Trans-10,cis-12-conjugated linoleic acid inhibits Caco-2 colon cancer cell growth

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 283, Issue 2 46-2, 2002, Pages

  Kim, Eun J ^a   Elly Holthuizen, P ^b   Park, Hyun S ^c   Ha, Yeong L ^d   Jung, Kyeong C ^a   Park, Jung H Y ^a  

^a Hallym University   (South Korea)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c Kyung Hee University   (South Korea)

^d Gyeongsang National University   (South Korea)

Author keywords

Apoptosis; Insulin like growth factor binding proteins

Indexed keywords

10,12 CONJUGATED LINOLEIC ACID; 9,11 CONJUGATED LINOLEIC ACID; LINOLEIC ACID; MONOCLONAL ANTIBODY; SOMATOMEDIN B; SOMATOMEDIN BINDING PROTEIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; CANCER GROWTH; CELL PROLIFERATION; CELL STRAIN CACO 2; CELL VIABILITY; COLON CANCER; CONCENTRATION (PARAMETERS); CONJUGATION; CONTROLLED STUDY; DNA SYNTHESIS; GROWTH INHIBITION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; ISOMER; LIGAND BINDING; MOLECULAR WEIGHT; PRIORITY JOURNAL; REDUCTION;

EID: 0036074418     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.00495.2001     Document Type: Article

References (52)

1. Insulin-like growth factor (IGF)-binding proteins: Interactions with IGFs and intrinsic bioactivities
2. Conjugated dienoic linoleate: A polyunsaturated fatty acid with unique chemoprotective properties
3. Dietary conjugated linoleic acid modulation of phorbol ester skin tumor promotion
4. Modulation of prostaglandin H synthase activity by conjugated linoleic acid (CLA) and specific CLA isomers
5. A reagent for the single-step simultaneous isolation of RNA, DNA and protein from cell and tissue samples
6. Production of insulin-like growth factor II (IGF-II) and different forms of IGF-binding proteins by HT-29 human colon carcinoma cell line
7. Direct detection of insulin-like growth factor II (IGF-II) by chemiluminescence without interference by IGF binding proteins
8. Differential polysomal localization of human insulin-like growth factor-2 mRNAs in cell lines and foetal liver
9. Rapid colorimetric assay for cell growth and survival: Modifications of the tetrazolium dye procedure giving improved sensitivity and reliability
10. 2 synthesis in Caco-2 human colon carcinoma cells
11. The growth inhibitory effect of conjugated linoleic acid on MCF-7 cells is related to estrogen response system
12. Octadeca-9,11-dienoic acid in foodstuffs and in lipids of human blood and breast milk
13. Characterization of insulinlike growth factor I receptors in human colon cancer
14. Dietary conjugated linoleic acid normalizes impaired glucose tolerance in the Zucker diabetic fatty fa/fa rat
15. Reduction of murine mammary tumor metastasis by conjugated linoleic acid
16. The insulin-like growth factor-binding protein (IGFBP) superfamily
17. The efficacy of conjugated linoleic acid in mammary cancer prevention is independent of the level or type of fat in the diet
18. Induction of apoptosis by conjugated linoleic acid in cultured mammary tumor cells and premalignant lesions of the rat mammary gland
19. Nucleotide sequences of cDNAs encoding precursors of human insulin-like growth factor II (IGF-II) and an IGF-II variant
20. Insulin-like growth factors and their binding proteins: Biological actions
21. Inhibition of Caco-2 cell proliferation by alltrans retinoic acid (tRA): Role of insulin-like growth factor binding protein-6
22. Inhibition of Caco-2 cell proliferation by (n-3) fatty acids: Possible mediation by increased secretion of insulin-like growth factor binding protein-6
23. Antimutagenic and some other effects of conjugated linoleic acid
24. Protection of conjugated linoleic acids against 2-amino-3-methylimidazo(4,5-f)quinoline-induced colon carcinogenesis in the F344 rat: A study of inhibitory mechanisms
25. 2 synthesis in murine keratinocytes
26. Insulin-like growth factor binding protein-2 (IGFBP-2) stimulates proliferation and decreases apoptosis in Caco-2 colon cancer cells
27. Role of insulin-like growth factor-I (IGF-I) receptor, IGF-I, and IGF binding protein-2 in human colorectal cancers
28. Inhibition of prostaglandin biosynthesis by 8-cis, 12-trans, 14-cis-eicosatrienoic acid and 5-cis, 8-cis, 12-trans, 14-cis-eicosatetraenoic acid
29. Naturally occurring conjugated octadecatrienoic acids are strong inhibitors of prostaglandin biosynthesis
30. Antioxidant enzyme defence responses of human MCF-7 and SW480 cancer cells to conjugated linoleic acid
31. Formation and action of anticarcinogenic fatty acids
32. Conjugated linoleic acid and the control of cancer and obesity
33. Dietary conjugated linoleic acid (CLA) induces apoptosis of colonic mucosa in 1,2-dimethylhydrazine-treated rats: A possible mechanism of the anticarcinogenic effect by CLA
34. Expression of insulin-like growth factor-II and insulin-like growth factor binding proteins during Caco-2 cell proliferation and differentiation
35. Secretion of insulinlike growth factor II (IGF-II) and IGF-binding protein-2 by intestinal epithelial (IEC-6) cells: Implication for autocrine growth regulation
36. Binding specificities and transducing function of the different molecular weight forms of insulin-like growth factor-II (IGF-II) on IGF-I receptors
37. Diet and colon cancer: Evidence from human and animal model studies
38. Circulating insulin-like growth factor II and colorectal adenomas
39. Effect of aspirin on cell proliferation and differentiation of colon adenocarcinoma Caco-2 cells
40. Inhibitory effect of conjugated dienoic derivatives of linoleic acid and beta-carotene on the in vitro growth of human cancer cells
41. Differential activation of IGF-II promoters P3 and P4 in Caco-2 cells during growth and differentiation
42. Insulin-like growth factors and binding proteins in colon cancer
43. Growth, differentiation, and survival: Multiple physiological functions for insulin-like growth factors
44. Identification of a family of insulin-like growth factor II secreted by cultured rat epithelial cell line 18,54-SF: Application of a monoclonal antibody
45. 2 in osteoblasts
46. Kinetics and regulation of site-specific endonucleolytic cleavage of human IGF-II mRNAs
47. Role of the insulin-like growth factor family in cancer development and progression
48. Expression of insulin-like growth factor (IGF)-II and IGF-I receptor during proliferation and differentiation of Caco-2 human colon carcinoma cells
49. Constitutive insulin-like growth factor-II expression interferes with the enterocyte-like differentiation of Caco-2 cells
50. Gene expression profiles in normal and cancer cells
51. Expression of IGF-II and IGF binding proteins in differentiating human intestinal Caco-2 cells