Psychiatric genetics: Progress, problems, and potential

Lancet

Volumn 354, Issue SUPPL.1, 1999, Pages 11-14

  Owen, Michael J ^a   Cardno, Alastair G ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOLISM; ALZHEIMER DISEASE; ATTENTION DEFICIT DISORDER; AUTISM; CLINICAL GENETICS; GENE MAPPING; GENETIC SUSCEPTIBILITY; HUMAN; MANIC DEPRESSIVE PSYCHOSIS; MENTAL DISEASE; PHENOTYPE; PRIORITY JOURNAL; SCHIZOPHRENIA; SHORT SURVEY;

EID: 0032764977     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0140-6736(99)90242-8     Document Type: Article

References (30)

1. McGuffin P, Owen MJ, O'Donovan MC, Thapar A, Gottesman I. Seminars in psychiatric genetics. London: Gaskell, 1994.
2. Kendler KS, Neale MC, Kessler RC, Heath AC, Eaves LJ. Major depression and generalized anxiety disorder: same genes, (partly) different environments? Arch Gen Psychiatry 1992; 49: 716-22.
3. Hardy J, Gwinn-Hardy K. Genetic classification of primary neurodegenerative disease. Science 1998; 282: 1075-79.
4. Hardy J, Israel A. Alzheimer's disease: in search of γ-secretase. Nature 1999; 398: 466-67.
5. McGuffin P, Owen MJ. Molecular genetic studies of schizophrenia. Cold Spring Harb Symp Quant Biol 1996; 61: 815-22.
6. Lander E, Kruglyak L. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 1995; 11: 241-47.
7. Suarez BK, Hampe CL, Van Eerdewegh P. Problems of replicating linkage claims in psychiatry. In: Gershon ES, Cloninger CR, eds. Genetic approaches to mental disorders. Washington, DC: American Psychiatric Press, 1994: 23-46.
8. Risch N, Merikangas K. The future of genetic studies of complex human diseases. Science 1996; 273: 1516-17.
9. Owen MJ, Holmans P, McGuffin P. Association studies in psychiatric genetics. Mol Psychiatry 1997; 2: 270-73.
10. Risch N, Teng J. The relative power of family-based and case-control designs for linkage disequilibrium studies of complex human diseases: I. DNA pooling. Genome Res 1998; 8: 1273-88.
11. Corder EH, Saunders AM, Strittmatter WJ, et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 1993; 261: 921-23.
12. National Institute on Aging/Alzheimer's Association Working Group. Apolipoprotein E genotyping in Alzheimer's disease. Lancet 1996; 347: 1091-95.
13. Williams J, Spurlock G, McGuffin P, Owen MJ. Association between schizophrenia and the T102C polymorphism of the 5-hydroxytryptamine type 2a-receptor gene. Lancet 1996; 347: 1294-96.
14. Williams J, McGuffin P, Nothen M, Owen MJ. Meta-analysis of association between the 5 HT2a receptor T102C polymorphism and schizophrenia. Lancet 1997; 349: 1221.
15. Farrer LA, Cupples LA, Haines JL, et al. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease: a meta-analysis. JAMA 1997; 278: 1349-56.
16. Houwen RHJ, Baharloo S, Blankenship K, et al. Genome screening by searching for shared segments: mapping a gene for benign recurrent intrahepatic cholestasis. Nat Genet 1994; 8: 380-86.
17. Kruglyak L. Prospects for whole-genome linkage disequilibrium mapping ofcommon disease genes. Nat Genet 1999; 22: 139-44.
18. Wang DG, Fan JB, Siao CJ, et al. Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome. Science 1998; 280: 1077-82.
19. Kendler KS, Tsuang MT, Hays P. Age at onset in schizophrenia: a familial perspective. Arch Gen Psychiatry 1987; 44: 881-90.
20. Kendler KS, Karkowski-Shuman L, O'Neill FA, Straub RE, MacLean CJ, Walsh D. Resemblance of psychotic symptoms and syndromes in affected sibling pairs from the Irish study of high-density schizophrenia families: evidence for possible etiologic heterogeneity. Am J Psychiatry 1997; 154: 191-98.
21. DeLisi LE. A critical overview of recent investigations into the genetics of schizophrenia. Curr Opin Psychiatry 1999: 12: 29-39.
22. Kruglyak L, Lander ES. Complete multipoint sib-pair analysis of qualitative and quantitative traits. Am J Hum Genet 1995; 57: 439-54.
23. Cardon LR, Smith SD, Fulker DW, Kimberling WJ, Pennington BF, DeFries JC. Quantitative trait locus for reading disability on chromosome 6. Science 1994; 266: 276-79.
24. Page GP, Amos CI. Comparison of linkage-disequilibrium methods for localization of genes influencing quantitative traits in humans. Am J Hum Genet 1999; 64: 1194-205.
25. Waldman ID, Rowe DC, Abramowitz A, et al. Association and linkage of the dopamine transporter gene and attention-deficit hyperactivity disorder in children: heterogeneity owing to diagnostic subtype and severity. A m J Hum Genet 1998; 63: 1767-76.
26. Flint J. Freezel Nat Genet 1997; 17: 250-51.
27. Flint J, Corley R, DeFries JC, et al. A simple genetic-basis for a complex psychological trait in laboratory mice. Science 1995; 269: 1432-35.
28. Murphy KC, Jones LA, Owen MJ. High rates of schizophrenia in adults with velo-cardio-facial syndrome. Arch Gen Psych (in press).
29. Skoultchi AI, Puech A, Saint-Jore B, et al. Comparative mapping of the human and mouse VCFS/DGS syntenic region discloses the presence of a large internal rearrangement. Am J Hum Genet 1997; 61: A296.
30. Nuffield Council on Bioethics. Mental disorders and genetics: the ethical context. London: Nuffield Council on Bioethics, 1998.