-
1
-
-
0034958947
-
Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care
-
Angus, D., W. T. Linde-Zwirble, J. Lidicker, G. Clermont, J. Carcillo, and M. R. Pinsky. 2001. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit. Care Med. 29:1303-1310.
-
(2001)
Crit. Care Med.
, vol.29
, pp. 1303-1310
-
-
Angus, D.1
Linde-Zwirble, W.T.2
Lidicker, J.3
Clermont, G.4
Carcillo, J.5
Pinsky, M.R.6
-
2
-
-
0003788831
-
-
Raven Press, New York, N.Y.
-
Arias, I., W. Jacoby, H. Popper, et al. 1988. The liver: biology and pathobiology, 2nd ed. Raven Press, New York, N.Y.
-
(1988)
The Liver: Biology and Pathobiology, 2nd Ed.
-
-
Arias, I.1
Jacoby, W.2
Popper, H.3
-
3
-
-
17644391784
-
Smad6s regulates plasminogen activator inhibitor-1 through a protein kinase C-beta-dependent up-regulation of transforming growth factor-beta
-
Berg, D. T., L. J. Myers, M. A. Richardson, G. Sandusky, and B. W. Grinnell. 2005. Smad6s regulates plasminogen activator inhibitor-1 through a protein kinase C-beta-dependent up-regulation of transforming growth factor-beta. J. Biol. Chem. 280:14943-14947.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 14943-14947
-
-
Berg, D.T.1
Myers, L.J.2
Richardson, M.A.3
Sandusky, G.4
Grinnell, B.W.5
-
4
-
-
0035826096
-
Efficacy and safety of recombinant human activated protein C for severe sepsis
-
Bernard, G., J. Vincent, P. Laterre, S. LaRosa, J. Dhainaut, A. Lopez-Rodriguez, J. Steingrub, G. Garber, J. Helterbrand, E. Ely, and C. Fisher. 2001. Efficacy and safety of recombinant human activated protein C for severe sepsis. N. Engl. J. Med. 344:699-705.
-
(2001)
N. Engl. J. Med.
, vol.344
, pp. 699-705
-
-
Bernard, G.1
Vincent, J.2
Laterre, P.3
LaRosa, S.4
Dhainaut, J.5
Lopez-Rodriguez, A.6
Steingrub, J.7
Garber, G.8
Helterbrand, J.9
Ely, E.10
Fisher, C.11
-
5
-
-
2342511466
-
Activated protein C inhibits the release of macrophage inflammatory protein-1-alpha from THP-1 cells and from human monocytes
-
Brueckmann, M., U. Hoffmann, L. De Rossi, H. M. Weiler, V. Liebe, S. Lang, J. J. Kaden, M. Borggrefe, K. K. Haase, and G. Huhle. 2004. Activated protein C inhibits the release of macrophage inflammatory protein-1-alpha from THP-1 cells and from human monocytes. Cytokine 26:106-113.
-
(2004)
Cytokine
, vol.26
, pp. 106-113
-
-
Brueckmann, M.1
Hoffmann, U.2
De Rossi, L.3
Weiler, H.M.4
Liebe, V.5
Lang, S.6
Kaden, J.J.7
Borggrefe, M.8
Haase, K.K.9
Huhle, G.10
-
6
-
-
0037352279
-
Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective
-
Cheng, T., D. Liu, J. Griffin, J. Fernandez, F. Castellino, E. Rosen, K. Fukudome, and B. Zlokovic. 2003. Activated protein C blocks p53-mediated apoptosis in ischemic human brain endothelium and is neuroprotective. Nat. Med. 9:338-342.
-
(2003)
Nat. Med.
, vol.9
, pp. 338-342
-
-
Cheng, T.1
Liu, D.2
Griffin, J.3
Fernandez, J.4
Castellino, F.5
Rosen, E.6
Fukudome, K.7
Zlokovic, B.8
-
7
-
-
0037200066
-
Insulin inhibits hepatocellular glucose production by utilizing liver-enriched transcriptional inhibitory protein to disrupt the association of CREB-binding protein and RNA polymerase 11 with the phosphoenolpyruvate carboxykinase gene promoter
-
Duong, D. T., M. E. Waltner-Law, R. Sears, L. Sealy, and D. K. Granner. 2002. Insulin inhibits hepatocellular glucose production by utilizing liver-enriched transcriptional inhibitory protein to disrupt the association of CREB-binding protein and RNA polymerase 11 with the phosphoenolpyruvate carboxykinase gene promoter. J. Biol. Chem. 277:32234-32242.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 32234-32242
-
-
Duong, D.T.1
Waltner-Law, M.E.2
Sears, R.3
Sealy, L.4
Granner, D.K.5
-
8
-
-
0032845209
-
Regulation and functions of the protein C anticoagulant pathway
-
Esmon, C. T., J. M. Gu, J. Xu, D. Qu, D. J. Stearns-Kurosawa, and S. Kurosawa. 1999. Regulation and functions of the protein C anticoagulant pathway. Haematologica 84:363-368.
-
(1999)
Haematologica
, vol.84
, pp. 363-368
-
-
Esmon, C.T.1
Gu, J.M.2
Xu, J.3
Qu, D.4
Stearns-Kurosawa, D.J.5
Kurosawa, S.6
-
9
-
-
0042530424
-
Endothelial protein C receptor-dependent inhibition of human eosinophil chemotaxis by protein C
-
Feistritzer, C., D. H. Sturn, N. C. Kaneider, A. Djanani, and C. J. Wiedermann. 2003. Endothelial protein C receptor-dependent inhibition of human eosinophil chemotaxis by protein C. J. Allergy Clin. Immunol. 112:375-381.
-
(2003)
J. Allergy Clin. Immunol.
, vol.112
, pp. 375-381
-
-
Feistritzer, C.1
Sturn, D.H.2
Kaneider, N.C.3
Djanani, A.4
Wiedermann, C.J.5
-
10
-
-
0033810792
-
Protein C levels as a prognostic indicator of outcome in sepsis and related diseases
-
Fisher, C. J., and S. B. Yan. 2000. Protein C levels as a prognostic indicator of outcome in sepsis and related diseases. Crit. Care Med. 28:S49-S56.
-
(2000)
Crit. Care Med.
, vol.28
-
-
Fisher, C.J.1
Yan, S.B.2
-
11
-
-
0034917319
-
Recombinant human activated protein C: A system modulator of vascular function for treatment of severe sepsis
-
Grinnell, B., and D. E. Joyce. 2001. Recombinant human activated protein C: a system modulator of vascular function for treatment of severe sepsis. Crit. Care Med. 29:S53-S61.
-
(2001)
Crit. Care Med.
, vol.29
-
-
Grinnell, B.1
Joyce, D.E.2
-
12
-
-
3142730480
-
Evaluation of protein C and other biomarkers as predictors of mortality in a rat cecal ligation and puncture model of sepsis
-
Heuer, J. G., G. R. Sharma, B. Gerlitz, T. Zhang, D. L. Bailey, C. Ding, D. T. Berg, D. Perkins, E. J. Stephens, K. C. Holmes, R. L. Grubbs, K. A. Fynboe, Y. F. Chen, B. Grinnell, and J. A. Jakubowski. 2004. Evaluation of protein C and other biomarkers as predictors of mortality in a rat cecal ligation and puncture model of sepsis. Crit. Care Med. 32:1570-1578.
-
(2004)
Crit. Care Med.
, vol.32
, pp. 1570-1578
-
-
Heuer, J.G.1
Sharma, G.R.2
Gerlitz, B.3
Zhang, T.4
Bailey, D.L.5
Ding, C.6
Berg, D.T.7
Perkins, D.8
Stephens, E.J.9
Holmes, K.C.10
Grubbs, R.L.11
Fynboe, K.A.12
Chen, Y.F.13
Grinnell, B.14
Jakubowski, J.A.15
-
14
-
-
0035815747
-
Gene expression profile of antithrombotic protein C defines new mechanisms modulating inflammation and apoptosis
-
Joyce, D. E., L. Gelbert, A. Ciaccia, B. Dehoff, and B. W. Grinnell. 2001. Gene expression profile of antithrombotic protein C defines new mechanisms modulating inflammation and apoptosis. J. Biol. Chem. 276:11199-11203.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 11199-11203
-
-
Joyce, D.E.1
Gelbert, L.2
Ciaccia, A.3
Dehoff, B.4
Grinnell, B.W.5
-
15
-
-
0036250817
-
Recombinant human activated protein C attenuates the inflammatory response in endothelium and monocytes by modulating nuclear factor-κB
-
Joyce, D. E., and B. W. Grinnell. 2002. Recombinant human activated protein C attenuates the inflammatory response in endothelium and monocytes by modulating nuclear factor-κB. Crit. Care Med. 30:S288-293.
-
(2002)
Crit. Care Med.
, vol.30
-
-
Joyce, D.E.1
Grinnell, B.W.2
-
16
-
-
2942738936
-
Leukocyte and endothelial cell interactions in sepsis: Relevance of the protein C pathway
-
Joyce, D. E., D. R. Nelson, and B. W. Grinnell. 2004. Leukocyte and endothelial cell interactions in sepsis: relevance of the protein C pathway. Crit. Care Med. 32:S280-S286.
-
(2004)
Crit. Care Med.
, vol.32
-
-
Joyce, D.E.1
Nelson, D.R.2
Grinnell, B.W.3
-
17
-
-
2942744467
-
Severe protein C deficiency predicts early death in severe sepsis
-
Macias, W. L., and D. R. Nelson. 2004. Severe protein C deficiency predicts early death in severe sepsis. Crit. Care Med. 32:S223-S228.
-
(2004)
Crit. Care Med.
, vol.32
-
-
Macias, W.L.1
Nelson, D.R.2
-
18
-
-
0033860427
-
Prognostic value of protein C levels in neutropenic patients at high risk of severe septic complications
-
Mesters, R., H. Helterbrand, B. G. Utterback, S. B. Yan, B. Chao, and J. A. Fernandez. 2000. Prognostic value of protein C levels in neutropenic patients at high risk of severe septic complications. Crit. Care Med. 28:2209-2216.
-
(2000)
Crit. Care Med.
, vol.28
, pp. 2209-2216
-
-
Mesters, R.1
Helterbrand, H.2
Utterback, B.G.3
Yan, S.B.4
Chao, B.5
Fernandez, J.A.6
-
19
-
-
0038682435
-
Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease activated receptor-1 and endothelial cell protein C receptor
-
Mosnier, L. O., and J. H. Griffin. 2003. Inhibition of staurosporine-induced apoptosis of endothelial cells by activated protein C requires protease activated receptor-1 and endothelial cell protein C receptor. Biochem. J. 373:65-70.
-
(2003)
Biochem. J.
, vol.373
, pp. 65-70
-
-
Mosnier, L.O.1
Griffin, J.H.2
-
20
-
-
3042820686
-
Prevention of endothelial cell injury by activated protein C: The molecular mechanism(s) and therapeutic implications
-
Okajima, K. 2004. Prevention of endothelial cell injury by activated protein C: the molecular mechanism(s) and therapeutic implications. Curr. Vasc. Pharmacol. 2:125-133.
-
(2004)
Curr. Vasc. Pharmacol.
, vol.2
, pp. 125-133
-
-
Okajima, K.1
-
21
-
-
11344281556
-
An international sepsis survey: A study of doctors' knowledge and perception about sepsis
-
Poeze, M., G. Ramsay, H. Gerlach, F. Rubulotta, and M. Levy. 2004. An international sepsis survey: a study of doctors' knowledge and perception about sepsis. Critical Care (London) 8:R409-R413.
-
(2004)
Critical Care (London)
, vol.8
-
-
Poeze, M.1
Ramsay, G.2
Gerlach, H.3
Rubulotta, F.4
Levy, M.5
-
22
-
-
0037221521
-
Association between hepatocyte nuclear factor 6 (HNF-6) and FoxA2 DNA binding domains stimulates FoxA2 transcriptional activity but inhibits HNF-6 DNA binding
-
Rausa, F., Y. Tan, and R. Costa. 2003. Association between hepatocyte nuclear factor 6 (HNF-6) and FoxA2 DNA binding domains stimulates FoxA2 transcriptional activity but inhibits HNF-6 DNA binding. Mol. Cell. Biol. 23:437-449.
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 437-449
-
-
Rausa, F.1
Tan, Y.2
Costa, R.3
-
23
-
-
0037036069
-
Activation of endothelial cell protease activated receptor 1 by the protein C pathway
-
Riewald, M., R. Petrovan, A. Donner, B. Mueller, and W. Ruf. 2002. Activation of endothelial cell protease activated receptor 1 by the protein C pathway. Science 296:1880-1882.
-
(2002)
Science
, vol.296
, pp. 1880-1882
-
-
Riewald, M.1
Petrovan, R.2
Donner, A.3
Mueller, B.4
Ruf, W.5
-
24
-
-
0034456899
-
Activated protein C inhibits tumor necrosis factor and macrophage migration inhibitory factor production in monocytes
-
Schmide-Supprian, M., C. Murphy, B. White, M. Lawler, A. Kapurniotu, W. Voelter, O. Smith, and J. Bernhagen. 2000. Activated protein C inhibits tumor necrosis factor and macrophage migration inhibitory factor production in monocytes. Eur. Cytokine Netw. 11:407-413.
-
(2000)
Eur. Cytokine Netw.
, vol.11
, pp. 407-413
-
-
Schmide-Supprian, M.1
Murphy, C.2
White, B.3
Lawler, M.4
Kapurniotu, A.5
Voelter, W.6
Smith, O.7
Bernhagen, J.8
-
25
-
-
0037284514
-
Chemokines in the pathogenesis of liver disease: So many players with poorly defined roles
-
Simpson, K. J., N. C. Henderson, C. L. Bone-Larson, N. W. Lukacs, C. M. Hogaboam, and S. L. Kunkel. 2003. Chemokines in the pathogenesis of liver disease: so many players with poorly defined roles. Clin. Sci. 104:47-63.
-
(2003)
Clin. Sci.
, vol.104
, pp. 47-63
-
-
Simpson, K.J.1
Henderson, N.C.2
Bone-Larson, C.L.3
Lukacs, N.W.4
Hogaboam, C.M.5
Kunkel, S.L.6
-
26
-
-
0028805704
-
Two mutations in the promoter region of the human protein C gene both cause type 1 protein C deficiency by disruption of two HNF-3 binding sites
-
Spek, C. A., J. S. Greengard, J. H. Griffin, R. M. Bertina, and P. H. Reitsma. 1995. Two mutations in the promoter region of the human protein C gene both cause type 1 protein C deficiency by disruption of two HNF-3 binding sites. J. Biol. Chem. 270:24216-24221.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 24216-24221
-
-
Spek, C.A.1
Greengard, J.S.2
Griffin, J.H.3
Bertina, R.M.4
Reitsma, P.H.5
-
27
-
-
0032562761
-
Type 1 protein C deficiency caused by disruption of a hepatocyte nuclear factor (HNF)-6/HNF-1 binding site in the human protein C gene promoter
-
Spek, C. A., V. J. Lannoy, F. P. Lemaigre, G. G. Rousseau, R. M. Bertina, and P. H. Reitsma. 1998. Type 1 protein C deficiency caused by disruption of a hepatocyte nuclear factor (HNF)-6/HNF-1 binding site in the human protein C gene promoter. J. Biol. Chem. 273:10168-10173.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 10168-10173
-
-
Spek, C.A.1
Lannoy, V.J.2
Lemaigre, F.P.3
Rousseau, G.G.4
Bertina, R.M.5
Reitsma, P.H.6
-
28
-
-
0043240071
-
Expression and function of the endothelial protein C receptor in human neutrophils
-
Sturn, D. H., N. C. Kaneider, C. Feistritzer, A. Djanani, K. Fukudome, and C. J. Wiedermann. 2003. Expression and function of the endothelial protein C receptor in human neutrophils. Blood 102:1499-1505.
-
(2003)
Blood
, vol.102
, pp. 1499-1505
-
-
Sturn, D.H.1
Kaneider, N.C.2
Feistritzer, C.3
Djanani, A.4
Fukudome, K.5
Wiedermann, C.J.6
-
29
-
-
0029801303
-
Characterization of human protein C gene promoter: Insights from natural human mutants
-
Tsay, W., Y. M. Lee, S. C. Lee, M. C. Shen, and P. J. Chen. 1996. Characterization of human protein C gene promoter: insights from natural human mutants. DNA Cell Biol. 15:907-919.
-
(1996)
DNA Cell Biol.
, vol.15
, pp. 907-919
-
-
Tsay, W.1
Lee, Y.M.2
Lee, S.C.3
Shen, M.C.4
Chen, P.J.5
-
30
-
-
0030953245
-
Synergistic transactivation of HNF-1α, HNF-3, and NF-I contributes to the activation of the liver-specific protein C gene
-
Tsay, W., Y. M. Lee, S. C. Lee, M. C. Shen, and P. J. Chen. 1997. Synergistic transactivation of HNF-1α, HNF-3, and NF-I contributes to the activation of the liver-specific protein C gene. DNA Cell Biol. 16:569-577.
-
(1997)
DNA Cell Biol.
, vol.16
, pp. 569-577
-
-
Tsay, W.1
Lee, Y.M.2
Lee, S.C.3
Shen, M.C.4
Chen, P.J.5
-
31
-
-
3142680906
-
Activated protein C induces endothelial cell proliferation by mitogen-activated protein kinase activation in vitro and angiogenesis in vivo
-
Uchiba, M., K. Okajima, Y. Oike, Y. Ito, K. Fukudome, H. Isobe, and T. Suda. 2004. Activated protein C induces endothelial cell proliferation by mitogen-activated protein kinase activation in vitro and angiogenesis in vivo. Circ. Res. 95:34-41.
-
(2004)
Circ. Res.
, vol.95
, pp. 34-41
-
-
Uchiba, M.1
Okajima, K.2
Oike, Y.3
Ito, Y.4
Fukudome, K.5
Isobe, H.6
Suda, T.7
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