Identification of neuromedin S and its possible role in the mammalian circadian oscillator system

EMBO Journal

Volumn 24, Issue 2, 2005, Pages 325-335

  Mori, Kenji ^a   Miyazato, Mikiya ^a   Ida, Takanori ^b   Murakami, Noboru ^b   Serino, Ryota ^c   Ueta, Yoichi ^c   Kojima, Masayasu ^d   Kangawa, Kenji ^a  

^a NATIONAL CEREBRAL AND CARDIOVASCULAR CENTER   (Japan)

^b UNIVERSITY OF MIYAZAKI   (Japan)

^c UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

^d KURUME UNIVERSITY   (Japan)

Author keywords

Circadian rhythm; Endogenous ligand; Neuropeptide; Orphan G protein coupled receptor; Suprachiasmatic nucleus

Indexed keywords

G PROTEIN COUPLED RECEPTOR; MESSENGER RNA; NEUROMEDIN S; NEUROMEDIN U RECEPTOR; NEUROPEPTIDE; PROTEIN C FOS; PROTEIN PRECURSOR; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; AUTOCRINE EFFECT; CENTRAL NERVOUS SYSTEM; CHO CELL; CIRCADIAN RHYTHM; CONTROLLED STUDY; EXPRESSED SEQUENCE TAG; HISTOCHEMISTRY; HUMAN; HYPOTHALAMUS; IN SITU HYBRIDIZATION; LIGHT DARK CYCLE; LOCOMOTION; MALE; MAMMAL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSCILLATION; PARACRINE SIGNALING; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPLEEN; SUPRACHIASMATIC NUCLEUS; TESTIS;

AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CIRCADIAN RHYTHM; DNA PRIMERS; HUMANS; IN SITU HYBRIDIZATION; INJECTIONS, INTRAVENTRICULAR; MICE; MOLECULAR SEQUENCE DATA; MOTOR ACTIVITY; NEUROPEPTIDES; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE HOMOLOGY, AMINO ACID; SUPRACHIASMATIC NUCLEUS;

ANIMALIA; MAMMALIA;

EID: 13444303901     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.emboj.7600526     Document Type: Article

References (52)

1. Barsh GS, Farooqi IS, O'Rahilly S (2000) Genetics of body-weight regulation. Nature 404: 644-651
2. Brown DR, Quito FL (1988) Neuromedin U octapeptide alters ion transport in porcine jejunum. Eur J Pharmacol 155: 159-162
3. Castel M, Belenky M, Cohen S, Wagner S, Schwartz WJ (1997) Light-induced c-Fos expression in the mouse suprachiasmatic nucleus: immunoelectron microscopy reveals co-localization in multiple cell types. Eur J Neurosci 9: 1950-1960
4. Cheng MY, Bullock CM, Li C, Lee AG, Bermak JC, Belluzzi J, Weaver DR, Leslie FM, Zhou QY (2002) Prokineticin 2 transmits the behavioural arcadian rhythm of the suprachiasmatic nucleus. Nature 417: 405-410
5. Chu C, Jin Q, Kunitake T, Kato K, Nabekura T, Nakazato M, Kangawa K, Kannan H (2002) Cardiovascular actions of central neuromedin U in conscious rats. Regul Peptides 105: 29-34
6. Civelli O, Nothacker HP, Saito Y, Wang Z, Lin SH, Reinscheid RK (2001) Novel neurotransmitters as natural ligands of orphan G-protein-coupled receptors. Trends Neurosci 24: 230-237
7. Colwell CS, Michel S, Itri J, Rodriguez W, Tam J, Lelievre V, Hu Z, Liu X, Waschek JA (2003) Disrupted circadian rhythms in VIP- and PHI-deficient mice. Am J Physiol Regul Integr Comp Physiol 285: R939-R949
8. Date Y, Ueta Y, Yamashita H, Yamaguchi H, Matsukura S, Kangawa K, Sakurai T, Yanagisawa M, Nakazato M (1999) Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems. Proc Natl Acad Sci USA 96: 748-753
9. Edelstein K, Amir S (1995) Non-photic manipulations induce expression of Fos protein in the suprachiasmatic nucleus and intergeniculate leaflet in the rat. Brain Res 690: 254-258
10. Fujii R, Hosoya M, Fukusumi S, Kawamata Y, Habata Y, Hinuma S, Onda H, Nishimura O, Fujino M (2000) Identification of neuromedin U as the cognate ligand of the orphan G protein-coupled receptor FM-3. J Biol Chem 275: 21068-21074
11. Gardiner SM, Compton AM, Bennett T, Domin J, Bloom SR (1990) Regional hemodynamic effects of neuromedin U in conscious rats. Am J Physiol 258: R32-R38
12. Ginty DD, Kornhauser JM, Thompson MA, Bading H, Mayo KE, Takahashi JS, Greenberg ME (1993) Regulation of CREB phosphorylation in the suprachiasmatic nucleus by light and a circadian clock. Science 260: 238-241
13. Gonzalez GA, Montminy MR (1989) Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133. Cell 59: 675-680
14. Gottschall PE, Tatsuno I, Miyata A, Arimura A (1990) Characterization and distribution of binding sites for the hypothalamic peptide, pituitary adenylate cyclase-activating polypeptide. Endocrinology 127: 272-277
15. Graham ES, Turnbull Y, Fotheringham P, Nilaweera K, Mercer JG, Morgan PJ, Barrett P (2003) Neuromedin U and neuromedin U receptor-2 expression in the mouse and rat hypothalamus: effects of nutritional status. J Neurochem 87: 1165-1173
16. Hamada T, LeSauter J, Venuti JM, Silver R (2001) Expression of period genes: rhythmic and nonrhythmic compartments of the suprachiasmatic nucleus pacemaker. J Neurosci 21: 7742-7750
17. Hanada R, Date Y, Shimbara T, Sakihara S, Murakami N, Hayashi Y, Kanai Y, Suda T, Kangawa K, Nakazato M (2003) Central action of neuromedin U via corticotropin-releasing hormone. Biochem Biophys Res Commun 311: 954-958
18. Hanada R, Nakazato M, Murakami N, Sakihara S, Yoshimatsu H, Toshinai K, Hanada T, Suda T, Kangawa K, Matsukura S (2001) A role for neuromedin U in stress response. Biochem Biophys Res Commun 289: 225-228
19. Hanada R, Teranishi H, Pearson JT, Kurokawa M, Hosoda H, Fukushima N, Fukue Y, Serino R, Fujihara H, Ueta Y, Ikawa M, Okabe M, Murakami N, Shirai M, Yoshimatsu H, Kangawa K, Kojima M (2004) Neuromedin U has a novel anorexigenic effect independent of the leptin signaling pathway. Nat Med 10: 1067-1073
20. Hannibal J (2002) Neurotransmitters of the retino-hypothalamic tract. Cell Tissue Res 309: 73-88
21. 2 receptor is essential for circadian function in the mouse suprachiasmatic nuclei. Cell 109: 497-508
22. Harrington ME (1997) The ventral lateral geniculate nucleus and the intergeniculate leaflet: interrelated structures in the visual and circadian systems. Neurosci Biobehav Rev 21: 705-727
23. Hedrick JA, Morse K, Shan L, Qiao X, Pang L, Wang S, Laz T, Gustafson EL, Bayne M, Monsma Jr FJ (2000) Identification of a human gastrointestinal tract and immune system receptor for the peptide neuromedin U. Mol Pharmacol 58: 870-875
24. Honzawa M, Sudoh T, Minamino N, Kangawa K, Matsuo H (1990) Neuromedin U-like immunoreactivity in rat intestine: regional distribution and immunohistochemical study. Neuropeptides 15: 1-9
25. Hosoya M, Moriya T, Kawamata Y, Ohkubo S, Fujii R, Matsui H, Shintani Y, Fukusumi S, Habata Y, Hinuma S, Onda H, Nishimura O, Fujino M (2000) Identification and functional characterization of a novel subtype of neuromedin U receptor. J Biol Chem 275: 29528-29532
26. Howard AD, Wang R, Pong SS, Mellin TN, Strack A, Guan XM, Zeng Z, Williams Jr DL, Feighner SD, Nunes CN, Murphy B, Stair JN, Yu H, Jiang Q, Clements MK, Tan CP, Mckee KK, Hreniuk DL, McDonald TP, Lynch KR, Evans JF, Austin CP, Caskey CT, Van der Ploeg LHT, Liu Q (2000) Identification of receptors for neuromedin U and its role in feeding. Nature 406: 70-74
27. Ida T, Nakahara K, Katayama T, Murakami N, Nakazato M (1999) Effect of lateral cerebroventricular injection of the appetite-stimulating neuropeptide, orexin and neuropeptide Y, on the various behavioural activities of rats. Brain Res 821: 526-529
28. Kojima M, Haruno R, Nakazato M, Date Y, Murakami N, Hanada R, Matsuo H, Kangawa K (2000) Purification and identification of neuromedin U as an endogenous ligand for an orphan receptor GPR66 (FM3). Biochem Biophys Res Commun 276: 435-438
29. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K (1999) Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 402: 656-660
30. Kramer A, Yang FC, Snodgrass P, Li X, Scammell TE, Davis FC, Weitz CJ (2001) Regulation of daily locomotor activity and sleep by hypothalamic EGF receptor signaling. Science 294: 2511-2515
31. Lo G, Legon S, Austin C, Wallis S, Wang Z, Bloom SR (1992) Characterization of complementary DNA encoding the rat neuromedin U precursor. Mol Endocrinol 6: 1538-1544
32. Lowrey PL, Takahashi JS (2000) Genetics of the mammalian circadian system: photic entrainment, circadian pacemaker mechanisms, and posttranslational regulation. Annu Rev Genet 34: 533-562
33. McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM (1998) RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor. Nature 393: 333-339
34. Minamino N, Kangawa K, Matsuo H (1985) Neuromedin U-8 and U-25: novel uterus stimulating and hypertensive peptides identified in porcine spinal cord. Biochem Biophys Res Commun 130: 1078-1085
35. Moore RY, Speh JC, Leak RK (2002) Suprachiasmatic nucleus organization. Cell Tissue Res 309: 89-98
36. Mrosovsky N (1996) Locomotor activity and non-photic influences on circadian clocks. Biol Rev 71: 343-372
37. Murakami N, Takahashi K (1983) Circadian rhythm of adenosine-3′, 5′-monophosphate content in suprachiasmatic nucleus (SCN) and ventromedial hypothalamus (VMH) in the rat. Brain Res 276: 297-304
38. Nakahara K, Hanada R, Murakami N, Teranishi H, Ohgusu H, Fukushima N, Moriyama M, Ida T, Kangawa K, Kojima M (2004) The gut-brain peptide neuromedin U is involved in the mammalian circadian oscillator system. Biochem Biophys Res Commun 318: 156-161
39. Nakazato M, Hanada R, Murakami N, Date Y, Mondal MS, Kojima M, Yoshimatsu H, Kangawa K, Matsukura S (2000) Central effects of neuromedin U in the regulation of energy homeostasis. Biochem Biophys Res Commun 277: 191-194
40. Ozaki Y, Onaka T, Nakazato M, Saito J, Kanemoto K, Matsumoto T, Ueta Y (2002) Centrally administered neuromedin U activates neurosecretion and induction of c-fos messenger ribonucleic acid in the paraventricular and supraoptic nuclei of rat. Endocrinology 143: 4320-4329
41. Piggins HD, Cutler DJ (2003) The roles of vasoactive intestinal polypeptide in the mammalian circadian clock. J Endocrinol 177: 7-15
42. Raddatz R, Wilson AE, Artymyshyn R, Bonini JA, Borowsky B, Boteju LW, Zhou S, Kouranova EV, Nagorny R, Guevarra MS, Dai M, Lerman GS, Vaysse PJ, Branchek TA, Gerald C, Forray C, Adham N (2000) Identification and characterization of two neuromedin U receptors differentially expressed in peripheral tissues and the central nervous system. J Biol Chem 275: 32452-32459
43. Reppert SM, Weaver DR (2001) Molecular analysis of mammalian circadian rhythms. Annu Rev Physiol 63: 647-676
44. Reppert SM, Weaver DR (2002) Coordination of circadian timing in mammals. Nature 418: 935-941
45. Rouille Y, Duguay SJ, Lund K, Furuta M, Gong Q, Lipkind G, Oliva Jr AA, Chan SJ, Steiner DF (1995) Proteolytic processing mechanisms in the biosynthesis of neuroendocrine peptides: the subtilisin-like proprotein convertases. Front Neuroendocrinol 16: 322-361
46. Schwartz MW, Woods SC, Porte Jr D, Seeley RJ, Baskin DG (2000) Central nervous system control of food intake. Nature 404: 661-671
47. Sumi S, Inoue K, Kogire M, Doi R, Takaori K, Suzuki T, Yajima H, Tobe T (1987) Effect of synthetic neuromedin U-8 and U-25, novel peptides identified in porcine spinal cord, on splanchnic circulation in dogs. Life Sci 41: 1585-1590
48. Turek FW Van Reeth O (1988) Altering the mammalian circadian clock with the short-acting benzodiazepine, triazolam. Trends Neurosci 11: 535-541
49. Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA (2003) The G protein-coupled receptor repertories of human and mouse. Proc Natl Acad Sci USA 100: 4903-4908
50. von Heijne G (1986) A new method for predicting signal sequence cleavage site. Nucleic Acids Res 14: 4683-4690
51. Wren AM, Small CJ, Abbott CR, Jethwa PH, Kennedy AR, Murphy KG, Stanley SA, Zollner AN, Ghatei MA, Bloom SR (2002) Hypothalamic actions of neuromedin U. Endocrinology 143: 4227-4234
52. Zhang Y, Van Reeth O, Zee PC, Takahashi JS, Turek FW (1993) Fos protein expression in the circadian clock is not associated with phase shifts induced by a nonphotic stimulus, triazolam. Neurosci Lett 164: 203-208