Light, immediate-early genes, and circadian rhythms

Behavior Genetics

Volumn 26, Issue 3, 1996, Pages 221-240

  Kornhauser, Jon M ^a   Mayo, Kelly E ^a   Takahashi, Joseph S ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

circadian rhythms; CREB; cyclic AMP response element; Fos; immediate early gene; Suprachiasmatic nucleus

Indexed keywords

CIRCADIAN RHYTHM; GENE INDUCTION; MAMMAL; NONHUMAN; ONCOGENE C FOS; PHOTOSTIMULATION; REVIEW; SUPRACHIASMATIC NUCLEUS;

ANIMALS; CIRCADIAN RHYTHM; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; GENES, IMMEDIATE-EARLY; HUMANS; LIGHT; MOLECULAR BIOLOGY; NEURONS; PROTO-ONCOGENE PROTEINS C-FOS; SIGNAL TRANSDUCTION; SUPRACHIASMATIC NUCLEUS;

MAMMALIA;

EID: 0030017669     PISSN: 00018244     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02359382     Document Type: Review

References (128)

1. Abe, H., Rusak, B., and Robertson, H. A. (1991). Photic induction of Fos protein in the suprachiasmatic nucleus is inhibited by the NMDA receptor antagonist MK-801. Neurosci. Lett. 127:9-12.
2. Abe, H., Rusak, B., and Robertson, H. A. (1992). NMDA and non-NMDA receptor antagonists inhibit photic induction of Fos protein in the hamster suprachiasmatic nucleus. Brain Res. Bull. 28:831-835.
3. Albers, H. E., Minamitani, N., Stopa, E., and Ferns, C. F. (1987). Light selectively alters vasoactive intestinal peptide and peptide histidine isoleucine immunoreactivity within the rat suprachiasmatic nucleus. Brain Res. 437: 189-192.
4. Albers, H. E., Stopa, E. G., Zoeller, R. T., Kauer, J. S., King, J. C., Fink, J. S., Mobtaker, H., and Wolfe, H. (1990). Day-night variation in prepro vasoactive intestinal peptide/peptide histidine isoleucine mRNA within the rat suprachiasmatic nucleus. Mol. Brain Res. 7:85-89.
5. Albers, H. E., Liou, S. Y., Stopa, E. G., and Zoeller, R. T. (1991). Interaction of colocalized neuropeptides: Functional significance in the circadian timing system. J. Neurosci. 11:846-851.
6. Aronin, N., and Schwartz, W. J. (1991). A new strategy to explore molecular mechanisms of suprachiasmatic nucleus function. In Klein, D. C., Moore, R. Y., and Reppert, S. M. (eds.), Suprachiasmatic Nucleus: The Mind's Clock, Oxford University Press, New York, pp. 445-456.
7. Aronin, N., Sagar, S. M., Sharp, F. R., and Schwartz, W. J. (1990). Light regulates expression of a Fos-related protein in rat suprachiasmatic nuclei. Proc. Natl. Acad. Sci. USA 87:5959-5962.
8. Aronson, B. D., Johnson, K. A., Loros, J. J., and Dunlap, J. C. (1994). Negative feedback defining a circadian clock: Autoregulation of the clock gene frequency. Science 263: 1578-1584.
9. Bading, H., Ginty, D. D., and Greenberg, M. E. (1993). Regulation of gene expression in hippocampal neurons by distinct calcium signaling pathways. Science 260:181-186.
10. Bartel, D. P., Sheng, M., Lau, L. F., and Greenberg, M. E. (1989). Growth factors and membrane depolarization activate distinct programs of early response gene expression: Dissociation of fos and jun induction. Genes Dev. 3:304-313.
11. Bohmann, D., Bos, T. J., Admon, A., Nishimura, T., Vogt, P. K., and Tjian, R. (1987). Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1. Science 238: 1386-1392.
12. Cahill, G. M., and Menaker, M. (1987). Kynurenic acid blocks suprachiasmatic nucleus responses to optic nerve stimulation. Brain Res. 410:125-129.
13. Card, J. P., and Moore, R. Y. (1984). The suprachiasmatic nucleus of the golden hamster: Immunohistochemical analysis of cell and fiber distribution. Neuroscience 13: 415-531.
14. Card, J. P., Brechna, N., Karten, H. J., and Moore, R. Y. (1981). Immunocytochemical localization of vasoactive intestinal polypeptide-containing cells and processes in the suprachiasmatic nucleus of the rat: Light and electron microscopic analysis. J. Neurosci. 1:1289-1303.
15. Cassone, V. M., Speh, J. C., Card, J. P., and Moore, R. Y. (1988). Comparative anatomy of the mammalian hypothalamic suprachiasmatic nucleus. J. Biol. Rhythms 3:71-91.
16. Chambille, I., Doyle, S., and Serviere, J. (1993). Photic induction and circadian expression of Fos-like protein. Immunohistochemical study in the retina and suprachiasmatic nuclei of hamster. Brain Res. 612:138-150.
17. Chiu, R., Angel, P., and Karin, M. (1989). Jun-B differs in its biological properties from, and is a negative regulator of, c-Jun. Cell 59:979-986.
18. Colwell, C. S., and Foster, R. (1991). The NMDA receptor antagonist MK-801 inhibits light-induced changes in Fos-like immunoreactivity in the mouse suprachiasmatic nucleus. Soc. Neurosci. Abstr. 17:668.
19. Colwell, C. S., and Foster, R. G. (1992). Photic regulation of Fos-like immunoreactivity in the suprachiasmatic nucleus of the mouse. J. Comp. Neurol. 324:135-142.
20. Colwell, C. S., and Menaker, M. (1992). NMDA as well as non-NMDA receptor antagonists can prevent the phase-shifting effects of light on the circadian system of the golden hamster. J. Biol. Rhythms 7:125-136.
21. Colwell, C. S., Ralph, M. R., and Menaker, M. (1990). Do NMDA receptors mediate the effects of light on circadian behavior? Brain Res 523:117-120.
22. Colwell, C. S., Kaufman, C. M., and Menaker, M. (1993). Phase-shifting mechanisms in the mammalian circadian system: New light on the carbachol paradox. J. Neurosci. 13:1454-1459.
23. Comb, M., Birnberg, N. C., Seasholtz, A., Herbert, E., and Goodman, H. M. (1986). A cyclic AMP-and phorbol ester-inducible DNA element. Nature 323:353-356.
24. Craner, S. L., Lund, J. S., Hoffman, G. E., and Lund, R. D. (1991). Moving visual stimuli induce cFos expression in the visual cortices of the rat. Soc. Neurosci. Abstr. 17: 115.
25. Craner, S. L., Hoffman, G. E., Lund, J. S., Humphrey, A. L., and Lund, R. D. (1992). cFos labeling in rat superior colliculus: Activation by normal retinal pathways and pathways from intracranial retinal transplants. Exp. Neurol. 117:219-229.
26. Curran, T., and Franza, B. R., Jr. (1988). Fos and Jun: The AP-1 connection. Cell 55:395-397.
27. Curran, T., Rauscher, F. J., Cohen, D. R., and Franza, B. R. (1988). Beyond the second messenger: Oncogenes and transcription factors. Cold Spring Harbor Symp. Quant. Biol. 53:769-777.
28. Daan, S., and Pittendrigh, C. S. (1976). A functional analysis of circadian pacemakers in nocturnal rodents. II. The variability of phase response curves. J. Comp. Physiol. 106: 253-266.
29. Diamond, M. I., Miner, J. N., Yoshinaga, S. K., and Yamamoto, K. R. (1990). Transcription factor interactions: Selectors of positive or negative regulation from a single DNA element. Science 249:1266-1272.
30. Dunlap, J. C. (1990). Closely watched clocks: Molecular analysis of circadian rhythms in Neurospora and Drosophila. Trends. Genet. 6:159-165.
31. Earnest, D. J., and Turek, F. W. (1985). Neurochemical basis for the photic control of circadian rhythms and seasonal reproduction cycles: Role for acetylcholine. Proc. Natl. Acad. Sci. USA 82:4277-4281.
32. Earnest, D. J., and Olschowka, J. A. (1993). Circadian regulation of c-fos expression in the suprachiasmatic pacemaker by light. J. Biol. Rhythms 8:S65-S71.
33. Earnest, D. J., Iadarola, M., Yeh, H. H., and Olschowka, J. A. (1990). Photic regulation of c-fos expression in neural components governing the entrainment of circadian rhythms. Exp. Neurol. 109:353-361.
34. Earnest, D. J., Ouyang, S., and Olschowka, J. A. (1992). Rhythmic expression of Fos-related proteins in the rat suprachiasmatic nucleus during constant retinal illumination. Neurosci. Lett. 140:19-24.
35. Ebling, F. J. P., Maywood, E. S., Staley, K., Humby, T., Hancock, D. C., Waters, C. M., Evan G. I., and Hastings, M. H. (1991). The role of N-methyl-D-aspartate-type glutamatergic neurotransmission in the photic induction of immediate-early gene expression in the suprachiasmatic nuclei of the Syrian hamster. J. Neuroendocrinol. 3:641-652.
36. Edery, I., Rutila, J. E., and Rosbash, M. (1994). Phase shifting of the circadian clock by induction of the Drosophila period protein. Science 263:237-240.
37. Fink, J. S., Verhave, M., Walton, K., Mandel, G., and Goodman, R. H. (1991). Cyclic AMP- and phorbol ester-induced transcriptional activation are mediated by the same enhancer element in the human vasoactive intestinal peptide gene. J. Biol. Chem. 266:3882-3887.
38. Ginty, D. D., Kornhauser, J. M., Thompson, M. A., Bading, H., Mayo, K. E., Takahashi, J. S., and Greenberg, M. E. (1993). Regulation of CREB phosphorylation in the suprachiasmatic nucleus by light and a circadian clock. Science 260:238-241.
39. Grassi-Zucconi, G., Menegazzi, M., Carcereri De Prati, A., Bassetti, A., Montagnese, P., Mandile, P., Cosi, C., and Bentivoglio, M. (1993). c-fos mRNA is spontaneously induced in the rat brain during the activity period of the circadian cycle. Eur. J. Neurosci. 5:1071-1078.
40. Greenberg, M. E., and Ziff, E. B. (1984). Stimulation of 3T3 cells induces transcription of the c-fos proto-oncogene. Nature 311:433-437.
41. Guthrie, K. M., Anderson, A. J., Leon, M., and Gall, C. (1993). Odor-induced increases in c-fos mRNA expression reveal an anatomical "unit" for odor processing in olfactory bulb. Proc. Natl. Acad. Sci. USA 90:3329-3333.
42. Hardin, P. E., Hall, J. C., and Rosbash, M. (1990). Feedback of the Drosophila period gene product on circadian cycling of its messenger RNA levels. Nature 343:536-540.
43. Hardin, P. E., Hall, J. C., and Rosbash, M. (1992). Circadian oscillations in period gene mRNA levels are transcriptionally regulated. Proc. Natl. Acad. Sci. USA 89:11711-11715.
44. Hazel, T. G., Nathans, D., and Lau, L. F. (1988). A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily. Proc. Natl. Acad. Sci. USA 85:8444-8448.
45. Hedrick, S. M., Cohen, D. I., Nielsen, E. A., and Davis, M. M. (1984). Isolation of cDNA clones encoding T cell-specific membrane-associated proteins. Nature 308:149-153.
46. Hunt, S. P., Pini, A., and Evan, G. (1987). Induction of c-fos like protein in spinal cord neurons following sensory stimulation. Nature 328:632-634.
47. Inouye, S. T., Takahashi, J. S., Wollnik, F., and Turek, F. W. (1988). Inhibitor of protein synthesis phase shifts a circadian pacemaker in mammalian SCN. Am. J. Physiol. 255:R1055-R1058.
48. Janik, D., and Mrosovsky, N. (1992). Gene expression in the geniculate induced by a nonphotic circadian phase shifting stimulus. Neuroreport 3:575-578.
49. Johnson, R. F., Morin, L. P., and Moore, R. Y. (1988). Retinohypothalamic projections in the hamster and rat demonstrated using cholera toxin. Brain Res. 462:301-312.
50. Keefe, D. L., Earnest, D. J., Nelson, D., Takahashi, J. S., and Turek, F. W. (1987). A cholinergic antagonist, mecamylamine, blocks the phase-shifting effects of light on the circadian rhythm of locomotor activity in the golden hamster. Brain Res. 403:308-312.
51. Kerppola, T. K., and Curran, T. (1991). Fos-Jun heterodimers and Jun homodimers bend DNA in opposite orientations: Implications for transcription factor cooperativity. Cell 66:317-326.
52. Kilduff, T. S., Landel, H. B., Nagy, G. S., Sutin, E. L., Dement, W. C., and Heller, H. C. (1992). Melatonin influences Fos expression in the rat suprachiasmatic nucleus. Mol. Brain Res. 16:47-56.
53. Kononen, J., Koistinaho, J., and Alho, H. (1990). Circadian rhythm in c-fos-like immunoreactivity in the rat brain. Neurosci. Lett. 120:105-108.
54. Kornhauser, J. M., Nelson, D. E., Mayo, K. E., and Takahashi, J. S. (1990). Photic and circadian regulation of c-fos gene expression in the hamster suprachiasmatic nucleus. Neuron 5:127-134.
55. Kernhauser, J. M., Nelson, D. E., Mayo, K. E., and Takahashi, J. S. (1992). Regulation of jun-B messenger RNA and AP-1 activity by light and a circadian clock. Science 255: 1581-1584.
56. Kornhauser, J. M., Ginty, D. D., Mayo, K. E., Greenberg, M. E., and Takahashi, J. S. (1993a). Use of phosphopeptide-specific antibodies against CREB and SRF in the suprachiasmatic nucleus. Soc. Neurosci. Abstr. 19:1703.
57. Kornhauser, J. M., Mayo, K. E., and Takahashi, J. S. (1993b). Immediate-early gene expression in a mammalian circadian pacemaker: The suprachiasmatic nucleus. In Young, M. W. (ed.), Molecular Genetics of Biological Rhythms, Marcel Dekker, New York, pp. 271-307.
58. Kruijer, W., Schubert, D., and Verma, I. M. (1985). Induction of the proto-oncogene fos by nerve growth factor. Proc. Natl. Acad. Sci. USA 82:7330-7334.
59. Lau, L. F., and Nathans, D. (1987). Expression of a set of growth-related immediate early genes in BALB/c 3T3 cells: Coordinate regulation with c-fos or c-myc. Proc. Natl. Acad. Sci. USA 84:1182-1186.
60. Lebacq-Verheyden, A.-M., Way, J., and Battey, J. (1990). Structural characterization of a brain-specific promoter region directing transcription of the rat prepro-gastrin-releasing peptide gene. Mol. Brain Res. 7:235-241.
61. Lee, W., Haslinger, A., Karin, M., and Tjian, R. (1987). Activation of transcription by two factors that bind promoter and enhancer sequences of the human metallothionein gene and SV40. Science 325:368-372.
62. Lee, W.-S., Smith, M. S., and Hoffman, G. E. (1990). Luteinizing hormone-releasing hormone neurons express Fos protein during the proestrous surge of luteinizing hormone. Proc. Natl. Acad. Sci. USA 87:5163-5167.
63. Liang, P., and Pardee, A. B. (1992). Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. Science 257:967-971.
64. 3H-GABA from the suprachiasmatic nucleus in slices of rat hypothalamus. Brain Res. Bull. 16:527-531.
65. Mason, R., and Rusak, B. (1991). NMDA-evoked responses in the Syrian hamster suprachiasmatic nucleus in vitro. J. Physiol. 435:39p.
66. Mead, S., Ebling, F. J., Maywood, E. S., Humby, T., Herbert, J., and Hastings, M. H. (1992). A nonphotic stimulus causes instantaneous phase advances of the light-entrainable circadian oscillator of the Syrian hamster but does not induce the expression of c-fos in the suprachiasmatic nuclei. J. Neurosci. 12:2516-2522.
67. Meijer, J. H., and Rietveld, W. J. (1989). Neurophysiology of the suprachiasmatic circadian pacemaker in rodents. Physiol. Rev. 69:671-707.
68. Meijer, J. H., van der Zee, E. A., and Dietz, M. (1988). Glutamate phase shifts circadian activity rhythms in hamsters. Neurosci. Lett. 86:177-183.
69. Milbrandt, J. (1986). Nerve growth factor rapidly induces c-fos mRNA in PC12 rat pheochromocytoma cells. Proc. Natl. Acad. Sci. USA 83:4789-4793.
70. Milbrandt, J. (1987). A nerve growth factor-induced gene encodes a possible transcriptional regulatory factor. Science 238:797-799.
71. Milbrandt, J. (1988). Nerve growth factor induces a gene homologous to the glucocorticoid receptor gene. Neuron 1: 183-188.
72. Montminy, M. R., Sevarino, K. A., Wagner, J. A., Mandel, G., and Goodman, R. H. (1986). Identification of a cyclic-AMP-responsive element within the rat somatostatin gene. Proc. Natl. Acad. Sci. USA 83:6682-6686.
73. Moore, R. Y. (1973), Retinohypothalamic projection in mammals: a comparative study. Brain Res. 49:403-409.
74. Moore, R. Y. (1983). Organization and function of a central nervous system circadian oscillator: The suprachiasmatic hypothalamic nucleus. Fed. Proc. 42:2783-2789.
75. Moratalla, R., Vickers, E. A., Robertson, H. A., Cochran, B. H., and Graybiel, A. M. (1993). Coordinate expression of c-fos and jun B is induced in the rat striatum by cocaine. J. Neurosci. 13:423-433.
76. Morgan, J. I., and Curran, T. (1989). Stimulus-transcription coupling in neurons: Role of cellular immediate-early genes. Trends Neurosci. 12:459-462.
77. Morgan, J. I., and Curran, T. (1991). Stimulus-transcription coupling in the nervous system: Involvement of the inducible proto-oncogenes fos and jun. Annu. Rev. Neurosci. 14:421-451.
78. Morgan, J. I., Cohen, D. R., Hempstead, J. L., and Curran, T. (1987). Mapping patterns of c-fos expression in the central nervous system after seizure. Science 237:192-197.
79. Müller, R., Bravo, R., Burckhardt, J., and Curran, T. (1984). Induction of c-fos gene and protein by growth factors precedes activation of c-myc. Nature 312:716-720.
80. Naranjo, J. R., Mellstrom, B., Achaval, M., Lucas, J. J., Del Rio, J., and Sassone-Corsi, P. (1991). Co-induction of jun B and c-fos in a subset of neurons in the spinal cord. Oncogene 6:223-227.
81. Nelson, D. E., and Takahashi, J. S. (1991). Sensitivity and integration in a visual pathway for circadian entrainment in the hamster (Mesocricetus auratus). J. Physiol. (Lond.) 439:115-145.
82. Park, H. T., Back, S. Y., Kim, B. S., Kim, J. B., and Kim, J. J. (1993). Profile of Fos-like immunoreactivity induction by light stimuli in the intergeniculate leaflet is different from that of the suprachiasmatic nucleus. Brain Res. 610: 334-339.
83. Pittendrigh, C. S., and Daan, S. (1976). A functional analysis of circadian pacemakers in nocturnal rodents. IV. Entrainment: Pacemaker as clock. J. Comp. Physiol. 106:291-331.
84. Raju, U., Koumenis, C., Nunez-Reguciro, M., and Eskin, A. (1991). Alteration of the phase and period of a circadian oscillator by a reversible transcription inhibitor. Science 253:673-675.
85. Ralph, M. R., and Menaker, M. (1988). A mutation of the circadian system in golden hamsters. Science 241:1225-1227.
86. Rauscher, F. J., III, Sambucetti, L. C., Curren, T., Distel, R. J., and Spiegelman, B. M. (1988). A common DNA binding site for Fos protein complexes and transcription factor AP-1. Cell 52:471-480.
87. Rea, M. A. (1989). Light increases fos-related protein immunoreactivity in the rat suprachiasmatic nuclei. Brain Res. Bull 23:577-581.
88. Rea, M. A., Buckley, B., and Lutton, L. M. (1993). Local administration of EAA antagonists blocks light-induced phase shifts and c-fos expression in hamster SCN. Am. J. Physiol. 265:R1191-R1198.
89. Robertson, L. M., Smeyne, R. J., Luk, D., Morgan, J. I., and Curran, T. (1991). Diurnal and photic regulation of c-fos expression in transgenic mice. Soc. Neurosci. Abstr. 17: 668.
90. Rosbash, M., and Hall, J. C. (1989). The molecular biology of circadian rhythms. Neuron 3:387-398.
91. Rusak, B., and Zucker, I. (1979). Neural regulation of circadian rhythms. Physiol. Rev. 59:449-526.
92. Rusak, B., Robertson, H. A., Wisden, W., and Hunt, S.P. (1990). Light pulses that shift rhythms induce gene expression in the suprachiasmatic nucleus. Science 248: 1237-1240.
93. Rusak, B., McNaughton, L., Robertson, H. A., and Hunt, S. P. (1992). Circadian variation in photic regulation of immediate-early gene mRNAs in rat suprachiasmatic nucleus cells. Mol. Brain Res 14:124-130.
94. Ryseck, R.-P., and Bravo, R. (1991). c-Jun, Jun B, and Jun D differ in their binding affinities to AP-1 and CRE consensus sequences: Effect of Fos proteins. Oncogene 6: 533-542.
95. Saffen, D. W., Cole, A. J., Worley, P. F., Christy, B. A., Ryder, K., and Baraban, J. M. (1988). Convulsant-induced increase in transcription factor messenger RNAs in rat brain. Proc. Natl. Acad. Sci. USA 85:7795-7799.
96. Sagar, S. M., and Sharp, F. R. (1990). Light induces a Fos-like nuclear antigen in retinal neurons. Mol. Brain Res 7: 17-21.
97. Sagar, S. M., Sharp, F. R., and Curran, T. (1988). Expression of c-fos protein in brain: Metabolic mapping at the cellular level. Science 240:1328-1331.
98. Sassone-Corsi, P., Lamph, W. W., and Verma, I. M. (1988). Regulation of protooncogene fos: A paradigm for early response genes. Cold Spring Harbor Symp. Quant. Biol. 53:749-760.
99. Schutte, J., Viallet, J., Nau, M., Segal, S., Fedorko, J., and Minna, J. (1989). jun-B inhibits and c-fos stimulates the transforming and trans-activating activities of c-jun. Cell 59:987-997.
100. Sheng, M., and Greenberg, M. E. (1990). The regulation and function of c-fos and other immediate early genes in the nervous system. Neuron 4:477-485.
101. Sheng, M., Dougan, S. T., McFadden, G., and Greenberg, M. E. (1988). Calcium and growth factor pathways of c-fos transcriptional activation require distinct upstream regulatory sequences. Mol. Cell. Biol. 8:2787-2796.
102. Sheng, M., and McFadden, G., and Greenberg, M. E. (1990). Membrane depolarization and calcium induce c-fos transcription via phosphorylation of transcription factor CREB. Neuron 4:571-582.
103. Shibata, S., Liou, S. Y., and Ueki, S. (1986). Influence of excitatory amino acid receptor antagonists and of baclofen on synaptic transmission in the optic nerve to the suprachiasmatic nucleus in slices of rat hypothalalmus. Neuropharmacology 28:403-409.
104. Shinohara, K., Tominaga, K., Isobe, Y., and Inouye, S.-I. T. (1993). Photic regulation of peptides located in the ventrolateral subdivision of the suprachiasmatic nucleus of the rat: Daily variations of vasoactive intestinal polypeptide, gastrin-releasing peptide, and neuropeptide Y. J. Neurosci. 13:793-800.
105. Smeyne, R. J., Schilling, K., Robertson, L., Luk, D., Oberdick, J., Curran, T., and Morgan, J. I. (1992). Fos-lacZ transgenic mice: Mapping sites of gene induction in the central nervous system. Neuron 8:13-23.
106. Sonnenberg, J. L., Macgregor-Leon, P. F., Curran, T., and Morgan, J. I. (1989a). Dynamic alterations occur in the levels and composition of transcription factor AP-1 complexes after seizure. Neuron 3:359-365.
107. Sonnenberg, J. L., Mitchelmore, C., Macgregor-Leon, P. F., Hempstead, J., Morgan, J. I., and Curran, T. (1989b). Glutamate receptor agonists increase the expression of Fos, Fra and AP-1 DNA binding activity in the mammalian brain. J. Neurosci. Res. 24:72-80.
108. Sonnenberg, J. L., Rauscher, F. J., III, Morgan, J. I., and Curran, T. (1989c). Regulation of proenkephalin by protooncogenes fos and jun. Science 246:1622-1625.
109. Sutin, E. L., and Kilduff, T. S. (1992). Circadian and light-induced expression of immediate early gene mRNAs in the rat suprachiasmatic nucleus. Mol. Brain Res. 15:281-290.
110. Takahashi, J. S. (1991). Circadian rhythms: from gene expression to behavior. Curr. Opin. Neurobiol. 1:556-561.
111. Takahashi, J. S. (1992). Circadian clock genes are ticking. Science 258:238-240.
112. Takahashi, J. S., and Turek, F. W. (1987). Anisomycin, an inhibitor of protein synthesis, perturbs the phase of a mammalian circadian pacemaker. Brain Res. 405:199-203.
113. Takahashi, J. S., and Zatz, M. (1982). Regulation of circadian rhythmicity. Science 217:1104-1111.
114. Takahashi, J. S., DeCoursey, P. J., Bauman, L., and Menaker, M. (1984) Spectral sensitivity of a novel photoreceptive system mediating entrainment of mammalian circadian rhythms. Nature 308:186-188.
115. Takeuchi, J., Shannon, W., Aronin, N., and Schwartz, W. J. (1993). Compositional changes of AP-1 DNA-binding proteins are regulated by light in a mammalian circadian clock. Neuron 11:825-836.
116. Travis, G. H., Milner, R. J., and Sutcliffe, J. G. (1990). Preparation and use of subtractive cDNA hybridization probes for cDNA cloning. In Boulton, A. A., Baker, G. B., and Campagnoni, A. T. (eds.), Neuromethods: Molecular Neurobiological Techniques, Humana Press, Clifton, NJ, pp. 49-78.
117. Treisman, R. (1985). Transient accumulation of c-fos RNA following serum stimulation requires a conserved 5′ element and c-fos 3′ sequences. Cell 42:889-902.
118. Uhl, G. R., Walther, D., Nishimori, R., Buzzi, M. G., and Moskowitz, M. A. (1991). Jun B, c-jun, jun D and c-fos mRNAs in nucleus caudalis neurons: Rapid selective enhancement by afferent stimulation. Mol. Brain Res. 11: 133-141.
119. van den Pol, A. N., and Tsujimoto, K. L. (1985). Neurotransmitters of the hypothalamic suprachiasmatic nucleus: Immunocytochemical analysis of 25 neuronal antigens. Neuroscience 15:1049-1086.
120. Vitatema, M. H., King, D. P., Chang, A.-M., Kornhauser, J. M., Lowrey, P. L., MacDonald, J. D., Dove, W. F., Pinto, L. H., Turek, F. W., and Takahashi, J. S. (1994). Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior. Science 264:719-725.
121. Wisden, W., Errington, M. L. Williams, S., Dunnett, S. B., Waters, C., Hitchcock, D., Evan, G., Bliss, T. V. P., and Hunt, S. P. (1990). Differential expression of immediate early genes in the hippocampus and spinal cord. Neuron 4:603-614.
122. Wollnik, F., Turek, F. W., Majewski, P., and Takahashi, J. S. (1989). Phase shifting the circadian clock with cycloheximide: Response of hamsters with an intact or a split rhythm of locomotor activity. Brain Res. 496:82-88.
123. Yoshida, K., Kawamura, K., and Imaki, J. (1993). Differential expression of c-fos mRNA in rat retinal cells: Regulation by light/dark cycle. Neuron 10:1049-1054.
124. Young, M. W. (ed.) (1993). Molecular Genetics of Biological Rhythms, Marcel Dekker, New York.
125. Zatz, M., and Herkenham, M. A. (1981). Intraventricular carbachol mimics the phase shifting effects of light on the circadian rhythm of wheel-running activity. Brain Res. 212:234-238.
126. Zhang, Y., Kornhauser, J. M., Zee, P. C., Mayo, K. E., Takahashi, J. S., and Turek, F. W. (1996). Effects of aging on light-induced phase-shifting of circadian behavioral rhythms, Fos expression and CREB phosphorylation in the hamster suprachiasmatic nucleus. Neuroscience 70: 951-961.
127. Zhang, Y., Van Reeth, O., Zee, P. C., Takahashi, J. S., and Turek, F. W. (1993b). Fos protein expression in the circadian clock is not associated with phase shifts induced by a nonphotic stimulus, triazolam. Neurosci. Lett. 164: 203-208.
128. Zhang, Y., Zee, P. C., Kirby, J. D., Takahashi, J. S., and Turek, F. W. (1993c). A cholinergic antagonist, mecamylamine, blocks light-induced Fos immunoreactivity in specific regions of the hamster suprachiasmatic nucleus. Brain Res. 615:107-112.