Regulation of glucocorticoidreceptor-mRNA in human blood cells by amitriptyline and dexamethasone

Journal of Psychiatric Research

Volumn 33, Issue 4, 1999, Pages 303-308

  Vedder, H ^a   Bening Abu Shach, U ^a   Lanquillon, S ^a   Krieg, J C ^a  

^a PHILIPPS UNIVERSITY MARBURG   (Germany)

Author keywords

Antidepressant; Glucocorticoid receptor; Human blood cells

Indexed keywords

AMITRIPTYLINE; ANTIDEPRESSANT AGENT; DEXAMETHASONE; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MESSENGER RNA; TRICYCLIC ANTIDEPRESSANT AGENT;

ADULT; ARTICLE; BLOOD CELL; DENSITOMETRY; HOUSEKEEPING GENE; HUMAN; HUMAN CELL; MALE; NORMAL HUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; BLOOD; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; METABOLISM; PHYSIOLOGY; UPREGULATION;

ADULT; AMITRIPTYLINE; ANTIDEPRESSIVE AGENTS, TRICYCLIC; DEXAMETHASONE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GLUCOCORTICOIDS; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASES; HUMANS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MALE; PITUITARY-ADRENAL SYSTEM; RECEPTORS, GLUCOCORTICOID; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRANSCRIPTION, GENETIC; UP-REGULATION;

EID: 0032587804     PISSN: 00223956     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-3956(99)00006-0     Document Type: Article

References (26)

1. Arana G.W., Santos A.B., Laraia M.T., McLeod-Bryant S., Beale M.D., Rames L.J., Roberts J.M., Dias J.K., Molloy M. Dexamethasone for the treatment of depression: a randomized, placebo-controlled, double-blind trial. Am J Psychiatry. 152:1995;265-267.
2. Barden N., Reul J.M.H.M., Holsboer F. Do antidepressants stabilize mood through actions on the hypothalamic-pituitary-adrenocortical system? Trends Neurosci. 18:1995;6-11.
3. Brady L.S., Whitfield H.J. Jr, Fox R.J., Gold P.W., Herkenham M. Long-term antidepressant adminstration alters corticotropin-releasing homone, tyrosine hydroxylase and mineralocorticoid receptor gene expression in rat brain. Clin Invest. 87:1991;831-837.
4. Calogero A.E., Galluchi W.T., Gold P.W., Chrousos G.P. Multiple feedback regulation loops upon rat hypothalamic corticotropin-releasing hormone secretion: potential clinical implications. J Clin Invest. 82:1988;676-774.
5. Danel-Moore L., Bronnegard M., Gustafsson J.A. Dexamethasone reverses glucocorticoid receptor RNA depression in multi-drug resistant (MDR) myeloma cell lines. Med Oncol Tumor Pharmacother. 9:1992;199-204.
6. Dinan T.G., Lavelle E., Cooney J., Burnett F., Scott L., Dash A., Thakore J., Berti C. Dexamethasone augmentation in treatment-resistant depression. Acta Psychiatr Scand. 95:1997;58-61.
7. Fink G., Rosie R., Sheward W.J., Thomson E., Wilson H. Steroid control of central neuronal interactions and function. J Steroid Biochem Mol Biol. 40:1991;123-132.
8. Heuser I., Yassouridis A., Holsboer F. The combined dexamethasone/CRH test: a refined laboratory test for psychiatric disorders. J Psychiatr Res. 28:1994;341-356.
9. Hofmann J., Kaiser U., Maasberg M., Havemann K. Glucocorticoid receptors and growth inhibitory effects of dexamethasone in human lung cancer cell lines. Eur J Cancer. 31A:1995;2053-2058.
10. Holsboer F. Neuroendocrinology of mood disorders. Bloom F.E., Kupfer D.J. Psychopharmacology: the fourth generation of progress. 1995;957 Raven Press, New York.
11. Holsboer F., Barden N. Antidepressants and hypothalamic-pituitary-adrenocortical regulation. Endocr Rev. 2:1996;187-205.
12. Ihl-Vahl R., Marquetant R., Bremerich J., Strasser R.H. Regulation of beta-adrenergic receptors in acute myocordial ischemia: subtype-selective increase of mRNA specific for beta 1-adrenergic receptors. J Mol Cell Cardiol. 27:1995;437-452.
13. Kaiser U., Hofmann J., Schilli M., Wegmann B., Klotz U., Wedel S., Virmani A.K., Wollmer E., Branscheid D., Gazdar A.F., Havemann K. Steroid-hormone receptors in cell lines and tumor biopsies of human lung cancer. Int J Cancer. 67:1996;357-364.
14. Lebrec H., Blot C., Pequet S., Roger R., Bohuon C., Pallardy M. Immunotoxical investigation using pharmaceutical drugs: in vivo evaluation of immune effects. Fund Appl Toxicol. 23:1994;159-168.
15. Linkowski P., Mendlewicz J., Leclercq R., Brasseur M., Hubain P., Golstein J., Copinschi G., Cauter E.V. The 24-h profile of adrenocorticotropin and cortisol in major depressive illness. J Clin Endocrinol Metab. 61:1985;429-438.
16. 1A receptor expression in adrenally intact rats: implication for the pathogenesis of depression. Neuroscience. 80:1997;419-426.
17. Miller A.H., Spencer R.L., Pulera M., Kang S., McEwen B.S., Stein M. Adrenal steroid receptor activation in rat brain and pituitary following dexamethasone: implications for the dexamethasone suppression test. Biol Psych. 32:1992;850-869.
18. Pariante C.M., Pearce B.D., Pisell T.L., Owens M.J., Miller A.H. Steroid-independent translocation of the glucocorticoid receptor by the antidepressant desipramine. Mol Pharmacol. 52:1997;571-581.
19. Peiffer A., Veilleux S., Barden N. Antidepressant and other centrally-acting drugs regulate glucocorticoid receptor messenger RNA levels in rat brain. Psychoneuroendocrinology. 16:1991;505-515.
20. Pepin M.C., Beaulieu S., Barden N. Antidepressants regulate glucocorticoid receptor messenger RNA concentrations in primary neural cultures. Mol Brain Res. 6:1989;77-83.
21. Pepin M.C., Govindan M.V., Barden N. Increased glucocorticoid receptor gene promoter activity after antidepressant treatment. Mol Pharmacol. 41:1992;1016-1022.
22. Reul J.M.H.M., Labeur M.S., Grigoriadis D.E., De Souza E.B., Holsboer F. Hypothalamic-pituitary-adrenocortical axis change in the rat after long-term treatment with the reversible monoamine oxidase-A inhibitor moclobemide. Neuroendocrinology. 60:1994;509-519.
23. Schreiber W., Lauer C.J., Krumrey K., Holsboer F., Krieg J.C. Dysregulation of the hypothalamo-pituitary-adrenocortical system in panic disorder. Neuropsycho-pharmacology. 15:1996;7-15.
24. Shimojo M., Hiroi N., Yakushiji F., Ueshiba H., Yamaguchi N., Miyachi Y. Differences in down-regulation of glucocorticoid receptor mRNA by cortisol, prednisolone and dexamethasone in HeLa cells. Endocr J. 42:1995;629-636.
25. von Bardeleben U., Holsboer F. Cortisol response to a combined dexamethasone-human corticotropin-releasing hormone challenge in patients with depression. J Neuroendocrinol. 1:1989;485-488.
26. Young E.A., Kwak S.P., Kottak J. Negative feedback regulation following administration of chronic exogenous corticosterone. J Neuroendocrinol. 7:1995;37-45.