Leptin receptor - Deficient obese zucker rats reduce their food intake in response to a systemic supply of calories from glucose

Diabetes

Volumn 52, Issue 2, 2003, Pages 277-282

  Gilbert, Marc ^a   Magnan, Christophe ^a   Turban, Sophie ^b   André, Jocelyne ^b   Guerre Millo, Michèle ^b,c  

^a CNRS   (France)

^b INSERM   (France)

^c CENTRE DE RECHERCHE DES CORDELIERS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2 FUROIC ACID; 5 (TETRADECYCLOXY) 2 FUROIC ACID; ACETYL COENZYME A CARBOXYLASE; GLUCOSE; INSULIN; INSULIN RECEPTOR; LEPTIN; LEPTIN RECEPTOR; MALONYL COENZYME A; UNCLASSIFIED DRUG;

ADAPTATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANOREXIA; ARTICLE; CALORIC INTAKE; CONTROLLED STUDY; FOOD INTAKE; GLUCOSE INFUSION; HYPOPHAGIA; MALE; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SPECIES DIFFERENCE;

ANIMALS; BLOOD GLUCOSE; CEREBRAL VENTRICLES; DIET, REDUCING; DIETARY CARBOHYDRATES; ENERGY INTAKE; FURANS; GLUCOSE CLAMP TECHNIQUE; INJECTIONS, INTRAVENTRICULAR; INSULIN; LEPTIN; OBESITY; RATS; RATS, ZUCKER; RECEPTORS, CELL SURFACE; THINNESS;

EID: 0037312819     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.52.2.277     Document Type: Article

References (37)

1. Seeley RJ, Matson CA, Chavez M, Woods SC, Dallman MF, Schwartz MW: Behavioral, endocrine, and hypothalamic responses to involuntary overfeeding. Am J Physiol 271:R819-R823, 1996
2. Hagan MM, Rushing PA, Schwartz MW, Yagaloff KA, Burn P, Woods SC, Seeley RJ: Role of the CNS melanocortin system in the response to overfeeding. J Neurosci 19:2362-2367, 1999
3. Laybutt DR, Chisholm DJ, Kraegen EW: Specific adaptations in muscle and adipose tissue in response to chronic systemic glucose oversupply in rats. Am J Physiol 273:E1-E9, 1997
4. Cusin I, Dryden S, Wang Q, Rohner-Jeanrenaud F, Jeanrenaud B, Williams G: Effect of sustained physiological hyperinsulinaemia on hypothalamic neuropeptide Y and NPY mRNA levels in the rat. J Neuroendocrinol 7:193-197, 1995
5. Koopmans SJ, Frolich M, Gribnau EH, Westendorp RG, DeFronzo RA: Effect of hyperinsulinemia on plasma leptin concentrations and food intake in rats. Am J Physiol 274:E998-E1001, 1998
6. Wang J, Obici S, Morgan K, Barzilai N, Feng Z, Rossetti L: Overfeeding rapidly induces leptin and insulin resistance. Diabetes 50:2786-2791, 2001
7. Ahima RS, Flier JS: Leptin. Annu Rev Physiol 62:413-437, 2000
8. Cusin I, Rohner-Jeanrenaud F, Stricker-Krongrad A, Jeanrenaud B: The weight-reducing effect of an intracerebroventricular bolus injection of leptin in genetically obese fa/fa rats: reduced sensitivity compared with lean animals. Diabetes 45:1446-1450, 1996
9. Phillips MS, Liu Q, Hammond HA, Dugan V, Hey PJ, Caskey CJ, Hess JF: Leptin receptor missense mutation in the fatty Zucker rat. Nat Genet 13:18-19, 1996
10. Chua SCJ, White DW, Wu-Peng XS, Liu SM, Okada N, Kershaw EE, Chung WK, Power-Kehoe L, Chua M, Tartaglia LA, Leibel RL: Phenotype of fatty due to Gln269Pro mutation in the leptin receptor (Lepr). Diabetes 45:1141-1143, 1996
11. Loftus TM, Jaworsky DE, Frehywot GL, Townsend CA, Ronnett GV, Lane MD, Kuhajda FP: Reduced food intake and body weight in mice treated with fatty acid synthase inhibitors. Science 288:2379-2381, 2000
12. Magnan C, Philippe J, Kassis N, Laury MC, Penicaud L, Gilbert M, Ktorza A: In vivo effects of glucose and insulin on secretion and gene expression of glucagon in rats. Endocrinology 136:5370-5376, 1995
13. Bernard C, Thibault C, Berthault MF, Magnan C, Saulnier C, Portha B, Pralong WF, Penicaud L, Ktorza A: Pancreatic beta-cell regeneration after 48-h glucose infusion in mildly diabetic rats is not correlated with functional improvement. Diabetes 47:1058-1065, 1998
14. Guerre-Millo M, Gervois P, Raspe E, Madsen L, Poulain P, Derudas B, Herbert JM, Winegar DA, Willson TM, Fruchart JC, Berge RK, Staels B: Peroxisome proliferator-activated receptor alpha activators improve insulin sensitivity and reduce adiposity. J Biol Chem 275:16638-16642, 2000
15. Halvorson DL, McCune SA: Inhibition of fatty acid synthesis in isolated adipocytes by 5-(tetradecyloxy)-2-furoic acid. Lipids 19:851-856, 1984
16. Pizer ES, Thupari J, Han WF, Pinn ML, Chrest FJ, Frehywot GL, Townsend CA, Kuhajda FP: Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts. Cancer Res 60:213-218, 2000
17. Magnan C, Gilbert M, Kahn BB: Chronic free fatty acid infusion in rats results in insulin resistance but no alteration in insulin-responsive glucose transporter levels in skeletal muscle. Lipids 31:1141-1149, 1996
18. Ahima RS, Prabakaran D, Mantzoros C, Qu D, Lowell B, Maratos-Flier E, Flier JS: Role of leptin in the neuroendocrine response to fasting. Nature 382:250-252, 1996
19. Barr VA, Malide D, Zarnowski MJ, Taylor SI, Cushman SW: Insulin stimulates both leptin secretion and production by rat white adipose tissue. Endocrinology 138:4463-4472, 1997
20. Bradley RL, Cheatham B: Regulation of ob gene expression and leptin secretion by insulin and dexamethasone in rat adipocytes. Diabetes 48:272-278, 1999
21. Turban S, Hainault I, Andre J, Ferre P, Quignard-Boulange A, Guerre-Millo M: Molecular and cellular mechanisms of adipose secretion: comparison of leptin and angiotensinogen. J Cell Biochem 82:666-673, 2001
22. Mueller WM, Gregoire FM, Stanhope KL, Mobbs CV, Mizuno TM, Warden CH, Stern JS, Havel PJ: Evidence that glucose metabolism regulates leptin secretion from cultured rat adipocytes. Endocrinology 139:551-558, 1998
23. Levy JR, Gyarmati J, Lesko JM, Adler RA, Stevens W: Dual regulation of leptin secretion: intracellular energy and calcium dependence of regulated pathway. Am J Physiol Endocrinol Metab 278:E892-E901, 2000
24. Wang J, Liu R, Hawkins M, Barzilai N, Rossetti L: A nutrient-sensing pathway regulates leptin gene expression in muscle and fat. Nature 393:684-688, 1998
25. Hardie LJ, Rayner DV, Holmes S, Trayhurn P: Circulating leptin levels are modulated by fasting, cold exposure and insulin administration in lean but not Zucker (fa/fa) rats as measured by ELISA. Biochem Biophys Res Commun 223:660-665, 1996
26. Rayner DV, Dalgliesh GD, Duncan JS, Hardie LJ, Hoggard N, Trayhurn P: Postnatal development of the ob gene system: elevated leptin levels in suckling fa/fa rats. Am J Physiol 273:R446-R450, 1997
27. Zhang Y, Olbort M, Schwarzer K, Nuesslein-Hildesheim B, Nicolson M, Murphy E, Kowalski TJ, Schmidt I, Leibel RL: The leptin receptor mediates apparent autocrine regulation of leptin gene expression. Biochem Biophys Res Commun 240:492-495, 1997
28. Turban S, Hainault I, Truccolo J, Andre J, Ferre P, Quignard-Boulange A, Guerre-Millo M: Specific increase in leptin production in obese (fa/fa) rat adipose cells. Biochem J 362:113-118, 2002
29. Mobbs CV, Kow LM, Yang XJ: Brain glucose-sensing mechanisms: ubiquitous silencing by aglycemia vs. hypothalamic neuroendocrine responses. Am J Physiol Endocrinol Metab 281:E649-E654, 2001
30. Ikeda H, West DB, Pustek JJ, Figlewicz DP, Greenwood MR, Porte DJ, Woods SC: Intraventricular insulin reduces food intake and body weight of lean but not obese Zucker rats. Appetite 7:381-386, 1986
31. Schwartz MW, Sipols AJ, Marks JL, Sanacora G, White JD, Scheurink A, Kahn SE, Baskin DG, Woods SC, Figlewicz DP: Inhibition of hypothalamic neuropeptide Y gene expression by insulin. Endocrinology 130:3608-3616, 1992
32. Bruning JC, Gautam D, Burks DJ, Gillette J, Schubert M, Orban PC, Klein R, Krone W, Muller-Wieland D, Kahn CR: Role of brain insulin receptor in control of body weight and reproduction. Science 289:2122-2125, 2000
33. Obici S, Feng Z, Karkanias G, Baskin DG, Rossetti L: Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in rats. Nat Neurosci 5:566-572, 2002
34. Leloup C, Arluison M, Kassis N, Lepetit N, Cartier N, Ferre P, Penicaud L: Discrete brain areas express the insulin-responsive glucose transporter GLUT4. Brain Res Mot Brain Res 38:45-53, 1996
35. Kobayashi M, Nikami H, Morimatsu M, Saito M: Expression and localization of insulin-regulatable glucose transporter (GLUT4) in rat brain. Neurosci Lett 213:103-106, 1996
36. Vannucci SJ, Koehler-Stec EM, Li K, Reynolds TH, Clark R, Simpson IA: GLUT4 glucose transporter expression in rodent brain: effect of diabetes. Brain Res 797:1-11, 1998
37. Obici S, Feng Z, Morgan K, Stein D, Karkanias G, Rossetti L: Central administration of oleic acid inhibits glucose production and food intake. Diabetes 51:271-275, 2002