Glucocorticoid regulation of diverse cognitive functions in normal and pathological emotional states

Neuroscience and Biobehavioral Reviews

Volumn 27, Issue 3, 2003, Pages 233-246

  Erickson, Kristine ^a   Drevets, Wayne ^a   Schulkin, Jay ^b,c  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

Author keywords

Amygdala; Cognition; Depression; Emotion; Glucocorticoids; Medial prefrontal; Orbitofrontal

Indexed keywords

ACETYLCHOLINE; ANGIOTENSIN; CORTICOSTERONE; CORTICOTROPIN RELEASING FACTOR; DOPAMINE; GLUCOCORTICOID; GLUTAMIC ACID; HYDROCORTISONE; NEUROPEPTIDE; NEUROPEPTIDE Y; NEUROTRANSMITTER; NORADRENALIN; SEROTONIN; VASOPRESSIN;

ADAPTATION; AMYGDALOID NUCLEUS; ANXIETY; AROUSAL; ATTENTION; BEHAVIORAL SCIENCE; BRAIN DEPTH STIMULATION; BRAIN FUNCTION; BRAIN LEVEL; BRAIN REGION; CHOLINERGIC SYSTEM; COGNITION; DENDRITIC CELL; DEPRESSION; EMOTION; EMOTIONAL ATTACHMENT; FEAR; HIPPOCAMPUS; HORMONAL REGULATION; HORMONE DETERMINATION; HUMAN; HUNGER; MEMORY; MOOD; MOOD DISORDER; NEUROBIOLOGY; NEUROMODULATION; NEUROPATHOLOGY; NEUROPHYSIOLOGY; NONHUMAN; PAIN; PERCEPTION; PREDICTION; PREFRONTAL CORTEX; PRIORITY JOURNAL; REGULATORY MECHANISM; REVIEW; REWARD; STRESS; TEMPERAMENT; THIRST;

EID: 0038279994     PISSN: 01497634     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0149-7634(03)00033-2     Document Type: Review

References (188)

1. Munck A., Guyre P.M., Holbrook N.J. Physiological functions of glucocorticoids in stress and their relation to pharmacological actions. Endocr Rev. 5:1984;25-44.
2. Swanson L.W., Simmons D.M. Differential steroid hormone and neural influences on peptide mRNA levels in CRH cells of the paraventricular nucleus: a hybridization histochemical study in the rat. J Comp Neurol. 285:1989;413-435.
3. Dallman M., Jones M. Corticosteroid feedback control of ACTH secretion: effect of stress-induced corticosterone secretion on subsequent stress responses in the rat. Endocrinology. 92:1973;1367-1375.
4. de Leon M.J., et al. Cortisol reduces hippocampal glucose metabolism in normal elderly, but not in Alzheimer's disease. J Clin Endocrinol Metab. 82:1997;3251-3259.
5. Endo Y., Nishimura J.I., Kobayashi S., Kimura F. Long-term glucocorticoid treatments decrease local cerebral blood flow in the rat hippocampus, in association with histological damage. Neuroscience. 79:1997;745-752.
6. Schulkin J., McEwen B.S., Gold P.W. Allostasis, amygdala, and anticipatory angst. Neurosci Biobehav Rev. 18:1994;385-396.
7. Watts A.G., Sanchez-Watts G. Region-specific regulation of neuropeptide mRNAs in rat limbic forebrain neurones by aldosterone and corticosterone. J Physiol. 484:(Pt 3):1995;721-736.
8. Sanchez M.M., Young L.J., Plotsky P.M., Insel T.R. Distribution of corticosteroid receptors in the rhesus brain: relative absence of glucocorticoid receptors in the hippocampal formation. J Neurosci. 20:2000;4657-4668.
9. Seckl J.R., Dickson K.L., Yates C., Fink G. Distribution of glucocorticoid and mineralocorticoid receptor messenger RNA expression in human postmortem hippocampus. Brain Res. 561:1991;332-337.
10. Schulkin J. The neuroendocrine regulation of behavior. 1999;Cambridge University Press, New York.
11. Wingfield J.C., Grimm A.S. Seasonal changes in plasma cortisol, testosterone and oestradiol-17beta-in the plaice, Pleuronectes Platesa L. Gen Comp Endocrinol. 31:1977;1-11.
12. Dallman M.F., et al. Feast and famine: critical role of glucocorticoids with insulin in daily energy flow. Front Neuroendocrinol. 14:1993;303-347.
13. Selye H. The stress of life. 1976;McGraw-Hill, New York.
14. McEwen B.S. Stress and hippocampal plasticity. Annu Rev Neurosci. 22:1999;105-122.
15. Adam E.K., Gunnar M.R. Relationship functioning and home and work demands predict individual differences in diurnal cortisol patterns in women. Psychoneuroendocrinology. 26:2001;189-208.
16. Zorrilla E.P., DeRubeis R.J., Redei E. High self-esteem, hardiness and affective stability are associated with higher basal pituitary-adrenal hormone levels. Psychoneuroendocrinology. 20:1995;591-601.
17. Cleare A., Blair D., Chambers S., Wessely S. Urinary free cortisol in chronic fatigue syndrome. Am J Psychiatry. 158:2001;641-643.
18. Heuser I. Anna-Monika-Prize paper. The hypothalamic-pituitary-adrenal system in depression. Pharmacopsychiatry. 31:1998;10-13.
19. Weber B., et al. Increased diurnal plasma concentrations of cortisone in depressed patients. J Clin Endocrinol Metab. 85:2000;1133-1136.
20. Joels M., de Kloet E.R. Mineralocorticoid and glucocorticoid receptors in the brain. Implications for ion permeability and transmitter systems. Prog Neurobiol. 43:1994;1-36.
21. Lopez J.F., Chalmers D.T., Little K.Y., Watson S.J. Regulation of serotonin 1A, glucocorticoid, and mineralocorticoid receptor in rat and human hippocampus: implications for neurobiology of depression. Biol Psychiatry. 43:1998;547-573.
22. Patel P.D., et al. Glucocorticoid and mineralocorticoid receptor mRNA expression in squirrel monkey brain. J Psychiatr Res. 34:2000;383-392.
23. Brooke S.M., de Haas-Johnson A.M., Kaplan J.R., Sapolsky R.M. Characterization of mineralocorticoid and glucocorticoid receptors in primate brain. Brain Res. 637:1994;303-307.
24. Harrison R.W. III, Lippman S.S., Hendry W.J. III, Chien M.C. Isolation of a genomic sublibrary enriched for glucocorticoid-regulated genes. DNA Cell Biol. 9:1990;95-102.
25. Yudt M.R., Cidlowski J.A. The glucocorticoid receptor: coding a diversity of proteins and responses through a single gene. Mol Endocrinol. 16:2002;1719-1726.
26. Brann D.W., Hendry L.B., Mahesh V.B. Emerging diversities in the mechanism of action of steroid hormones. J Steroid Biochem Mol Biol. 52:1995;113-133.
27. Joels M., de Kloet E.R. Control of neuronal excitability by corticosteroid hormones. Trends Neurosci. 15:1992;25-30.
28. Lupien S.J., et al. Stress-induced declarative memory impairment in healthy elderly subjects: relationship to cortisol reactivity. J Clin Endocrinol Metab. 82:1997;2070-2075.
29. Orchinik M., Murray T.F., Moore F.L. A corticosteroid receptor in neuronal membranes. Science. 252:1991;1848-1851.
30. de Quervain D.J., Roozendaal B., McGaugh J.L. Stress and glucocorticoids impair retrieval of long-term spatial memory. Nature. 394:1998;787-790.
31. Moore F., Evans S. Steroid hormones use non-genomic mechanisms to control brain functions and behaviors: a review of evidence. Brain Behav Evol. 54:1999;41-50.
32. Lowry C.A., Burke K.A., Renner K.J., Moore F.L., Orchinik M. Rapid changes in monoamine levels following administration of corticotropin-releasing factor or corticosterone are localized in the dorsomedial hypothalamus. Horm Behav. 39:2001;195-205.
33. Makino S., Gold P.W., Schulkin J. Corticosterone effects on corticotropin-releasing hormone mRNA in the central nucleus of the amygdala and the parvocellular region of the paraventricular nucleus of the hypothalamus. Brain Res. 640:1994;105-112.
34. Fumagalli F., Jones S.R., Caron M.G., Seidler F.J., Slotkin T.A. Expression of mRNA coding for the serotonin transporter in aged vs. young rat brain: differential effects of glucocorticoids. Brain Res. 719:1996;225-228.
35. Szot P., et al. Norepinephrine transporter mRNA is elevated in the locus coeruleus following short- and long-term desipramine treatment. Brain Res. 618:1993;308-312.
36. Patterson T., Zavosh A., Schenk J., Wilkinson C., Figlewicz D. Acute corticosterone incubation in vitro inhibits the function of the dopamine transporter in nucleus accumbens but not striatum of the rat brain. Soc Neurosci Abstr. 23:1997;693.
37. Bouzat C., Barrantes F.J. Modulation of muscle nicotinic acetylcholine receptors by the glucocorticoid hydrocortisone. Possible allosteric mechanism of channel blockade. J Biol Chem. 271:1996;25835-25841.
38. Moghaddam B., Bolinao M.L., Stein-Behrens B., Sapolsky R. Glucocorticoids mediate the stress-induced extracellular accumulation of glutamate. Brain Res. 655:1994;251-254.
39. Kumar B.A., Leibowitz S.F. Impact of acute corticosterone administration on feeding and macronutrient self-selection patterns. Am J Physiol. 254:1988;R222-R228.
40. Beckwith B., Petros T., Scaglione C., Nelson J. Dose-dependent effects of hydrocortisone on memory in human males. Physiol Behav. 36:1986;283-286.
41. Leibowitz S.F. Brain peptides and obesity: pharmacologic treatment. Obes Res. 3:(Suppl. 4):1995;573S-589S.
42. Barrot M., et al. The dopaminergic hyper-responsiveness of the shell of the nucleus accumbens is hormone-dependent. Eur J Neurosci. 12:2000;973-979.
43. Beck K., Luine V. Food deprivation modulates chronic stress effects on object recognition in male rats: role of monoamines and amino acids. Brain Res. 122:1999;883-893.
44. Marinelli M., Aouizerate B., Barrot M., Le Moal M., Piazza P.V. Dopamine-dependent responses to morphine depend on glucocorticoid receptors. Proc Natl Acad Sci USA. 95:1998;7742-7747.
45. Piazza P.V., et al. Corticosterone in the range of stress-induced levels possesses reinforcing properties: implications for sensation-seeking behaviors. Proc Natl Acad Sci USA. 90:1993;11738-11742.
46. Plihal W., Krug R., Pietrowsky R., Fehm H.L., Born J. Corticosteroid receptor mediated effects on mood in humans. Psychoneuroendocrinology. 21:1996;515-523.
47. Schmidt L.A., Fox N.A., Goldberg M.C., Smith C.C., Schulkin J. Effects of acute prednisone administration on memory, attention and emotion in healthy human adults. Psychoneuroendocrinology. 24:1999;461-483.
48. Brown E.S., Khan D.A., Nejtek V.A. The psychiatric side effects of corticosteroids. Ann Allergy Asthma Immunol. 83:1999;495-503. quiz 503-4.
49. Brown E.S., Suppes T., Khan D.A., Carmody I.T. Mood changes during prednisone bursts in outpatients with asthma. J Clin Psychopharmacol. 22:2002;55-61.
50. Wolkowitz O.M., et al. Cognitive effects of corticosteroids. Am J Psychiatry. 147:1990;1297-1303.
51. Douma B.R., et al. Repeated blockade of mineralocorticoid receptors, but not of glucocorticoid receptors impairs food rewarded spatial learning. Psychoneuroendocrinology. 23:1998;33-44.
52. McLay R.N., Freeman S.M., Zadina J.E. Chronic corticosterone impairs memory performance in the Barnes maze. Physiol Behav. 63:1998;933-937.
53. Marinelli M., Piazza P.V. Interaction between glucocorticoid hormones, stress and psychostimulant drugs. Eur J Neurosci. 16:2002;387-394.
54. Deroche V., Marinelli M., Le Moal M., Piazza P.V. Glucocorticoids and behavioral effects of psychostimulants. II: cocaine intravenous self-administration and reinstatement depend on glucocorticoid levels. J Pharmacol Exp Ther. 281:1997;1401-1407.
55. Berridge K.C., Robinson T.E. What is the role of dopamine in reward: hedonic impact, reward learning, or incentive salience? Brain Res Brain Res Rev. 28:1998;309-369.
56. Schultz W., Tremblay L., Hollerman J.R. Reward prediction in primate basal ganglia and frontal cortex. Neuropharmacology. 37:1998;421-429.
57. Piazza P.V., Le Moal M.L. Pathophysiological basis of vulnerability to drug abuse: role of an interaction between stress, glucocorticoids, and dopaminergic neurons. Annu Rev Pharmacol Toxicol. 36:1996;359-378.
58. Inoue T., Koyama T. Effects of acute and chronic administration of high-dose corticosterone and dexamethasone on regional brain dopamine and serotonin metabolism in rats. Prog Neuropsychopharmacol Biol Psychiatry. 20:1996;147-156.
59. Born J., Hitzler V., Pietrowsky R., Pauschinger P., Fehm H.L. Influences of cortisol on auditory evoked potentials (AEPs) and mood in humans. Neuropsychobiology. 20:1989;145-151.
60. Plihal W., Born J. Memory consolidation in human sleep depends on inhibition of glucocorticoid release. Neuroreport. 10:1999;2741-2747.
61. Gunnar M. Psychoendocrine studies of temperament and stress in early childhood: expanding current models. Bates J., Wachs T. Temperament: individual differences at the interface of biology and behavior. 1994;175-198 American Psychological Association, Washington, DC.
62. Granger D.A., Weisz J.R., Kauneckis D. Neuroendocrine reactivity, internalizing behavior problems, and control-related cognitions in clinic-referred children and adolescents. J Abnorm Psychol. 103:1994;267-276.
63. Davis E.P., Donzella B., Krueger W.K., Gunnar M.R. The start of a new school year: individual differences in salivary cortisol response in relation to child temperament. Dev Psychobiol. 35:1999;188-196.
64. Kagan J., Reznick J.S., Snidman N. The physiology and psychology of behavioral inhibition in children. Child Dev. 58:1987;1459-1473.
65. Schmidt L.A., et al. Behavioral and neuroendocrine responses in shy children. Dev Psychobiol. 30:1997;127-140.
66. Newcomer J.W., et al. Decreased memory performance in healthy humans induced by stress-level cortisol treatment. Arch Gen Psychiatry. 56:1999;527-533.
67. Lupien S.J., Gillin C.J., Hauger R.L. Working memory is more sensitive than declarative memory to the acute effects of corticosteroids: a dose-response study in humans. Behav Neurosci. 113:1999;420-430.
68. Jones R., Beuving G., Blokhuis H. Tonic immobility and heterophil/lymphocyte responses of the domestic fowl to corticosterone infusion. Physiol Behav. 42:1988;249-253.
69. Corodimas K.P., LeDoux J.E., Gold P.W., Schulkin J. Corticosterone potentiation of conditioned fear in rats. Ann N Y Acad Sci. 746:1994;392-393.
70. Irwin J., Ahluwalia P., Zacharko R.M., Anisman H. Central norepinephrine and plasma corticosterone following acute and chronic stressors: influence of social isolation and handling. Pharmacol Biochem Behav. 24:1986;1151-1154.
71. Kvetnansky R., et al. Endogenous glucocorticoids restrain catecholamine synthesis and release at rest and during immobilization stress in rats. Endocrinology. 133:1993;1411-1419.
72. Eriksen H.R., Olff M., Murison R., Ursin H. The time dimension in stress responses: relevance for survival and health. Psychiatry Res. 85:1999;39-50.
73. Fehm-Wolfsdorf G., Nagel D. Differential effects of glucocorticoids on human auditory perception. Biol Psychol. 42:1996;117-130.
74. Martel F.L., et al. Salivary cortisol levels in socially phobic adolescent girls. Depress Anxiety. 10:1999;25-27.
75. Roozendaal B. 1999 Curt P Richter award. Glucocorticoids and the regulation of memory consolidation. Psychoneuroendocrinology. 25:2000;213-238.
76. Maratos E.J., Dolan R.J., Morris J.S., Henson R.N., Rugg M.D. Neural activity associated with episodic memory for emotional context. Neuropsychologia. 39:2001;910-920.
77. Braak H., Braak E., Yilmazer D., Bohl J. Functional anatomy of human hippocampal formation and related structures. J Child Neurol. 11:1996;265-275.
78. Price J.L., Amaral D.G. An autoradiographic study of the projections of the central nucleus of the monkey amygdala. J Neurosci. 1:1981;1242-1259.
79. LeDoux J. The emotional brain. 1996;Simon and Schuster, New York.
80. Morris J.S., et al. A neuromodulatory role for the human amygdala in processing emotional facial expressions. Brain. 121:(Pt 1):1998;47-57.
81. Armony J.L., Quirk G.J., LeDoux J.E. Differential effects of amygdala lesions on early and late plastic components of auditory cortex spike trains during fear conditioning. J Neurosci. 18:1998;2592-2601.
82. Morris J.S., Buchel C., Dolan R.J. Parallel neural responses in amygdala subregions and sensory cortex during implicit fear conditioning. Neuroimage. 13:2001;1044-1052.
83. Rubin R.T., Mandell A.J., Crandall P.H. Corticosteroid responses to limbic stimulation in man: localization of stimulus sites. Science. 153:1966;767-768.
84. van Honk J., et al. Conscious and preconscious selective attention to social threat: different neuroendocrine response patterns. Psychoneuroendocrinology. 25:2000;577-591.
85. Buchanan T.W., Brechtel A., Sollers J.J., Lovallo W.R. Exogenous cortisol exerts effects on the startle reflex independent of emotional modulation. Pharmacol Biochem Behav. 68:2001;203-210.
86. McGaugh J.L. Memory - a century of consolidation. Science. 287:2000;248-251.
87. Michiels V., Cluydts R. Neuropsychological functioning in chronic fatigue syndrome: a review. Acta Psychiatr Scand. 103:2001;84-93.
88. Starkman M.N., Giordani B., Berent S., Schork M.A., Schteingart D.E. Elevated cortisol levels in Cushing's disease are associated with cognitive decrements. Psychosom Med. 63:2001;985-993.
89. Roozendaal B., McGaugh J.L. Glucocorticoid receptor agonist and antagonist administration into the basolateral but not central amygdala modulates memory storage. Neurobiol Learn Mem. 67:1997;176-179.
90. De Kloet E.R., Vreugdenhil E., Oitzl M.S., Joels M. Brain corticosteroid receptor balance in health and disease. Endocr Rev. 19:1998;269-301.
91. Kim J.J., Diamond D.M. The stressed hippocampus, synaptic plasticity and lost memories. Nat Rev Neurosci. 3:2002;453-462.
92. Newcomer J., Craft S., Hershey T., Askins K., Bardgett M. Glucocorticoid-induced impairmant in declarative memory performance in adult humans. Neuroscience. 14:1994;2047-2053.
93. Keenan P.A., Jacobson M.W., Soleymani R.M., Newcomer J.W. Commonly used therapeutic doses of glucocorticoids impair explicit memory. Ann N Y Acad Sci. 761:1995;400-402.
94. Kirschbaum C., Wolf O.T., May M., Wippich W., Hellhammer D.H. Stress- and treatment-induced elevations of cortisol levels associated with impaired declarative memory in healthy adults. Life Sci. 58:1996;1475-1483.
95. Lupien S.J., et al. The modulatory effects of corticosteroids on cognition: studies in young human populations. Psychoneuroendocrinology. 27:2002;401-416.
96. de Quervain D.J., Roozendaal B., Nitsch R.M., McGaugh J.L., Hock C. Acute cortisone administration impairs retrieval of long-term declarative memory in humans. Nat Neurosci. 3:2000;313-314.
97. Fink G.R., et al. Cerebral representation of one's own past: neural networks involved in autobiographical memory. J Neurosci. 16:1996;4275-4282.
98. Akirav I., Richter-Levin G. Mechanisms of amygdala modulation of hippocampal plasticity. J Neurosci. 22:2002;9912-9921.
99. Feldman S., Papir-Kricheli D., Dafny N. Single-cell and multiunit activity in freely moving rats after corticosterone administration. Exp Neurol. 80:1983;427-438.
100. Buchanan T.W., Lovallo W.R. Enhanced memory for emotional material following stress-level cortisol treatment in humans. Psychoneuroendocrinology. 26:2001;307-317.
101. Cahill L., Prins B., Weber M., McGaugh J.L. Beta-adrenergic activation and memory for emotional events. Nature. 371:1994;702-704.
102. Quirarte G.L., Roozendaal B., McGaugh J.L. Glucocorticoid enhancement of memory storage involves noradrenergic activation in the basolateral amygdala. Proc Natl Acad Sci USA. 94:1997;14048-14053.
103. Power A.E., Roozendaal B., McGaugh J.L. Glucocorticoid enhancement of memory consolidation in the rat is blocked by muscarinic receptor antagonism in the basolateral amygdala. Eur J Neurosci. 12:2000;3481-3487.
104. Roozendaal B., McGaugh J.L. Amygdaloid nuclei lesions differentially affect glucocorticoid-induced memory enhancement in an inhibitory avoidance task. Neurobiol Learn Mem. 65:1996;1-8.
105. Lyons D.M., et al. Separation induced changes in squirrel monkey hypothalamic-pituitary-adrenal physiology resemble aspects of hypercortisolism in humans. Psychoneuroendocrinology. 24:1999;131-142.
106. Takahashi L.K. Organizing action of corticosterone on the development of behavioral inhibition in the preweanling rat. Brain Res Dev Brain Res. 81:1994;121-127.
107. Pugh C.R., Tremblay D., Fleshner M., Rudy J.W. A selective role for corticosterone in contextual-fear conditioning. Behav Neurosci. 111:1997;503-511.
108. Darlington D.N., Neves R.B., Ha T., Chew G., Dallman M.F. Fed, but not fasted, adrenalectomized rats survive the stress of hemorrhage and hypovolemia. Endocrinology. 127:1990;759-765.
109. Roosevelt T., Ruhmann-Wennhold A., Nelson D. A protective effect of glucocorticoids in hypoxic stress. Am J Physiol. 223:1972;30-33.
110. Udelsman R., et al. Adaptation during surgical stress. A reevaluation of the role of glucocorticoids. J Clin Invest. 77:1986;1377-1381.
111. Butler P.D., Weiss J.M., Stout J.C., Nemeroff C.B. Corticotropin-releasing factor produces fear-enhancing and behavioral activating effects following infusion into the locus coeruleus. J Neurosci. 10:1990;176-183.
112. Davis M., Walker D.L., Lee Y. Roles of the amygdala and bed nucleus of the stria terminalis in fear and anxiety measured with the acoustic startle reflex. Possible relevance to PTSD. Ann N Y Acad Sci. 821:1997;305-331.
113. Schulkin J., Gold P.W., McEwen B.S. Induction of corticotropin-releasing hormone gene expression by glucocorticoids: implication for understanding the states of fear and anxiety and allostatic load. Psychoneuroendocrinology. 23:1998;219-243.
114. Shepard J.D., Barron K.W., Myers D.A. Corticosterone delivery to the amygdala increases corticotropin-releasing factor mRNA in the central amygdaloid nucleus and anxiety-like behavior. Brain Res. 861:2000;288-295.
115. Makino S., Gold P.W., Schulkin J. Effects of corticosterone on CRH mRNA and content in the bed nucleus of the stria terminalis; comparison with the effects in the central nucleus of the amygdala and the paraventricular nucleus of the hypothalamus. Brain Res. 657:1994;141-149.
116. Thompson B.L., Schulkin J., Rosen J.B. Chronic corticosterone enhanced contextual fear conditioning and CRH mRNA expression in the amygdala. 2000;Society for Neuroscience, New Orleans.
117. Cook C.J. Glucocorticoid feedback increases the sensitivity of the limbic system to stress. Physiol Behav. 75:2002;455-464.
118. Lehnert H., Schulz C., Dieterich K. Physiological and neurochemical aspects of corticotropin-releasing factor actions in the brain: the role of the locus coeruleus. Neurochem Res. 23:1998;1039-1052.
119. Schulz C., Lehnert H. Activation of noradrenergic neurons in the locus coeruleus by corticotropin-releasing factor. A microdialysis study. Neuroendocrinology. 63:1996;454-458.
120. Davis M., Whalen P.J. The amygdala: vigilance and emotion. Mol Psychiatry. 6:2001;13-34.
121. Sapolsky R.M. Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. Archives of General Psychiatry. 57:2000;925-935.
122. Starkman M.N., Schteingart D.E. Neuropsychiatric manifestations of patients with Cushing's syndrome. Relationship to cortisol and adrenocorticotropic hormone levels. Arch Intern Med. 141:1981;215-219.
123. McEwen B. Protective and damaging effects of stress mediators. N Engl J Med. 338:1998;171-179.
124. Sapolsky R.M., Uno H., Rebert C.S., Finch C.E. Hippocampal damage associated with prolonged glucocorticoid exposure in primates. J Neurosci. 10:1990;2897-2902.
125. Wellman C.L. Dendritic reorganization in pyramidal neurons in medial prefrontal cortex after chronic corticosterone administration. J Neurobiol. 49:2001;245-253.
126. Michelson D., et al. Bone mineral density in women with depression. N Engl J Med. 335:1996;1176-1181.
127. Stansbury K., Haley D., Koeneker A. Higher cortisol values facilitate spatial memory in toddlers. Brief report. Ann N Y Acad Sci. 911:2000;456-458.
128. Young A.H., Sahakian B.J., Robbins T.W., Cowen P.J. The effects of chronic administration of hydrocortisone on cognitive function in normal male volunteers. Psychopharmacology (Berl). 145:1999;260-266.
129. Keenan P.A., et al. The effect on memory of chronic prednisone treatment in patients with systemic disease. Neurology. 47:1996;1396-1402.
130. Forget H., Lacroix A., Somma M., Cohen H. Cognitive decline in patients with Cushing's syndrome. J Int Neuropsychol Soc. 6:2000;20-29.
131. Roozendaal B., et al. Memory retrieval impairment induced by hippocampal CA3 lesions is blocked by adrenocortical suppression. Nat Neurosci. 4:2001;1169-1171.
132. Roozendaal B., Nguyen B.T., Power A.E., McGaugh J.L. Basolateral amygdala noradrenergic influence enables enhancement of memory consolidation induced by hippocampal glucocorticoid receptor activation. Proc Natl Acad Sci USA. 96:1999;11642-11647.
133. Brand H.S. Anxiety and cortisol excretion correlate prior to dental treatment. Int Dent J. 49:1999;330-336.
134. Schedlowski M., et al. Psychophysiological, neuroendocrine and cellular immune reactions under psychological stress. Neuropsychobiology. 28:1993;87-90.
135. Iidaka T., et al. Neural interaction of the amygdala with the prefrontal and temporal cortices in the processing of facial expressions as revealed by fMRI. J Cogn Neurosci. 13:2001;1035-1047.
136. Williams L.M., et al. Arousal dissociates amygdala and hippocampal fear responses: evidence from simultaneous fMRI and skin conductance recording. Neuroimage. 14:2001;1070-1079.
137. Coplan J.D., et al. Persistent elevations of cerebrospinal fluid concentrations of corticotropin-releasing factor in adult nonhuman primates exposed to early-life stressors: implications for the pathophysiology of mood and anxiety disorders. Proc Natl Acad Sci USA. 93:1996;1619-1623.
138. Steckler T., Holsboer F. Corticotropin-releasing hormone receptor subtypes and emotion. Biol Psychiatry. 46:1999;1480-1508.
139. Baker D.G., et al. Serial CSF corticotropin-releasing hormone levels and adrenocortical activity in combat veterans with posttraumatic stress disorder. Am J Psychiatry. 156:1999;585-588.
140. Heuser I., Yassouridis A., Holsboer F. The combined dexamethasone/CRH test: a refined laboratory test for psychiatric disorders. J Psychiatr Res. 29:1994;341-356.
141. Baghai T.C., et al. Evaluation of a salivary based combined dexamethasone/CRH test in patients with major depression. Psychoneuroendocrinology. 27:2002;385-399.
142. Schmider J., et al. Combined dexamethasone/corticotropin-releasing hormone test in acute and remitted manic patients, in acute depression, and in normal controls: I. Biol Psychiatry. 38:1995;797-802.
143. Van Londen L., et al. Neuropsychological performance and plasma cortisol, arginine vasopressin and oxytocin in patients with major depression. Psychol Med. 28:1998;275-284.
144. Rubinow D.R., Post R.M., Savard R., Gold P.W. Cortisol hypersecretion and cognitive impairment in depression. Arch Gen Psychiatry. 41:1984;279-283.
145. Belanoff J.K., Kalehzan M., Sund B., Fleming Ficek S.K., Schatzberg A.F. Cortisol activity and cognitive changes in psychotic major depression. Am J Psychiatry. 158:2001;1612-1616.
146. Moffoot A.P., et al. Diurnal variation of mood and neuropsychological function in major depression with melancholia. J Affect Disord. 32:1994;257-269.
147. Ellenbogen M.A., Schwartzman A.E., Stewart J., Walker C.D. Stress and selective attention: the interplay of mood, cortisol levels, and emotional information processing. Psychophysiology. 39:2002;723-732.
148. Allen N.B., Trinder J., Brennan C. Affective startle modulation in clinical depression: preliminary findings. Biol Psychiatry. 46:1999;542-550.
149. Murphy F.C., et al. Emotional bias and inhibitory control processes in mania and depression. Psychol Med. 29:1999;1307-1321.
150. Suslow T., Junghanns K., Arolt V. Detection of facial expressions of emotions in depression. Percept Mot Skills. 92:2001;857-868.
151. Bouhuys A.L., Bloem G.M., Groothuis T.G. Induction of depressed and elated mood by music influences the perception of facial emotional expressions in healthy subjects. J Affect Disord. 33:1995;215-226.
152. David A.S. Perceptual asymmetry for happy-sad chimeric faces: effects of mood. Neuropsychologia. 27:1989;1289-1300.
153. Bouhuys A.L., Geerts E., Gordijn M.C. Depressed patients' perceptions of facial emotions in depressed and remitted states are associated with relapse: a longitudinal study. J Nerv Ment Dis. 187:1999;595-602.
154. Mikhailova E.S., Vladimirova T.V., Iznak A.F., Tsusulkovskaya E.J., Sushko N.V. Abnormal recognition of facial expression of emotions in depressed patients with major depression disorder and schizotypal personality disorder. Biol Psychiatry. 40:1996;697-705.
155. Rubinow D.R., Post R.M. Impaired recognition of affect in facial expression in depressed patients. Biol Psychiatry. 31:1992;947-953.
156. Williams J.M., Scott J. Autobiographical memory in depression. Psychol Med. 18:1988;689-695.
157. Kuyken W., Dalgleish T. Autobiographical memory and depression. Br J Clin Psychol. 34:(Pt 1):1995;89-92.
158. Drevets W.C. Neuroimaging and neuropathological studies of depression: implications for the cognitive-emotional features of mood disorders. Curr Opin Neurobiol. 11:2001;240-249.
159. Drevets W.C., et al. Glucose metabolism in the amygdala in depression: relationship to diagnostic subtype and plasma cortisol levels. Pharmacol Biochem Behav. 71:2002;431-447.
160. Thomas K.M., et al. Amygdala response to fearful faces in anxious and depressed children. Arch Gen Psychiatry. 58:2001;1057-1063.
161. Siegle G.J., Steinhauer S.R., Thase M.E., Stenger V.A., Carter C.S. Can't shake that feeling: event-related fMRI assessment of sustained amygdala activity in response to emotional information in depressed individuals. Biol Psychiatry. 51:2002;693-707.
162. Sheline Y.I., et al. Increased amygdala response to masked emotional faces in depressed subjects resolves with antidepressant treatment: an fMRI study. Biol Psychiatry. 50:2001;651-658.
163. Drevets W.C. Neuroimaging studies of mood disorders. Biol Psychiatry. 48:2000;813-829.
164. Drevets W., et al. A functional anatomical study of unipolar depression. J Neurosci. 12:1992;3628-3641.
165. Axelson D., Doraiswamy P.M., McDonald W.M., Boyko O.B., Tupler L.A., Patterson L.J., Nemeroff C.B., Ellinwood E.H. Jr., Krishnan K.R. Hypercortisolemia and hippocampal changes in depression. Psychiatry Res. 47:1993;163-173.
166. Bremner J.D., et al. Hippocampal volume reduction in major depression. Am J Psychiatry. 157:2000;115-118.
167. Mervaala E., et al. Quantitative MRI of the hippocampus and amygdala in severe depression. Psychol Med. 30:2000;117-125.
168. Drevets W., et al. Abnormal hemodynamic responses to facially expressed emotion in major depression. Soc Neurosci Abstr. 27:2001;785.1.
169. Brody A.L., et al. Brain metabolic changes associated with symptom factor improvement in major depressive disorder. Biol Psychiatry. 50:2001;171-178.
170. Drevets W.C., Raichle M.E. Reciprocal suppression of regional cerebral blood flow during emotional versus higher cognitive processes: implications for interactions between emotion and cognition. Cogn Emotion. 12:1998;353-385.
171. Kalin N., Irwin W., Anderle M., Davidson R. Venlafaxine induces early and late changes in the neural circuitry of emotion that correlate with treatment response. Biol Psychiatry. 49:2001;92S.
172. Rajkowska G., et al. Morphometric evidence for neuronal and glial prefrontal cell pathology in major depression. Biol Psychiatry. 45:1999;1085-1098.
173. Rajkowska G. Postmortem studies in mood disorders indicate altered numbers of neurons and glial cells. Biol Psych. 2000;776-777.
174. Drevets W.C., et al. PET imaging of serotonin 1A receptor binding in depression. Biol Psychiatry. 46:1999;1375-1387.
175. Cheetham S.C., Crompton M.R., Katona C.L., Horton R.W. Brain 5-HT2 receptor binding sites in depressed suicide victims. Brain Res. 443:1988;272-280.
176. Cheetham S.C., Crompton M.R., Katona C.L., Horton R.W. Brain 5-HT1 binding sites in depressed suicides. Psychopharmacology (Berl). 102:1990;544-548.
177. Karten Y.J., Stienstra C.M., Joels M. Corticosteroid effects on serotonin responses in granule cells of the rat dentate gyrus. J Neuroendocrinol. 13:2001;233-238.
178. Hesen W., Joels M. Modulation of 5HT1A responsiveness in CA1 pyramidal neurons by in vivo activation of corticosteroid receptors. J Neuroendocrinol. 8:1996;433-438.
179. Meijer O.C., de Kloet E.R. Corticosterone suppresses the expression of 5-HT1A receptor mRNA in rat dentate gyrus. Eur J Pharmacol. 266:1994;255-261.
180. Piazza P.V., et al. Glucocorticoids have state-dependent stimulant effects on the mesencephalic dopaminergic transmission. Proc Natl Acad Sci USA. 93:1996;8716-8720.
181. Barrot M., et al. Influence of glucocorticoids on dopaminergic transmission in the rat dorsolateral striatum. Eur J Neurosci. 13:2001;812-818.
182. Barrot M., et al. The dopaminergic hyper-responsiveness of the shell of the nucleus accumbens is hormone-dependent. Eur J Neurosci. 12:2000;973-979.
183. Dziedzicka-Wasylewska M., Willner P., Papp M. Changes in dopamine receptor mRNA expression following chronic mild stress and chronic antidepressant treatment. Behav Pharmacol. 8:1997;607-618.
184. Papp M., Klimek V., Willner P. Parallel changes in dopamine D2 receptor binding in limbic forebrain associated with chronic mild stress-induced anhedonia and its reversal by imipramine. Psychopharmacology (Berl). 115:1994;441-446.
185. Willner P., Muscat R., Papp M. Chronic mild stress-induced anhedonia: a realistic animal model of depression. Neurosci Biobehav Rev. 16:1992;525-534.
186. Maccari S., et al. Noradrenergic regulation of type-I and type-II corticosteroid receptors in amygdala and hypothalamus. Brain Res. 587:1992;313-318.
187. Cordero M.I., Sandi C. A role for brain glucocorticoid receptors in contextual fear conditioning: dependence upon training intensity. Brain Res. 786:1998;11-17.
188. Gold P.W., Drevets W.C., Charney D.S. New insights into the role of cortisol and the glucocorticoid receptor in severe depression. Biol Psychiatry. 52:2002;381-385.