Morphological heterogeneity of the GABAergic network in the suprachiasmatic nucleus, the brain's circadian pacemaker

Journal of Anatomy

Volumn 196, Issue 1, 2000, Pages 1-13

  Castel, Mona ^b   Morris, John F ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

GABA; Neuronal networks; Neuropeptides

Indexed keywords

4 AMINOBUTYRIC ACID; ANTISERUM; GLUTAMATE DECARBOXYLASE; GOLD; NEUROPEPTIDE; NEUROPHYSIN; PEROXIDASE; VASOACTIVE INTESTINAL POLYPEPTIDE; VASOPRESSIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN MITOCHONDRION; CELL NUCLEUS; CELL SIZE; CELL VACUOLE; CELLULAR DISTRIBUTION; CIRCADIAN RHYTHM; CYTOPLASM; DENDRITE; GABAERGIC TRANSMISSION; IMMUNOGOLD STAINING; IMMUNOPEROXIDASE STAINING; IMMUNOREACTIVITY; LUMINESCENCE; MALE; MOUSE; NERVE ENDING; NERVE FIBER; NONHUMAN; PEPTIDERGIC NERVOUS SYSTEM; POSTSYNAPTIC MEMBRANE; PRIORITY JOURNAL; RAT; SOMATIC CELL; SUPRACHIASMATIC NUCLEUS; SYNAPSE VESICLE; SYNAPTIC TRANSMISSION; ULTRASTRUCTURE;

ANIMALS; CIRCADIAN RHYTHM; GAMMA-AMINOBUTYRIC ACID; IMMUNOHISTOCHEMISTRY; MICE; MICROSCOPY, ELECTRON; NERVE NET; NEURONS; NEUROPEPTIDES; RATS; SUPRACHIASMATIC NUCLEUS;

ANIMALIA; MAMMALIA;

EID: 0033950174     PISSN: 00218782     EISSN: None     Source Type: Journal    
DOI: 10.1017/S0021878299005683     Document Type: Article

References (41)

1. AGUILAR-ROBLERO R, VERDUZCO-CARBAJAL L, RODRIGUEZ C, MENDEZ-FRANCO J, MORAN J, PEREZ DE LA MORA M (1993) Circadian rhythmicity in the GABAergic system in the suprachiasmatic nucleus of the rat. Neuroscience Letters 158, 199-202.
2. BELENKY M, WAGNER S, YAROM Y, MATZNER H, COHEN S, CASTEL M (1996) The suprachiasmatic nucleus in stationary organotypic culture. Neuroscience 70, 127-143.
3. BUIJS RM, MARKMAN M, NUNES-CARDOZA B, HOU Y-X, SHINN S (1993) Projections of the suprachiasmatic nucleus to stress-related areas in the rat hypothalamus: a light and electron microscopic study. Journal of Comparative Neurology 358, 42-54.
4. BUIJS RM, HOU Y-X, SHINN S, RENAUD LP (1994) Ultrastructural evidence for intra- and extracellular projections of GABAergic neurons of the suprachiasmatic nucleus. Journal of Comparative Neurology 340, 381-391.
5. BUIJS RM, WORTEL J, HOU Y-X (1995) Colocalization of gamma-amino butyric acid with vasopressin, vasoactive intestinal peptide and somatostatin in the rat suprachiasmatic nucleus. Journal of Comparative Neurology 358, 343-352.
6. CARD JP, MOORE RY (1989) Organization of the lateral geniculate-hypothalamic connections in the rat. Journal of Comparative Neurology 284, 134-147.
7. CASTEL M, COHEN S, GAINER H (1990a) GABAergic innervation of the mouse suprachiasmatic nucleus. European Journal of Neuroscience, Suppl. 3, Abstr. 31, 1112.
8. CASTEL M, FEINSTEIN N, COHEN S, HARARI N (1990b) Vasopressinergic innervation of the mouse suprachiasmatic nucleus: an immune-electron microscopic analysis. Journal of Comparative Endocrinology 298, 172-187.
9. CASTEL M, COHEN S (1991) Synaptology of the mouse suprachiasmatic nucleus: an immuno-ultrastructural study. Proceedings of the 20th International Conference on Chronobiology. Tel Aviv, Israel, Abstract 8.1.
10. CASTEL M, BELENKY M, COHEN S, OTTERSEN OP, STORM-MATHISEN J (1993) Glutamate-like immunoreactivity in retinal terminals of the mouse suprachiasmatic nucleus. European Journal of Neuroscience 5, 368-381.
11. CASTEL M, MORRIS JF, BELENKY M (1996) Non-synaptic and dendritic exocytosis from dense-cored vesicles in the suprachiasmatic nucleus. NeuroReport 7, 543-547.
12. CUI LN, SAEB-PARSEY K, DYBALL REJ (1997) Neurones in the supraoptic nucleus of the rat are regulated by a projection from the suprachiasmatic nucleus. Journal of Physiology (London) 502, 149-159.
13. DECAVEL C, VAN DEN POL AN (1990) GABA: a dominant neurotransmitter in the hypothalamus. Journal of Comparative Neurology 302, 1019-1037.
14. DUNLAP J (1998) An end in the beginning. Science 280, 1548-1549.
15. FORSLING ML (1993) Neurohypophysial hormones and circadian rhythm, In The Neurohypophysis: a Window on Brain Function (ed. North WG, Moses AM, Share L). Annals of the New York Academy of Sciences 689, 1019-1037.
16. GREENOUGH WT, WEST RW, DEVOOGT T-J (1978) Subsynaptic plate perforations: changes with age and experience in the rat. Science 202, 1096-1098.
17. HALASY K, BUHL EH, LORINCZI Z, TAMAS G, SOMOGYI P (1996) Synaptic target selectivity and input of GABAergic basket and bistratified interneurons in the CA1 area of the rat hippocampus. Hippocampus 6, 306-329.
18. INGRAM CD, SNOWBALL RK, MIHAI R (1996) Circadian rhythm of neuronal activity in suprachiasmatic nucleus slices from the vasopressin-deficient Brattleboro rat. Neuroscience 75, 635-641.
19. INOUYE S-IT (1996) Orcadian rhythms of neuropeptides in the suprachiasmatic nucleus. In Hypothalamic Integration of Circadian Rhythms (ed. Buijs RM, Kalsbeek A, Romijn HJ, Pennartz CMA, Mirmiran M), pp. 75-90, Amsterdam: Elsevier.
20. JANSEN HT, GONG Q, NORGREN RB, LEHMAN MN (1994) Single- and double-label immunocytochemical study of the ovine suprachiasmatic nucleus: GABAergic and peptidergic relationships. Brain Research Bulletin 34, 499-506.
21. JIANG Z-G, YANG Y-Q, LIU Z-P, ALLEN CN (1997) Membrane properties and synaptic inputs of the suprachiasmatic nucleus in rat brain slices. Journal of Physiology 499, 141-159.
22. KLEIN DC, MOORE RY, REPPERT SM (ed.) (1991) Suprachiasmatic Nucleus, the Brain's Clock. New York: Oxford University Press.
23. LANGLEY K, GRANT NJ (1997) Are exocytosis mechanisms neurotransmitter specific? Neurochemistry International 31, 739-757.
24. MOORE RY, EICHLER VP (1972) Loss of adrenal corticosterone rhythm following suprachiasmatic lesions in the rat. Brain Research 42, 201-206.
25. MOORE RY, SPEH JC (1993) GABA is the principal neurotransmitter of the circadian system. Neuroscience Letters 150, 112-116.
26. OKAMURA H, BEROD A, JULIEN J-F, GEFFARD M, KITAHAMA K, MALLET J et al. (1989) Demonstration of GABAergic cell bodies in the suprachiasmatic nucleus: in situ hybridization of glutamic acid decarboxylase (GAD) mRNA and immunocytochemistry of GAD and GABA. Neuroscience Letters 102, 131-136.
27. PENNARTZ CMA, GEURSTEN AMS, DE JEU MTG, SLUITER AA, HERMES MHLJ (1998a) Electrophysiological and morphological heterogeneity of neurons in slices of rat suprachiasmatic nucleus. Journal of Physiology (Lond.) 506, 775-793.
28. PENNARTZ CMA, BOS NPA, DE JEU MTG, GEURSTEN AMS, MIRMIRAN M, SLUITER AA et al. (1998b) Membrane properties and morphology of vasopressin neurons in slices of rat suprachiasmatic nucleus. Journal of Neurophysiology 80, 2710-2717.
29. POW DV, MORRIS JF (1991) Dendrites of hypothalamic magnocellular neurons release neurohypophysial peptides by exocytosis. Neuroscience 32, 435-439.
30. RAMON A, CAGAMPANG A, RATTRAY M, POWELL JF, CAMPBELL IC, COEN CW (1996) Circadian changes of glutamate decarboxylase 65 and 67 mRNA in the rat suprachiasmatic nucleus. NeuroReport 7, 1925-1928.
31. REPPERT SM, WEAVER DR (1997) Forward genetics approach strikes gold: cloning of a mammalian Clock gene. Cell 89, 487-490.
32. SILVER R, LE SAUTER J, TRESCO PA, LEHMAN MN (1996) A diffusible coupling signal from the transplanted suprachiasmatic nucleus controlling circadian locomotor rhythms. Nature 382, 810-813.
33. SOMOGYI P, HODGSON AJ, CHUBB IW, PENKE B, ERDEI A (1985) Antisera to gamma-aminobutyric acid. II. Immunocytochemical application to the central nervous system. Journal of Histochemistry and Cytochemistry 33, 240-248.
34. STEPHAN FK, ZUCKER I (1972) Circadian rhythms in drinking behaviour and locomotor activity of rats are eliminated by hypothalamic lesions. Proceedings of the National Academy of Sciences of the USA 69, 1583-1586.
35. STRECKER GJ, BOUSKILA Y, DUDEK FE (1995) Neurotransmission and electrophysiological mechanisms in the suprachiasmatic nucleus. The Neurosciences 7, 43-51.
36. A-mediated local synaptic pathways connect neurons in the rat suprachiasmatic nucleus. Journal of Neurophysiology 78, 2217-2220.
37. TANAKA M, TOMOYUKI M, SHIGEYOSHI Y, IBATA Y, OKAMURA H (1997) Peptide expression in GABAergic neurons in the rat suprachiasmatic nucleus in comparison with other forebrain structures: a double labelling in situ hybridization study. Journal of Histochemistry and Cytochemistry 45, 1231-1237.
38. THEODOSIS DT, PAUT L, TAPPAZ ML (1986) Immunocytochemical analysis of the GABAergic innervation of oxytocin-and vasopressin-secreting neurons in the rat supraoptic nucleus. Neuroscience 19, 207-222.
39. VRANG N, MIKKELSEN JD, LARSEN PJ (1997) Direct link from the suprachiasmatic nucleus to the hypothalamic neurons projecting to the spinal cord: a combined tracing study using cholera toxin subunit B and Phaseolus vulgaris-leucoagglutinin. Brain Research Bulletin 44, 671-680.
40. WAGNER S, CASTEL M, GAINER H, YAROM Y (1997) GABA in the mammalian suprachiasmatic nucleus and its role in diurnal rhythmicity. Nature 387, 598-603.
41. WELSH DK, LOGOTHETIS DE, MEISTER M, REPPERT SM (1995) Individual neurons dissociated from rat suprachiasmatic nucleus express independently phased circadian firing rhythms. Neuron 14, 697-706.