Overexpression of hypoxia-inducible factor-1 alpha in gastric adenocarcinoma

Gastric Cancer

Volumn 9, Issue 1, 2006, Pages 44-49

  Urano, Naomi ^a   Fujiwara, Yoshiyuki ^a   Doki, Yuichirou ^a   Tsujie, Masaki ^a   Yamamoto, Hirofumi ^a   Miyata, Hiroshi ^a   Takiguchi, Shuji ^a   Yasuda, Takushi ^a   Yano, Masahiko ^a   Monden, Morito ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

Gastric cancer; Hypoxia inducible factor 1 ; Immunohistochemistry; p53; VEGF

Indexed keywords

CISPLATIN; DOCETAXEL; EPIDERMAL GROWTH FACTOR RECEPTOR 2; EPIRUBICIN; FLUOROURACIL; FOLINIC ACID; HYPOXIA INDUCIBLE FACTOR 1ALPHA; METHOTREXATE; MITOMYCIN C; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PIRARUBICIN; PROTEIN P53; VON HIPPEL LINDAU PROTEIN;

ARTICLE; CANCER CHEMOTHERAPY; CONTROLLED STUDY; GENE CONTROL; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; ONCOGENE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; STOMACH ADENOCARCINOMA; TUMOR SUPPRESSOR GENE;

ADENOCARCINOMA; CELL DIFFERENTIATION; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOENZYME TECHNIQUES; LYMPH NODES; LYMPHATIC METASTASIS; NEOPLASM INVASIVENESS; STOMACH NEOPLASMS; SURVIVAL RATE; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 33645241816     PISSN: 14363291     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10120-005-0356-1     Document Type: Article

References (32)

1. RA Gatenby HB Kessler JS Rosenblum LR Coia PJ Moldofsky WH Hartz 1988 Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy Int J Radiat Oncol Biol Phys 14 831 8
2. GL Semenza 2001 Hypoxia inducible factor 1: oxygen homeostasis and disease pathophysiology Trends Mol Med 7 345 50
3. TN Seagroves HE Ryan H Lu BG Wouters M Knapp P Thibault 2001 Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian calls Mol Cell Biol 21 3436 44
4. R Ravi B Mookerjee ZM Bhujwalla CH Sutter D Artemov Q Zeng 2000 Regulation of tumor angiogenesis by p53 induced degradation of hypoxia-inducible factor 1α Genes Dev 14 34 44
5. AL Kung S Wang JM Klco WG Kaelin DM Livingston 2000 Suppression of tumor growth through disruption of hypoxia inducible transcription Nat Med 6 1335 40
6. N Akakura M Kobayashi I Horiuchi A Suzuki J Wang J Chen 2001 Constitutive expression of hypoxia-inducible factor-1 alpha renders pancreatic cancer cells resistant to apoptosis induced by hypoxia and nutrient deprivation Cancer Res 61 6548 54
7. CL Dalgard H Lu A Mohyedin A Verma 2004 Endogenous 2-oxoacids differentially regulate expression of oxygen sensors Biochem J 380 419 24
8. GL Semnza 2004 Intratumoral hypoxia, radiation resistance, and HIF-1 Cancer Cell 5 405 6
9. E Laughner P Taghavi K Chiles PC Mahon GL Semenza 2001 HER2(neu) signaling increases the rate of hypoxia-inducible factor 1α (HIF-1α) synthesis: novel mechanism for HIF-1 mediated vascular endothelial growth factor expression Mol Cell Biol 21 3995 4004
10. H Zhong K Chiles D Feldser E Laughner C Hanrahan MM Georgescu 2000 Modulation of HIF-1α expression by the epidermal growth factor/phosphatidylinositol 3 kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implication for tumor angiogenesis and therapeutics Cancer Res 60 1541 5
11. W Zundel C Schindler D Haas-Cogan A Koong F Kaper E Chen 2000 Loss of PTEN facilitates HIF-1 mediated gene expression Genes Dev 14 391 6
12. PH Maxwell MS Wiesener GW Chang SC Clifford EC Vaux ME Cockman 1999 The tumor suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis Nature 399 271 5
13. P Jaakkola DR Mole YM Tian MI Wilson J Gielbert SJ Gaskell 2001 Targeting of HIF-α to the von Hippel Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation Science 292 468 72
14. M Ivan K Kondo H Yang W Kim J Valiano M Ohh 2001 HIF-1α targets for VHL mediated destruction by proline hydroxylation: implication for O2 sensing Science 292 464 8
15. D Zagzag H Zhong JM Scalzitti E Laughner JW Simons GL Semenza 2000 Expression of hypoxia-inducible factor-1α in brain tumor: association with angiogenesis, invasion, and progression Cancer 88 2606 18
16. P Birner B Gatterhauer G Oberhuber M Schindl K Rossler A Prodinger 2001 Expression of hypoxia-inducible factor-1α in oligodendroglioma: its impact on prognosis and on neoangigenesis Cancer 92 165 71
17. VE Theodoropoulos A Lazaris F Sofras I Gerzelis V Tsukala I Ghikonti 2004 Hypoxia-inducible factor 1 alpha expression correlates with angiogenesis and unfavorable prognosis in bladder cancer Eur Urol 46 200 8
18. R Bos H Zhang CF Hanrahan ECM Mommers GL Semenza HM Piando 2001 Levels of hypoxia-inducible factor-1α during breast carcinogenesis J Natl Cancer Inst 93 309 14
19. T Kuwa Y Kitada S Tanaka S Onogawa N Matsutani E Kaio 2003 Expression of hypoxia-inducible factor-1 α is associated with tumor vascularization in human colorectal carcinoma Int J Cancer 105 176 81
20. K Nakayama A Kanzaki K Hata H Katabuchi H Okamura K Miyazaki 2002 Hypoxia-inducible factor alpha (HIF-1α) gene expression in human ovarian cancer Cancer Lett 176 215 23
21. P Buchler HA Reber M Buchler S Shrinkante MW Buchler H Friess 2003 Hypoxia-inducible factor 1 regulates vascular endothelial growth factor expression in human pancreatic cancer Pancreas 26 56 64
22. MS Wiesener PM Munchenhagen I Berger NV Morgan J Roigas A Schwiertz 2001 Constitutive activation of hypoxia-inducible gene related to overexpression of hypoxia-inducible factor-1α in clear cell renal carcinoma Cancer Res 61 5215 22
23. OR Saramaki KJ Savinainen NN Nuppponen O Bratt T Visakorpi 2001 Amplification of hypoxia-inducible factor 1 alpha gene in prostate cancer Cancer Genet Cytogenet 128 31 4
24. P Birner M Schindi A Obermair G Breitenecker G Oberhuber 2001 Hypoxia-inducible factor 1α expression in epithelial ovarian cancer tumors: its impact on prognosis and on response to chemotherapy Clin Cancer Res 7 1661 8
25. T Matuyama K Nakanishi T Hayashi Y Yoshizumi S Aiko Y Suzura 2005 Expression of hypoxia-inducible factor-1α in esophageal squamous cell carcinoma Cancer Sci 96 176 82
26. DM Aebersold P Burri KT Beer J Laissue V Djonov RH Greiner 2001 Expression of hypoxia-inducible factor-1α - a novel predictive and prognosis parameter in the radiotherapy of oropharyngeal cancer Cancer Res 61 2911 6
27. MI Koukourakis A Giatromanolaki J Skarlatos L Corti S Blandamurra M Piaaza 2001 Hypoxia inducible factor (HIF-1α and HIF-2α) expression in early esophageal cancer and response to photodynamic therapy and radiotherapy Cancer Res 61 1830 2
28. NJP Beasley R Leek M Alam H Turley GJ Cox K Gatter 2002 Hypoxia-inducible factor HIF-1α and HIF-2α in head and neck cancer: relationship to tumor biology and treatment outcome in surgically resected patients Cancer Res 62 2493 7
29. JOA Forsythe BH Jiang N Iyer F Agani SW Leung RD Koos 1996 Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1 Mol Cell Biol 16 4604 13
30. Y Liu SR Cox T Morita S Kourembanas 1995 Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Identification of a 5'enhancer Circ Res 77 638 43
31. O Stoeltzing MF [tmp] McCarty JS Wey F Fan W Liu A Belcheva 2004 Role of hypoxia-inducible factor 1α in gastric cancer cell growth, angiogenesis, and vessel maturation J Natl Cancer Inst 96 946 56
32. SP Huang MS Wu CT Shun HP Wang CY Hsieh ML Kuo 2005 Cyclooxygenase-2 increases hypoxia-inducble factor-1 and vascular endothelial growth factor to promote angiogenesis in gastric carcinoma J Biomed Sci 12 229 41