The erythroid phenotype of EKLF-null mice: Defects in hemoglobin metabolism and membrane stability

Molecular and Cellular Biology

Volumn 25, Issue 12, 2005, Pages 5205-5214

  Drissen, Roy ^a   Von Lindern, Marieke ^a   Kolbus, Andrea ^b,c   Driegen, Siska ^a   Steinlein, Peter ^b   Beug, Hartmut ^b   Grosveld, Frank ^a   Philipsen, Sjaak ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; ERYTHROID KRUPPEL LIKE FACTOR; HEMOGLOBIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ERYTHROCYTE MEMBRANE; ERYTHROID CELL; ERYTHROID PRECURSOR CELL; FETUS; FETUS LIVER; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; ANTINEOPLASTIC AGENTS, HORMONAL; BLOOD PROTEINS; CELL DIFFERENTIATION; CELL MEMBRANE; DNA-BINDING PROTEINS; ERYTHROCYTES; ERYTHROPOIESIS; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; HEMOGLOBINS; KRUPPEL-LIKE TRANSCRIPTION FACTORS; MICE; MICE, KNOCKOUT; MOLECULAR CHAPERONES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENOTYPE; PHOSPHOPROTEINS; RECOMBINANT FUSION PROTEINS; TAMOXIFEN; TRANSCRIPTION FACTORS;

EID: 20344364878     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.25.12.5205-5214.2005     Document Type: Article

References (38)

1. Bakker, W. J., M. Blazquez-Domingo, A. Kolbus, J. Besooyen, P. Steinlein, H. Beug, P. J. Coffer, B. Lowenberg, M. Von Lindern, and T. B. Van Dijk. 2004. FoxO3a regulates erythroid differentiation and induces BTG1, an activator of protein arginine methyl transferase 1. J. Cell Biol. 164:175-184.
2. Beug, H., S. Palmieri, C. Freudenstein, H. Zentgraf, and T. Graf. 1982. Hormone-dependent terminal differentiation in vitro of chicken erythroleukemia cells transformed by ts mutants of avian erythroblastosis virus. Cell 28:907-919.
3. Chen, J. J., and I. M. London. 1995. Regulation of protein synthesis by heme-regulated eIF-2 alpha kinase. Trends Biochem. Sci. 20:105-108.
4. Chen, X., and J. J. Bieker. 2004. Stage-specific repression by the EKLF transcriptional activator. Mol. Cell. Biol. 24:10416-10424.
5. Dolznig, H., F. Boulme, K. Stangl, E. M. Deiner, W. Mikulits, H. Beug, and E. W. Mullner. 2001. Establishment of normal, terminally differentiating mouse erythroid progenitors: molecular characterization by cDNA arrays. FASEB J. 15:1442-1444.
6. Drissen, R., R. J. Palstra, N. Gillemans, E. Splinter, F. Grosveld, S. Philipsen, and W. de Laat. 2004. The active spatial organization of the beta-globin locus requires the transcription factor EKLF. Genes Dev. 18:2485-2490.
7. Faustino, P., J. Lavinha, M. G. Marini, and P. Mol. 1996. beta-Thalassemia mutation at -90C->T impairs the interaction of the proximal CACCC box with both erythroid and nonerythroid factors. Blood 88:3248-3249.
8. Feng, W. C., C. M. Southwood, and J. J. Bieker. 1994. Analyses of beta-thalassemia mutant DNA interactions with erythroid Kruppel-like factor (EKLF), an erythroid cell-specific transcription factor. J. Biol. Chem. 269:1493-1500.
9. Fujita, H., M. Yamamoto, T. Yamagami, N. Hayashi, and S. Sassa. 1991. Erythroleukemia differentiation. Distinctive responses of the erythroid cell-specific and the nonspecific delta-aminolevulinate synthase mRNA. J. Biol. Chem. 266:17494-17502.
10. Gallagher, P. G., and E. J. Benz. 2001. The erythrocyte membrane and cytoskeleton: structure, function and disorders, p. 275-361. In G. Stamatoyannopoulos, P. W. Majerus, R. M. Perlmutter, and H. Varmus (ed.), The molecular basis of blood diseases, 3rd ed. W.B. Saunders & Company, Philadelphia, Pa.
11. Han, A. P., C. Yu, L. Lu, Y. Fujiwara, C. Browne, G. Chin, M. Fleming, P. Leboulch, S. H. Orkin, and J. J. Chen. 2001. Heme-regulated eIF2alpha kinase (HRI) is required for translational regulation and survival of erythroid precursors in iron deficiency. EMBO J. 20:6909-6918.
12. Katz, J. P., N. Perreault, B. G. Goldstein, C. S. Lee, P. A. Labosky, V. W. Yang, and K. H. Kaestner. 2002. The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon. Development 129:2619-2628.
13. Khanna, R., S. H. Chang, S. Andrabi, M. Azam, A. Kim, A. Rivera, C. Brugnara, P. S. Low, S. C. Liu, and A. H. Chishti. 2002. Headpiece domain of dematin is required for the stability of the erythrocyte membrane. Proc. Natl. Acad. Sci. USA 99:6637-6642.
14. Kihm, A. J., Y. Kong, W. Hong, J. E. Russell, S. Rouda, K. Adachi, M. C. Simon, G. A. Blobel, and M. J. Weiss. 2002. An abundant erythroid protein that stabilizes free alpha-haemoglobin. Nature 417:758-763.
15. Kolbus, A., M. Blazquez-Domingo, S. Carotta, W. Bakker, S. Luedemann, M. von Lindern, P. Steinlein, and H. Beug. 2003. Cooperative signaling between cytokine receptors and the glucocorticoid receptor in the expansion of erythroid progenitors: molecular analysis by expression profiling. Blood 102:3136-3146.
16. Kulozik, A. E., A. Bellan-Koch, S. Bail, E. Kohne, and E. Kleihauer. 1991. Thalassemia intermedia: moderate reduction of beta globin gene transcriptional activity by a novel mutation of the proximal CACCC promoter element. Blood 77:2054-2058.
17. Lee, T. H., S. U. Kim, S. L. Yu, S. H. Kim, S. Park do, H. B. Moon, S. H. Dho, K. S. Kwon, H. J. Kwon, Y. H. Han, S. Jeong, S. W. Kang, H. S. Shin, K. K. Lee, S. G. Rhee, and D. Y. Yu. 2003. Peroxiredoxin II is essential for sustaining life span of erythrocytes in mice. Blood 101:5033-5038.
18. Lim, S. K., J. J. Bieker, C. S. Lin, and F. Costantini. 1997. A shortened life span of EKLF-/- adult erythrocytes, due to a deficiency of beta-globin chains, is ameliorated by human gamma-globin chains. Blood 90:1291-1299.
19. Luo, Q., X. Ma, S. M. Wahl, J. J. Bieker, M. Crossley, and L. J. Montaner. 2004. Activation and repression of interleukin-12 p40 transcription by erythroid Kruppel-like factor in macrophages. J. Biol. Chem. 279:18451-18456.
20. Miller, I. J., and J. J. Bieker. 1993. A novel, erythroid cell-specific murine transcription factor that binds to the CACCC element and is related to the Kruppel family of nuclear proteins. Mol. Cell. Biol. 13:2776-2786.
21. Muta, K., and S. B. Krantz. 1995. Inhibition of heme synthesis induces apoptosis in human erythroid progenitor cells. J. Cell Physiol. 163:38-50.
22. Nathan, D. G., and R. B. Gunn. 1966. Thalassemia: the consequences of unbalanced hemoglobin synthesis. Am. J. Med. 41:815-830.
23. Nuez, B., D. Michalovich, A. Bygrave, R. Ploemacher, and F. Grosveld. 1995. Defective haematopoiesis in fetal liver resulting from inactivation of the EKLF gene. Nature 375:316-318.
24. Oishi, Y., I. Manabe, K. Tobe, K. Tsushima, T. Shindo, K. Fujiu, G. Nishimura, K. Maemura, T. Yamauchi, N. Kubota, R. Suzuki, T. Kitamura, S. Akira, T. Kadowaki, and R. Nagai. 2005. Krüppel-like transcription factor KLF5 is a key regulator of adipocyte differentiation. Cell Metab. 1:27-39.
25. Perkins, A. C., K. R. Peterson, G. Stamatoyannopoulos, H. E. Witkowska, and S. H. Orkin. 2000. Fetal expression of a human Agamma globin transgene rescues globin chain imbalance but not hemolysis in EKLF null mouse embryos. Blood 95:1827-1833.
26. Perkins, A. C., A. H. Sharpe, and S. H. Orkin. 1995. Lethal beta-thalassaemia in mice lacking the erythroid CACCC- transcription factor EKLF. Nature 375:318-322.
27. Philipsen, S., and G. Suske. 1999. A tale of three fingers: the family of mammalian Sp/XKLF transcription factors. Nucleic Acids Res. 27:2991-3000.
28. Porcher, C., G. Pitiot, M. Plumb, S. Lowe, H. de Verneuil, and B. Grandchamp. 1991. Characterization of hypersensitive sites, protein-binding motifs, and regulatory elements in both promoters of the mouse porphobilinogen deaminase gene. J. Biol. Chem. 266:10562-10569.
29. Raich, N., and P. H. Romeo. 1993. Erythroid regulatory elements. Stem Cells 11:95-104.
30. Sadlon, T. J., T. Dell'Oso, K. H. Surinya, and B. K. May. 1999. Regulation of erythroid 5-aminolevulinate synthase expression during erythropoiesis. Int. J. Biochem. Cell Biol. 31:1153-1167.
31. Segre, J. A., C. Bauer, and E. Fuchs. 1999. Klf4 is a transcription factor required for establishing the barrier function of the skin. Nat. Genet. 22:356-360.
32. Southwood, C. M., K. M. Downs, and J. J. Bieker. 1996. Erythroid Kruppel-like factor exhibits an early and sequentially localized pattern of expression during mammalian erythroid ontogeny. Dev. Dyn. 206:248-259.
33. Spadaccini, A., P. A. Tilbrook, M. K. Sarna, M. Crossley, J. J. Bieker, and S. P. Klinken. 1998. Transcription factor erythroid Kruppel-like factor (EKLF) is essential for the erythropoietin-induced hemoglobin production but not for proliferation, viability, or morphological maturation. J. Biol. Chem. 273:23793-23798.
34. Tewari, R., N. Gillemans, M. Wijgerde, B. Nuez, M. von Lindern, F. Grosveld, and S. Philipsen. 1998. Erythroid Kruppel-like factor (EKLF) is active in primitive and definitive erythroid cells and is required for the function of 5′HS3 of the beta-globin locus control region. Embo J. 17:2334-2341.
35. Trimborn, T., J. Gribnau, F. Grosveld, and P. Fraser. 1999. Mechanisms of developmental control of transcription in the murine alpha- and beta-globin loci. Genes Dev. 13:112-124.
36. von Lindern, M., E. M. Deiner, H. Dolznig, M. Parren-Van Amelsvoort, M. J. Hayman, E. W. Mullner, and H. Beug. 2001. Leukemic transformation of normal murine erythroid progenitors: v- and c-ErbB act through signaling pathways activated by the EpoR and c-Kit in stress erythropoiesis. Oncogene 20:3651-3664.
37. Weatherall, D. J. 2001. The thalassemias, p. 183-226. In G. Stamatoyannopoulos, P. W. Majerus, R. M. Perlmutter, and H. Varmus (ed.), The molecular basis of blood diseases, 3rd ed. W.B. Saunders & Company, Philadelphia, Pa.
38. Yin, X., and H. A. Dailey. 1998. Erythroid 5-aminolevulinate synthase is required for erythroid differentiation in mouse embryonic stem cells. Blood Cells Mol. Dis. 24:41-53.