Acute and chronic administration of immunomodulators induces anorexia in Zucker rats

Physiology and Behavior

Volumn 84, Issue 1, 2005, Pages 165-173

  Lugarini, F ^a   Hrupka, B J ^a   Schwartz, G J ^b   Plata Salaman, C R ^c   Langhans, W ^a  

^a SWISS FEDERAL INSTITUTE OF TECHNOLOGY   (Switzerland)

^b Department of Obstetrics Gynecology   (United States)

^c Johnson Johnson Pharmaceutical R D   (United States)

Author keywords

Anorexia; Body weight; Cytokines; Feeding; Food intake; Genotype; Interleukin; Leptin; Obesity

Indexed keywords

IMMUNOMODULATING AGENT; INTERLEUKIN 1; LEPTIN; LIPOPOLYSACCHARIDE; MURAMYL DIPEPTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANOREXIA; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; FOOD INTAKE; GENOTYPE; INTERMETHOD COMPARISON; LEAN BODY WEIGHT; MALE; NONHUMAN; OBESITY; OSMOTIC PUMP; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT STRAIN; WEIGHT GAIN; WEIGHT REDUCTION;

EID: 11844271446     PISSN: 00319384     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.physbeh.2004.11.003     Document Type: Article

References (58)

1. A. Adam, and E. Lederer Muramyl peptides: immunomodulators, sleep factors, and vitamins Med. Res. Rev. 4 1984 111 152
2. R.S. Ahima, D. Prabakaran, C. Mantzoros, D. Qu, B. Lowell, and E. Maratos-Flier Role of leptin in the neuroendocrine response to fasting Nature 382 1996 250 252
3. C.R. Alving Lipopolysaccharide, lipid A, and liposomes containing lipid A as immunologic adjuvants Immunobiology 187 1993 430 446
4. D. Arsenijevic, I. Garcia, C. Vesin, D. Vesin, Y. Arsenijevic, and J. Seydoux Differential roles of tumor necrosis factor-alpha and interferon-gamma in mouse hypermetabolic and anorectic responses induced by LPS Eur. Cytokine Netw. 11 2000 662 668
5. C.A. Baile, M.A. Della-Fera, and R.J. Martin Regulation of metabolism and body fat mass by leptin Annu. Rev. Nutr. 20 2000 105 127
6. H. Baumann, K.R. Prowse, K.A. Won, S. Marinkovic, and G.P. Jahreis Regulation of acute phase protein genes by hepatocyte-stimulating factors, monokines and glucocorticoids Tokai J. Exp. Clin. Med. 13 1988 277 292
7. R.M. Bluthe, S. Laye, B. Michaud, C. Combe, R. Dantzer, and P. Parnet Role of interleukin-1beta and tumour necrosis factor-alpha in lipopolysaccharide-induced sickness behaviour: a study with interleukin-1 type I receptor-deficient mice Eur. J. Neurosci. 12 2000 4447 4456
8. J.L. Bret-Dibat, R.M. Bluthe, S. Kent, K.W. Kelley, and R. Dantzer Lipopolysaccharide and interleukin-1 depress food-motivated behavior in mice by a vagal-mediated mechanism Brain Behav. Immun. 9 1995 242 246
9. B. Burguera, M.E. Couce, G.L. Curran, M.D. Jensen, R.V. Lloyd, and M.P. Cleary Obesity is associated with a decreased leptin transport across the blood-brain barrier in rats Diabetes 49 2000 1219 1223
10. T.A. Callahan, and D.T. Piekut Differential Fos expression induced by IL-1beta and IL-6 in rat hypothalamus and pituitary gland J. Neuroimmunol. 73 1997 207 211
11. L.A. Campfield, F.J. Smith, Y. Guisez, R. Devos, and P. Burn Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks Science 269 1995 546 549
12. S.C. Chua Jr., W.K. Chung, X.S. Wu-Peng, Y. Zhang, S.M. Liu, and L. Tartaglia Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor Science 271 1996 994 996
13. M.J. Dascombe, A. Hardwick, R.A. Lefeuvre, and N.J. Rothwell Impaired effects of interleukin-1 beta on fever and thermogenesis in genetically obese rats Int. J. Obes. 13 1989 367 373
14. H. Doring, K. Schwarzer, B. Nuesslein-Hildesheim, and I. Schmidt Leptin selectively increases energy expenditure of food-restricted lean mice Int. J. Obes. Relat. Metab. Disord. 22 1998 83 88
15. S. Dryden, H.M. Frankish, Q. Wang, and G. Williams Increased feeding and neuropeptide Y (NPY) but not NPY mRNA levels in the hypothalamus of the rat following central administration of the serotonin synthesis inhibitor p-chlorophenylalanine Brain Res. 724 1996 232 237
16. S. Dryden, Q. Wang, H.M. Frankish, and G. Williams Differential effects of the 5-HT 1B/2C receptor agonist mCPP and the 5-HT1A agonist flesinoxan on hypothalamic neuropeptide Y in the rat: evidence that NPY may mediate serotonin's effects on food intake Peptides 17 1996 943 949
17. J.K. Elmquist, T.E. Scammell, C.D. Jacobson, and C.B. Saper Distribution of Fos-like immunoreactivity in the rat brain following intravenous lipopolysaccharide administration J. Comp. Neurol. 371 1996 85 103
18. R. Faggioni, G. Fantuzzi, J. Fuller, C.A. Dinarello, K.R. Feingold, and C. Grunfeld IL-1 beta mediates leptin induction during inflammation Am. J. Physiol. 274 1998 R204 R208
19. R. Faggioni, J. Fuller, A. Moser, K.R. Feingold, and C. Grunfeld LPS-induced anorexia in leptin-deficient (ob/ob) and leptin receptor-deficient (db/db) mice Am. J. Physiol. 273 1997 R181 R186
20. J. Francis, P.S. MohanKumar, S.M. MohanKumar, and S.K. Quadri Systemic administration of lipopolysaccharide increases plasma leptin levels: blockade by soluble interleukin-1 receptor Endocrine 10 1999 291 295
21. J. Gauldie, L. Lamontagne, and A. Stadnyk Acute phase response in infectious disease Surv. Synth. Pathol. Res. 4 1985 126 151
22. C. Grunfeld, C. Zhao, J. Fuller, A. Pollack, A. Moser, and J. Friedman Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters J. Clin. Invest. 97 1996 2152 2157
23. J.L. Halaas, K.S. Gajiwala, M. Maffei, S.L. Cohen, B.T. Chait, and D. Rabinowitz Weight-reducing effects of the plasma protein encoded by the obese gene Science 269 1995 543 546
24. L.K. Heisler, M.A. Cowley, L.H. Tecott, W. Fan, M.J. Low, and J.L. Smart Activation of central melanocortin pathways by fenfluramine Science 297 2002 609 611
25. B.J. Hrupka, and W. Langhans A role for serotonin in lipopolysaccharide- induced anorexia in rats Pharmacol. Biochem. Behav. 68 2001 355 362
26. B.J. Hrupka, and W. Langhans Prostaglandin E2 may act at the raphe nucleus to mediate the anorexia following peripheral lipopolysaccharide administration Appetite 39 2002 80
27. Q.H. Huang, V.J. Hruby, and J.B. Tatro Role of central melanocortins in endotoxin-induced anorexia Am. J. Physiol. 276 1999 R864 R871
28. A.I. Ivanov, and A.A. Romanovsky Fever responses of Zucker rats with and without fatty mutation of the leptin receptor Am. J. Physiol. 282 2002 R311 R316
29. P. Kristensen, M.E. Judge, L. Thim, U. Ribel, K.N. Christjansen, and B.S. Wulff Hypothalamic CART is a new anorectic peptide regulated by leptin Nature 393 1998 72 76
30. W. Langhans Bacterial products and the control of ingestive behavior: clinical implications Nutrition 12 1996 303 315
31. W. Langhans, G. Balkowski, and D. Savoldelli Differential feeding responses to bacterial lipopolysaccharide and muramyl dipeptide Am. J. Physiol. 261 1991 R659 R664
32. W. Langhans, R. Harlacher, G. Balkowski, and E. Scharrer Comparison of the effects of bacterial lipopolysaccharide and muramyl dipeptide on food intake Physiol. Behav. 47 1990 805 813
33. W. Langhans, and B.J. Hrupka Interleukins and tumor necrosis factor as inhibitors of food intake Neuropeptides 33 1999 415 424
34. W. Langhans, F. Lugarini, B.J. Hrupka, G.J. Schwartz, and C.R. Plata-Salaman Chronic lipopolysaccharide (LPS) anorexia is unaltered in obese Zucker rats, but leptin enhances acute LPS anorexia in normal rats Abstr.-Soc. Neurosci. 26 2000 1071
35. W. Langhans, D. Savoldelli, and S. Weingarten Comparison of the feeding responses to bacterial lipopolysaccharide and interleukin-1 beta Physiol. Behav. 53 1993 643 649
36. C.D. McMahon, D.F. Buxton, T.H. Elsasser, D.R. Gunter, L.G. Sanders, and B.P. Steele Neuropeptide Y restores appetite and alters concentrations of GH after central administration to endotoxic sheep J. Endocrinol. 161 1999 333 339
37. J.G. Mercer, N. Hoggard, L.M. Williams, C.B. Lawrence, L.T. Hannah, and P. Trayhurn Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization FEBS Lett. 387 1996 113 116
38. K. Nakamura, Y.Q. Li, T. Kaneko, H. Katoh, and M. Negishi Prostaglandin EP3 receptor protein in serotonin and catecholamine cell groups: a double immunofluorescence study in the rat brain Neuroscience 103 2001 763 775
39. C.R. Plata-Salaman Meal patterns in response to the intracerebroventricular administration of interleukin-1 beta in rats Physiol. Behav. 55 1994 727 733
40. C.R. Plata-Salaman, E. Peloso, and E. Satinoff Cytokine-induced fever in obese (fa/fa) and lean (Fa/Fa) Zucker rats Am. J. Physiol. 275 1998 R1353 R1357
41. C.R. Plata-Salaman, G. Sonti, J.P. Borkoski, C.D. Wilson, and J.M. French-Mullen Anorexia induced by chronic central administration of cytokines at estimated pathophysiological concentrations Physiol. Behav. 60 1996 867 875
42. C.R. Plata-Salaman, J.R. Vasselli, and G. Sonti Differential responsiveness of obese (fa/fa) and lean (Fa/Fa) Zucker rats to cytokine-induced anorexia Obes. Res. 5 1997 36 42
43. M.H. Porter, B.J. Hrupka, W. Langhans, and G.J. Schwartz Vagal and splanchnic afferents are not necessary for the anorexia produced by peripheral IL-1beta, LPS, and MDP Am. J. Physiol. 275 1998 R384 R389
44. E.T. Rietschel, T. Kirikae, F.U. Schade, U. Mamat, G. Schmidt, and H. Loppnow Bacterial endotoxin: molecular relationships of structure to activity and function FASEB J. 8 1994 217 225
45. P. Sarraf, R.C. Frederich, E.M. Turner, G. Ma, N.T. Jaskowiak, and D.J. Rivet III Multiple cytokines and acute inflammation raise mouse leptin levels: potential role in inflammatory anorexia J. Exp. Med. 185 1997 171 175
46. N. Satoh, Y. Ogawa, G. Katsuura, T. Tsuji, H. Masuzaki, and J. Hiraoka Pathophysiological significance of the obese gene product, leptin, in ventromedial hypothalamus (VMH)-lesioned rats: evidence for loss of its satiety effect in VMH-lesioned rats Endocrinology 138 1997 947 954
47. G.J. Schwartz, C.R. Plata-Salaman, and W. Langhans Subdiaphragmatic vagal deafferentation fails to block feeding-suppressive effects of LPS and IL-1 beta in rats. Am. J. Physiol. 273 1997 R1193 R1198
48. M.W. Schwartz, R.J. Seeley, S.C. Woods, D.S. Weigle, L.A. Campfield, and P. Burn Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus Diabetes 46 1997 2119 2123
49. V. Sergeyev, C. Broberger, and T. Hokfelt Effect of LPS administration on the expression of POMC, NPY, galanin, CART and MCH mRNAs in the rat hypothalamus Brain Res. Mol. Brain Res. 90 2001 93 100
50. A.H. Swiergiel, and A.J. Dunn Lack of evidence for a role of serotonin in interleukin-1-induced hypophagia Pharmacol. Biochem. Behav. 65 2000 531 537
51. L.A. Tartaglia, M. Dembski, X. Weng, N. Deng, J. Culpepper, and R. Devos Identification and expression cloning of a leptin receptor, OB-R Cell 83 1995 1263 1271
52. E. Tiligada, and J.F. Wilson Regulation of alpha-melanocyte-stimulating hormone release from superfused slices of rat hypothalamus by serotonin and the interaction of serotonin with the dopaminergic system inhibiting peptide release Brain Res. 503 1989 225 228
53. R. Tocco-Bradley, M. Georgieff, C.T. Jones, L.L. Moldawer, C.A. Dinarello, and G.L. Blackburn Changes in energy expenditure and fat metabolism in rats infused with interleukin-1 Eur. J. Clin. Invest. 17 1987 504 510
54. J.R. Vasselli, and D. Casey Increase responsiveness of Zucker obese rats to the feeding-inhibitory effect of systemic TNFα FASEB J. 10 1996 A823
55. C. von Meyenburg, W. Langhans, and B.J. Hrupka Evidence for a role of the 5-HT2C receptor in central lipopolysaccharide-, interleukin-1 beta-, and leptin-induced anorexia Pharmacol. Biochem. Behav. 74 2003 1025 1031
56. C. von Meyenburg, W. Langhans, and B.J. Hrupka Evidence that the anorexia induced by lipopolysaccharide is mediated by the 5-HT2C receptor Pharmacol. Biochem. Behav. 74 2003 505 512
57. Q. Wang, C. Bing, K. Al Barazanji, D.E. Mossakowaska, X.M. Wang, and D.L. McBay Interactions between leptin and hypothalamic neuropeptide Y neurons in the control of food intake and energy homeostasis in the rat Diabetes 46 1997 335 341
58. H. Xaio, W.A. Banks, M.L. Niehoff, and J.E. Morley Effect of LPS on the permeability of the blood-brain barrier to insulin Brain Res. 896 2001 36 42