Regulation of gene expression by 1α,25-dihydroxyvitamin D3 and its analog EB1089 under growth-inhibitory conditions in squamous carcinoma cells

Molecular Endocrinology

Volumn 15, Issue 7, 2001, Pages 1127-1139

  Akutsu, Naotake ^a   Lin, Roberto ^a   Bastien, Yolande ^a   Bestawros, Alain ^a   Enepekides, Danny J ^b   Black, Martin J ^b   White, John H ^a  

^a MCGILL UNIVERSITY   (Canada)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITRIOL; CELL ADHESION MOLECULE; COLECALCIFEROL; COLECALCIFEROL RECEPTOR; COMPLEMENTARY DNA; CYCLINE; DNA; GENE PRODUCT; GROWTH FACTOR; MESSENGER RNA; OXYGENASE; PHOSPHOTRANSFERASE; PROTEIN GADD45ALPHA; PROTEIN P21; PROTEIN SGK; SEOCALCITOL; STEROID 24 HYDROXYLASE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CANCER GROWTH; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; GENE CONTROL; GENE EXPRESSION; GENE TARGETING; GENETIC TRANSFECTION; GROWTH INHIBITION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MITOSIS INHIBITION; PRIORITY JOURNAL; REPORTER GENE; SQUAMOUS CELL CARCINOMA; WESTERN BLOTTING;

BLOTTING, NORTHERN; CALCITRIOL; CARCINOMA, SQUAMOUS CELL; CELL CYCLE PROTEINS; CELL DIVISION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; CYCLINS; DRUG RESISTANCE; GENE EXPRESSION REGULATION, NEOPLASTIC; HEAD AND NECK NEOPLASMS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTEINS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSFECTION; TUMOR CELLS, CULTURED; TUMOR SUPPRESSOR PROTEINS;

EID: 0034976117     PISSN: 08888809     EISSN: None     Source Type: Journal    
DOI: 10.1210/me.15.7.1127     Document Type: Article

References (58)

1. The nuclear receptor superfamily: The second decade
2. The nuclear vitamin D receptor: Biological and molecular regulatory properties revealed
3. Current understanding of the molecular actions of vitamin D
4. 3 leads to the induced differentiation of the myelomonocytic cell line U937
5. Antiproliferative effect of 1α, 25-dihydroxyvitamin D3 in human prostate cancer cell line LNCaP involves reduction of cyclin-dependent kinase 2 activity and persistent G1 accumulation
6. 1,25-Dihydroxycholecalciferol (1,25-D3) inhibits the growth of squamous cell carcinoma and down-modulates p21(Naf1/Cip1) in vitro and in vivo
7. Toward therapeutic intervention of cancer by vitamin D compounds
8. 3 analog that inhibits the growth of breast cancer cells in vivo and in vitro
9. 3 analog EB1089
10. Seocalcitol (EB 1089): A vitamin D analogue of anticancer potential. Background, design, synthesis, preclinical and clinical evaluation
11. Head and neck cancer
12. Recent advances in head and neck cancer -larynx preservation and cancer chemoprevention
13. Prevention of second primary tumors with isotretinoin in squamous cell carcinoma of the head and neck
14. Abnormal expression of retinoid receptors and keratin 19 by human oral and epidermal squamous cell carcinoma lines
15. Retinoic acid receptor β induces terminal differentiation of squamous cell carcinoma lines in the absence of cyclin-dependent kinase inhibitor expression
16. Suppression of squamous cell carcinoma growth and differentiation by retinoids
17. Implication of retinoic acid receptor ψ in squamous differentiation and response to retinoic acid in head and neck SqCC/Y1 squamous carcinoma cells
18. Roles of retinoids and their receptors in the development and prevention of upper aerodigestive tract cancers
19. Inappropriate retinoic acid receptor-β expression in oral dysplasias: Correlation with acquisition of the immortal phenotype
20. 3 or its derivatives
21. 3
22. A new series of vitamin D analogs is highly active for clonal inhibition, differentiation and induction of WAF1 in myeloid leukemia
23. 3 in human prostate cancer cell line LNCaP involves reduction of cyctin-dependent kinase 2 activity and persistent G1 accumulation
24. Vitamin D analogs up-regulate p21 and p27 during growth inhibition of pancreatic carcinoma cells
25. The significance of digital gene expression profiles
26. Normalization strategies for cDNA microarrays
27. Importance of replication in microarray gene expression studies: Statistical methods and evidence from repetitive cDNA hybridizations
28. Processing and quality control of DNA array hybridization data
29. 3 in human osteoblast-like cells
30. Anabolic effects of 1,25-dihydroxyvitamin D3 on osteoblasts are enhanced by vascular endothelial growth factor produced by osteoblasts and by growth factors produced by endothelial cells
31. 3
32. Thyroid hormone regulation of hepatic genes in vivo detected by complementary cDNA microarray
33. Induction by ionizing radiation of the gadd45 gene in cultured human cells: Lack of medication by protein kinase C
34. The gadd and Myd genes define a novel set of mammalian genes encoding proteins that synergistically suppress cell growth
35. Genomic instability in Gadd45α-deficient mice
36. Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen
37. waf1/cip1 with PCNA
38. Characterization of the interaction between PCNA and Gadd45
39. 3 analogue EB1089 in head and neck squamous cell carcinoma
40. Squamous carcinoma cell lines fail to respond to 1,25-dihydroxyvitamin D3 despite normal levels of the vitamin D receptor
41. Differential regulation of vitamin D responsive elements in normal and transformed keratinocytes
42. Induction of GADD45 and JNK/SAP-dependent apoptosis following inducible expression of BRCA1
43. The Wilms tumor suppressor WT1 encodes a transcriptional activator of amphiregulin
44. Cell cycle and hormonal control of nuclear-cytoplasmic localization by serum- and glucocorticold-inducible kinase, Sgk, in mammary tumor cells. A novel convergence point of antiproliferative and proliferative cell signaling pathways
45. Proliferating cell nuclear antigen is required for DNA excision repair
46. p53-mediated DNA repair responses to UV radiation: Studies of mouse cells lacking p53, p21, and/or gadd45 genes
47. Gadd45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatin
48. High levels of p53 protein in UV-irradiated normal human skin
49. The p21 inhibitor of cyclin-dependent kinases controls DNA replication by interaction with PCNA
50. Direct interaction of Gadd45 with PCNA and evidence for competitive interaction of Gadd45 and p21Waf1/Cip1 with PCNA
51. Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal
52. Vascular endothelial growth factor expression in head and neck squamous cell carcinoma
53. 3 synergism toward transforming growth factor-β1-induced AP-1 transcriptional activity in mouse osteoblastic cells via its nuclear receptor
54. 1,25-Dihydroxyvitamin D(3) stimulates activator protein-1-dependent caco-2 cell differentiation
55. 3 induced differentiation of cultured human keratinocytes is accompanied by a PKC-independent regulation of AP-1 DNA binding activity
56. Inducible expression of an hsp68-IacZ hybrid gene in transgenic mice
57. Luciferase reporter gene vectors for analysis of promoters and enhancers
58. Human estrogen receptor has two independent non-acidic transactivation functions