Genotoxic profiling of MCF-7 breast cancer cell line elucidates gene expression modifications underlying toxicity of the anticancer drug 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole

Molecular Pharmacology

Volumn 63, Issue 3, 2003, Pages 766-772

  Monks, Anne ^a,c   Harris, Erik ^a   Hose, Curtis ^a   Connelly, John ^a   Sausville, Edward A ^b  

^a SAIC FREDERICK INC   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (4 AMINO 3 METHYLPHENYL) 5 FLUOROBENZOTHIAZOLE; ANTINEOPLASTIC AGENT; AROMATIC HYDROCARBON RECEPTOR; BONE MORPHOGENETIC PROTEIN; CYTOCHROME P450; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; DNA BINDING PROTEIN; F5 203; FAS ANTIGEN; MESSENGER RNA; PROTEIN P21; PROTEIN P53; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER INHIBITION; CONTROLLED STUDY; DNA DAMAGE; DNA MICROARRAY; DRUG MECHANISM; DRUG RECEPTOR BINDING; ENZYME ACTIVATION; GENE EXPRESSION; GENE INDUCTION; GENOTOXICITY; HUMAN; HUMAN CELL; ONCOGENE C MYC; PRIORITY JOURNAL; PROTEIN INDUCTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; HUMANS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; THIAZOLES; TUMOR CELLS, CULTURED;

EID: 0037334157     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.63.3.766     Document Type: Article

References (28)

1. Alizadeh AA, Eisen MB, Davis RE, Ma C, Lossos IS, Rosenwald A, Boldrick JC, Sabet H, Tran T, Yu X, et al. (2000) Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling. Nature (Lond) 403:503-511.
2. Amundson SA, Bittner M, Chen Y, Trent J, Meltzer P, and Fornace AJ Jr (1999) Fluorescent cDNA microarray hybridization reveals complexity and heterogeneity of cellular genotoxic stress responses. Oncogene 18:3666-3672.
3. Baek SJ, Kim KS, Nixon JB, Wilson LC, and Eling TE (2001) Cyclooxygenase inhibitors regulate the expression of a TGF-beta superfamily member that has proapoptotic and antitumorigenic activities. Mol Pharmacol 59:901-908.
4. Blattner C, Tobiasch E, Litfen M, Rahmsdorf HJ, and Herrlich P (1999) DNA damage induced p53 stabilization: no indication for an involvement of p53 phosphorylation. Oncogene 18:1723-1732.
5. Bradshaw TD, Chua MS, Browne HL, Trapani V, Sausville EA, and Stevens MF (2002) In vitro evaluation of amino acid prodrugs of novel antitumour 2-(4-amino-3-methylphenyl)benzothiazoles. Br J Cancer 86:1348-1354.
6. Bradshaw TD, Shi DF, Schultz RJ, Paull KD, Kelland L, Wilson A, Garner C, Fiebig HH, Wrigley S, and Stevens MF (1998a) Influence of 2-(4-aminophenyl)benzothiazoles on growth of human ovarian carcinoma cells in vitro and in vivo. Br J Cancer 78:421-429.
7. Bradshaw TD, Wrigley S, Shi DF, Schultz RJ, Paull KD, and Stevens MF (1998b) 2-(4-Aminophenyl)benzothiazoles: novel agents with selective profiles of in vitro anti-tumour activity. Br J Cancer 77:745-752.
8. Brantley EI, Trapani V, Stinson SF, and Stevens MFG (2001) Metabolism and subcellular binding of novel fluorinated 2-(4-amino-3-methylphenyl) benzothiazoles in human cancer cells. Proc Am Assoc Cancer Res 42:325-326.
9. Chua MS, Kashiyama E, Bradshaw TD, Stinson SF, Brantley E, Sausville EA, and Stevens MF (2000) Role of Cyp1A1 in modulation of antitumor properties of the novel agent 2-(4-amino-3-methylphenyl)benzothiazole (DF 203, NSC 674495) in human breast cancer cells. Cancer Res 60:5196-5203.
10. Fairlie WD, Moore AG, Bauskin AR, Russell PK, Zhang HP, and Breit SN (1999) MIC-1 is a novel TGF-beta superfamily cytokine associated with macrophage activation. J Leukoc Biol 65:2-5.
11. Hai T and Hartman MG (2001) The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasis. Gene 273:1-11.
12. Hai T, Wolfgang CD, Marsee DK, Allen AE, and Sivaprasad U (1999) ATF3 and stress responses. Gene Expr 7:321-335.
13. Hutchinson I, Chua MS, Browne HL, Trapani V, Bradshaw TD, Westwell AD, and Stevens MF (2001) Antitumor benzothiazoles. 14. (1) synthesis and in vitro biological properties of fluorinated 2-(4-aminophenyl)benzothiazoles. J Med Chem 44:1446-1455.
14. Imamura T, Takase M, Nishihara A, Oeda E, Hanai J, Kawabata M, and Miyazono K (1997) SMAD6 inhibits signaling by the TGF-beta superfamily. Nature (Lond) 389:622-626.
15. Kashiyama E, Hutchinson I, Chua MS, Stinson SF, Phillips LR, Kaur G, Sausville EA, Bradshaw TD, Westwell AD, and Stevens MF (1999) Antitumor benzothiazoles. 8. Synthesis, metabolic formation and biological properties of the C- and N-oxidation products of antitumor 2-(4-aminophenyl)benzothiazoles. J Med Chem 42:4172-4184.
16. Kudoh K, Ramanna M, Ravatn R, Elkahloun AG, Bittner ML, Meltzer PS, Trent JM, Dalton WS, and Chin KV (2000) Monitoring the expression profiles of doxorubicin-induced and doxorubicin-resistant cancer cells by cDNA microarray. Cancer Res 60:4161-4166.
17. Li P-X, Wong J, Ayed A, Ngo D, Brade AM, Arrowsmith C, Austin RC, and Klamut HJ (2000) Placental transforming growth factor-beta is a downstream mediator of the growth arrest and apoptotic response of tumor cells to DNA damage and p53 overexpression. J Biol Chem 275 20127-20135.
18. Loaiza-Perez AI, Trapani V, Hose C, Singh SS, Trepel JB, Stevens MF, Bradshaw TD, and Sausville EA (2002) Aryl hydrocarbon receptor mediates sensitivity of MCF-7 breast cancer cells to antitumor agent 2-(4-amino-3-methylphenyl) benzothiazole. Mol Pharmacol 61:13-19.
19. Mashima T, Udagawa S, and Tsuruo T (2001) Involvement of transcriptional repressor ATF3 in acceleration of caspase protease activation during DNA damaging agent-induced apoptosis. J Cell Physiol 188:352-358.
20. Nakao A, Imamura T, Souchelnytskyi S, Kawabata M, Ishisaki A, Oeda E, Tamaki K, Hanai J, Heldin CH, Miyazono K, et al. (1997) TGF-beta receptor-mediated signaling through Smad2, Smad3 and Smad4. EMBO (Eur Mol Biol Organ) J 16:5353-5362.
21. Paralkar VM, Vail AL, Grasser WA, Brown TA, Xu H, Vukicevic S, Ke HZ, Qi H, Owen TA, and Thompson DD (1998) Cloning and characterization of a novel member of the transforming growth factor-beta/bone morphogenetic protein family. J Biol Chem 273:13760-13767.
22. Paull KD, Shoemaker RH, Hodes L, Monks A, Scudiero DA, Rubinstein L, Plowman J, and Boyd MR (1989) Display and analysis of patterns of differential activity of drugs against human tumor cell lines: development of mean graph and COMPARE algorithm. J Natl Cancer Inst 81:1088-1092.
23. Pirkkala L, Nykanen P, and Sistonen L (2001) Roles of the heat shock transcription factors in regulation of the heat shock response and beyond. FASEB J 15:1118-1131.
24. Shi DF, Bradshaw TD, Wrigley S, McCall CJ, Lelieveld P, Fichtner I, and Stevens MF (1996) Antitumor benzothiazoles. 3. Synthesis of 2-(4-aminophenyl)benzothiazoles and evaluation of their activities against breast cancer cell lines in vitro and in vivo. J Med Chem 39:3375-3384.
25. Stevens MFG, Heydon RT, Martin EA, Farmer PB, Bradshaw TD, Hutchinson I, Westwell AD, Browne HL, and Trapani V (2001) Induction of CYP1A1 by 2-(4-aminophenyl) benzothiazoles leads to DNA adducts in sensitive tumor cells (Abstract). Proc Am Assoc Cancer Res 42:A1754.
26. Strelau J, Sullivan A, Bottner M, Lingor P, Falkenstein E, Suter-Crazzolara C, Galter D, Jaszai J, Krieglstein K, and Unsicker K (2000) Growth/differentiation factor- 15/macrophage inhibitory cytokine-1 is a novel trophic factor for midbrain dopaminergic neurons in vivo. J Neurosci 20:8597-8603.
27. Tang W, Yang L, Yang YC, Leng SX, and Elias JA (1998) Transforming growth factor-beta stimulates interleukin-11 transcription via complex activating protein-1-dependent pathways. J Biol Chem 273:5506-5513.
28. Zaharevitz DW, Holbeck SL, Bowerman C, and Svetlik PAJ (2002) COMPARE: a web accessible tool for investigating mechanisms of cell growth inhibition. Mol Graph Model 20:297-303.