Neurotransmitters of the suprachiasmatic nuclei

Journal of Circadian Rhythms

Volumn 4, Issue , 2006, Pages

  Reghunandanan, Vallath ^a   Reghunandanan, Rajalaxmy ^a  

^a University of Malaysia   (Malaysia)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; ACETYLCHOLINE; ANGIOTENSIN II; ARGIPRESSIN; CALBINDIN; CALRETININ; GALANIN; GASTRIN RELEASING PEPTIDE; GLUTAMIC ACID; HISTAMINE; MELATONIN; METENKEPHALIN; NEUROKININ; NEUROPEPTIDE Y; NEUROTENSIN; NEUROTRANSMITTER; NITRIC OXIDE; PEPTIDE HISTIDINE ISOLEUCINE; SEROTONIN; SOMATOSTATIN; VASOACTIVE INTESTINAL POLYPEPTIDE; VASOPRESSIN;

ANTERIOR HYPOTHALAMUS; BIOLOGICAL RHYTHM; CELL FUNCTION; CELLULAR DISTRIBUTION; CIRCADIAN RHYTHM; DEPRESSION; DIABETES MELLITUS; EFFERENT NERVE; GENE EXPRESSION; GENETIC LINKAGE; GENETIC TRANSCRIPTION; HUMAN; HUMAN VERSUS ANIMAL COMPARISON; HYPERTENSION; MEDICAL RESEARCH; MOLECULAR MECHANICS; NEUROTRANSMISSION; NONHUMAN; PROTEIN LOCALIZATION; REVIEW; SIGNAL TRANSDUCTION; SUPRACHIASMATIC NUCLEUS;

EID: 33646176405     PISSN: 17403391     EISSN: 17403391     Source Type: Journal    
DOI: 10.1186/1740-3391-4-2     Document Type: Review

References (283)

1. Reppert SM, Weaver DR: Coordination of circadian timing in mammals. Nature 2002, 418:935-941.
2. Morre DJ, Chueh PJ, Pletcher J, Tang X, Wu LY, Morre DM: Biochemical basis for the biological clock. Biochemistry 2002, 41:11941-11945.
3. Meijer JH: Photic entrainment of mammals. In Handbook of Behavioral Neurobiology. Circadian clocks Edited by: Takahashi JS, Turek FW, Moore RY. New York, Plenum; 2002:183-222.
4. Mrosovsky N: Locomotor activity and non-photic influences on circadian clocks. Biological Reviews 1996, 71:343-372.
5. Antle MC, Silver R: Orchestrating time: arrangements of the brain circadian clock. Trends in Neurosci 2005, 28:145-151.
6. Piggins HD, Cutler DJ: The roles of vasoactive intestinal polypeptide in the mammalian circadian clock. J Endocrinol 2003, 177:7-15.
7. Van Gelder RN: Recent insights into mammalian circadian rhythms. Sleep 2004, 27:166-171.
8. Reppert SM, Weaver DR: Molecular analysis of mammalian circadian rhythms. Annu Rev Physiol 2001, 63:647-676.
9. van Esseveldt KE, Lehman MN, Boer GJ: The suprachiasmatic nucleus and the circadian time keeping system revisited. Brain Res Rev 2000, 33:34-77.
10. Hastings MH, Reddy AB, Maywood ES: A clockwork web: circadian timing in brain and periphery, in health and disease. Nat Rev Neurosci 2003, 4:649-661.
11. Card JP, Moore RY: The suprachiasmatic nucleus of the golden hamster. Immunohistochemical analysis of cell and fiber distribution. Neuroscience 1984, 13:415-431.
12. van den Pol AN: Gamma-aminobutyrate, gastrin releasing peptide, serotonin, somatostatin, and vasopressin: ultrastructural immunocytochemical localization in presynaptic axons in the suprachiasmatic nucleus. Neuroscience 1986, 17:643-659.
13. Rusak B, Bina KG: Neurotransmitters in the mammalian circadian system. Ann Rev Neurosci 1990, 13:387-401.
14. Reghunandanan V, Reghunandanan R, Marya RK: Vasopressin: Its possible role in circadian time keeping. Chronobiologia 1991, 18:39-47.
15. Abrahamson EE, Moore RY: Suprachiasmatic nucleus in the mouse: retinal innervation, intrinsic organization and efferent projections. Brain Res 2001, 916:172-191.
16. van den Pol AN, Tsujimoto KL: Neurotransmitters of the hypothalamic suprachiasmatic nucleus: Immunocytochemical analysis of 25 neuronal antigens. Neuroscience 1985, 15:1049-1086.
17. Moore RY: Organization and function of a central nervous system oscillator: the suprachiasmatic nucleus. Fed Proc 1983, 42:2783-2789.
18. Mai JK, Kedziora O, Teckhaus L, Sofroniew MV: Evidence for subdivisions in the human suprachiasmatic nucleus. J Gomp Neurol 1991, 305:508-525.
19. Reghunandanan V, Reghunandanan R, Singh PI: Neurotransmitters of the suprachiasmatic nucleus: role in the regulation of circadian rhythms. Prog Neurobiol 1993, 41:647-655.
20. Hannibal J: Neurotransmitters of the retino-hypothalamic tract. Cell Tissue Res 2002, 309:73-88.
21. Harmar AJ: An essential role for peptidergic signalling in the control of circadian rhythms in the suprachiasmatic nuclei. J Neuroendocrinol 2003, 15:335-338.
22. Golombek DA, Agostino PV, Piano SA, Ferreyra GA: Signaling in the mammalian circadian clock: the NO/cGMP pathway. Neurochem Int 2004, 45:929-936.
23. Aton SJ, Herzog ED: Come together, right...now: synchronization of rhythms in a mammalian circadian clock. Neuron 2005, 48:531-534.
24. Moore RY: Entrainment pathways and functional organization of the circadian system. In Hypothalamic integration of circadian rhythms. Progress in Brain Research Volume 111. Edited by: Buijs RM, Kasbeek A, Romijn HJ, Pennartz CMA, Mirmiran M. Amsterdam Elsevier; 1966:103-119.
25. Shirakawa T, Honma S, Honma K: Multiple oscillators in the suprachiasmatic nucleus. Chronobiol Int 2001, 18:371-387.
26. Welsh DK, Logothetis DE, Meister M, Reppert SM: Individual neurons dissociated from rat suprachiasmatic nucleus express independently phased circadian firing rhythms. Neuron 1995, 14:697-706.
27. Honma S, Nakamura W, Shirakawa T, Honma K: Diversity in the circadian periods of single neurons of the rat suprachiasmatic nucleus depends on nuclear structure and intrinsic period. Neurosci Lett 2004, 358:173-176.
28. Gonze D, Bernard S, Waltermann C, Kramer A, Herzel H: Spontaneous synchronization of coupled circadian oscillators. Biophys J 2005, 89:120-129.
29. Hastings MH, Herzog ED: Clock genes, oscillators, and cellular networks in the suprachiasmatic nuclei. J Biol Rhythms 2004, 19:400-413.
30. Yamaguchi S, Isejima H, Matsuo T, Okura R, Yagita K, Kobayashi M, Okamura H: Synchronization of cellular clocks in the suprachiasmatic nucleus. Science 2003, 302:1408-1412.
31. Mai JK, Tripel J, Metz J: Neurotensin in the human brain. Neuroscience 1987, 22:499-524.
32. Moore RY: The organization of the human circadian timing system. In The human hypothalamus in health and disease Edited by: Swaab DF, Holfman MA, Mirmiran M, Ravid R, Van Leeuwen FW. Amsterdam, Progress in Brain research Elsevier; 1992:101-118.
33. Romijn HJ, van Uum JF, Emmering J, Goncharuk V, Buijs RM: Colocalization of VIP with AVP in neurons of the human paraventricular, supraoptic and suprachiasmatic nucleus. Brain Res 1999, 832:47-53.
34. Kalsbeek A, van Heerikhuize JJ, Wortel J, Buijs RM: A diurnal rhythm of stimulatory input to the hypothalamo-pituitaryadrenal system as revealed by timed intrahypothalamic administration of the vasopressin VI antagonist. J Neurosci 1996, 16:5555-5565.
35. Kalsbeek A, Garidou ML, Palm IF, Van Der Vliet J, Simonneaux V, Pevet P, Buijs RM: Melatonin sees the light: blocking GABA-ergic transmission in the paraventricular nucleus induces daytime secretion of melatonin. Eur J Neurosci 2000, 12:3146-3154.
36. Buijs RM, Kalsbeek A: Hypothalamic integration of central and peripheral clocks. Nature Rev Neurosci 2001, 2:521-526.
37. Colwell CS, Menaker M: Regulation of circadian rhythms by excitatory amino acids. In Excitatory amino acids: Their role in neuroendocrine function Edited by: Brann DW, Mahesh VB. New York: CRC Press; 1996:223-252.
38. Ebling FJP: The role of glutamate in the photic regulation of the suprachiasmatic nucleus. Prog Neurobiol 1996, 50:109-132.
39. Johnson RF, Moore RY, Morin LP: Loss of entrainment and anatomical plasticity after lesions of the hamster retinohypothalamic tract. Brain Res 1988, 460:297-313.
40. Myers MP, Wagner-Smith K, Rothenfluh-Hilfiker A, Young MW: Light induced degradation of TIMELESS and entrainment of the Drosophila circadian clock. Science 1996, 271:1736-1740.
41. Castel M, Belenky M, Cohen S, Ottersen OP, Storm-Mathisen J: Glutamate-like immunoreactivity in retinal terminals of the mouse suprachiasmatic nucleus. Eur J Neurosci 1993, 5:368-381.
42. Hannibal J, Moller M, Ottersen OP, Fahrenkrug J: PACAP and glutamate are co-stored in the retinohypothalamic tract. J Comp Neurol 2000, 418:147-155.
43. Hannibal J, Fahrenkrug J: Immuncireactive substance P is not part of the retinohypothalamic tract in the rat. Cell Tissue Res 2002, 309:293-299.
44. Piggins HD, Samuels RE, Coogan AN, Cutler DJ: Distribution of substance P and neurokinin-I receptor immuncireactivity in the suprachiasmatic nuclei and intergeniculate leaflet of hamster, mouse, and rat. J Comp Neurol 2001, 438:50-65.
45. Hannibal J, Hindersson P, Knudsen SM, Georg B, Fahrenkrug J: The photopigment melanopsin is exclusively present in pituitary adenylate cyclase-activating polypeptide-containing retinal ganglion cells of the retinohypothalamic tract. J Neurosci 2002, 22:RC191.
46. Piggins HD, Rusak B: Effects of microinjections of substance P into the suprachiasmatic nucleus region, on hamster wheel-running rhythms. Brain Res Bull 1997, 42:451-455.
47. Mikkelsen JD, Larsen PJ, Mick G, Vrang N, Ebling FJP, Maywood ES, Hastings MH, Moller M: Gating of retinal inputs through the suprachiasmatic nucleus: role of excitatory neurotransmission. Neurochem Int 1992, 27:263-272.
48. Ding JM, Chen D, Weber ET, Faiman LE, Rea MA, Gillette MU: Resetting the biological clock: mediation of nocturnal circadian shifts by glutamate and NO. Science 1994, 266:1713-1717.
49. Vries MJD, Treep JA, Pauw ESDD, Meijer JH: The effects of electrical stimulation of the optic nerves and anterior optic chiasm on the circadian activity rhythm of the Syrian hamster: involvement of excitatory amino acids. Brain Res 1994, 642:206-212.
50. DeVries MJ, Cardozo BN, van der Want J, de Wolf A, Meijer JH: Glutamate immunoreactivity in terminals of the retinohypothalamic tract of the brown Norwegian rat. Brain Res 1993, 612:231-237.
51. Gannon RL, Rea MA: In situ hybridization of antisense mRNA oligonucleoticles for AMPA, NMDA and metabotropic glutamate receptor subtypes in the rat suprachiasmatic nucleus at different phases of the circadian cycle. Mol Brain Res 1994, 23:338-344.
52. Harrington ME, Hoque S, Hall A. Golombek D, Biello S: Pituitary adenylate cyclase activating peptide phase shifts circadian rhythms in a manner similar to light. J Neurosci 1999, 19:6637-6642.
53. Minami Y, Furuno K, Akiyama M, Moriya T, Shibata S: Pituitary adenylate cyclase-activating polypeptide produces a phase shift associated with induction of mPer expression in the mouse suprachiasmatic nucleus. Neuroscience 2002, 113:37-45.
54. Bos NP, Mirmiran M: Effects of excitatory and Inhibitory amino acids on neuronal discharges in the cultured suprachiasmatic nucleus. Brain Res Bull 1993, 31:67-72.
55. Scott G, Rusak B: Activation of hamster suprachiasmatic neurons in vitro via metabotropic glutamate receptors. Neuroscience 1996, 71:533-541.
56. Abe H, Rusak B, Robertson HA: NMDA and non-NMDA antagonists inhibit photic induction of Fos protein in the hamster suprachiasmatic nucleus. Brain Res Bull 1992, 28:831-835.
57. Colwell CS, Menaker M: NMDA as well as non-NMDA receptor antagonists can prevent the phase shifting effects of light on the circadian system of the golden hamster. J Biol Rhythms 1992, 7:125-136.
58. Decker K, Reuss S: Nitric oxide -synthesizing neurons in the hamster suprachiasmatic nucleus: a combined NOS -and NADPH-staining and retinohypothalamic tract tracing study. Brain Res 1994, 666:284-288.
59. Reuss S, Decker K, Rosseler L, Layes E, Scholl-mayer A, Sppessert R: Nitric oxide synthase in the hypothalamic suprachiasmatic nucleus of rat: evidence from histochemistry, immunochemistry and western blot and colocalization with VIP. Brain Res 1995, 695:257-262.
60. Chen D, Hurst WJ, Ding JM, Faiman le, Mayer B, Gillette MU: Localization and characterization of nitric oxide synthase in the rat suprachiasmatic nucleus: evidence for a nitergic plexus in the biological clock. J Neurochem 1997, 68:855-861.
61. Caillol M, Devinoy E, Lacroix MC, Schirar A: Endothelial and neuronal nitric oxide synthases are present in the suprachiasmatic nuclei of Syrian hamsters and rats. Eur J Neurosci 2000, 12:649-661.
62. Prosser RA, McArther AJ, Gillette MU: cGMP induces phase shifts of mammalian circadian pacemaker at night in antiphase to cAMP effect. Proc Natl Acad Sci USA 1989, 86:6812-6815.
63. Amir S: Blocking NMDA receptors or nitric oxide production disrupts light transmission to the suprachiasmatic nucleus. Brain Res 1992, 586:336-339.
64. Watanabe A, Hamada T, Shibata S, Watanabe S: Effects of nitric oxide synthase inhibitors on N-methyl-D-aspartate-induced phase delay of circadian rhythm of neuronal activity in the rat suprachiasmatic nucleus in vitro. Brain Res 1994, 646:161-164.
65. Weber ET, Gannon RL, Michel AM, Gillette MU, Rea MA: Nitric oxide synthase inhibitor blocks light-induced phase shifts of the circadian activity rhythm, but not c-fos expression in the suprachiasmatic nucleus of the Syrian hamster. Brain Res 1995, 692:137-142.
66. Ding JM, Faiman LE, Hurst WJ, Kuriashkina LP, Gillette MU: Resetting the biological clock: mediation of nocturnal CREB phosphorylation via light, glutamate and nitric oxide. J Neurosci 1997, 17:667-675.
67. Golombek DA, Ferreyra GA, Katz ME, Marpegan L, Pinto FD, Alfonso TF, Yannielli PC: Neurochemistry of mammalian entrainment: Signal transduction pathways in the suprachiasmatic nuclei. Biol Rhythm Res 2000, 31:56-70.
68. Starkey SJ, Grant AL, Hagan RM: A rapid and transient synthesis of nitric oxide (NO) by a constitutively expressed type II NO synthase in the guinea -pig suprachiasmatic nucleus. Br J Pharmocol 2001, 34:1084-1092.
69. Kriegsfeld LJ, Demas GE, Lee SE, Dawson TM, Dawson VL, Nelson RJ: Circadian locomotor analysis of male mice lacking the gene for neuronal nitric oxide synthase (nNOS-l-). J Biol Rhythms 1999, 14:20-27.
70. Kriegsfeld LJ, Drazen DL, Nelson RJ: Circadian organization in male mice lacking the gene for endothelial nitric oxide synthase (eNOS-l-). J Biol Rhythms 2001, 16:142-148.
71. Bellingham J, Foster RG: Opsins and mammalian photoentrainment. Cell Tissue Res 2002, 309:57-71.
72. Provencio I, Rodriguez IR, Jiang G, Hayes WP, Moreira EF, Rollag MD: A novel human opsin in the inner retina. J Neurosci 2000, 20:600-605.
73. Hattar S, Liao HW, Takao M, Berson DM, Yau KW: Melanopsin-containing retinal ganglion cells: architecture, projections, and intrinsic photosensitivity. Science 2002, 295:1065-70.
74. Gooley JJ, Lu J, Chou TC, Scammell TE, Saper CB: Melanopsin in cells of origin of the retinohypothalamic tract. Nat Neurosci 2001, 4:1165.
75. Takatsuji K, Miguel-Hidalgo JJ, Tohyama M: Substance P-immunoreactive innervation from the retina to the suprachiasmatic nucleus in the rat. Brain Res 1991, 568:223-229.
76. Kim YI, Kim SH, Kim DY, Lee HW, Shin HC, Chung JM, Han HC, Na HS, Hong SK: Electrophysiological evidence for the role of substance P in retinohypothalamic transmission in the rat. Neurosci Lett 1999, 274:99-102.
77. Kim DY, Kang HC, Shin HC, Lee KJ, Yoon YW, Han HC, Na HS, Hong SK, Kim YI: Substance p plays a critical role in photic resetting of the circadian pacemaker in the rat hypothalamus. J Neurosci 2001, 21:4026-4031.
78. Tuomisto L: Involvement of histamine in circadian and other rhythms. In Histaminergic neurons: Mophology and function Edited by: Watanabe T, Wada H. Inc Boca Raton FL CRC Press; 1991:283-295.
79. Stephan FK, Berkley KJ, Moss RL: Efferent connections of the rat suprachiasmatic nucleus. Neuroscience 1981, 6:2625-2641.
80. Jacobs EH, Yamatodani A, Timmerman H: Is histamine the final neurotransmitter in the entrainment of circadian rhythms in mammals? Trends Pharmacol Sci 2000, 21:293-298.
81. Itowi N, Yamatodani A, Mochizuki T, Wada H: Effects of intracerebroventricular histamine injection on circadian activity phase entrainment during rapid illumination changes. Neurosci Lett 1991, 123:53-56.
82. Liou SY, Shibata S, Yamakawa K, Ueki S: Inhibitory and excitatory effects of histamine on suprachiasmatic neurons in rat hypothalamic slice preparation. Neurosci Lett 1983, 41:109-113.
83. Stehle J: Effects of histamine on spontaneous electrical activity of neurons in rat suprachiasmatic nucleus. Neurosci Lett 1991, 130:217-220.
84. Eaton SJ, Cote NK, Harrington ME: Histamine synthesis inhibition reduces light-induced phase shifts of circadian rhythms. Brain Res 1995, 695:227-230.
85. Eaton SJ, Eoh S, Meyer J, Hoque S, Harrington ME: Circadian rhythm photic phase shifts are not altered by histamine receptor antagonists. Brain Res Bull 1996, 41:227-229.
86. Alexander MJ, Leeman SE: Widespread expression in adult rat forebrain of mRNA encoding high-affinity neurotensin receptor. J Comp Neurol 1998, 402:475-500.
87. Boudin H, Pelaprat D, Rostene W, Beaudet A: Cellular distribution of neurotensin receptors in rat brain: immunohistochemical study using an antipeptide antibody against the cloned high affinity receptor. J Comp Neurol 1996, 373:76-89.
88. Francois-Bellan AM, Bosler O, Tonon MC, Wei LT, Beaudet A: Association of neurotensin receptors with VIP-containing neurons and serotonin-containing axons in the suprachiasmatic nucleus of the rat. Synapse 1992, 10:282-290.
89. Meyer-Spasche A, Reed HE, Piggins HD: Neurotensin phase-shifts the firing rate rhythm of neurons in the rat suprachiasmatic nuclei in vitro. Eur J Neurosci 2002, 16:339-44.
90. Coogan AN, Rawlings N, Luckman SM, Piggins HD: Effects of neurotensin on discharge rates of rat suprachiasmatic nucleus neurons in vitro. Neuroscience 2001, 103:663-672.
91. Schmahl C, Bohmer G: Effects of excitatory amino acids and neuropeptide Y on the discharge activity of suprachiasmatic neurons in rat brain slices. Brain Res 1997, 746:151-163.
92. Cutler DJ, Piggins HD, Selbie LA, Mason R: Responses to neuropeptide Y in adult hamster suprachiasmatic nucleus neurones in vitro. Eur J Pharmacol 1998, 345:155-162.
93. Gribkoff VK, Pieschl RL, Wisialowski TA, van den Pol AN, Yocca FD: Phase shifting of circadian rhythms and depression of neuronal activity in the rat suprachiasmatic nucleus by neuropeptide Y: mediation by different receptor subtypes. J Neurosci 1998, 18:3014-3022.
94. Xu H, Hu XY, Wu L, Zhou JN: Neurotensin expressing neurons developed earlier than vasoactive intestinal polypeptide and vasopressin expressing neurons in the human suprachiasmatic nucleus. Neurosci Lett 2003, 335:175-178.
95. Nakahara K, Hanada R, Murakami N, Teranishi H, Ohgusu H, Fukushima N, Moriyama M, Ida T, Kangawa K, Kojima M: he gut-brain peptide neuromedin U is involved in the mammalian circadian oscillator system. Biochem Biophys Res Commun 2004, 318:156-161.
96. Mori K, Miyazato M, Ida T, Murakami N, Serino R, Ueta Y, Kojima M, Kangawa K: Identification of neuromedin S and its possible role in the mammalian circadian oscillator system. EMBO J 2005, 24:325-335.
97. Graham ES, Littlewood P, Turnbull Y, Mercer JG, Morgan PJ, Barrett P: Neuromedin -U is regulated by circadian clock in the SCN of the mouse. Eur J Neurosci 2005, 21:814-819.
98. Battey J, Wada E: Two distinct receptor subtypes for mammalian bombesin-like peptides. Trends Neurosci 1991, 14:524-528.
99. Ladenheim EE, Jensen RT, Mantey SA, McHugh PR, Moran TH: Receptor heterogeneity for bombesin-like peptides in the rat central nervous system. Brain Res 1990, 537:233-240.
100. Ladenheim EE, Jensen RT, Mantey SA, Moran TH: Distinct distributions of two bombesin receptor subtypes in the rat central nervous system. Brain Res 1992, 593:168-178.
101. Tanaka M, Hayashi S, Tamada Y, Ikeda T, Hisa Y, Takamatsu T, Ibata Y: Direct retinal projections to GRP neurons in the suprachiasmatic nucleus of the rat. NeuroReport 1997, 8:2187-2191.
102. Aïoun J, Chambille I, Peytevin J, Martinet L: Neurons containing gastrin-releasing peptide and vasoactive intestinal polypeptide are involved in the reception of the photic signal in the suprachiasmatic nucleus of the Syrian hamster: an immunocytochemical ultrastructural study. Cell Tissue Res 1988, 291:239-253.
103. Piggins HD, Rusak B: Intercellular interactions and the physiology of circadian rhythms in mammals. In Handbook of behavioral state control: cellular and molecular mechanisms Edited by: Lydic R, Baghdoyan HA. Boca Raton FL CRC; 1999:31-44.
104. McArthur AJ, Coogan AN, Ajpru S, Sugden D, Biello SM, Piggins HD: Gastrin-releasing peptide phase-shifts suprachiasmatic nuclei neuronal rhythms in vitro. J Neurosci 2000, 20:5496-5502.
105. Antle MC, Kriegsfeld LJ, Silver R: Signaling within the master clock of the brain: localized activation of mitogen-activated protein kinase by gastrin-releasing peptide. J Neurosci 2005, 25:2447-2454.
106. Bina KG, Rusak B, Semba K: Localization of cholinergic neurons in the forebrain and brainstem that project to the suprachiasmatic nucleus of the hypothalamus in rats. J Comp Neurol 1993, 335:295-307.
107. Nishino H, Koizumi K: Responses of neurons in the suprachiasmatic nuclei of the hypothalamus to putative transmitters. Brain Res 1977, 120:167-172.
108. Zatz M, Brownstein MJ: Injection of alpha-bungarotoxin near the suprachiasmatic nucleus blocks the effects of light on nocturnal pineal enzyme activity. Brain Res 1981, 213:438-442.
109. Earnest DJ, Turek FW: Neurochemical basis for the photic control of circadian rhythms and seasonal reproductive cycles: role for acetylcholine. Proc Natl Acad Sci U S A 1985, 82:4277-4281.
110. Liu C, Gillette MU: Cholinergic regulation of the SCN circadian rhythm via a muscarinic mechanism at night. J Neurosci 1996, 16:744-752.
111. Colwell CS, Kaufman CM, Menaker M: Phase shifting mechanisms in the mammalian circadian system: new light on the carbachol paradox. J Neurosci 1993, 13:1454-1459.
112. Janik D, Mrosovsky N: Intergeniculate leaflet lesions and behaviorally-induced shifts of circadian rhythms. Brain Res 1994, 651:174-182.
113. Rusak B, Meijer JH, Harrington ME: Hamster circadian rhythms are phase-shifted by electrical stimulation of the geniculo-hypothalamic tract. Brain Res 1989, 493:283-291.
114. Menet J, Vuillez P, Jacob N, Pevet P: Intergeniculate leaflets lesion delays but does not prevent the integration of photoperiodic change by the suprachiasmatic nuclei. Brain Res 2001, 906:176-179.
115. Harrington ME: The ventral lateral geniculate nucleus and the intergeniculate leaflet: interrelated structures in the visual and circadian systems. Neurosci Biobehav Rev 1997, 21:705-727.
116. Moore RY, Speh JC: GABA is the principal neurotransmitter of the circadian system. Neurosci Lett 1993, 150:112-116.
117. Morin LP, Blanchard J: Organization of the hamster intergeniculate leaflet: NPY and ENK projections to the suprachiasmatic nucleus, intergeniculate leaflet and posterior limitans nucleus. Vis Neurosci 1995, 12:57-67.
118. Byku M, Legutko R, Gannon RL: Distribution of delta opioid receptor immunoreactivity in the hamster suprachiasmatic nucleus and intergeniculate leaflet. Brain Res 2000, 857:1-7.
119. Byku M, Gannon RL: SNC 80, a delta-opioid agonist, elicits phase advances in hamster circadian activity rhythms. Neuroreport 2000, 11:1449-1452.
120. Moore RY, Gustafson EL, Card JP: Identical immunoreactivity of afferents to the rat suprachiasmatic nucleus with antisera against avian pancreatic polypeptide, molluscan cardioexcitatory peptide and neuropeptide Y. Cell Tissue Res 1984, 236:41-46.
121. Biello SM, Golombek DA, Schak KM, Harrington ME: Circadian phase shifts to neuropeptide Y In vitro: cellular communication and signal transduction. J Neurosci 1997, 17:8468-8475.
122. Moore RY, Card JP: Intergeniculate leaflet: an anatomically and functionally distinct subdivision of the lateral geniculate complex. J Comp Neurol 1994, 344:403-430.
123. Mrosovsky N: A non -photic gateway to the circadian clcok of hamsters. In Circadian clocks and their adjustment Edited by: Chadwick Dj, Ackrill K. New York, John Wiley; 1995:154-174.
124. Turek FW, Pinto LH, Vitaterna MH, Penev PD, Zee PC, Takahashi JS: Pharmacological and genetic approaches for the study of circadian rhythms in mammals. Front Neuroendocrinol 1995, 16:191-223.
125. Huhman KL, Babagbemi TO, Albers HE: Bicuculline blocks neuropeptide Y-induced phase advances when microinjected in the suprachiasmatic nucleus of Syrian hamsters. Brain Res 1995, 675:333-336.
126. Chen G, van den Pol AN: Multiple NPY receptors coexist in pre-and postsynaptic sites: inhibition of GABA release in isolated self-innervating SCN neurons. J Neurosci 1996, 16:7711-7724.
127. Moore RY, Halaris AE, Jones BE: Serotonin neurons of the midbrain raphe: ascending projections. J Comp Neurol 1978, 180:417-438.
128. Bons N, Combes A, Szafarczyk A, Assenmacher I: Efferences dextrahypothalamiques de noyau suprachiasmatique chez le rat. C R Acad Sci 1983, 297:347-350.
129. Medanic M, Gillette MU: Serotonin regulates the phase of the rat suprachiasmatic circadian pacemaker in vitro during the subjective day. J Physiol 1992, 450:629-642.
130. Edgar DM, Miller JD, Prosser RA, Dean RR, Dement WC: Serotonin and the mammalian circadian system: phase shifting rat behavioral rhythms with serotonergic agonists. J Biol Rhythms 1993, 8:17-31.
131. Block M, Zucker I: Circadian rhythms of rat locomotor activity after lesions of the midbrain raphe nuclei. J Comp Physiol 1976, 109:235-247.
132. Okamura H, Takahashi Y, Terubayashi H, Hamada S, Ynaihara N, Ibata Y: VIP-like immunoreactive neurons and retinal projections in the rat suprachiasmatic nucleus. Biomed Res 1987, 8:253-262.
133. Fite KV, Janusonis S, Foote W, Bengston L: Retinal afferents to the dorsal raphe nucleus in rats and Mongolian gerbils. J Comp Neurol 1999, 414:469-484.
134. Prosser RA: Serotonergic actions and interactions on the SCN circadian pacemaker: In vitro investigations. Biol Rhythm Res 2000, 31:315-339.
135. Jiang ZG, Teshima K, Yang Y, Yoshioka T, Allen CN: Pre- and post-synaptic actions of serotonin on rat suprachiasmatic nucleus neurons. Brain Res 2000, 866:247-256.
136. Rea MA, Glass JD, Colwell CS: Serotonin modulates photic responses in the hamster suprachiasmatic nuclei. J Neurosci 1994, 14:3635-3642.
137. Ying SW, Rusak B: Effects of serotonergic agonists on firing rates of photically responsive cells in the hamster suprachiasmatic nucleus. Brain Res 1994, 651:37-46.
138. Rea MA, Barrera J, Glass JD, Gannon RL: Serotonergic potentiation of photic phase shifts of the circadian activity rhythm. Neuroreport 1995, 6:1289-1292.
139. Castel M, Morris JF: Morphological heterogeneity of the GABAergic network in the suprachiasmatic nucleus, the brain's circadian pacemaker. J Anat 2000, 196:1-13.
140. Naum OG, Fernanda Rubio M, Golombek DA: Rhythmic variation in gamma-aminobutyric acid(A)-receptor subunit composition in the circadian system and median eminence of Syrian hamsters. Neurosci Lett 2001, 310:178-182.
141. van den Pol AN: Glutamate and GABA presence and action in the suprachiasmatic nucleus. J Biol Rhythms 1993, 8:11-15.
142. A-receptor subunit composition in the circadian timing system. Brain Res 1995, 700:142-156.
143. O'Hara BF, Andretic R, Heller HC, Carter DB, Kilduff TS: GABAA, GABAC, and NMDA receptor subunit expression in the suprachiasmatic nucleus and other brain regions. Brain Res Mol Brain Res 1995, 28:239-250.
144. Gribkoff VK, Pieschl RL, Wisialowski TA, Park WK, Strecker GJ, deJeu MTG, Pennartz CMA, Dudek FE: A re-examination of the role of GABA in the mammalian suprachiasmatic nucleus. J Biol Rhythms 1999, 14:126-130.
145. Gribkoff VK, Pieschl RL, Dudek FE: GABA receptor -mediated inhibition of neuronal activity in rat SCN in vitro: Pharmacology and influence of circadian phase. J Neurophysiol 2003, 90: 1438-1448.
146. Wagner S, Sagiv N, Yarom Y: GABA-induced current and circadian regulation of chloride in neurons of the rat suprachiasmatic nucleus. J Physiol 2001, 537:853-869.
147. A-mediated local synaptic pathways connect neurons in the rat suprachiasmatic nucleus. J Neurophysiol 1997, 78:2217-2220.
148. Wagner S, Castel M, Gainer H, Yaroin Y: GABA in the mammalian suprachiasmatic nucleus and its role in diurnal rhythmicity. Nature 1997, 387:598-603.
149. Han SK, Abraham IM, Herbison AE: Effect of GABA on GnRH neurons switches from depolarization to hyperpolarization at puberty in the female mouse. Endocrinology 2002, 143:1459-1466.
150. 2+ elevating to depressing. J Neurosci 1995, 15:5065-5077.
151. A receptors. Science 1995, 269:977-981.
152. de Jeu M, Pennartz C: Circadian modulation of GABA function in the rat suprachiasmatic nucleus: excitatory effects during the night phase. J Neurophysiol 2002, 87:834-844.
153. Huhman KL, Hennessey AC, Albers HE: Rhythms of glutamic acid decarboxylase mRNA in the suprachiasmatic nucleus. J Biol Rhythms 1996, 11:311-316.
154. Huhman KL, Jasnow AM, Sisitsky AK, Albers HE: Glutamic acid decarboxylase mRNA in the suprachiasmatic nucleus of rats housed in constant darkness. Brain Res 1999, 851:266-269.
155. Itri J, Michel S, Waschek JA, Colwell CS: Circadian rhythm in inhibitory synaptic transmission in the mouse suprachiasmatic nucleus. J Neurophysiol 2004, 92:311-319.
156. Liu C, Reppert SM: GABA synchronizes clock cells within the suprachiasmatic circadian clock. Neuron 2000, 25:123-128.
157. Ohta H, Yamazaki S, McMahon DG: Constant light desynchronizes mammalian clock neurons. Nat Neurosci 2005, 8:267-269.
158. Herzog ED, Aton SJ, Numano R, Sakaki Y, Tei H: Temporal precision in the mammalian circadian system: a reliable clock from less reliable neurons. J Biol Rhythms 2004, 19:35-46.
159. Kawamoto K, Nagano M, Kanda F, Chihara K, Shigyoshi Y, Okamura H: Two types of VIP neuronal components in rat suprachiasmatic nucleus. J Neurosci Res 2003, 74:852-857.
160. Dardente H, Poirel VJ, Klosen P, Pevet P, Masson-Pevet M: Per and neuropeptide expression in the rat suprachiasmatic nuclei: compartmentalization and differential cellular induction by light. Brain Res 2002, 958:261-271.
161. Dardente H, Klosen P, Caldelas I, Pevet P, Masson-Pevet M: Phenotype of Per1 - and Per2-expressing neurons in the suprachiasmatic nucleus of a diurnal rodent (Arvicanthis ansorgei): comparison with a nocturnal species, the rat. Cell Tissue Res 2002, 310:85-92.
162. Moore RY, Speh J, Card JP: Vasoactive intestinal peptide (VIP) and peptide histidine isoleucine (PHI) colocalize in neurons of the rat suprachiasmatic nucleus(SCN)[abstract]. Soc Neuroscir 1985, 11:s1139.
163. Stopa EG, Jonassen JA, Minamitani N, King JC, Wolfe H, Mobtaker H, Albers HE: mRNA of vasoactive intestinal peptide (VIP) and peptide histidineisoleucine (PHI) within the suprachiasmatic nucleus(SCN)[abstract]. Soc Neurosci 1986, 12:s597.
164. Reed HE, Cutler DJ, Brown TM, Brown J, Coen CW, Piggins HD: Effects of vasoactive intestinal peptide on neurons of the rat suprachiasmatic nuclei in vitro. J Neuroendocrinol 2002, 14:639-646.
165. Cutler DJ, Haraura M, Reed HE, Shen S, Sheward WJ, Morrison CF, Marston HMJ, Harmar AJ, Piggins HD: The mouse VPAC2 receptor confers suprachiasmatic nuclei cellular rhythmicity and responsiveness to vasoactive intestinal polypeptide in vitro. Eur J Neurosci 2003, 17:197-204.
166. Dardente H, Menet js, chalet E, Tournier BB, Pevet P, Masson-Pevet M: Daily and circadian expression of neuropeptides in the suprachiasmatic nuclei of nocturnal and diurnal rodents. Brain Res Mol Brain Res 2004, 124:143-151.
167. Takeuchi J, Nagasaki H, Shinohara K, Inouye SIT: A circadian rhythm of somatostatin messenger RNA levels, but not of vasoactive intestinal polypeptide/peptide histidine isoleucine messenger RNA levels in rat suprachiasmatic nucleus. Mol Cell Neurosci 1992, 3:29-35.
168. Shinohara K, Tominaga K, Isobe Y, Inouye ST: Photic regulation of peptides located in the ventrolateral subdivision of the suprachiasmatic nucleus of the rat: daily variations of vasoactive intestinal polypeptide, gastrin-releasing peptide, and neuropeptide Y. J Neurosci 1993, 13:793-800.
169. Ban Y, Shigeyoshi Y, Okamura H: Development of vasoactive intestinal peptide mRNA rhythm in the rat suprachiasmatic nucleus. J Neurosci 1997, 17:3920-3931.
170. Shinohara K, Funabashi T, Mitushima D, Kimura F: Effects of gap junction blocker on vasopressin and vasoactive intestinal polypeptide rhythms in the rat suprachiasmatic nucleus in vitro. Neurosci Res 2000, 38:43-47.
171. Reed HE, Meyer-Spasche A, Cutler DJ, Coen CW, Piggins HD: Vasoactive intestinal polypeptide (VIP) phase- shifts the rat suprachiasmatic nucleus clock in vitro. Eur J Neurosci 2001, 13:839-843.
172. Nielsen HS, Hannibal J, Fahrenkrug J: Vasoactive intestinal polypeptide induces per1 and per2 gene expression in the rat suprachiasmatic nucleus late at night. Eur J Neurosci 2002, 15:570-574.
173. Aton SJ, Colwell CS, Harmar AJ, Waschek J, Herzog ED: Vasoactive intestinal polypeptide mediates circadian rhythmicity and synchrony in mammalian clock neurons. Nat Neurosci 2005, 8:476-483.
174. Castel M, Feinstein N, Cohen S, Harari N: Vasopressinergic innervation of the mouse suprachiasmatic nucleus: An immunoelectron microscopic analysis. J Comp Neurol 1990, 298:172-187.
175. Van den Pol AN, Gorcs T: Synaptic relationship between neurons containing vasopressin, gastrin releasing peptide, vasoactive intestinal peptide and glutamate decarboxylase immunoreactivity in the suprachiasmatic nucleus: Dual ultrastructural immunocytochemistry with gold-substituted silver peroxidase. J Comp Neurol 1986, 252:507-521.
176. Ingram CD, Snowball RK, Mihai R: Circadian rhythm of neuronal activity in suprachiasmatic nucleus slices from the vasopressin-deficient Brattleboro rat. Neuroscience 1996, 75:635-641.
177. Ingram CD, Ciobanu R, Coculescu IL, Tanasescu R, Coculescu M, Mihai R: Vasopressin neurotransmission and the control of circadian rhythms in the suprachiasmatic nucleus. Prog Brain Res 1998, 119:351-364.
178. Mihai R, Juss TS, Ingram CD: Suppression of suprachiasmatic nucleus neuron activity with a vasopressin receptor antagonist: possible role for endogenous vasopressin in circadian activity cycles in vitro. Neurosci Lett 1994, 179:95-99.
179. Mihai R, Coculescu M, Wakerley JB, Ingram CD: The effects of [Arg8] vasopressin and [Arg8] vasotocin on the firing rate of suprachiasmatic neurons in vitro. Neuroscience 1994, 62:783-792.
180. Albers HE, Ferris CF, Leeman SE, Goldman BD: Avian pancreatic polypeptide phase shifts hamster circadian rhythms when microinjected into the suprachiasmatic region. Science 1984, 223:833-835.
181. Reghunandanan V, Badgaiyan RD, Marya RK, Maini BK: Suprachiasmatic injection of a vasopressin antagonist modifies the circadian rhythm of food intake. Behav Neural Biol 1987, 48:344-351.
182. Reghunandanan V, Reghunandanan R, Marya RK, Singh PI: Vasopressin antagonist disrupts the circadian rhythm of water intake on suprachiasmatic injection. Chronobiol Int. 1992, 9:356-361.
183. Decoursey PJ, Buggy J: Restoration of locomotor activity in SCN-lesioned golden hamsters by transplantation of fetal SCN. [abstract]. Neurosci 1986, 12:210.
184. Lehman MN, Silver R, Gladstone WR, Kahn RM, Gibso M, Bittman EL: Circadian rhythmicity restored by neural transplant. Immunocytochemical characterization of the graft and its integration with the host brain. J Neurosci 1987, 7:1626-1638.
185. Stoynev AG, Nagai K: Lack of effect of suprachiasmatic infusion of a vasopressin antagonist on the circadian rhythm of wheel-running activity in rats. Acta Physiol Pharmacol Bulg 1996, 22:39-43.
186. Boer GJ, van Esseveldt KE, van der Geest BAM, Duindam H, Rietveld WJ: Vasopressin-deficient suprachiasmatic nucleus grafts reinstate circadian rhythmicity in suprachiasmatic nucleus-lesioned arrhythmic rats. Neuroscience 1999, 89:375-385.
187. Zhou JN, Riemersma RF, Unmehopa UA, Hoogendijk WJ, van Heerikhuize JJ, Hofman MA, Swaab DF: Alterations in arginine vasopressin neurons in the suprachiasmatic nucleus in depression. Arch Gen Psychiatry 2001, 58:655-662.
188. Arima H, House SB, Gainer H, Aguilera G: Neuronal activity is required for the circadian rhythm of vasopressin gene transcription in the suprachiasmatic nucleus in vitro. Endocrinology 2002, 143:4165-4171.
189. Hofman MA, Swaab DF: Alterations in circadian rhythmicity of the vasopressin-producing neurons of the human suprachiasmatic nucleus (SCN) with aging. Brain Res 1994, 651:134-142.
190. Hofman MA, Swaab DF: Influence of aging on the seasonal rhythm of the vasopressin-expressing neurons in the human suprachiasmatic nucleus. Neurobiol Aging 1995, 16:965-971.
191. Lucassen PJ, Hofman MA, Swabb DF: Increased light intensity prevents the age related loss of vasopressin-expressing neurons in the rat suprachiasmatic nucleus. Brain Res 1995, 693:261-266.
192. Hochstetler KJ, Garland T Jr, Swallow JG, Carter PA, Bult-Ito A: Number of arginine-vasopressin neurons in the suprachiasmatic nuclei is not related to level or circadian characteristics of wheel-running activity in house mice. Behav Genet 2004, 34:131-136.
193. Kalamatianos T, Kallo I, Coen CW: Ageing and the diurnal expression of the mRNAs for vasopressin and for the VIa and VIb vasopressin receptors in the suprachiasmatic nucleus of male rats. J Neuroendocrinol 2004, 16:493-501.
194. Biemans BAM, Van der Zee EA, Gerkema MP, Bult A, Daan S: A double role for vasopressin in the SCN? In Chronobiology Gordon Research Conference Salve Regina University, Newport, Rode Island. 5-10, August 2001
195. Groblewski TA, Nunez AA, Gold RM: Circadian rhythms in vasopressin deficient rats. Brain Res Bull 1981, 6:125-130.
196. Stoinev AG, Ikonomov OK: Effect of continuous infusion of vasopressin on circadian rhythms of food and water intake, diuresis and electrolyte excretion in Brattleboro rats. Bull Exp Biol Med 1990, 09:122-124.
197. Castel M, Morris J, Belenky M: Non-synaptic and dendritic exocytosis from dense-cored vesicles in the suprachiasmatic nucleus. NeuroReport 1996, 7:543-547.
198. Isobe Y, Nishino, H: AVP rhythm in the suprachiasmatic nucleus in relation to locomotor activity under constant light. Peptides 1998, 9:827-832.
199. Van der Zee EA, Oklejewicz M, Jansen K, Daan S, Gerkema MP: Vasopressin immunoreactivity and release in the suprachiasmatic nucleus of wild-type and tau mutant Syrian hamsters. Brain Res 2002, 936:38-46.
200. Reppert SM, Weaver DR, Rivkees SA, Stopa EG: Putative melatonin receptors in a human biological clock. Science 1988, 242:78-83.
201. Van den Top M, Buijs RM, Ruijter JM, Delagrange P, Spanswick D, Hermes ML: Melatonin generates an outward potassium current in rat suprachiasmatic nucleus neurones in vitro independent of their circadian rhythm. Neuroscience 2001, 107:99-108.
202. Watanabe K, Yamaoka S, Vanecek J: Melatonin inhibits spontaneous and VIP-induced vasopressin release from suprachiasmatic neurons. Brain Res 1998, 801:216-219.
203. Dollins AB, Zhdanova IV, Wurtman RJ, Lynch HJ, Deng MH: Effect of inducing nocturnal serum melatonin concentrations in daytime on sleep, mood, body temperature, and performance. Proc Natl Acad Sci USA 1994, 91:1824-1828.
204. Lockley SW, Skene DJ, James K, Thapan K, Wright J, Arendt J: Melatonin administration can entrain the free-running circadian system of blind subjects. J Endocrinol 2000, 164:R1-R6.
205. Sack RL, Brandes RW, Kendall AR, Lewy AJ: Entrainment of free-running circadian rhythms by melatonin in blind people. N Engl J Med 2000, 343:1070-1077.
206. Mishima K, Okawa M, Hozumi S, Hishikawa Y: Supplementary administration of artificial bright light and melatonin as potent treatment for disorganized circadian rest-activity and dysfunctional autonomic and neuroendocrine systems in institutionalized demented elderly persons. Chronobiol Int 2000, 17:419-432.
207. Sack RL, Lewy AJ: Melatonin as a chronobiotic, treatment of circadian desynchrony in night workers and the blind. J Biol Rhythms 1997, 12:595-603.
208. Revell VL, Burgess HJ, Gazda CJ, Smith MR, Fogg LF, Eastman CL: Advancing human circadian rhythms with afternoonmelatonin and morning intermittent bright light. J Clin Endocrinol Metab in press.
209. Wehr TA: Melatonin and seasonal rhythms. J Biol Rhythms 1997, 12:518-527.
210. Pévet P: Melatonin: From Seasonal to Circadian Signal. J Néuroendocrinol 2003, 15:422-426.
211. Lincoln GA, Andersson H, Loudon A: Clock genes in calendar cells as the basis of annual timekeeping in mammals - a unifying hypothesis. J Endocrinol 2003, 179:1-13.
212. Kalsbeek A, Teclemariam-Mesbah R, Pevet P: Efferent projections of the suprachiasmatic nucleus in the golden hamster (Mesocricetus auratus). J Comp Neurol 1993, 332:293-314.
213. Saper CB, Lu J, Chou TC, Gooley J: The hypothalamic integrator for circadian rhythms. Trends Neurosci 2005, 28:152-157.
214. Deurveilher S, Semba K: Indirect projections from the suprachiasmatic nucleus to the median preoptic nucleus in rat. Brain Res 2003, 987:100-106.
215. Gooley JJ, Lu J, Fischer D, Saper CB: A broad role for melanopsin in nonvisual photoreception. J Neurosci 2003, 23:7093-7106.
216. Deurveilher S, Burns J, Semba K: Indirect projections from the suprachiasmatic nucleus to the ventrolateral preoptic nucleus: a dual tract-tracing study in rat. Eur J Neurosci 2002, 16:1195-1213.
217. Watts AG: The efferent projections of the suprachiasmatic nucleus: anatomical insights into the control of circadian rhythms. In Suprachiasmatic nucleus: the mind's clock Edited by: Klein DC, Moore RY Reppert SM. New York, Oxford Univ Press; 1991:77-106.
218. Masubuchi S, Honma S, Abe H, Ishizaki K, Namihira M, Ikeda M, Honma K: Clock genes outside the suprachiasmatic nucleus involved in manifestation of locomotor activity rhythm in rats. Eur J Neurosci 2000, 12:4206-4214.
219. Balsalobre A, Damiola F, Schibler U: A serum shock induces circadian gene expression in mammalian tissue culture cells. Cell 1998, 93:929-937.
220. Allen G, Rappe J, Earnest DJ, Cassone VM: Oscillating on borrowed time: diffusible signals from immortalized suprachiasmatic nucleus cells regulate circadian rhythmicity in cultured fibroblasts. J Neurosci 2001, 21:7937-7943.
221. Oishi K, Sakamoto K, Okada T, Nagase T, Ishida N: Humoral signals mediate the circadian expression of rat period homologue (rPer2) mRNA in peripheral tissues. Neurosci Lett 1998, 256:117-119.
222. Kramer A, Yang FC, Snodgrass P, Li X, Scammell TE, Davis FC, Weitz CJ: Regulation of daily locomotor activity and sleep by hypothalamic EGF receptor signaling. Science 2001, 294:2511-2515.
223. Junier MP: What role(s) for TGFα in the central nervous system? Prog Neurobiol 2000, 62:443-473.
224. Ma YJ, Junier MP, Costa ME, Ojeda SR: Transforming growth factor-alpha gene expression in the hypothalamus is developmentally regulated and linked to sexual maturation. Neuron 1992, 9:657-670.
225. Seroogy KB, Lundgren KH, Lee DC, Guthrie KM, Gall CM: Cellular localization of transforming growth factor-alpha mRNA in rat forebrain. J Neurochem 1993, 60:1777-1782.
226. Jobst EE, Robinson DW, Allen CN: Potential pathways for intercellular communication within the calbindin subnucleus of the hamster suprachiasmatic nucleus. Neuroscience 2004, 123:87-99.
227. Li X, Sankrithi N, Davis FC: Transforming growth factor-alpha is expressed in astrocytes of the suprachiasmatic nucleus in hamster: role of glial cells in circadian clocks. Neuroreport 2002, 13:2143-2147.
228. Van der Zee EA, Roman V, Ten Brinke O, Meerlo P: TGFα and AVP in the mouse suprachiasmatic nucleus: Anatomical relationship and daily profiles. Brain Research 2005, 1054:159-166.
229. Leak RK, Card JP, Moore RY: Suprachiasmatic pacemaker organization analyzed by viral transynaptic transport. Brain Res 1999, 819:23-32.
230. Kalsbeek A, Fliers E, Franke AN, Wortel J, Buijs RM: Functional connections between the suprachiasmatic nucleus and the thyroid gland as revealed by lesioning and viral tracing techniques in the rat. Endocrinology 2000, 141:3832-3841.
231. la Fleur SE, Kalsbeek A, Wortel J, Buijs RM: Polysynaptic neural pathways between the hypothalamus, including the suprachiasmatic nucleus, and the liver. Brain Res 2000, 871:50-56.
232. De la Iglesia HO, Meyer J, Schwartz WJ: Lateralization of circadian pacemaker output: Activation of left- and right-sided luteinizing hormone-releasing hormone neurons involves a neural rather than a humoral pathway. J Neurosci 2003, 23:7412-7414.
233. Ralph MR, Lehman MN: Transplantation: a new tool in the analysis of the mammalian hypothalamic circadian pacemaker. Trends Neurosci 1991, 14:362-366.
234. Silver R, LeSauter J: Efferent signals of the suprachiasmatic nucleus. J Biol Rhythms 1993, 8:89-92.
235. Silver R, Lehman MN, Gibson M, Gladstone WR, Bittman EL: Dispersed cell suspensions of fetal SCN restore circadian rhythmicity in SCN-lesioned adult hamsters. Bruin Res 1990, 525:45-58.
236. Cheng MY, Bullock CM, Li C, Lee AG, Bermak JC, Belluzzi J, Weaver DR, Leslie FM, Zhou QY: Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus. Nature 2002, 417:405-410.
237. Tanaka M, Okamura H, Matsuda T, Shigeyoshi Y, Hisa Y, Chihara K, Ibata Y: Somatostatin neurons form a distinct peptidergic neuronal group in the rat suprachiasmatic nucleus: a double labeling in situ hybridization study. Neurosci Lett 1996, 215:119-122.
238. Shigeyoshi Y, Maebayashi Y, Okamura H: Co-localization of pre-prosomatostatin mRNA and preprotachykinin A mRNA in neurons of the rat suprachiasmatic nucleus. Brain Res Mol Brain Res 1997, 48:159-163.
239. Daikoku S, Hisano S, Kagotani Y: Neuronal associations in the rat suprachiasmatic nucleus demonstrated by immunoelectron microscopy. J Comp Neurol 1992, 325:559-571.
240. Biemans BA, Gerkema MP, Van der Zee EA: Increase in somatostatin immunoreactivity in the suprachiasmatic nucleus of aged Wistar rats. Brain Res 2002, 958:463-467.
241. Duncan MJ, Herron JM, Hill SA: Aging selectively suppresses vasoactive intestinal peptide messenger RNA expression in the suprachiasmatic nucleus of the Syrian hamster. Brain Res Mol Brain Res 2001, 87:196-203.
242. Fukuhara C, Hamada T, Shibata S, Watanabe S, Aoki K, Inouye SI: Phase advances of circadian rhythms in somatostatin depleted rats: effects of cysteamine on rhythms of locomotor activity and electrical discharge of the suprachiasmatic nucleus. J Comp Physiol [A] 1994, 175:677-685.
243. Shibata S, Tsuneyoshi A, Hamada T, Tominaga K, Watanabe S: Effect of substance P on circadian rhythms of firing activity and the 2-deoxyglucose uptake in the rat suprachiasmatic nucleus in vitro. Brain Res 1992, 597:257-263.
244. Fukuhara C, Nishiwaki T, Cagampang FR, Inouye ST: Emergence of VIP rhythmicity following somatostatin depletion in the rat suprachiasmatic nucleus. Brain Res 1994, 645:343-346.
245. Silver R, Romero MT, Besmer HR, Leak R, Nunez JM: Calbindin-D28K cells in the hamster SCN express light-induced Fos. Neuroreport 1996, 7:1224-1228.
246. Bryant DN, Le Sauter J, Silver R, Romero MT: Retinal innervation of calbindin-D28K cells in the hamster suprachiasmatic nucleus: ultrastructural characterization. J Biol Rhythms 2000, 15:103-111.
247. LeSauter J, Leak RK, Silver R, Moore RY: Hamster suprachiasmatic nucleus: chemoarchitecture and topography of projections. Soc Neurosci Abst 1999, 25:s552.
248. LeSauter J, Kriegsfels LJ, Hon J, Silver R: Calbindin-D(28 K) cells selectively contact intra-SCN neurons. Neuroscience 2002, 111:575-585.
249. Hamada T, LeSauter J, Lokshin M, Romero MT, Yan L, Venuti JM, Silver R: Calbindin influences response to photic input in suprachiasmatic nucleus. J Neurosci 2003, 23:8820-8826.
250. O Ikeda M, Allen CN: Developmental changes in calbindin-D28k and calretinin expression in the mouse suprachiasmatic nucleus. Eur J Neurosci 2003, 17:1111-1118.
251. Tatemoto K, Rokaeus A, Jornvall H, McDonald TJ, Mutt V: Galanin - a novel biologically active peptide from porcine intestine. FEBS Lett 1983, 164:124-128.
252. Skolitsch G, Jacobowitz DM: Immunohistochemical mapping of galanin-like neurons in the rat central nervous system. Peptides 1985, 6:509-546.
253. Gai WP, Geffen LB, Blessing WW: Galanin immunoreactive neurons in the human hypothalamus: colocalization with vasopressin-containing neurons. J Comp Neurol 1990, 298:265-280.
254. Mitchell V, Bouret S, Howard AD, Beauvillain JC: Expression of the galanin receptor subtype Gal-R2 mRNA in the rat hypothalamus. J Chem Neuroanat 1999, 16:265-277.
255. Lind RW, Swanson LW, Ganten D: Organization of angiotensin II immunoreactive cells and fibers in the rat central nervous system. An immunohistochemical study. Neuroendocrinology 1985, 40:2-24.
256. Thomas MA, Fleissner G, Stohr M, Hauptfleisch S, Lemmer B: Localization of components of the renin-angiotensin system in the suprachiasmatic nucleus of normotensive Sprague-Dawley rats: part A. angiotensin I/II, a light and electron microscopic study. Brain Res 2004, 1008:212-223.
257. Thomas MA, Fleissner G, Stohr M, Hauptfleisch S, Lemmer B: Localization of components of the renin-angiotensin system in the suprachiasmatic nucleus of normotensive Sprague-Dawley rats: part B. anglotensin II (ATI)-receptors, a light and electron microscopic study. Brain Res 2004, 1008:224-235.
258. Takatsuji K, Tohyama M: Geniculo-geniculate projection of enkephalin and neuropeptide Y containing neurons in the intergeniculate leaflet of the thalamus in the rat. J Chem Neuroanat 1989, 2:19-27.
259. Ostrowski NL, Hill JM, Pert CB, Pert A: Autoradiographic visualization of sex differences in the pattern and density of opiate receptors in hamster hypothalamus. Brain Res 1987, 421:1-13.
260. Tubbiola ML, Nock B, Bittman EL: Photoperiodic changes in opiate binding and their functional implications in golden hamsters. Brain Res 1989, 503:91-99.
261. Cutler DJ, Mundey MK, Mason R: Electrophysiological effects of opioid receptor activation on Syrian hamster suprachiasmatic nucleus neurones in vitro. Brain Res Bull 1999, 50:119-125.
262. Reghunandanan V, Marya RK, Maini BK, Reghunandanan R: Bilateral suprachiasmatic injection of naloxone disrupts circadian rhythm of food intake. Indian J Exp Biol 1988, 26:954-956.
263. Reghunandanan V, Reghunandanan R, Singh PI: Effect of naloxone injection into the suprachiasmatic nuclei on the circadian rhythm of water intake. J Parasitol Appl Biol 1992, 1:33.
264. Cheng MY, Bittman EL, Hattar S, Zhou QY: Regulation of prokineticin 2 expression by light and the circadian clock. BMC Neurosci 2005, 6:17.
265. Lambert CM, Machida KK, Smale L, Nunez AA, Weaver DR: Analysis of the prokineticin 2 system in a diurnal rodent, the unstriped Nile grass rat (Arvicanthis niloticus). J Biol Rhythms 2005, 20:206-18.
266. Schwartz WJ, Busis NA, Hedley-Whyte ET: A discrete lesion of ventral hypothalamus and optic chiasm that disturbed the daily temperature rhythm. J Neurol 1986, 233:1-4.
267. Cohen RA, Albers HE: Disruption of human circadian and cognitive regulation following a discrete hypothalamic lesion: A case study. Neurology 1991, 41:726-729.
268. Scheer FA, Kalsbeek A, Buijs RM: Cardiovascular control by the suprachiasmatic nucleus: neural and neuroendocrine mechanisms in human and rat. Biol Chem 2003, 384:697-709.
269. Bell-Pedersen D, Cassone VM, Earnest DJ, Golden SS, Hardin PE, Thomas TL, Zoran MJ: Circadian rhythms from multiple oscillators: lessons from diverse organisms. Nat Rev Genet 2005, 6:544-556.
270. Fu L, Pelicano H, Liu J, Huang P, Lee C: The Circadian Gene Period2 plays an important role in tumor suppression and DNA damage response in vivo. Cell 2002, 111:41-50.
271. Matsuo T, Yamaguchi S, Mitsui S, Emi A, Shimoda F, Okamura H: Control mechanism of the circadian clock for timing of cell division in vivo. Science 2003, 302:255-259.
272. Green CB: Time for chronotherapy? Clock genes dictate sensitivity to cyclophosphamide. Proc Nat Acad Sci USA 2005, 102:3529-3530.
273. Von Schantz M, Archer SN: Clocks, genes and sleep. J R Soc Med 2003, 96:486-489.
274. Kornhauser JM, Mayo KE, Takahashi JS: Light, immediate-early genes, and circadian rhythms. Behav Genet 1996, 26:221-240.
275. Field MD, Maywood ES, O'Brien JA, Weaver DR, Reppert SM, Hastings MH: Analysis of clock proteins in mouse SCN demonstrates phylogenetic divergence of the circadian clockwork and resetting mechanisms. Neuron 2000, 25:437-447.
276. Akiyama M, Kouzu Y, Takahashi S, Wakamatsu H, Moriya T, Maetani M, Watanabe S, Tei H, Sakaki Y, Shibata S: Inhibition of light- or glutamate-induced mPer1 expression represses the phase shifts into the mouse circadian locomotor and suprachiasmatic firing rhythms. J Neurosci 1999, 19:1115-1121.
277. Yan L, Takekida S, Shigeyoshi Y, Okamura H: Per1 and Per2 gene expression in the rat suprachiasmatic nucleus: circadian profile and the compartment-specific response to light. Neuroscience 1999, 94:141-150.
278. Pickering TG: The clinical significance of diurnal blood pressure variations. Dippers and nondippers. Circulation 1990, 81:700-702.
279. Yamamoto M, Yamasaki Y, Kodama M, Matsuhisa M, Kishimoto M, Ozaki H, Tani A, Ueda N, Iwasaki M, Hori M: Impaired diurnal cardiac autonomic function in subjects with type 2 diabetes. Diabetes Care 1999, 2:2072-2077.
280. Goncharuk VD, Van Heerikhuize J, Swaab DF, Buijs RM: Paraventricular nucleus of the human hypothalamus in primary hypertension: activation of corticotropin-releasing hormone neurons. J Comp Neurol 2002, 443:321-331.
281. Goncharuk VD, van Heerikhuize J, Dai JP, Swaab DF, Buijs RM: Neuropeptide changes in the suprachiasmatic nucleus in primary hypertension indicate functional impairment of the biological clock. J Comp Neurol 2001, 31:320-330.
282. Borghi C, Costa FV, Boschi S, Mussi A, Ambrosioni E: Predictors of stable hypertension in young borderline subjects: a five-year follow-up study. J Cordiovasc Pharmacol 1986, 8(Suppl 5):s138-41.
283. Eilam R, Malach R, Bergmann F, Segal M: Hypertension induced by hypothalamic transplantation from genetically hypertensive to normotensive rats. J Neurosci 1991, 11:401-411.