GABA receptor-mediated inhibition of neuronal activity in rat SCN in vitro: Pharmacology and influence of circadian phase

Journal of Neurophysiology

Volumn 90, Issue 3, 2003, Pages 1438-1448

  Gribkoff, Valentin K ^a   Pieschl, Rick L ^a   Dudek, F Edward ^b  

^a BRISTOL MYERS SQUIBB   (United States)

^b Immunology and Pathology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; 4 AMINOBUTYRIC ACID B RECEPTOR STIMULATING AGENT; 4 AMINOBUTYRIC ACID RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; BACLOFEN; BICUCULLINE; PHACLOFEN; PICROTOXIN;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN SLICE; CIRCADIAN RHYTHM; CONCENTRATION RESPONSE; CONTROLLED STUDY; GABAERGIC TRANSMISSION; HORMONE RECEPTOR INTERACTION; IN VITRO STUDY; MALE; NERVE CELL; NERVE CELL EXCITABILITY; NERVE CELL INHIBITION; NERVE CELL PLASTICITY; NERVE CONDUCTION; NONHUMAN; PRIORITY JOURNAL; RAT; SUPRACHIASMATIC NUCLEUS;

ACTION POTENTIALS; ANIMALS; CIRCADIAN RHYTHM; DOSE-RESPONSE RELATIONSHIP, DRUG; GABA AGONISTS; GABA ANTAGONISTS; MALE; NEURAL INHIBITION; RATS; RATS, LONG-EVANS; RECEPTORS, GABA; SUPRACHIASMATIC NUCLEUS;

EID: 0141788657     PISSN: 00223077     EISSN: None     Source Type: Journal    
DOI: 10.1152/jn.01082.2002     Document Type: Article

References (63)

1. Abe H, Honma S, Shinohara K, and Honma K. Substance P receptor regulates the photic induction of Fos-like protein in the suprachiasmatic nucleus of Syrian hamsters. Brain Res 708: 135-142, 1996.
2. Aguilar-Roblero R, Verduzco-Carbajal L, Rodriguez C, Mendez-Franco J, Moran J, and de la Mora MP. Circadian rhythmicity in the GABAergic system in the suprachiasmatic nuclei of the rat. Neurosci Lett 157: 199-202, 1993.
3. Bae K, Jin X, Maywood ES, Hastings MH, Reppert SM, and Weaver DR. Differential functions of mPer1, mPer2, and mPer3 in the SCN circadian clock. Neuron 30: 525-536, 2001.
4. Bos NP and Mirmiran M. Effects of excitatory and inhibitory amino acids on neuronal discharges in the cultured suprachiasmatic nucleus. Brain Res Bull 31: 67-72, 1993.
5. Bouskila Y and Dudek FE. Neuronal synchronization without calcium-dependent synaptic transmission in the hypothalamus. Proc Natl Acad Sci USA 90: 3207-3210, 1993.
6. Buijs RM, Hou YX, Shinn S, and Renaud LP. Ultrastructural evidence for intra- and extranuclear projections of GABAergic neurons of the suprachiasmatic nucleus. J Comp Neurol 15: 381-391, 1994.
7. Burgoon PW and Boulant JA. Synaptic inhibition: its role in suprachiasmatic nucleus thermosensitivity and temperature compensation in the rat. J Physiol 512: 793-807, 1998.
8. Cardinali DP and Golombek DA. The rhythmic GABAergic system. Neurochem Res 23: 607-614, 1998.
9. Cassone VM. Melatonin's role in vertebrate circadian rhythms. Chronobiol Int 15:457-473, 1998.
10. Castel M and Morris JF. Morphological heterogeneity of the GABAergic network in the suprachiasmatic nucleus, the brain's circadian pacemaker. J Anat 196: 1-13, 2000.
11. Chang DC and Reppert SM. The circadian clocks of mice and men. Neuron 29: 555-558, 2001.
12. Chen G, Trombley PQ, and van den Pol AN. Excitatory actions of GABA in developing rat hypothalamic neurones. J Physiol 494: 451-464, 1996.
13. Cherubini E, Gaiarsa JL, and Ben-Ari Y. GABA: an excitatory transmitter in early postnatal life, Trends Neurosci 14: 515-519, 1991.
14. Decavel C and Van den Pol AN. GABA: a dominant neurotransmitter in the hypothalamus. J Comp Neurol 302: 1019-1037, 1990.
15. de Jeu M and Pennartz C. Circadian modulation of GABA function in the rat suprachiasmatic nucleus: excitatory effects during the night phase. J Neurophysiol 87: 834-844, 2002.
16. de Vries MI, Nunes Cardozo B, van der Want J, de Wolf A, and Meijer JH. Glutamate immunoreactivity in terminals of the retinohypothalamic tract of the brown Norwegian rat. Brain Res 612: 231-237, 1993.
17. Dunlap JC. Molecular basis for circadian clocks. Cell 96: 271-290, 1999.
18. Earnest DJ, Liang FQ, Ratcliff M, and Cassone VM. Immortal time: circadian clock properties of rat suprachiasmatic cell lines. Science 283: 693-695, 1999.
19. Ehlen JC, Grossman GH, and Glass JD. In vivo resetting of the hamster circadian clock by 5-HT7 receptors in the suprachiasmatic nucleus. J Neurosci 21: 5351-5357, 2001.
20. A-receptor subunit composition in the circadian timing system. Brain Res 700: 142-156, 1995.
21. Gillette MU and Reppert SM. The hypothalamic suprachiasmatic nuclei: circadian patterns of vasopressin secretion and neuronal activity in vitro. Brain Res Bull 19: 135-139, 1987.
22. Gribkoff VK, Pieschl RL, Wisialowski TA, Park WK, Strecker GJ, deJeu MTG, Pennartz CMA, and Dudek FE. A re-examination of the role of GABA in the mammalian suprachiasmatic nucleus. J Biol Rhythms 14: 126-130, 1999.
23. Gribkoff VK, Pieschl RL, Wisialowski TA, van den Pol AN, and Yocca FD. Phase shifting of circadian rhythms and depression of neuronal activity in the rat suprachiasmatic nucleus by neuropeptide Y: mediation by different receptor subtypes, J Neurosci 18: 3014-3022, 1998.
24. Haas HL, Schaerer B, and Vosmansky M. A simple perfusion chamber for the study of nervous tissue slices in vitro. J Neurosci Methods 1: 323-325, 1979.
25. Han SK, Abraham IM, and Herbison AE, Effect of GABA on GnRH neurons switches from depolarization to hyperpolarization at puberty in the female mouse. Endocrinology 143: 1459-1466, 2002.
26. Hannibal J, Moller M, Ottersen OP, and Fahrenkrug J. PACAP and glutamate are co-stored in the retinohypothalamic tract, J Comp Neurol 418: 147-155, 2000.
27. Herzog ED, Takahashi JS, and Block GD. Clock controls circadian period in isolated suprachiasmatic nucleus neurons. Nat Neurosci 1: 708-713, 1998.
28. Huhman KL, Hennessey AC, and Albers HE. Rhythms of glutamic acid decarboxylase mRNA in the suprachiasmatic nucleus, J Biol Rhythms 11: 311-316, 1996.
29. Kim YI, Kim SH, Kim DY, Lee HW, Shin HC, Chung JM, Han HC, Na HS, and Hong SK. Electrophysiological evidence for the role of substance P in retinohypothalamic transmission in the rat. Neurosci Lett 274: 99-102, 1999.
30. Liou SY and Albers HE. Single unit response of neurons within the hamster suprachiasmatic nucleus to GABA and low chloride perfusate during the day and night. Brain Res Bull 25: 93-98, 1990.
31. Liou SY, Shibata S, Albers HE, and Ueki S. Effects of GABA and anxiolytics on the single unit discharge of suprachiasmatic neurons in rat hypothalamic slices. Brain Res Bull 25: 103-107, 1990.
32. Liu C and Reppert SM. GABA synchronizes clock cells within the suprachiasmatic nucleus, Neuron 25: 123-128, 2000.
33. Liu C, Weaver DR, Jin X, Shearman LP, Pieschl RL, Gribkoff VK, and Reppert SM. Molecular dissection of two distinct actions of melatonin on the suprachiasmatic circadian clock. Neuron 19: 91-102. 1997.
34. Mason R. Circadian variation in the sensitivity of suprachiasmatic and lateral geniculate neurons to 5-hydroxytryptamine in the rat, J Physiol 377: 1-13, 1986.
35. Mason R, Biello SM, and Harrington ME. The effects of GABA and benzodiazepines on neurones in the suprachiasmatic nucleus (SCN) of Syrian hamsters. Brain Res 552: 53-57, 1991.
36. Miche S and Colwell CS. Cellular communication and coupling within the suprachiasmatic nucleus. Chronobiol Int 18: 579-600, 2001.
37. Mintz EM, Jasnow AM, Gillespie CF, Huhman KL, and Albers HE. GABA interacts with photic signaling in the suprachiasmatic nucleus to regulate circadian phase shifts. Neuroscience 109: 773-778, 2002.
38. Moore RY and Speh JC. GABA is the principal neurotransmitter of the circadian system, Neurosci Lett 150: 112-116, 1993.
39. Moore RY, Speh JC, and Leak RK. Suprachiasmatic nucleus organization. Cell Tissue Res 309: 89-98, 2002.
40. Naum OG, Fernanda Rubio M, and Golombek DA. Rhythmic variation in gamma-aminobutyric acid(A)-receptor subunit composition in the circadian system and median eminence of Syrian hamsters. Neurosci Lett 310: 178-182, 2001.
41. 2+ elevating to depressing. J Neurosci 15: 5065-5077, 1995.
42. O'Hara BF, Andretic R, Heller HC, Carter DB, and Kilduff TS. GABAA, GABAC, and NMDA receptor subunit expression in the suprachiasmatic nucleus and other brain regions. Brain Res Mol Brain Res 28: 239-250, 1995.
43. Okamura H, Berod A, Julien JF, Geffard M, Kitahama K, Mallet J, and Bobillier P. Demonstration of GABAergic cell bodies in the suprachiasmatic nucleus: in situ hybridization of glutamic acid decarboxylase (GAD) mRNA and immunocytochemistry of GAD and GABA. Neurosci Lett 102: 131-136, 1989.
44. Panda S, Antoch MP, Miller BH, Su AI, Schook AB, Straume M, Schultz PG, Kay SA, Takahashi JS, and Hogenesch JB. Coordinated transcription of key pathways in the mouse by the circadian clock. Cell 109: 307-320, 202.
45. Ralph MR, Foster RG, Davis FC, and Menaker M. Transplanted suprachiasmatic nucleus determines circadian period. Science 247: 975-978, 1990.
46. Ralph MR and Menaker M. Bicuculline blocks circadian phase delays but not advances. Brain Res 325: 362-365, 1985.
47. B receptors. J Neurosci 9: 2858-2865, 1989.
48. Rangarajan R, Heller HC, and Miller JD. Chloride channel block phase advances the single-unit activity rhythm in the SCN. Brain Res Bull 34: 69-72, 1994.
49. Rusak B and Zucker I. Neural regulation of circadian rhythms. Physiol Rev 59: 449-526, 1979.
50. Shibata S, Liou SY, and Ueki S. Different effects of amino acids, acetylcholine and monamines on neuronal activity of suprachiasmatic nucleus in rat pups and adults. Neurosci Lett 39: 187-192, 1983a.
51. Shibata S, Liou SY, and Ueki S. Effect of amino acids and monamines on the neuronal activity of suprachiasmatic nucleus in hypothalamic slice preparations. Jpn J Pharmacol 33: 1225-1231, 1983b.
52. - activity of acutely dissociated neurons of suprachiasmatic nucleus, Am J Physiol Cell Physiol 282: C366-C373, 2002.
53. Shirakawa T, Honma S, Katsuno Y, Oguchi H, and Honma K. Synchronization of circadian firing rhythms in cultured rat suprachiasmatic neurons. Eur J Neurosci 12: 2833-2838, 2000.
54. A receptors. Science 269: 977-981, 1995.
55. A receptor agonist muscimol can reset the phase of neural activity rhythm in the rat suprachiamatic nucleus in vitro. Neurosci Lett 166: 81-84, 1994.
56. Trachsel L, Dodt HU, and Zieglgansberger W. The intrinsic optical signal evoked by chiasm stimulation in the rat suprachiasmatic nuclei exhibits GABAergic day-night variation, Eur J Neurosci 8: 319-328, 1996.
57. van den Pol AN. Gamma-aminobutyrate, gastrin releasing peptide, serotonin, somatostatin, and vasopressin: ultrastructural immunocytochemical localization in presynaptic axons in the suprachiasmatic nucleus. Neuroscience 17: 643-659, 1986.
58. van den Pol AN. Glutamate and GABA presence and action in the suprachiasmatic nucleus. J Biol Rhythms Suppl 8: S11-S15, 1993.
59. van den Pol AN and Dudek FE. Cellular communication in the circadian clock, the suprachiasmatic nucleus, Neuroscience 56: 793-811, 1993.
60. van den Pol AN and Gorcs T. Synaptic relationships between neurons containing vasopressin, gastrin-releasing peptide, vasoactive intestinal polypeptide, and glutamate decarboxylase immunoreactivity in the supra-chiasmatic nucleus: dual ultrastructural immunocytochemistry with gold-substituted silver peroxidase. J Comp Neurol 252: 507-521, 1986.
61. Wagner S, Castel M, Gainer H, and Yarom Y. GABA in the mammalian suprachiasmatic nucleus and its role in diurnal rhythmicity. Nature 387: 598-603, 1997.
62. Wagner S, Sagiv N, and Yarom Y. GABA-induced current and circadian regulation of chloride in neurones of the rat suprachiasmatic nucleus. J Physiol 537: 853-869, 2001.
63. Welsh DK, Logothetis DE, Meister M, and Reppert SM. Individual neurons dissociated from rat suprachiasmatic nucleus express independently phased circadian firing rhythms, Neuron 14: 697-706, 1995.