Responses of lean and obese Zucker rats to centrally administered leptin

Physiology and Behavior

Volumn 65, Issue 2, 1998, Pages 333-341

  Wang, Tianlun ^a,b   Hartzell, Diane L ^a   Flatt, William P ^a   Martin, Roy J ^a   Baile, Clifton A ^a  

^a UNIVERSITY OF GEORGIA   (United States)

^b UNIVERSITY OF GEORGIA   (United States)

Author keywords

Body weight; Food intake; Heat production; Respiratory quotient; Water intake

Indexed keywords

LEPTIN; LEPTIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BODY WEIGHT; CALORIMETRY; CEREBROSPINAL FLUID; CONTROLLED STUDY; FEMALE; FLUID INTAKE; FOOD INTAKE; INTRACEREBROVENTRICULAR DRUG ADMINISTRATION; LIPID METABOLISM; NONHUMAN; OBESITY; PRIORITY JOURNAL; RAT; RESPIRATORY QUOTIENT;

EID: 0031736973     PISSN: 00319384     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0031-9384(98)00173-5     Document Type: Article

References (30)

1. Brouwer, E. Report of sub-committee on constants and factors. In: Blaxter, K.L., ed. Energy Metabolism. Proceedings of the 3rd Symposium, European Assoc. Animal Prod. Publ. 11. London: Academic Press, 1965:441-332.
2. Campfield, L. A.; Smith, F. J.; Guisez, Y.; Devos, R.; Burn, P. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269:546-549; 1995.
3. Chua, Jr., S. C.; Chung, W. K.; Wu-Peng, X. S.; Zhang, Y.; Liu, S-M; Tartaglia, L.; Leibel, R. L. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science 271:994-996; 1996.
4. Chua, Jr., S. C.; White, D. W.; Wu-Peng, X. S.; Liu, S.-M.; Okada, N.; Kershaw, E. E.; Chung, W. K.; Power-Kehoe, L.; Chua, M.; Tartaglia, L. A..; Leibel, R. L. Phenotype of fatty due to Gln269Pro Mutation in the leptin receptor (Lepr). Diabetes 15:1141-1143; 1996.
5. Cusin, I.; Rohner-Jeanrenaud, F.; Stricker-Krongard, A..; Jeanrenaud, B. The weight reducing effect of an intracerebroventricular bolus injection of leptin in genetically obese fa/fa rats: Reduced sensitivity compared with lean animals. Diabetes 45:1446-1450; 1996.
6. Elmquist, J. K.; R. Ahima, R. S.; Maratos-Flier, E.; Flier, J. S.; Saper, C. B. Leptin activates neurons in ventrobasal hypothalamus and brainstem. Endocrinology 138:839-842; 1997.
7. Funahashi, T.; Shimomura, I; Hiraoka, H.; Arai, T.; Takahashi, M.; Nakamura, T.; Nozaki, S; Yamashita, S.; Takemura, K.; Tokunaga, K; Matsuzawa, Y. Enhanced expression of rat obese (ob) gene in adipose tissues of ventromedial hypothalamus (VMH)-lesioned rats. Biochem. Biophys. Res. Commun. 211:469-475; 1995.
8. Ghilardi, N. S; Ziegler, A.; Wiestner, R.; Stoffel, R.; Heim, M. H..; Skoda, R. C. Defective STAT signaling by the leptin receptor in diabetic mice. Proc. Natl. Acad. Sci. USA 93:6231-6235; 1996.
9. Glaum, S. R.; Hara, M.; Bindokas, V. P.; Lee, C. C.; Polonsky, K. S.; Bell, G. I.; Miller, R. J. Leptin, the obese gene product, rapidly modulates synaptic transmission in the hypothalamus. Mol. Pharm. 50:230-235; 1996.
10. Halaas, J. L.; Boozer, C.; Blair-West, J.; Fidahusein, N.; Denton, D. A.; Friedman, J. M. Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. Proc. Natl. Acad. Sci. USA 94:8878-8883; 1997.
11. Haynes, W. G.; Morgan, D. A.; Walsh, S. A.; Mark, A. L.; Sivitz, W. I.. Receptor-mediated regional sympathetic nerve activation by leptin. J. Clin. Invest. 100:270-278; 1997.
12. Haynes, W. G.; Sivitz, W. I.; Morgan, D. A.; Walsh, S. A.; Mark, A. L. Sympathetic and cardiorenal actions of leptin. Hypertension 30:619-623; 1997.
13. Iida, M.; Murakami, T.; Ishida, K.; Mizuno, A.; Kuwajima, M.; Shima, K. Substitution at codon 269 (glutamine→proline) of the leptin receptor (OB-R) cDNA is the only mutation found in the Zucker fatty (fa/fa) rat. Biochem. Biophysical Res. Commun. 224:597-604; 1996.
14. Jackson, E.K.; Li, P. Human leptin may function as a diuretic/natriuretic hormone. Hypertension 28:517; 1996.
15. Lee, G.-H.; Proenca, R.; Montez, J. M.; Carroll, K. M.; Darvishzadeh, J. G.; Lee, J. I.; Friedman, J. M. Abnormal splicing of the leptin receptor in diabetic mice. Nature 379:632-635; 1996.
16. Lin, L.; Truett, G. E.; Levens, N.; York, D. A. Central but not peripheral administration of leptin reduced the food intake and body weight in Zucker fatty (fa/fa) and lean (Fa/?) rats. Obesity Res. 4(Suppl. 10):2s; 1996.
17. Mercer, J. G.; Hoggard, N.; Williams, L. M.; Lawrence, C. B.; Hannah, L. T.; Trayhurn, P. Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEBS Lett. 387:113-116; 1996.
18. Phillips, M. S.; Liu, Q.; Hammond, H. A.; Dugan, V.; Hey, P. J.; Caskey, C. T.; Hess, J. F. Leptin receptor missense mutation in the fatty Zucker rat. Nature Genetics 13:18-19; 1996.
19. Qian, H.; Azain, M. J.; Compton, M. M.; Hartzell, D. L.; Hausman, G. J.; Baile, C. A. Brain administration of leptin causes deletion of adipocytes by apoptosis. Endocrinology 139:791-795; 1998.
20. Seeley, R. J.; Baskin, D. G.; Bernstein, E. M.; Wonner, M. H.; Campfield, L. A.; Schwartz, M. W. i.c.v. leptin (OB protein) suppresses food intake and fasting-induced changes in hypothalamic gene expression for corticotropin releasing factor (CRF) and neuropeptide Y (NPY) in lean but not obese Zucker rats. Soc. Neurosci. Abst. 22:1685; 1996.
21. Seeley, R. J.; Van Dijk, G.; Campfield, L. A.; Smith, F.; Bell, S. M.; Woods, S. C.; Schwartz, M. W. Intracerebroventricular leptin reduces food intake and body weight of lean rats but not obese Zucker rats. Horm. Metab. Res. 28:664-668; 1996.
22. Takaya, K.; Ogawa, Y.; Isse, N.; Okazaki, T.; Satoh, N.; Masuzaki, H.; Mori, K.; Tamura, N.; Hosoda, K.; Nakao, K. Molecular cloning of rat leptin receptor isoform complementary DNAs-identification of a missense mutation in Zucker fatty (fa/fa) rats. Biochem. Biophys. Res. Commun. 225:75-83; 1996.
23. Tartaglia, L. A.; Dembski, M.; Weng, X.; Deng, N.; Culpepper, J.; Devos, R.; Richards, G. J.; Campfield, L. A.; Clark, F. T.; Deeds, J.; Muir, C.; Sanker, S.; Moriarty, A.; Moore, K. J.; Smutko, J. S.; Mays, G. G.; Woolf, E. A.; Monroe, C. A.; Tepper, R. I. Identification and expression cloning of a leptin receptor, OB-R. Cell 83:1263-1271; 1995.
24. Truett, G. E.; Bahary, N.; Friedman, J. M.; Leibel, R. L. Rat obesity gene fatty (fa) maps to chromosome 5: Evidence for homology with the mouse gene diabetes (db). Proc. Natl. Acad. Sci. USA 88:7806-7809; 1991.
25. Vasselli, J. R.; Chu, K.; Maggio, C. A. Differential responsiveness of Zucker obese (fa/fa), lean (Fa/Fa) and Sprague-Dawley (S-D) rats to s.c. injections of murine leptin (rMuLep). FASEB J. 11:A357; 1997.
26. Wang, M.-Y.; Zhou, Y. T.; Newgard, C. B.; Unger, R. H. A novel leptin receptor isoform in rat. FEBS Lett. 392:87-90; 1996.
27. White, D. W.; Wang, Y.; Chua, Jr., S. C.; Morgenstern, J. P.; Leibel, R. L.; Baumann, H.; Tartaglia, L. A. Constitutive and impaired signaling of leptin receptors containing the Gln→Pro extracellular domain fatty mutation. Proc. Natl. Acad. Sci. USA 94:10657-10662; 1997.
28. Wu-Peng, X. S.; Chua, Jr., S. C.; Okada, N.; Liu, S.-M.; Nicolson, M.; Leibel, R. L. Phenotype of the obese Kolesky (f) rat due to Tyr763Stop mutation in the extracellular domain of the leptin receptor (Lepr): Evidence for deficient plasma- to-CSF transport of leptin in both the Zucker and Koletsky obese rat. Diabetes 46:513-518; 1997.
29. Zhang, Y.; Proenca, R.; Maffei, M.; Barone, M.; Leopold, L.; Friedman, J. M. Positional cloning of the mouse obese gene and its human homolog. Nature 372:425-432; 1994.
30. Zucker, L. M.; Zucker, T. F. Fatty, a new mutation in the rat. J. Hered. 52:275-278; 1961.