Leptin receptor-deficient obese Zucker rats reduce their food intake in response to hypobaric hypoxia

American Journal of Physiology - Endocrinology and Metabolism

Volumn 290, Issue 3, 2006, Pages

  Simler, Nadine ^a   Grosfeld, Alexandra ^b,c   Peinnequin, André ^a   Guerre Millo, Michèle ^b,c   Bigard, André Xavier ^a  

^a CENTRE DE RECHERCHES   (France)

^b INSERM   (France)

^c SORBONNE UNIVERSITÉ   (France)

Author keywords

Adipose tissue; Altitude; Anorexia; Energy balance

Indexed keywords

GLUCOSE; INSULIN; LEPTIN; LEPTIN RECEPTOR; NEUROPEPTIDE Y; VASCULOTROPIN; CELL SURFACE RECEPTOR; MESSENGER RNA; VASCULAR ENDOTHELIAL GROWTH FACTOR A, RAT; VASCULOTROPIN A;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANOREXIA; ARTICLE; CONTROLLED STUDY; FOOD INTAKE; GLUCOSE BLOOD LEVEL; HEMATOCRIT; HYPOBARISM; HYPOPHAGIA; HYPOTHALAMUS; HYPOXIA; INSULIN BLOOD LEVEL; LEAN BODY WEIGHT; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; OBESITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; RAT; RAT STRAIN; REAL TIME POLYMERASE CHAIN REACTION; WEIGHT CHANGE; WEIGHT REDUCTION; ANIMAL; ANOXIA; BODY WEIGHT; CHEMISTRY; EATING; GENE EXPRESSION; GENETICS; METABOLISM; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ZUCKER RAT;

ADIPOSE TISSUE; ANIMALS; ANOXIA; BODY WEIGHT; EATING; GENE EXPRESSION; HEMATOCRIT; LEPTIN; MALE; NEUROPEPTIDE Y; OBESITY; RATS; RATS, ZUCKER; RECEPTORS, CELL SURFACE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 33645089966     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00289.2005     Document Type: Article

References (54)

1. Ahima RS and Flier JS. Leptin. Annu Rev Physiol 62: 413-437, 2000.
2. Ambrosini G, Nath AK, Sierra-Honigmann MR, and Flores-Riveros J. Transcriptional activation of the human leptin gene in response to hypoxia. J Biol Chem 277: 34601-34609, 2002.
3. Bennett BD, Solar GP, Yuan JQ, Thomas GR, and Mattews W. A role for leptin and its cognate in hematopoiesis. Curr Biol 6: 1170-1180, 1996.
4. Bigard AX, Douce P, Merino D, Lienhard F, and Guezennec CY. Changes in dietary protein intake fail to prevent decrease in muscle growth induced by severe hypoxia in rats. J Appl Physiol 80: 208-215, 1996.
5. Chin K, Shimizu K, Nakamura T, Narai N, Masuzaki H, Ogawa Y, Mishima M, Nakamura T, Nakao K, and Ohi M. Changes in intraabdominal visceral fat and serum leptin levels in patients with obstructive sleep apnea syndrome following nasal continuous positive airway pressure therapy. Circulation 100: 706-712, 1999.
6. Chua SC, White DW, Wu-Peng XS, Okada N, Kershaw EE, Chung WK, Power-Kehoe L, Chua M, Tartaglia LA, and Leibel RL. Phenotype of fatty due to Gln269Pro mutation in the leptin receptor (Lepr). Diabetes 45: 1141-1143, 1996.
7. Cusin I, Rohner-Jeanrenaud F, Stricker-Krongrad A, and Jeanrenaud B. The weight-reducing effect of an intracerebroventricular bolus injection of leptin in genetically obese fa/fa rats. Reduced sensitivity compared with lean animals. Diabetes 45: 1446-1450, 1996.
8. Daneshrad Z, Novel-Chate V, Birot O, Serrurier B, Sanchez H, Bigard AX, and Rossi A. Diet restriction plays an important role in the alterations of heart mitochondrial function following exposure of young rats to chronic hypoxia. Pflügers Arch 442: 12-18, 2001.
9. Faggioni R, Fuller J, Feingold KR, and Grunfeld C. LPS-induced anorexia in leptin-deficient (ob/ob) and leptin receptor-deficient (db/db) mice. Am J Physiol Regul Integr Comp Physiol 273: R181-R186, 1997.
10. Friedman MI, Harris RB, Ramirez I, and Tordoff MG. Fatty acid oxidation affects food intake by altering hepatic energy status. Am J Physiol Regul Integr Comp Physiol 276: R1046-R1053, 1999.
11. Gettys TW, Harkness PJ, and Watson PM. The beta 3-adrenergic receptor inhibits insulin-stimulated leptin secretion from isolated rat adipocytes. Endocrinology 137: 4054-4057, 1996.
12. Gilbert M, Magnan C, Turban S, André J, and Guerre-Millo M. Leptin receptor-deficient obese Zucker rats reduce their food intake in response to a systemic supply of calories from glucose. Diabetes 52: 277-282, 2003.
13. Grosfeld A, André J, Haugel-de Mouzon S, Berra E, Pouysségur J, and Guerre-Millo M. Hypoxia-inducible factor 1 transactivates the human leptin gene promoter. J Biol Chem 45: 42953-42957, 2002.
14. Grosfeld A, Turban S, André J, Cauzac M, Challier JC, Hauguel-de-Mouzon S, and Guerre-Millo M. Transcriptional effect of hypoxia on placental leptin. FEBS Lett 502: 122-126, 2001.
15. Grosfeld A, Zilberfarb V, Turban S, André J, Guerre-Millo M, and Issad T. Hypoxia increases leptin expression in human PAZ6 adipose cells. Diabetologia 45: 527-530, 2002.
16. Iida M, Murakami T, Ishida K, Mizuno A, Kuwajima M, and Shima K. Substitution at codon 269 (glutamine - proline) of the leptin receptor (OB-R) cDNA is the only mutation found in the Zucker fatty (fa/fa) rat. Biochem Biophys Res Commun 224: 597-604, 1996.
17. Ip MS, Lam KS, Ho C, Tsang KW, and Lam W. Serum leptin and vascular risk factors in obstructive sleep apnea. Chest 118: 580-586, 2000.
18. Kayser B. Nutrition and high altitude exposure. Int J Sports Med 13: S129-S132, 1992.
19. Kosaki A, Yamada K, and Kuzuya H. Reduced expression of the leptin gene (ob) by catecholamine through a G(S) protein-coupled pathway in 3T3-L1 adipocytes. Diabetes 45: 1744-1749, 1996.
20. Krzywicki HJ, Consolazio CF, Johnson HL, Nielsen WC, and Barhart RA. Water metabolism in humans during high altitude exposure (4300 m). J Appl Physiol 30: 806-809, 1971.
21. Livak KJ and Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2[Delta Delta C(T)] method. Methods 25: 402-408, 2001.
22. Loftus TM, Jaworsky DE, Frehywot GL, Townsend CA, Ronnett GV, Lane MD, and Kuhajda FP. Reduced food-intake and body weight in mice treated with fatty acid synthase inhibitors. Science 288: 2379-2381, 2000.
23. Lolmede K, Durand de Saint Front V, Galitzky J, Lafontan M, and Bouloumie A. Effects of hypoxia on the expression of proangiogenic factors in differentiated 3T3-F442 adipocytes. Int J Obes Relat Metab Disord 27: 1187-1195, 2003.
24. Lugarini F, Hrupa BJ, Schwartz GJ, Plata-Salaman CR, and Langhans W. Acute and chronic administration of immunomodulators induces anorexia in Zucker rats. Physiol Behav 84: 165-173, 2005.
25. Meißner U, Hänisch C, Östreicher I, Knerr I, Hofbauer KH, Blum W, Allabauer I, Rascher W, and Dötsch J. Differential regulation of leptin synthesis in rats during short-term hypoxia and short-term carbon monoxide inhalation. Endocrinology 146: 215-220, 2005.
26. Moran TH, Kornbluh R, Moore K, and Schwartz GJ. Cholecystokinin inhibits gastric emptying and contracts the pyloric sphincter in rats by interacting with low affinity CCK receptor sites. Regul Pept 52: 165-172, 1994.
27. Mory G, Wiel M, Adli H, Diot-Dupuy F, Ferre P, and Bazin R. Impaired beta-adrenergic signalling pathway in white adipocytes of suckling fa/fa Zucker rats: a defect in receptor coupling. Int J Obes Relat Metab Disord 25: 1592-1598, 2001.
28. Paxinos G and Watson C. The Rat Brain in Stereotaxic Coordinates (2nd ed.). San Diego, CA: Academic, 1986.
29. Peinnequin A, Mouret C, Birot O, Alonso A, Mathieu J, Clarençon D, Agay D, Chancerelle Y, and Multon E. Rat pro-inflammatory cytokine and cytokine related mRNA quantification by real-time polymerase chain reaction using SYBR green. BMC Immunol 5: 3, 2004.
30. Phillips MS, Liu Q, Hammond HA, Dugan V, Hey PJ, Caskey CJ, and Hess JF. Leptin receptor missense mutation in the fatty Zucker rat. Nat Genet 13: 18-19, 1996.
31. Polotsky VY, Li J, Punjabi NM, Rubin AE, Smith PL, Schwartz AR, and O'Donnell C. Intermittent hypoxia increases insulin resistance in genetically obese mice. J Physiol 552: 253-264, 2003.
32. Post GB, Lujan C, San Miquel JL, Kemper HC. The nutritional intake of Bolivian boys. The relation between altitude and socioeconomic status. Int J Sports Med 15: S100-S105, 1994.
33. Preedy VS, Smith DM, and Sugden PH. The effects of 6 hours hypoxia on protein synthesis in rat tissues in vivo and in vitro. Biochem J 228: 179-185, 1985.
34. Raff H, Bruder ED, and Jankowski BM. The effect of hypoxia on plasma leptin and insulin in newborn and juvenile rats. Endocrine 11: 37-39, 1999.
35. Raff H. Total and active ghrelin in developing rats during hypoxia. Endocrine 21: 159-161, 2003.
36. Ramos E, Meguid M, Campos A, and Coelho J. Neuropeptide Y, α-melanocyte-stimulating hormone, and monoamines in food intake regulation. Nutrition 21: 269-279, 2005.
37. Rayner DV and Trayhurn P. Regulation of leptin production: sympathetic nervous system interactions. J Mol Med 79: 8-20, 2001.
38. Richalet JP. The heart and the adrenergic system. In: Hypoxia, the Adaptations, edited by Sutton JR, Coates G, and Remmers JE. New York: Dekker, 1990.
39. Rohner-Jeanrenaud F. Neuroendocrine regulation of nutrient partitioning. Ann NY Acad Sci 892: 261-271, 1999.
40. Schwartz MW and Porte D. Diabetes, obesity, and the brain. Science 307: 375-379, 2005.
41. Schwartz MW, Woods SC, Porte D, Seeley RJ, and Baskin DG. Central nervous system control of food intake. Nature 404: 661-671, 2000.
42. Schwartz MW, Woods SC, Seeley RJ, Barsch GS, Baskin DG, and Leibel RL. Is the energy homeostasis system inherently biased toward weight gain? Diabetes 52: 132-238, 2003.
43. Semenza GL. HIF-1: mediator of physiological and pathophysiological responses to hypoxia. J Appl Physiol 88: 1474-1480, 2000.
44. Slieker LJ, Sloop KW, Surface PL, Kriauciunas A, LaQuier F, Manetta J, Bue-Valleskey J, and Stephens TW. Regulation of expression of ob mRNA and protein by glucocorticoids and cAMP. J Biol Chem 271: 5301-5304, 1996.
45. Sridharan K, Malhotra MS, Upadhayay TN, Grover SK, and Dua GL. Changes in gastro-intestinal function in humans at an altitude of 3,500 m. Eur J Appl Physiol 50: 145-154, 1982.
46. Tschöp M, Strasburger CJ, Hartmann G, Biollaz J, and Bärtsch P. Raised leptin concentrations at high altitude associated with loss of appetite. Lancet 352: 1119-1120, 1998.
47. Turnbull AV and Rivier C. Corticotropin-releasing factor (CRF) and endocrine responses to stress: CRF receptors, binding protein, and related peptides. Proc Soc Exp Biol Med 215: 1-10, 1997.
48. Vasselli JR, Chu K, and Maggio CA. Differential responsiveness of Zucker obese (fa/fa), lean (Fa/Fa) and Sprague-Dawley (S-D) rats to sc injections of murine leptin (rMuLep). FASEB J 11: A357, 1997.
49. Wang T, Hartzell DL, Flatt WP, Martin RJ, and Bailey CA. Responses of lean and obese Zucker rats to centrally administered leptin. Physiol Behav 65: 233-241, 1998.
50. Westerterp KR, Kayser B, Wouters L, Le Trong JL, and Richalet JP. Energy balance at high altitude of 6542m. J Appl Physiol 77: 862-866, 1994.
51. Westerterp KR, Meijer EP, Rubbens M, Robach P, and Richalet JP. Operation Everest III: energy and water balance. Pflügers Arch 439: 483-488, 2000.
52. Westerterp-Plantenga MS, Westerterp KR, Rubbens M, Verwegen CRT, Richalet JP, and Gardette B. Appetite at "high altitude" [Operation Everest III (Comex-'97)]: a simulated ascent of Mount Everest. J Appl Physiol 87: 391-399, 1999.
53. Westerterp-Plantenga MS. Effects of extreme environments on food intake in human subjects. Proc Nutr Soc 58: 791-798, 1999.
54. Zaccaria M, Ermolao A, Bonvici P, Travain G, and Varnier M. Decreased serum leptin levels during prolonged high altitude. Eur J Appl Physiol 92: 249-253, 2004.