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Volumn 18, Issue 3, 2006, Pages 314-320

The role of serine/threonine kinases in T-cell activation

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; DIACYLGLYCEROL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LYMPHOCYTE ANTIGEN RECEPTOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PROTEIN KINASE D; PROTEIN SERINE THREONINE KINASE;

EID: 33646148511     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2006.03.006     Document Type: Review
Times cited : (17)

References (54)
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    • •] both show that PKCθ is dispensable for Th1-mediated immune responses but is important for Th2 cell differentiation and function. However, purified naïve PKCθ-deficient T cells show enhanced IFNγ production during T cell activation, suggesting that PKCθ might well control some aspect of Th1 cell function. In this context, PKCθ regulates Th1 cytokine production in a model of experimental autoimmune encephalomyelitis [50]. How and why PKCθ regulates Th1/2 cell differentiation and/or function is not known.
    • •] both show that PKCθ is dispensable for Th1-mediated immune responses but is important for Th2 cell differentiation and function. However, purified naïve PKCθ-deficient T cells show enhanced IFNγ production during T cell activation, suggesting that PKCθ might well control some aspect of Th1 cell function. In this context, PKCθ regulates Th1 cytokine production in a model of experimental autoimmune encephalomyelitis [50]. How and why PKCθ regulates Th1/2 cell differentiation and/or function is not known.
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