.-M.2    Oikarinen, S.I.3
  • 40
    • 70449158340 scopus 로고
    • A simple method for the isolation and purification of total lipids from animal tissues
    • Folch, J., Lees, M. & Sloan-Stanley, G. H. (1957) A simple method for the isolation and purification of total lipids from animal tissues. J. Biol. Chem. 226: 497-507.
    • (1957) J. Biol. Chem. , vol.226 , pp. 497-507
    • Folch, J.1    Lees, M.2    Sloan-Stanley, G.H.3
  • 41
    • 33947460432 scopus 로고
    • Analysis of long-chain fatty acids by gas liquid chromatography
    • Stoffel, W., Chu, F. & Ahrens, E. H., Jr. (1959) Analysis of long-chain fatty acids by gas liquid chromatography. Anal. Chem. 31: 307-308.
    • (1959) Anal. Chem. , vol.31 , pp. 307-308
    • Stoffel, W.1    Chu, F.2    Ahrens E.H., Jr.3
  • 42
    • 0032194170 scopus 로고    scopus 로고
    • Identification of two NF-κB sites in mouse CD95 ligand (Fas ligand) promoter: Functional analysis in T cell hybridoma
    • Matsui, K., Fine, A., Zhu, B., Marshak-Rothstein, A. & Ju, S.-T. (1998) Identification of two NF-κB sites in mouse CD95 ligand (Fas ligand) promoter: functional analysis in T cell hybridoma. J. Immunol. 161: 3469-3473.
    • (1998) J. Immunol. , vol.161 , pp. 3469-3473
    • Matsui, K.1    Fine, A.2    Zhu, B.3    Marshak-Rothstein, A.4    Ju, S.-T.5
  • 43
    • 0033011889 scopus 로고    scopus 로고
    • Activation-dependent transcriptional regulation of the human fas promoter requires NF-κB p50-p65 recruitment
    • Chan, H., Bartos, D. P. & Owen-Schaub, L. B. (1999) Activation-dependent transcriptional regulation of the human fas promoter requires NF-κB p50-p65 recruitment. Mol. Cell. Biol. 19: 2098-2108.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 2098-2108
    • Chan, H.1    Bartos, D.P.2    Owen-Schaub, L.B.3
  • 44
    • 0028167599 scopus 로고
    • NF-κB activation of p53
    • Wu, H. & Lozano, G. (1994) NF-κB activation of p53. J. Biol. Chem. 269: 20067-20074.
    • (1994) J. Biol. Chem. , vol.269 , pp. 20067-20074
    • Wu, H.1    Lozano, G.2
  • 45
    • 0035348486 scopus 로고    scopus 로고
    • Aspirin-induced activation of the NF-κB signaling pathway: A novel mechanism for aspirin-mediated apoptosis in colon cancer cells
    • Stark, L. A., Din, F.V.N., Zwacka, R. M. & Dunlop, M. G. (2001) Aspirin-induced activation of the NF-κB signaling pathway: a novel mechanism for aspirin-mediated apoptosis in colon cancer cells. FASEB J. 15: 1273-1275.
    • (2001) FASEB J. , vol.15 , pp. 1273-1275
    • Stark, L.A.1    Din, F.V.N.2    Zwacka, R.M.3    Dunlop, M.G.4
  • 46
    • 0030895978 scopus 로고    scopus 로고
    • Down-regulation of NF-κB activity and NF-κB p65 subunit expression by ras and polynoma middle T oncogenes in human colonic Caco-2 cells
    • Cadoret, A., Bertrand, F., Baron-Delage, S., Lévy, P., Curtois, G., Gespach, C., Capeau, J. & Cherqui, G. (1997) Down-regulation of NF-κB activity and NF-κB p65 subunit expression by ras and polynoma middle T oncogenes in human colonic Caco-2 cells. Oncogene 14: 1589-1600.
    • (1997) Oncogene , vol.14 , pp. 1589-1600
    • Cadoret, A.1    Bertrand, F.2    Baron-Delage, S.3    Lévy, P.4    Curtois, G.5    Gespach, C.6    Capeau, J.7    Cherqui, G.8
  • 47
    • 0031028265 scopus 로고    scopus 로고
    • Concurrent overexpression of cyclin D1 and cyclin-dependent kinase 4 (Cdk4) in intestinal adenomas from multiple intestinal neoplasia (Min) mice and human familial adenomatous polyposis patients
    • Zang, T., Nanney, L. B., Luongo, C., Lamps, L., Heppner, K. L., DuBois, R. N. & Beauchamp, R. D. (1997) Concurrent overexpression of cyclin D1 and cyclin-dependent kinase 4 (Cdk4) in intestinal adenomas from multiple intestinal neoplasia (Min) mice and human familial adenomatous polyposis patients. Cancer Res. 57: 169-175.
    • (1997) Cancer Res. , vol.57 , pp. 169-175
    • Zang, T.1    Nanney, L.B.2    Luongo, C.3    Lamps, L.4    Heppner, K.L.5    DuBois, R.N.6    Beauchamp, R.D.7


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