Association between hepatocyte nuclear factor 6 (HNF-6) and FoxA2 DNA binding domains stimulates FoxA2 transcriptional activity but inhibits HNF-6 DNA binding

Molecular and Cellular Biology

Volumn 23, Issue 2, 2003, Pages 437-449

  Rausa, Francisco M ^a   Tan, Yongjun ^a   Costa, Robert H ^a  

^a UNIVERSITY OF ILLINOIS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; GLUCOSE TRANSPORTER 2; HEPATOCYTE NUCLEAR FACTOR 3ALPHA; HEPATOCYTE NUCLEAR FACTOR 3BETA; HEPATOCYTE NUCLEAR FACTOR 3GAMMA; HEPATOCYTE NUCLEAR FACTOR 6; PROTEIN; PROTEIN P300; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DNA BINDING; GENE ACTIVATION; GENE EXPRESSION; GENE FUNCTION; GENE INTERACTION; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DNA BINDING; PROTEIN FUNCTION; TRANSCRIPTION INITIATION; WESTERN BLOTTING;

ADENOVIRIDAE; AMINO ACID MOTIFS; ANIMALS; BINDING SITES; BLOTTING, WESTERN; CARCINOMA, HEPATOCELLULAR; DNA; DNA, COMPLEMENTARY; DNA-BINDING PROTEINS; E1A-ASSOCIATED P300 PROTEIN; GLUTATHIONE TRANSFERASE; HEPATOCYTE NUCLEAR FACTOR 3-BETA; HEPATOCYTE NUCLEAR FACTOR 6; HOMEODOMAIN PROTEINS; HUMANS; LIVER; LUCIFERASES; MICROSCOPY, FLUORESCENCE; MODELS, BIOLOGICAL; MODELS, GENETIC; NUCLEAR PROTEINS; PLASMIDS; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RATS; RECOMBINANT FUSION PROTEINS; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR CELLS, CULTURED;

ADENOVIRIDAE; MUS MUSCULUS;

EID: 0037221521     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.23.2.437-449.2003     Document Type: Article

References (54)

1. Cereghini, S., M. Blumenfeld, and M. Yaniv. 1988. A liver-specific factor essential for albumin transcription differs between differentiated and dedifferentiated rat hepatoma cells. Genes Dev. 2:957-974.
2. Chan, H. M., and N. B. La Thangue. 2001. p300/CBP proteins: HATs for transcriptional bridges and scaffolds. J. Cell Sci. 114:2363-2373.
3. Chen, H., M. Tini, and R. M. Evans. 2001. HATs on and beyond chromatin. Curr, Opin. Cell. Biol. 13:218-224.
4. Clark, K. L., E. D. Halay, E. Lai, and S. K. Burley. 1993. Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5. Nature 364:412-420.
5. Clotman, F., V. J. Lannoy, M. Reber, S. Cereghini, D. Cassiman, P. Jacquemin, T. Roskams, G. G. Rousseau, and F. P. Lemaigre. 2002. The onecut transcription factor HNF6 is required for normal development of the biliary tract. Development 129:1819-1828.
6. Costa, R. H., and D. R. Grayson. 1991. Site-directed mutagenesis of hepatocyte nuclear factor (HNF) binding sites in the mouse transthyretin (transthyretin) promoter reveal synergistic interactions with its enhancer region. Nucleic Acids Res. 19:4139-4145.
7. Costa, R. H., D. R. Grayson, and J. E. Darnell, Jr. 1989. Multiple hepatocyte-enriched nuclear factors function in the regulation of transthyretin and α1-antitrypsin genes. Mol. Cell. Biol. 9:1415-1425.
8. Costa, R. H., A.-X. Holterman, F. M. Rausa, and G. Adami. 2001. Gene regulation and in vivo function of liver transcription factors, p. 59-75. In I. M. Arias et al. (ed.), The Liver: Biology and Pathobiology, 4th Ed. Lippincott Williams & Wilkins, Philadelphia, Pa.
9. Costa, R. H., V. V. Kalinichenko, and L. Lim. 2001. Transcription factors in mouse lung development and function. Am. J. Physiol. Lung Cell Mol. Physiol. 280:L823-L838.
10. Courtois, G., S. Baumhueter, and G. R. Crabtree. 1988. Purified hepatocyte nuclear factor 1 interacts with a family of hepatocyte-specific promoters. Proc. Natl. Acad. Sci. USA 85:7937-7941.
11. DiPersio, C. M., D. A. Jackson, and K. S. Zaret. 1991. The extracellular matrix coordinately modulates liver transcription factors and hepatocyte morphology. Mol. Cell. Biol. 11:4405-4414.
12. Duncan, S. A. 2000. Transcriptional regulation of liver development. Dev. Dyn. 219:131-142.
13. Grayson, D. R., R. H. Costa, K. G. Xanthopoulos, and J. E. Darnell. 1988. One factor recognizes the liver-specific enhancers in α1-antitrypsin and transthyretin genes. Science 239:786-788.
14. Guo, Y., R. Costa, H. Ramsey, T. Starnes, G. Vance, K. Robertson, M. Kelley, R. Reinbold, H. Scholer, and R. Hromas. 2002. The embryonic stem cell transcription factors Oct-4 and FoxD3 interact to regulate endodermalspecific promoter expression. Proc. Natl. Acad. Sci. USA 99:3663-3667.
15. Hatzis, P., and I. Talianidis. 2001. Regulatory mechanisms controlling human hepatocyte nuclear factor 4a gene expression. Mol. Cell. Biol. 21:7320-7330.
16. Herbst, R. S., U. Nielsch, F. Sladek, E. Lai, L. E. Babiss, and J. E. Darnell, Jr. 1991. Differential regulation of hepatocyte-enriched transcription factors explains changes in albumin and transthyretin gene expression among hepatoma cells. New Biol. 3:289-296.
17. Jacob, A., S. Budhiraja, X. Qian, D. Clevidence, R. H. Costa, and R. R. Reichel. 1994. Retinoic acid-mediated activation of HNF-3α during EC stem cell differentiation. Nucleic Acids Res. 22:2126-2133.
18. Jacquemin, P., S. M. Durviaux, J. Jensen, C. Godfraind, G. Gradwohl, F. Guillemot, O. D. Madsen, P. Carmeliet, M. Dewerchin, D. Collen, G. G. Rousseau, and F. P. Lemaigre. 2000. Transcription factor hepatocyte nuclear factor 6 regulates pancreatic endocrine cell differentiation and controls expression of the proendocrine gene ngn3. Mol. Cell. Biol. 20:4445-4454.
19. Kaestner, K. H. 2000. The hepatocyte nuclear factor 3 (HNF3 or FOXA) family in metabolism. Trends Endocrinol. Metab. 11:281-285.
20. Kaestner, K. H., W. Knochel, and D. E. Martinez. 2000. Unified nomenclature for the winged-helix/forkhead transcription factors. Genes Dev. 14:142-146.
21. Kaufmann, E., and W. Knochel. 1996. Five years on the wings of fork head. Mech. Dev. 57:3-20.
22. Lai, E., V. R. Prezioso, E. Smith, O. Litvin, R. H. Costa, and J. E. Darnell, Jr. 1990. HNF-3A, a hepatocyte-enriched transcription factor of novel structure is regulated transcriptionally. Genes Dev. 4:1427-1436.
23. Lai, E., V. R. Prezioso, W. F. Tao, W. S. Chen, and J. E. Darnell, Jr. 1991. Hepatocyte nuclear factor 3a belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head. Genes Dev. 5:416-427.
24. Landry, C., F. Clotman, T. Hioki, H. Oda, J. J. Picard, F. P. Lemaigre, and G. G. Rousseau. 1997. HNF-6 is expressed in endoderm derivatives and nervous system of the mouse embryo and participates to the cross-regulatory network of liver-enriched transcription factors. Dev. Biol. 192:247-257.
25. Lannoy, V. J., T. R. Burglin, G. G. Rousseau, and F. P. Lemaigre. 1998. Isoforms of hepatocyte nuclear factor-6 differ in DNA-binding properties, contain a bifunctional homeodomain, and define the new ONECUT class of homeodomain proteins. J. Biol. Chem. 273:13552-13562.
26. Lannoy, V. J., A. Rodolosse, C. E. Pierreux, G. G. Rousseau, and F. P. Lemaigre. 2000. Transcriptional stimulation by hepatocyte nuclear factor-6. Target-specific recruitment of either CREB-binding protein (CBP) or p300/CBP-associated factor (p/CAF). J. Biol. Chem. 275:22098-22103.
27. Lemaigre, F. P., S. M. Durviaux, and G. G. Rousseau. 1993. Liver-specific factor binding to the liver promoter of a 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase gene. J. Biol. Chem. 268:19896-19905.
28. Lemaigre, F. P., S. M. Durviaux, O. Truong, V. J. Lannoy, J. J. Hsuan, and G. G. Rousseau. 1996. Hepatocyte nuclear factor 6, a transcription factor that contains a novel type of homeodomain and a single cut domain. Proc. Natl. Acad. Sci. USA 93:9460-9464.
29. Liu, J. K., C. M. DiPersio, and K. S. Zaret. 1991. Extracellular signals that regulate liver transcription factors during hepatic differentiation in vitro. Mol. Cell. Biol. 11:773-784.
30. Monaci, P., A. Nicosia, and R. Cortese. 1988. Two different liver-specific factors stimulate in vitro transcription from the human al-antitrypsin promoter. EMBO J. 7:2075-2087.
31. Monaghan, A. P., K. H. Kaestner, E. Grau, and G. Schutz. 1993. Postimplantation expression patterns indicate a role for the mouse forkhead/HNF-3 α, β and γ genes in determination of the definitive endoderm, chordamesoderm and neuroectoderm. Development 119:567-578.
32. Naar, A. M., B. D. Lemon, and R. Tjian. 2001. Transcriptional coactivator complexes. Annu. Rev. Biochem. 70:475-501.
33. Narlikar, G. J., H. Y. Fan, and R. E. Kingston. 2002. Cooperation between complexes that regulate chromatin structure and transcription. Cell 108:475-487.
34. Overdier, D. G., A. Porcella, and R. H. Costa. 1994. The DNA-binding specificity of the hepatocyte nuclear factor 3/forkhead domain is influenced by amino acid residues adjacent to the recognition helix. Mol. Cell. Biol. 14:2755-2766.
35. Pani, L., D. G. Overdier, A. Porcella, X. Qian, E. Lai, and R. H. Costa. 1992. Hepatocyte nuclear factor 3β contains two transcriptional activation domains, one of which is novel and conserved with the Drosophila forkhead protein. Mol. Cell. Biol. 12:3723-3732.
36. Pani, L., X. B. Qian, D. Clevidence, and R. H. Costa. 1992. The restricted promoter activity of the liver transcription factor hepatocyte nuclear factor 3β involves a cell-specific factor and positive autoactivation. Mol. Cell. Biol. 12:552-562.
37. Park, S. H., and D. J. Wamnan. 2001. Inhibitory cross-talk between STAT5b and liver nuclear factor HNF3β. Impact on the regulation of growth hormone pulse-stimulated, male-specific liver cytochrome P-450 gene expression. J. Biol. Chem. 276:43031-43039.
38. Perl, A. K., and J. A. Whitsett. 1999. Molecular mechanisms controlling lung morphogenesis. Clin. Genet. 56:14-27.
39. Qian, X., and R. H. Costa. 1995. Analysis of HNF-3β protein domains required for transcriptional activation and nuclear targeting. Nucleic Acids Res. 23:1184-1191.
40. Rausa, F., U. Samadani, H. Ye, L. Lim, C. F. Fletcher, N. A. Jenkins, N. G. Copeland, and R. H. Costa. 1997. The cut-homeodomain transcriptional activator HNF-6 is coexpressed with its target gene HNF-3β in the developing murine liver and pancreas. Dev. Biol. 192:228-246.
41. Rausa, F. M., L. Galarneau, B. I. L, and R. H. Costa. 1999. The nuclear receptor fetoprotein transcription factor is coexpressed with its target gene HNF-3β in the developing murine liver intestine and pancreas. Mech. Dev. 89:185-188.
42. Rausa, F. M., Y. Tan, H. Zhou, K. Yoo, D. B. Stolz, S. Watkins, R. R. Franks, T. G. Unterman, and R. H. Costa. 2000. Elevated levels of HNF-3β in mouse hepatocytes influence expression of genes involved in bile acid and glucose homeostasis. Mol. Cell. Biol. 20:8264-8282.
43. Roth, S. Y., J. M. Denu, and C. D. Allis. 2001. Histone acetyltransferases. Annu. Rev. Biochem. 70:81-120.
44. Samadani, U., and R. H. Costa. 1996. The transcriptional activator hepatocyte nuclear factor six regulates liver gene expression. Mol. Cell. Biol. 16: 6273-6284.
45. Samadani, U., A. Porcella, L. Pani, P. F. Johnson, J. Burch, R. Pine, and R. H. Costa. 1995. Cytokine regulation of the liver transcription factor HNF-3β is mediated by the C/EBP family and interferon regulatory factor 1. Cell Growth Differ. 6:879-890.
46. Soutoglou, E., N. Katrakili, and I. Talianidis. 2000. Acetylation regulates transcription factor activity at multiple levels. Mol. Cell 5:745-751.
47. Streeper, R. S., L. A. Hornbuckle, C. A. Svitek, J. K. Goldman, J. K. Oeser, and R. M. O'Brien. 2001. Protein kinase A phosphorylates hepatocyte nuclear factor-6 and stimulates glucose-6-phosphatase catalytic subunit gene transcription. J. Biol. Chem. 276:19111-19118.
48. Tan, Y., G. Adami, and R. H. Costa. 2002. Maintaining HNF-6 expression prevents AdHNF3β Mediated decrease in hepatic levels of Glut2 and glycogen. Hepatology 35:790-798.
49. Tan, Y., R. H. Costa, I. Kovesdi, and R. R. Reichel. 2001. Adenovirusmediated increase of HNF-3 levels stimulates transthyretin and sonic hedgehog expression which is associated with F9 cell differentiation toward the visceral endoderm lineage. Gene Expr. 9:237-248.
50. Tan, Y., D. E. Hughes, X. Wang, and R. H. Costa. 2002. Adenovirus-mediated hepatic increase in HNF-3β or HNF-3α shows differences in levels of liver glycogen and gene expression. Hepatology 35:30-39.
51. Wang, J. C., M. Waltner-Law, K. Yamada, H. Osawa, S. Stifani, and D. K. Granner. 2000. Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3β. J. Biol. Chem. 275:18418-18423.
52. Wang, X., E. Quail, N.-J. Hung, Y. Tan, H. Ye, and R. H. Costa. 2001. Increased levels of forkhead box M1B transcription factor in transgenic mouse hepatocytes prevents age-related proliferation defects in regenerating liver. Proc. Natl. Acad. Sci. USA 98:11468-11473.
53. Ye, H., T. F. Kelly, U. Samadani, L. Lim, S. Rubio, D. G. Overdier, K. A. Roebuck, and R. H. Costa. 1997. Hepatocyte nuclear factor 3/fork head homolog 11 is expressed in proliferating epithelial and mesenchymal cells of embryonic and adult tissues. Mol. Cell. Biol. 17:1626-1641.
54. Zaret, K. 1999. Developmental competence of the gut endoderm: Genetic potentiation by GATA and HNF3/fork head proteins. Dev. Biol. 209:1-10.